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NO20031129D0 - Varianter av human koagulasjonsfaktor VII - Google Patents

Varianter av human koagulasjonsfaktor VII

Info

Publication number
NO20031129D0
NO20031129D0 NO20031129A NO20031129A NO20031129D0 NO 20031129 D0 NO20031129 D0 NO 20031129D0 NO 20031129 A NO20031129 A NO 20031129A NO 20031129 A NO20031129 A NO 20031129A NO 20031129 D0 NO20031129 D0 NO 20031129D0
Authority
NO
Norway
Prior art keywords
variants
coagulation factor
human coagulation
factor vii
nucleic acid
Prior art date
Application number
NO20031129A
Other languages
English (en)
Other versions
NO20031129L (no
NO331251B1 (no
Inventor
Egon Persson
Ole Hvilsted Olsen
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/DK2001/000596 external-priority patent/WO2002022776A2/en
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Publication of NO20031129D0 publication Critical patent/NO20031129D0/no
Publication of NO20031129L publication Critical patent/NO20031129L/no
Publication of NO331251B1 publication Critical patent/NO331251B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/647—Blood coagulation factors not provided for in a preceding group or according to more than one of the proceeding groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6437—Coagulation factor VIIa (3.4.21.21)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21021—Coagulation factor VIIa (3.4.21.21)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
NO20031129A 2000-09-13 2003-03-12 Faktor VII-polypeptidvariant, nukleinsyrekonstruksjon, rekombinant vertscelle, ikke-humant transgent dyr, fremgangsmate for fremstilling av faktor VII-poly¬peptidet, samt anvendelse av et faktor VII-polypeptid til fremstilling av et medi¬kament for behandling av blodningsepisoder NO331251B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200001361 2000-09-13
PCT/DK2001/000596 WO2002022776A2 (en) 2000-09-13 2001-09-13 Human coagulation factor vii variants

Publications (3)

Publication Number Publication Date
NO20031129D0 true NO20031129D0 (no) 2003-03-12
NO20031129L NO20031129L (no) 2003-05-12
NO331251B1 NO331251B1 (no) 2011-11-07

Family

ID=8159711

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20031129A NO331251B1 (no) 2000-09-13 2003-03-12 Faktor VII-polypeptidvariant, nukleinsyrekonstruksjon, rekombinant vertscelle, ikke-humant transgent dyr, fremgangsmate for fremstilling av faktor VII-poly¬peptidet, samt anvendelse av et faktor VII-polypeptid til fremstilling av et medi¬kament for behandling av blodningsepisoder

Country Status (11)

Country Link
US (3) US7176288B2 (no)
KR (1) KR100882482B1 (no)
CN (2) CN100475959C (no)
BR (1) BR0113854A (no)
CA (1) CA2420892A1 (no)
CZ (1) CZ2003611A3 (no)
ES (1) ES2429523T3 (no)
MX (1) MXPA03001984A (no)
NO (1) NO331251B1 (no)
RU (1) RU2326126C2 (no)
ZA (1) ZA200301610B (no)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050032690A1 (en) * 1997-09-10 2005-02-10 Rojkjaer Lisa Payne Factor VII polypeptides for preventing formation of inhibitors in subjects with haemophilia
US7786070B2 (en) 1997-09-10 2010-08-31 Novo Nordisk Healthcare A/G Subcutaneous administration of coagulation factor VII
US6747003B1 (en) * 1997-10-23 2004-06-08 Regents Of The University Of Minnesota Modified vitamin K-dependent polypeptides
US7247708B2 (en) * 1997-10-23 2007-07-24 Regents Of The University Of Minnesota Modified vitamin K-dependent polypeptides
JP2003521930A (ja) * 2000-02-11 2003-07-22 マキシゲン・エイピーエス 第ＶＩＩ因子または第ＶＩＩａ因子様分子
US7220837B1 (en) 2000-04-28 2007-05-22 Regents Of The University Of Minnesota Modified vitamin K-dependent polypeptides
US7812132B2 (en) 2000-04-28 2010-10-12 Regents Of The University Of Minnesota Modified vitamin K-dependent polypeptides
US20030211094A1 (en) * 2001-06-26 2003-11-13 Nelsestuen Gary L. High molecular weight derivatives of vitamin k-dependent polypeptides
WO2002038162A1 (en) * 2000-11-09 2002-05-16 The Scripps Research Institute MODIFIED FACTOR VIIa
RU2004134726A (ru) * 2002-04-30 2005-06-10 Максиджен Холдингз Лтд. (Ky) Варианты полипептида фактора vii или viia
CA2840692A1 (en) * 2002-09-30 2004-04-08 Bayer Healthcare Llc Fvii or fviia variants having increased clotting activity
JP4847856B2 (ja) * 2003-03-20 2011-12-28 バイエル ヘルスケア エルエルシー ＦＶＩＩおよびＦＶＩＩａの変種
DK1644504T3 (da) * 2003-06-19 2010-05-25 Bayer Healthcare Llc Faktor VII- eller -VIIA-Gla-domænevarianter
KR20060133575A (ko) * 2004-02-05 2006-12-26 노보 노르디스크 헬스 케어 악티엔게젤샤프트 외상 치료용 인자 ⅴⅰⅰａ의 용도
AU2005274406B2 (en) * 2004-08-17 2010-07-01 Csl Behring Gmbh Modified vitamin K dependent polypeptides
US7846445B2 (en) * 2005-09-27 2010-12-07 Amunix Operating, Inc. Methods for production of unstructured recombinant polymers and uses thereof
JP2009543841A (ja) * 2006-07-17 2009-12-10 ノボ ノルディスク ヘルス ケア アーゲー 増加した活性を有する第ｖｉｉａ因子アナログの新規用途
EP2099475B1 (en) * 2007-01-03 2016-08-24 Novo Nordisk Health Care AG Subcutaneous administration of coagulation factor viia-related polypeptides
EP2147096B1 (en) * 2007-04-13 2015-03-25 Catalyst Biosciences, Inc. Modified factor VII polypeptides and uses thereof
EP2014299A1 (en) * 2007-07-11 2009-01-14 Novo Nordisk A/S Subcutaneous administration of coagulation factor VII
TWI538916B (zh) * 2008-04-11 2016-06-21 介控生化科技公司 經修飾的因子vii多肽和其用途
KR20110017359A (ko) 2008-05-30 2011-02-21 노보 노르디스크 헬스 케어 악티엔게젤샤프트 폴리펩티드 변형 반응의 제어 방법
CN105727261A (zh) 2008-06-27 2016-07-06 杜克大学 包含弹性蛋白样肽的治疗剂
EP2149603A1 (en) * 2008-07-28 2010-02-03 DRK-Blutspendedienst Baden-Württemberg-Hessen gGmbH Factor IX variants with clotting activity in absence of their cofactor and their use for treating bleeding disorders
AU2010290077C1 (en) 2009-08-24 2015-12-03 Bioverativ Therapeutics Inc. Coagulation factor IX compositions and methods of making and using same
EP2633058B1 (en) 2010-10-26 2016-07-20 Hanmi Science Co., Ltd. Method for mass production of factor vii/viia
DK2814840T3 (da) 2012-02-15 2020-02-03 Bioverativ Therapeutics Inc Faktor viii-sammensætninger og fremgangsmåder til fremstilling og anvendelse deraf
US10370430B2 (en) 2012-02-15 2019-08-06 Bioverativ Therapeutics Inc. Recombinant factor VIII proteins
CN104704118A (zh) * 2012-10-15 2015-06-10 诺和诺德保健Ag（股份有限公司） 凝血因子vii多肽
EP3033097B1 (en) 2013-08-14 2021-03-10 Bioverativ Therapeutics Inc. Factor viii-xten fusions and uses thereof
KR102659212B1 (ko) 2015-08-03 2024-04-18 바이오버라티브 테라퓨틱스 인크. 인자 ix 융합 단백질 및 이의 제조 방법 및 사용 방법
IL266972B2 (en) 2016-12-02 2024-04-01 Bioverativ Therapeutics Inc Methods for the treatment of hemophilic arthritis with the help of chimeric blood coagulation factors
MX2020012397A (es) 2018-05-18 2021-04-12 Bioverativ Therapeutics Inc Metodos de tratamiento de la hemofilia a.
US20210069306A1 (en) 2019-08-15 2021-03-11 Catalyst Biosciences, Inc. Modified factor vii polypeptides for subcutaneous administration and on-demand treatment

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR860984B (en) 1985-04-17 1986-08-18 Zymogenetics Inc Expression of factor vii and ix activities in mammalian cells
DK323587D0 (da) 1987-06-25 1987-06-25 Novo Industri As Protein
US5580560A (en) 1989-11-13 1996-12-03 Novo Nordisk A/S Modified factor VII/VIIa
DE69131292T2 (de) * 1990-01-29 1999-09-30 Zymogenetics, Inc. Antikoagulierende proteine
WO1994007515A1 (en) 1992-10-06 1994-04-14 The Scripps Research Institute Mutant tissue factor lacking factor vii activation activity
HU219682B (hu) 1993-05-21 2001-06-28 Novo Nordisk A/S. Módosított VII faktor
US5736364A (en) 1995-12-04 1998-04-07 Genentech, Inc. Factor viia inhibitors
DK0866870T3 (da) 1995-12-01 2003-06-23 Genentech Inc Vævsfaktor-Kunitz-domæne-fusionsproteiner som inhibitorer for faktor Vlla
JPH1059866A (ja) 1996-08-19 1998-03-03 Chemo Sero Therapeut Res Inst 血液凝固第ｖｉｉ因子及び／もしくは活性化血液凝固第ｖｉｉ因子の製造方法
BR9806793A (pt) 1997-01-22 2000-05-16 Univ Texas Processos e composições de fator tissular para coagulação e tratamento de tumores.
WO2001082943A2 (en) 2000-05-03 2001-11-08 Novo Nordisk A/S Subcutaneous administration of coagulation factor vii
US5994296A (en) 1998-03-05 1999-11-30 The Scripps Research Institute Human mutant tissue factor compositions useful as tissue factor antagonists
JP4451514B2 (ja) 1999-08-24 2010-04-14 財団法人化学及血清療法研究所 血液凝固第ｖｉｉ因子改変体
JP2003521930A (ja) * 2000-02-11 2003-07-22 マキシゲン・エイピーエス 第ＶＩＩ因子または第ＶＩＩａ因子様分子
WO2001075086A2 (en) 2000-03-31 2001-10-11 Zymogenetics, Inc. Multi-domain proteinase inhibitor
US6905683B2 (en) * 2000-05-03 2005-06-14 Novo Nordisk Healthcare A/G Human coagulation factor VII variants
EP1282693B1 (en) 2000-05-03 2010-10-20 Novo Nordisk Health Care AG Human coagulation factor vii variants
US7015194B2 (en) * 2000-05-10 2006-03-21 Novo Nordisk A/S Pharmaceutical composition comprising factor VIIa and anti-TFPI
JP2004505016A (ja) 2000-05-10 2004-02-19 ノボ　ノルディスク　アクティーゼルスカブ 第ＶＩＩａ因子及び第ＸＩＩＩ因子を含んで成る医薬組成物
AU2001287550B2 (en) 2000-09-13 2007-03-22 Novo Nordisk Health Care Ag Human coagulation factor VII variants
WO2002038162A1 (en) 2000-11-09 2002-05-16 The Scripps Research Institute MODIFIED FACTOR VIIa
ES2301624T3 (es) 2001-02-05 2008-07-01 Novo Nordisk Health Care Ag Uso combinado de polipeptidos de factor vii y polipeptidos de factor viii.
WO2003027147A2 (en) 2001-09-27 2003-04-03 Novo Nordisk Health Care Ag Human coagulation factor vii polypeptides
US6960657B2 (en) * 2001-11-02 2005-11-01 Novo Nordisk Healthcare A/G Human coagulation factor VII polypeptides
AU2003266214A1 (en) 2002-09-25 2004-04-19 Novo Nordisk A/S Human coagulation factor vii polypeptides

Also Published As

Publication number Publication date
NO20031129L (no) 2003-05-12
US7176288B2 (en) 2007-02-13
US20060252129A1 (en) 2006-11-09
US20030104978A1 (en) 2003-06-05
ZA200301610B (en) 2003-09-05
US7026524B2 (en) 2006-04-11
CN1630721A (zh) 2005-06-22
CZ2003611A3 (cs) 2003-08-13
CN100475959C (zh) 2009-04-08
KR20030067669A (ko) 2003-08-14
RU2326126C2 (ru) 2008-06-10
NO331251B1 (no) 2011-11-07
KR100882482B1 (ko) 2009-02-06
CN101486761A (zh) 2009-07-22
US20030100740A1 (en) 2003-05-29
US7695935B2 (en) 2010-04-13
MXPA03001984A (es) 2003-08-29
CA2420892A1 (en) 2002-03-21
ES2429523T3 (es) 2013-11-15
BR0113854A (pt) 2004-07-06

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Legal Events

Date Code Title Description
CHAD Change of the owner's name or address (par. 44 patent law, par. patentforskriften)

Owner name: NOVO NORDISK HEALTH CARE AG, CH

MM1K Lapsed by not paying the annual fees