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NO20014755D0 - C(7)-karbonatsubstituerte taksaner som antitumormidler - Google Patents

C(7)-karbonatsubstituerte taksaner som antitumormidler

Info

Publication number
NO20014755D0
NO20014755D0 NO20014755A NO20014755A NO20014755D0 NO 20014755 D0 NO20014755 D0 NO 20014755D0 NO 20014755 A NO20014755 A NO 20014755A NO 20014755 A NO20014755 A NO 20014755A NO 20014755 D0 NO20014755 D0 NO 20014755D0
Authority
NO
Norway
Prior art keywords
antitumor agents
carbonate substituted
substituted taxanes
taxanes
carbonate
Prior art date
Application number
NO20014755A
Other languages
English (en)
Other versions
NO20014755L (no
Inventor
Robert A Holton
Original Assignee
Univ Florida State Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Florida State Res Found filed Critical Univ Florida State Res Found
Publication of NO20014755D0 publication Critical patent/NO20014755D0/no
Publication of NO20014755L publication Critical patent/NO20014755L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
NO20014755A 2000-02-02 2001-10-01 C(7)-karbonatsubstituerte taxaner som antitumormidler NO20014755L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17967100P 2000-02-02 2000-02-02
PCT/US2001/003554 WO2001057030A1 (en) 2000-02-02 2001-02-02 C7 carbonate substituted taxanes as antitumor agents

Publications (2)

Publication Number Publication Date
NO20014755D0 true NO20014755D0 (no) 2001-10-01
NO20014755L NO20014755L (no) 2001-11-29

Family

ID=22657501

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20014755A NO20014755L (no) 2000-02-02 2001-10-01 C(7)-karbonatsubstituerte taxaner som antitumormidler

Country Status (25)

Country Link
US (3) US6780879B2 (no)
EP (1) EP1165552A1 (no)
JP (1) JP2003522170A (no)
KR (1) KR20010112395A (no)
CN (1) CN1362958A (no)
AU (1) AU776122B2 (no)
BG (1) BG64890B1 (no)
BR (1) BR0104351A (no)
CA (1) CA2368540A1 (no)
CZ (1) CZ20013429A3 (no)
GE (1) GEP20043226B (no)
HK (1) HK1047934A1 (no)
HU (1) HUP0200756A3 (no)
IL (1) IL145637A0 (no)
MX (1) MXPA01009906A (no)
NO (1) NO20014755L (no)
NZ (1) NZ514380A (no)
PL (1) PL350315A1 (no)
RO (1) RO121271B1 (no)
RU (1) RU2265019C2 (no)
SK (1) SK13702001A3 (no)
TR (1) TR200102857T1 (no)
UA (1) UA74331C2 (no)
WO (1) WO2001057030A1 (no)
ZA (1) ZA200108051B (no)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6649632B2 (en) * 2000-02-02 2003-11-18 Fsu Research Foundation, Inc. C10 ester substituted taxanes
RO121271B1 (ro) * 2000-02-02 2007-02-28 Florida State University Research Foundation, Inc. Taxani substituiţi cu carbonat la c7, ca agenţiantitumorali
US7390898B2 (en) 2002-08-02 2008-06-24 Immunogen Inc. Cytotoxic agents containing novel potent taxanes and their therapeutic use
WO2004013093A2 (en) 2002-08-02 2004-02-12 Immunogen, Inc. Cytotoxic agents containing novel potent taxanes and their therapeutic use
HN2005000054A (es) * 2004-02-13 2009-02-18 Florida State University Foundation Inc Taxanos sustituidos con esteres de ciclopentilo en c10
US20060189679A1 (en) * 2005-02-14 2006-08-24 Florida State University Research Foundation, Inc. C10 cyclopropyl ester substituted taxane compositions
RU2370261C2 (ru) * 2007-08-03 2009-10-20 Закрытое Акционерное Общество "Биокад" Стабильная эмульсия для парентерального введения плохо растворимых в воде соединений, обладающих противоопухолевой активностью, и способ ее получения
US8242166B2 (en) * 2008-03-31 2012-08-14 Florida State University Research Foundation, Inc. C(10) ethyl ester and C(10) cyclopropyl ester substituted taxanes

Family Cites Families (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2601675B1 (fr) * 1986-07-17 1988-09-23 Rhone Poulenc Sante Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent
US5175315A (en) 1989-05-31 1992-12-29 Florida State University Method for preparation of taxol using β-lactam
MX9102128A (es) 1990-11-23 1992-07-08 Rhone Poulenc Rorer Sa Derivados de taxano,procedimiento para su preparacion y composicion farmaceutica que los contiene
US5350866A (en) 1991-09-23 1994-09-27 Bristol-Myers Squibb Company 10-desacetoxytaxol derivatives
US5227400A (en) 1991-09-23 1993-07-13 Florida State University Furyl and thienyl substituted taxanes and pharmaceutical compositions containing them
US5721268A (en) 1991-09-23 1998-02-24 Florida State University C7 taxane derivatives and pharmaceutical compositions containing them
US5714513A (en) 1991-09-23 1998-02-03 Florida State University C10 taxane derivatives and pharmaceutical compositions
US5243045A (en) 1991-09-23 1993-09-07 Florida State University Certain alkoxy substituted taxanes and pharmaceutical compositions containing them
US5430160A (en) 1991-09-23 1995-07-04 Florida State University Preparation of substituted isoserine esters using β-lactams and metal or ammonium alkoxides
US5283253A (en) 1991-09-23 1994-02-01 Florida State University Furyl or thienyl carbonyl substituted taxanes and pharmaceutical compositions containing them
ATE280240T1 (de) 1992-01-15 2004-11-15 Squibb & Sons Inc Enzymatische verfahren zur aüftrennüng von enantiomeren-mischungen nützlich als zwischenprodukte zur herstellung von taxanen
FR2687150B1 (fr) 1992-02-07 1995-04-28 Rhone Poulenc Rorer Sa Procede de preparation de derives du taxane.
US5272171A (en) 1992-02-13 1993-12-21 Bristol-Myers Squibb Company Phosphonooxy and carbonate derivatives of taxol
US5698712A (en) 1992-03-06 1997-12-16 Indena S.P.A. Baccatine III derivatives
US5939561A (en) 1992-03-10 1999-08-17 Rhone-Poulence Rorer S.A. Process for the preparation of β-phenylisoserine and β-lactam and their analogues
US5319112A (en) 1992-08-18 1994-06-07 Virgnia Tech Intellectual Properties, Inc. Method for the conversion of cephalomannine to taxol and for the preparation of N-acyl analogs of taxol
US5470866A (en) 1992-08-18 1995-11-28 Virginia Polytechnic Institute And State University Method for the conversion of cephalomannine to taxol and for the preparation of n-acyl analogs of taxol
MX9307777A (es) * 1992-12-15 1994-07-29 Upjohn Co 7-HALO-Y 7ß, 8ß-METANO-TAXOLES, USO ANTINEOPLASTICO Y COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN.
MX9308012A (es) 1992-12-24 1994-08-31 Bristol Myers Squibb Co Eteres fosfonooximetilicos de derivados de taxano, solubles en agua y composiciones farmaceuticas que los incluyen.
ATE253563T1 (de) * 1993-02-05 2003-11-15 Bryn Mawr College Synthese von taxol, seinen analogen und intermediaten mit variablen a-ring seitenketten
US5703247A (en) 1993-03-11 1997-12-30 Virginia Tech Intellectual Properties, Inc. 2-Debenzoyl-2-acyl taxol derivatives and methods for making same
US5475011A (en) 1993-03-26 1995-12-12 The Research Foundation Of State University Of New York Anti-tumor compounds, pharmaceutical compositions, methods for preparation thereof and for treatment
IT1261667B (it) * 1993-05-20 1996-05-29 Tassano ad attivita' antitumorale.
ATE192147T1 (de) * 1993-06-11 2000-05-15 Upjohn Co Delta 6, 7-taxolen, antineoplastische verwendung und diese enthaltende pharmazeutische zusammenstellungen
IL109926A (en) 1993-06-15 2000-02-29 Bristol Myers Squibb Co Methods for the preparation of taxanes and microorganisms and enzymes utilized therein
TW397866B (en) 1993-07-14 2000-07-11 Bristol Myers Squibb Co Enzymatic processes for the resolution of enantiomeric mixtures of compounds useful as intermediates in the preparation of taxanes
CA2129288C (en) 1993-08-17 2000-05-16 Jerzy Golik Phosphonooxymethyl esters of taxane derivatives
WO1995011020A1 (en) * 1993-10-20 1995-04-27 Enzon, Inc. 2'- and/or 7- substituted taxoids
FR2711369B1 (fr) 1993-10-20 1995-11-17 Rhone Poulenc Rorer Sa Nouveaux taxoïdes, leur préparation et les compositions qui les contiennent.
US5824701A (en) * 1993-10-20 1998-10-20 Enzon, Inc. Taxane-based prodrugs
EP0788493A1 (en) 1994-10-28 1997-08-13 The Research Foundation Of State University Of New York Taxoid derivatives, their preparation and their use as antitumor agents
US5801191A (en) 1995-06-01 1998-09-01 Biophysica Foundation Taxoids
TW354293B (en) 1995-06-06 1999-03-11 Bristol Myers Squibb Co Prodrugs of paclitaxel derivatives
US5780653A (en) 1995-06-07 1998-07-14 Vivorx Pharmaceuticals, Inc. Nitrophenyl, 10-deacetylated substituted taxol derivatives as dual functional cytotoxic/radiosensitizers
CA2231837A1 (en) 1995-09-13 1997-03-20 Florida State University Radiosensitizing taxanes and their pharmaceutical preparations
CN1221412A (zh) 1996-05-06 1999-06-30 佛罗里达州立大学 1－脱氧浆果赤霉素ⅲ,1－脱氧紫杉醇和1－脱氧紫杉醇类似物及其制备方法
US5811452A (en) 1997-01-08 1998-09-22 The Research Foundation Of State University Of New York Taxoid reversal agents for drug-resistance in cancer chemotherapy and pharmaceutical compositions thereof
US5912264A (en) 1997-03-03 1999-06-15 Bristol-Myers Squibb Company 6-halo-or nitrate-substituted paclitaxels
US7288665B1 (en) 1997-08-18 2007-10-30 Florida State University Process for selective derivatization of taxanes
CN1186340C (zh) * 2000-02-02 2005-01-26 佛罗里达州立大学研究基金有限公司 用作抗肿瘤剂的c10碳酸酯取代的紫杉烷
JP2003521545A (ja) * 2000-02-02 2003-07-15 フロリダ・ステイト・ユニバーシティ・リサーチ・ファウンデイション・インコーポレイテッド 改良された溶解性を有するタキサン製剤
AU3481001A (en) 2000-02-02 2001-08-14 Florida State University Research Foundation, Inc. Taxane formulations having improved solubility
US6649632B2 (en) * 2000-02-02 2003-11-18 Fsu Research Foundation, Inc. C10 ester substituted taxanes
RO121271B1 (ro) 2000-02-02 2007-02-28 Florida State University Research Foundation, Inc. Taxani substituiţi cu carbonat la c7, ca agenţiantitumorali

Also Published As

Publication number Publication date
US20050165051A1 (en) 2005-07-28
JP2003522170A (ja) 2003-07-22
AU3479301A (en) 2001-08-14
RO121271B1 (ro) 2007-02-28
SK13702001A3 (sk) 2002-06-04
ZA200108051B (en) 2003-12-01
NZ514380A (en) 2005-03-24
TR200102857T1 (tr) 2002-06-21
UA74331C2 (uk) 2005-12-15
CA2368540A1 (en) 2001-08-09
US7226944B2 (en) 2007-06-05
WO2001057030A1 (en) 2001-08-09
BR0104351A (pt) 2002-01-02
US20020065304A1 (en) 2002-05-30
GEP20043226B (en) 2004-04-26
HK1047934A1 (zh) 2003-03-14
HUP0200756A2 (hu) 2002-07-29
CZ20013429A3 (cs) 2002-04-17
RU2265019C2 (ru) 2005-11-27
EP1165552A1 (en) 2002-01-02
AU776122B2 (en) 2004-08-26
IL145637A0 (en) 2002-06-30
US6780879B2 (en) 2004-08-24
BG64890B1 (bg) 2006-08-31
US20040138267A1 (en) 2004-07-15
NO20014755L (no) 2001-11-29
PL350315A1 (en) 2002-12-02
HUP0200756A3 (en) 2005-02-28
MXPA01009906A (es) 2003-07-28
BG105966A (en) 2002-07-31
US6992104B2 (en) 2006-01-31
KR20010112395A (ko) 2001-12-20
CN1362958A (zh) 2002-08-07

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