NO2003004I2 - Dexmedetomidin - Google Patents

Dexmedetomidin

Info

Publication number: NO2003004I2
Authority: NO; Norway
Prior art keywords: dexmedetomidine; medetomidine; enantiomers; selective; salts
Prior art date: 1987-07-16

Application number

NO2003004C

Other languages

English (en)

Original Assignee

Orion Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-07-16

Filing date

2003-07-01

Publication date

2005-03-21

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10620775&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO2003004(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2003-07-01 Application filed by Orion Corp filed Critical Orion Corp

2005-03-21 Publication of NO2003004I2 publication Critical patent/NO2003004I2/no

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C07D233/58—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Epidemiology (AREA)
Pain & Pain Management (AREA)
Anesthesiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Optical Fibers, Optical Fiber Cores, And Optical Fiber Bundles (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Optical Record Carriers And Manufacture Thereof (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Saccharide Compounds (AREA)
Photoreceptors In Electrophotography (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

NO2003004C 1987-07-16 2003-07-01 Dexmedetomidin NO2003004I2 (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB8716803A GB2206880B (en)	1987-07-16	1987-07-16	Optical isomers of an imidazole derivative

Publications (1)

Publication Number	Publication Date
NO2003004I2 true NO2003004I2 (no)	2005-03-21

Family

ID=10620775

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
NO883155A NO170579C (no)	1987-07-16	1988-07-15	Analogifremgangsmaate for fremstilling av den terapeutisk aktive d-enantiomeren av medetomidin
NO2003004C NO2003004I2 (no)	1987-07-16	2003-07-01	Dexmedetomidin

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
NO883155A NO170579C (no)	1987-07-16	1988-07-15	Analogifremgangsmaate for fremstilling av den terapeutisk aktive d-enantiomeren av medetomidin

Country Status (29)

Country	Link
US (1)	US4910214A (no)
EP (1)	EP0300652B1 (no)
JP (1)	JPH0625138B2 (no)
KR (1)	KR940007311B1 (no)
CN (1)	CN1022323C (no)
AT (1)	ATE71941T1 (no)
AU (1)	AU600839B2 (no)
BG (1)	BG60473B2 (no)
CA (1)	CA1337659C (no)
CY (2)	CY1787A (no)
DD (1)	DD281807A5 (no)
DE (2)	DE3867945D1 (no)
DK (1)	DK165788C (no)
ES (1)	ES2038757T3 (no)
FI (1)	FI95375C (no)
GB (1)	GB2206880B (no)
GR (1)	GR3003878T3 (no)
HK (1)	HK56094A (no)
HU (1)	HU198693B (no)
IE (1)	IE60456B1 (no)
IL (1)	IL87076A0 (no)
LU (1)	LU91010I2 (no)
NL (1)	NL300117I2 (no)
NO (2)	NO170579C (no)
NZ (1)	NZ225362A (no)
PT (1)	PT88013B (no)
SU (1)	SU1648248A3 (no)
UA (1)	UA5560A1 (no)
ZA (1)	ZA885134B (no)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB2215206B (en) *	1988-02-29	1991-07-03	Farmos Oy	4-substituted imidazole derivatives useful in perioperative care
US5124157A (en) *	1989-08-18	1992-06-23	Cygnus Therapeutic Systems	Method and device for administering dexmedetomidine transdermally
US5120713A (en) *	1990-09-10	1992-06-09	Applied Research Systems Ars Holding N.V.	Treatment of obesity with an alpha-2-adrenergic agonist and a growth hormone releasing peptide
GB9111732D0 (en) *	1991-05-31	1991-07-24	Orion Yhtymae Oy	The use of certain salts of medetomidine and its optically active enantiomers to regulate the rate of transdermal administration of the drugs
GB2281206A (en) *	1993-08-25	1995-03-01	Orion Yhtymae Oy	Use of dexmedetomidine
GB9425211D0 (en) *	1994-12-14	1995-02-15	Ucb Sa	Substituted 1H-imidazoles
IN187238B (no) *	1995-06-30	2002-03-09	Astra Ab
GB9521680D0 (en) *	1995-10-23	1996-01-03	Orion Yhtymo Oy	New use of imidazole derivatives
US5866579A (en) *	1997-04-11	1999-02-02	Synaptic Pharmaceutical Corporation	Imidazole and imidazoline derivatives and uses thereof
AR015744A1 (es) *	1998-04-01	2001-05-16	Orion Corp	Uso de dexmedetomidina para sedacion en terapia intensiva
US6716867B1 (en)	1998-04-01	2004-04-06	Orion Corporation	Use of dexmedetomidine for ICU sedation
WO2001030347A1 (en)	1999-10-29	2001-05-03	Orion Corporation	Treatment or prevention of hypotension and shock
US6388090B2 (en) *	2000-01-14	2002-05-14	Orion Corporation	Imidazole derivatives
US7141597B2 (en) *	2003-09-12	2006-11-28	Allergan, Inc.	Nonsedating α-2 agonists
ZA200804550B (en)	2005-11-09	2009-08-26	Combinatorx Inc	Methods, compositions, and kits for the treatment of medical conditions
EP2018160B1 (en)	2006-03-16	2011-12-14	Tris Pharma, Inc.	Modified release formulations containing drug-ion exchange resin complexes
US7795263B2 (en) *	2008-07-08	2010-09-14	Wildlife Laboratories, Inc.	Pharmaceutical combination for and method of anesthetizing and immobilizing non-domesticated mammals
WO2010065547A1 (en) *	2008-12-01	2010-06-10	Map Pharmaceuticals, Inc.	Inhalation delivery methods and devices
US8555875B2 (en)	2008-12-23	2013-10-15	Map Pharmaceuticals, Inc.	Inhalation devices and related methods for administration of sedative hypnotic compounds
AU2010248776B2 (en) *	2009-05-15	2013-06-06	Baudax Bio, Inc.	Sublingual dexmedetomidine compositions and methods of use thereof
CN101671305A (zh) *	2009-09-29	2010-03-17	北京华禧联合科技发展有限公司	一种拆分美托咪定的左旋及右旋对映体的方法
CN102464619A (zh) *	2010-11-17	2012-05-23	桑迪亚医药技术（上海）有限责任公司	一种左旋4-[1-(2,3-二甲基苯基)乙基]-1r-咪唑消旋化方法
US20130096170A1 (en)	2011-10-14	2013-04-18	Hospira, Inc.	Methods of treating pediatric patients using dexmedetomidine
WO2013069025A1 (en)	2011-11-11	2013-05-16	Neon Laboratories Ltd.	"process for the preparation of dexmedetomidine"
CN104470516A (zh)	2011-12-11	2015-03-25	瑞克欧制药有限公司	鼻内右美托咪定组合物和其使用方法
US8242158B1 (en)	2012-01-04	2012-08-14	Hospira, Inc.	Dexmedetomidine premix formulation
ITMI20120311A1 (it) *	2012-02-29	2013-08-30	Edmond Pharma Srl	Procedimento per la risoluzione di medetomidina e recupero dell'enantiomero indesiderato
BR112015003120B1 (pt)	2012-08-15	2022-08-09	Tris Pharma , Inc	Tablete mastigável de liberação estendida de metilfenidato e seu uso
JP6224115B2 (ja) *	2012-10-15	2017-11-01	オリオンコーポレーション	騒音嫌悪を軽減する獣医学的方法
ES2847936T3 (es)	2013-10-07	2021-08-04	Teikoku Pharma Usa Inc	Métodos y composiciones para el suministro transdérmico de una cantidad no sedante de dexmedetomidina
RU2018105761A (ru)	2013-10-07	2019-02-26	ТЕЙКОКУ ФАРМА ЮЭсЭй, ИНК.	Устройства для трансдермальной доставки дексмедетомидина и способы их применения
CN106456561B (zh)	2013-10-07	2020-02-28	帝国制药美国公司	使用右旋美托咪啶经皮组合物治疗注意力缺陷多动症、焦虑症和失眠症的方法和组合物
CN105175339B (zh) *	2015-10-09	2018-01-16	辰欣药业股份有限公司	一种制备盐酸右美托咪定的方法
US9717796B1 (en)	2016-04-20	2017-08-01	Slypharma, Llc	Heat sterilizeable, premixed, ready to use dexmedetomidine solution packaged in a flexible plastic container
FR3054218B1 (fr) *	2016-07-22	2020-03-06	Universite De Rouen	Procede de dedoublement de sels de baclofene
US11160791B2 (en)	2018-11-01	2021-11-02	Medefil, Inc.	Dexmedetomidine injection premix formulation in ready to use (RTU) bags
CN114671811A (zh) *	2022-04-14	2022-06-28	南京正科医药股份有限公司	一种右美托咪定拆分副产物的外消旋化回收方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU518569B2 (en) *	1979-08-07	1981-10-08	Farmos-Yhtyma Oy	4-benzyl- and 4-benzoyl imidazole derivatives
GB2092569B (en) *	1981-02-05	1984-09-19	Farmos Oy	Substituted imidazole derivatives and their preparation and use
GB2101114B (en) *	1981-07-10	1985-05-22	Farmos Group Ltd	Substituted imidazole derivatives and their preparation and use
FI844786A0 (fi)	1984-12-04	1984-12-04	Farmos Oy	Terapeutiskt utnyttjbar foerening.
DE3531682A1 (de) *	1985-09-05	1987-03-12	Thomae Gmbh Dr K	(+)-6-chlor-5,10-dihydro-5-((1-methyl-4- piperidinyl)acetyl)-11h-dibenzo(b,e)(1,4) diazepin-11-on, seine isolierung und verwendung als arzneimittel

1987
- 1987-07-16 GB GB8716803A patent/GB2206880B/en not_active Expired - Lifetime
1988
- 1988-06-14 FI FI882819A patent/FI95375C/fi active Protection Beyond IP Right Term
- 1988-06-28 UA UA4356076A patent/UA5560A1/uk unknown
- 1988-06-28 SU SU884356076A patent/SU1648248A3/ru active
- 1988-07-08 AT AT88306250T patent/ATE71941T1/de active
- 1988-07-08 EP EP88306250A patent/EP0300652B1/en not_active Expired - Lifetime
- 1988-07-08 ES ES198888306250T patent/ES2038757T3/es not_active Expired - Lifetime
- 1988-07-08 DE DE8888306250T patent/DE3867945D1/de not_active Expired - Lifetime
- 1988-07-08 DE DE2003199005 patent/DE10399005I2/de active Active
- 1988-07-11 AU AU18941/88A patent/AU600839B2/en not_active Expired
- 1988-07-11 NZ NZ225362A patent/NZ225362A/xx unknown
- 1988-07-11 DK DK386288A patent/DK165788C/da not_active IP Right Cessation
- 1988-07-12 IL IL87076A patent/IL87076A0/xx not_active IP Right Cessation
- 1988-07-14 DD DD88317936A patent/DD281807A5/de not_active IP Right Cessation
- 1988-07-14 CA CA000572086A patent/CA1337659C/en not_active Expired - Lifetime
- 1988-07-15 KR KR1019880008937A patent/KR940007311B1/ko not_active Expired - Lifetime
- 1988-07-15 IE IE217488A patent/IE60456B1/en not_active IP Right Cessation
- 1988-07-15 ZA ZA885134A patent/ZA885134B/xx unknown
- 1988-07-15 US US07/219,637 patent/US4910214A/en not_active Expired - Lifetime
- 1988-07-15 HU HU883708A patent/HU198693B/hu unknown
- 1988-07-15 PT PT88013A patent/PT88013B/pt not_active IP Right Cessation
- 1988-07-15 NO NO883155A patent/NO170579C/no not_active IP Right Cessation
- 1988-07-16 JP JP63177959A patent/JPH0625138B2/ja not_active Expired - Lifetime
- 1988-07-16 CN CN88104440A patent/CN1022323C/zh not_active Expired - Lifetime
1992
- 1992-02-21 GR GR920400299T patent/GR3003878T3/el unknown
1994
- 1994-01-18 BG BG098380A patent/BG60473B2/bg unknown
- 1994-05-24 HK HK56094A patent/HK56094A/en not_active IP Right Cessation
1995
- 1995-10-20 CY CY178795A patent/CY1787A/xx unknown
2003
- 2003-02-14 LU LU91010C patent/LU91010I2/fr unknown
- 2003-03-03 NL NL300117C patent/NL300117I2/nl unknown
- 2003-07-01 NO NO2003004C patent/NO2003004I2/no unknown
2004
- 2004-10-27 CY CY200400006C patent/CY2004006I2/el unknown

Also Published As

Publication number	Publication date
DK165788C (da)	1993-06-14
EP0300652B1 (en)	1992-01-22
AU600839B2 (en)	1990-08-23
DK386288A (da)	1989-01-17
CA1337659C (en)	1995-11-28
ATE71941T1 (de)	1992-02-15
IE60456B1 (en)	1994-07-13
GB2206880A (en)	1989-01-18
GB2206880B (en)	1991-04-24
CY1787A (en)	1995-10-20
FI95375C (fi)	1996-01-25
CY2004006I1 (el)	2009-11-04
ZA885134B (en)	1989-04-26
FI882819A0 (fi)	1988-06-14
DK165788B (da)	1993-01-18
IL87076A0 (en)	1988-12-30
ES2038757T3 (es)	1993-08-01
DE10399005I1 (de)	2003-06-05
GB8716803D0 (en)	1987-08-19
KR890002030A (ko)	1989-04-07
KR940007311B1 (ko)	1994-08-12
NL300117I1 (nl)	2003-05-01
DE3867945D1 (de)	1992-03-05
IE882174L (en)	1989-01-16
JPH0625138B2 (ja)	1994-04-06
DK386288D0 (da)	1988-07-11
NO170579B (no)	1992-07-27
PT88013A (pt)	1989-06-30
NO170579C (no)	1992-11-04
US4910214A (en)	1990-03-20
NO883155L (no)	1989-01-17
FI882819L (fi)	1989-01-17
CN1022323C (zh)	1993-10-06
DE10399005I2 (de)	2012-06-06
NZ225362A (en)	1990-07-26
LU91010I2 (fr)	2003-06-19
HU198693B (en)	1989-11-28
AU1894188A (en)	1989-01-19
CY2004006I2 (el)	2009-11-04
NO883155D0 (no)	1988-07-15
HK56094A (en)	1994-06-03
JPS6434968A (en)	1989-02-06
DD281807A5 (de)	1990-08-22
HUT48218A (en)	1989-05-29
SU1648248A3 (ru)	1991-05-07
NL300117I2 (nl)	2003-10-01
EP0300652A1 (en)	1989-01-25
PT88013B (pt)	1995-03-01
GR3003878T3 (no)	1993-03-16
FI95375B (fi)	1995-10-13
BG60473B2 (bg)	1995-04-28
CN1030576A (zh)	1989-01-25
UA5560A1 (uk)	1994-12-28

Publication	Publication Date	Title
LU91010I2 (fr)	2003-06-19	Dexmedetomidine hydrochloride-Dexdomitor
BG40655A3 (en)	1987-01-15	Method for preparing n- (bi heterocyclic)- 4- piperidineamines
BG37377A3 (en)	1985-05-15	Method for preparing salts of benzothiazine dioxide
BG40148A3 (bg)	1986-10-15	Метод за получаване на хетероциклично съединение
BG39639A3 (bg)	1986-07-15	Метод за получаване на 1н, 3н- пироло/1,2-с/ тиазолови производни
ES2042726T3 (es)	1993-12-16	Beta-alquilmelatoninas.
ES2058056T3 (es)	1994-11-01	Procedimiento para la preparacion de cefodizim.
DE68911610D1 (de)	1994-02-03	Antigeschwür-Alkyldithio-Chinolin-Derivate.
DK207086D0 (da)	1986-05-05	Anvendelse af dopaminagonister
FI883555A7 (fi)	1989-01-30	Benzimidazolderivat.
NO881275D0 (no)	1988-03-23	Fluidtap-regulerende tilsetningsstoff for cementoppslemminger for cementering av broennhull.
BG39977A3 (en)	1986-09-15	Method for preparing derivatives of furyloxazolylacetic acid
BG41127A3 (en)	1987-04-15	Method for preparing 1, 4- dihydropyridine derivatives
BG40812A3 (en)	1987-02-16	Method for preparing derivatives of pyroxycam
IT1217727B (it)	1990-03-30	Tornio per la lavorazione di legname squadrato
NO890859D0 (no)	1989-02-28	Roterende trebearbeidningsverktoey.
IT1212594B (it)	1989-11-30	Utensile per forare dotato di effetto autocentrante.
BG40804A3 (en)	1987-02-16	Method for preparing aniline derivatives