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NO20011459L - Genes of the 1-deoxy-D-xylulose biosynthesis pathway - Google Patents

Genes of the 1-deoxy-D-xylulose biosynthesis pathway

Info

Publication number
NO20011459L
NO20011459L NO20011459A NO20011459A NO20011459L NO 20011459 L NO20011459 L NO 20011459L NO 20011459 A NO20011459 A NO 20011459A NO 20011459 A NO20011459 A NO 20011459A NO 20011459 L NO20011459 L NO 20011459L
Authority
NO
Norway
Prior art keywords
deoxy
xylulose
genes
biosynthesis pathway
gene
Prior art date
Application number
NO20011459A
Other languages
Norwegian (no)
Other versions
NO20011459D0 (en
Inventor
Hassan Jomaa
Original Assignee
Jomaa Pharmaka Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19923567A external-priority patent/DE19923567A1/en
Application filed by Jomaa Pharmaka Gmbh filed Critical Jomaa Pharmaka Gmbh
Publication of NO20011459D0 publication Critical patent/NO20011459D0/en
Publication of NO20011459L publication Critical patent/NO20011459L/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/711—Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0093—Oxidoreductases (1.) acting on CH or CH2 groups (1.17)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1022—Transferases (2.) transferring aldehyde or ketonic groups (2.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01267—1-Deoxy-D-xylulose-5-phosphate reductoisomerase (1.1.1.267)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y117/00—Oxidoreductases acting on CH or CH2 groups (1.17)
    • C12Y117/07—Oxidoreductases acting on CH or CH2 groups (1.17) with an iron-sulfur protein as acceptor (1.17.7)
    • C12Y117/07001—(E)-4-Hydroxy-3-methylbut-2-enyl-diphosphate synthase (1.17.7.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y202/00—Transferases transferring aldehyde or ketonic groups (2.2)
    • C12Y202/01—Transketolases and transaldolases (2.2.1)
    • C12Y202/01007—1-Deoxy-D-xylulose-5-phosphate synthase (2.2.1.7)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Plant Pathology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Cell Biology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Foreliggende oppfinnelse omfatter l -deoksy- D-xyIulose-5-fosfatreduktoismerasegenet, l -deoksy- D-xylulose-5-fosfatsyntasegenet og gcpE-genet i 1- deoksy-D-xylulosebiosyntesereaksjonsveienog anvendelse av disse for transformasjon av vektorer, vertsorganismer og planter og for påvisning av stoffer som hemmer denne biosyntesereaksjonsvei.The present invention encompasses the 1-deoxy-D-xyulose-5-phosphate reductoismerase gene, the 1-deoxy-D-xylulose-5-phosphate synthase gene and the gcpE gene in the 1-deoxy-D-xylolose biosynthesis reaction pathway and their use for transformation of vectors and their weights for transformation. for the detection of substances that inhibit this biosynthesis pathway.

NO20011459A 1998-09-22 2001-03-22 Genes of the 1-deoxy-D-xylulose biosynthesis pathway NO20011459L (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19843279 1998-09-22
DE19923567A DE19923567A1 (en) 1998-09-22 1999-05-21 Genes of the 1-deoxy-D-xylulose biosynthetic pathway
PCT/EP1999/007055 WO2000017233A2 (en) 1998-09-22 1999-09-22 Genes of the 1-desoxy-d-xylulose biosynthetic pathway

Publications (2)

Publication Number Publication Date
NO20011459D0 NO20011459D0 (en) 2001-03-22
NO20011459L true NO20011459L (en) 2001-05-22

Family

ID=26048996

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20011459A NO20011459L (en) 1998-09-22 2001-03-22 Genes of the 1-deoxy-D-xylulose biosynthesis pathway

Country Status (23)

Country Link
EP (1) EP1115849B1 (en)
JP (1) JP2002526061A (en)
CN (1) CN1319134A (en)
AP (1) AP2001002104A0 (en)
AT (1) ATE317007T1 (en)
AU (1) AU767213B2 (en)
BG (1) BG105361A (en)
BR (1) BR9914028A (en)
CA (1) CA2343919A1 (en)
CZ (1) CZ2001990A3 (en)
DE (1) DE59913101D1 (en)
EE (1) EE200100174A (en)
HR (1) HRP20010215A2 (en)
HU (1) HUP0203649A2 (en)
ID (1) ID29772A (en)
IL (1) IL141888A0 (en)
IS (1) IS5872A (en)
NO (1) NO20011459L (en)
OA (1) OA11656A (en)
PL (1) PL348428A1 (en)
SK (1) SK3922001A3 (en)
TR (1) TR200100836T2 (en)
WO (1) WO2000017233A2 (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2325798C (en) 1998-04-14 2008-08-26 Kyowa Hakko Kogyo Co., Ltd. A process for producing isoprenoid compounds by microorganisms and a method for screening compounds with antibiotic or weeding activity
AU777584B2 (en) 1999-04-15 2004-10-21 Monsanto Company Nucleic acid sequences to proteins involved in isoprenoid synthesis
DE19918949A1 (en) * 1999-04-27 2000-11-23 Basf Ag Overexpression of a DNA sequence coding for a 1-deoxy-D-xylulose-5-phosphate reductoisomerase in plants
HUP0201386A2 (en) * 1999-05-21 2002-08-28 Jomaa Pharmaka Gmbh Use of genes of the deoxy-d-xylulose phosphate biosynthetic pathway for altering the concentration of isoprenoid
DE60036477T2 (en) 1999-08-04 2008-06-12 Bacher, Adelbert, Prof. Dr.med. Dr.rer.nat. ISOPRENOID BIOSYNTHESIS
US6872815B1 (en) 2000-10-14 2005-03-29 Calgene Llc Nucleic acid sequences to proteins involved in tocopherol synthesis
DE10021688A1 (en) * 2000-05-05 2001-11-15 Hassan Jomaa New DNA sequences involved in isoprenoid biosynthesis, useful in screening for compounds with e.g. antimicrobial and herbicidal activity
DE10027821A1 (en) 2000-06-05 2001-12-06 Adelbert Bacher New intermediate in isoprenoid biosynthesis, useful in screening for potential herbicides, comprises mutant encoding-enzymes sequences for imparting herbicide resistance
AR030124A1 (en) * 2000-08-07 2003-08-13 Monsanto Technology Llc GENES OF THE METHYL-D-ERITRITOL PHOSPHATE VIA
DE10201458A1 (en) 2001-04-11 2002-10-17 Adelbert Bacher New proteins involved in isoprenoid biosynthesis, useful in screening for inhibitors, also new intermediates, potential therapeutic agents, nucleic acids and antibodies
US7161061B2 (en) 2001-05-09 2007-01-09 Monsanto Technology Llc Metabolite transporters
WO2002089561A1 (en) 2001-05-09 2002-11-14 Monsanto Technology Llc. Tyra genes and uses thereof
PT1408984E (en) * 2001-07-20 2008-12-26 Bioagency Ag Organo-phosphorous compounds for activating gamma/delta t cells
AU2002329759A1 (en) 2001-08-17 2003-03-03 Monsanto Technology Llc Methyltransferase genes and uses thereof
AR036962A1 (en) 2001-10-25 2004-10-13 Monsanto Technology Llc AROMATIC METHYLTRANSPHERASES AND USES OF THE SAME
BR0308740A (en) 2002-03-19 2007-01-09 Monsanto Technology Llc homogenous prenyl transferase ("hpt") nucleic acids and polypeptides, and their use
CA2492945A1 (en) 2002-08-05 2004-02-12 Monsanto Technology, Llc Tocopherol biosynthesis related genes and uses thereof
CN106978425B (en) * 2017-02-17 2019-10-18 华中农业大学 1-deoxy-D-xylulose-5-phosphate reductoisomerase gene and its encoded protein from Babesia orientalis
KR20200095534A (en) 2017-12-07 2020-08-10 지머젠 인코포레이티드 Biosynthetic pathway engineered for the production of (6E)-8-hydroxygeraniol by fermentation
KR20200111172A (en) 2017-12-21 2020-09-28 지머젠 인코포레이티드 Nepetalactol redox enzyme, nepetalactol synthase, and microorganisms capable of producing nepetalactone
CN109342634A (en) * 2018-12-07 2019-02-15 西北大学 A method of pre-column derivatization-HPLC to measure the catalytic activity of DXS enzyme

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19752700A1 (en) * 1997-11-28 1999-06-02 Hoechst Schering Agrevo Gmbh 1-Deoxy-D-xylulose-5-phosphate synthase protein and modulators
MXPA00010069A (en) * 1998-04-14 2002-08-06 Jomaa Hassan Method for identifying chemical active agents and active agents for inhibiting the 1-desoxy-d-xylulose-5-phosphate biosynthetic pathway.

Also Published As

Publication number Publication date
TR200100836T2 (en) 2001-10-22
ID29772A (en) 2001-10-11
OA11656A (en) 2004-12-08
CA2343919A1 (en) 2000-03-30
AU6194799A (en) 2000-04-10
WO2000017233A2 (en) 2000-03-30
IL141888A0 (en) 2002-03-10
CZ2001990A3 (en) 2002-01-16
PL348428A1 (en) 2002-05-20
CN1319134A (en) 2001-10-24
SK3922001A3 (en) 2001-09-11
EE200100174A (en) 2002-08-15
EP1115849A2 (en) 2001-07-18
ATE317007T1 (en) 2006-02-15
IS5872A (en) 2001-02-28
NO20011459D0 (en) 2001-03-22
AU767213B2 (en) 2003-11-06
DE59913101D1 (en) 2006-04-13
HUP0203649A2 (en) 2003-02-28
BG105361A (en) 2001-10-31
WO2000017233A3 (en) 2000-05-25
EP1115849B1 (en) 2006-02-01
HRP20010215A2 (en) 2002-06-30
AP2001002104A0 (en) 2001-03-31
JP2002526061A (en) 2002-08-20
BR9914028A (en) 2001-07-03

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