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NO20010319L - Fremgangsmate for fremstilling av Citalopram - Google Patents

Fremgangsmate for fremstilling av Citalopram

Info

Publication number
NO20010319L
NO20010319L NO20010319A NO20010319A NO20010319L NO 20010319 L NO20010319 L NO 20010319L NO 20010319 A NO20010319 A NO 20010319A NO 20010319 A NO20010319 A NO 20010319A NO 20010319 L NO20010319 L NO 20010319L
Authority
NO
Norway
Prior art keywords
citalopram
preparation
Prior art date
Application number
NO20010319A
Other languages
English (en)
Other versions
NO20010319D0 (no
NO328542B1 (no
Inventor
Hans Peterson
Michael Harold Rock
Henrik Svane
Original Assignee
Lundbeck & Co As H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Publication of NO20010319D0 publication Critical patent/NO20010319D0/no
Publication of NO20010319L publication Critical patent/NO20010319L/no
Publication of NO328542B1 publication Critical patent/NO328542B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J23/00—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00
    • B01J23/38—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals
    • B01J23/40—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals of the platinum group metals
    • B01J23/44—Palladium
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Materials Engineering (AREA)
  • Rheumatology (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Steroid Compounds (AREA)
NO20010319A 1999-06-25 2001-01-19 Fremgangsmate og forbindelse for fremstillingen av Citalopram NO328542B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA199900920 1999-06-25
PCT/DK1999/000640 WO2000013648A2 (en) 1999-06-25 1999-11-22 Method for the preparation of citalopram

Publications (3)

Publication Number Publication Date
NO20010319D0 NO20010319D0 (no) 2001-01-19
NO20010319L true NO20010319L (no) 2001-02-23
NO328542B1 NO328542B1 (no) 2010-03-15

Family

ID=8099035

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20010319A NO328542B1 (no) 1999-06-25 2001-01-19 Fremgangsmate og forbindelse for fremstillingen av Citalopram

Country Status (36)

Country Link
US (2) US20020077353A1 (no)
EP (1) EP1159274B1 (no)
JP (1) JP3447267B2 (no)
KR (1) KR100491368B1 (no)
CN (2) CN1140521C (no)
AR (1) AR020863A1 (no)
AT (3) ATE235478T1 (no)
AU (2) AU2001100440B4 (no)
BG (1) BG65574B1 (no)
BR (1) BR9917368B1 (no)
CA (2) CA2475401A1 (no)
CH (1) CH691305A5 (no)
CZ (1) CZ292198B6 (no)
DE (2) DE19983487C1 (no)
DK (2) DK1159274T3 (no)
EA (1) EA002560B1 (no)
ES (2) ES2194545T3 (no)
FI (1) FI108641B (no)
GB (2) GB2354239B (no)
HK (1) HK1049002B (no)
HU (1) HUP0103235A3 (no)
IL (2) IL145959A0 (no)
IS (1) IS2343B (no)
IT (1) ITMI991581A1 (no)
MX (1) MXPA01010989A (no)
NO (1) NO328542B1 (no)
NZ (1) NZ514979A (no)
PL (1) PL205579B1 (no)
PT (1) PT1159274E (no)
SE (1) SE516690C2 (no)
SI (1) SI1159274T1 (no)
SK (1) SK285813B6 (no)
TR (1) TR200103702T2 (no)
UA (1) UA63034C2 (no)
WO (1) WO2000013648A2 (no)
ZA (1) ZA200108854B (no)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1140886E (pt) 1998-12-23 2003-08-29 Lundbeck & Co As H Metodo para a preparacao de 5- cianoftalida
AR022329A1 (es) 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
DE69907037T3 (de) 1999-04-14 2010-02-18 H. Lundbeck A/S Verfahren zur herstellung von citalopram
ITMI991579A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
DK1228056T3 (da) 1999-10-25 2005-01-24 Lundbeck & Co As H Fremgangsmåde til fremstilling af citalopram
CH692421A5 (de) 1999-10-25 2002-06-14 Lundbeck & Co As H Verfahren zur Herstellung von Citalopram.
AR026063A1 (es) 1999-11-01 2002-12-26 Lundbeck & Co As H Metodo para la preparacion de 5-carboxiftalida.
IL150335A0 (en) 1999-12-28 2002-12-01 Lundbeck & Co As H Method for the preparation of citalopram
CZ20022627A3 (cs) 1999-12-30 2002-10-16 H. Lundbeck A/S Způsob výroby citalopramu
DK1254129T3 (da) 2000-01-14 2004-03-29 Lundbeck & Co As H Fremgangsmåde til fremstilling af 5-cyanophthalid
FR2805812A1 (fr) 2000-02-24 2001-09-07 Lundbeck & Co As H Procede de preparation du citalopram
IES20010157A2 (en) 2000-03-03 2002-03-06 Lundbeck & Co As H Method for the preparation of citalopram
GB2357762B (en) 2000-03-13 2002-01-30 Lundbeck & Co As H Crystalline base of citalopram
IES20010206A2 (en) 2000-03-13 2002-03-06 Lundbeck & Co As H Method for the preparation of citalopram
IL151566A0 (en) 2000-03-13 2003-04-10 Lundbeck & Co As H Stepwise alkylation of 5-substituted 1-(4-fluorophenyl)-1,3-dihydroisobenzofurans
HUP0300274A2 (hu) 2000-03-13 2003-06-28 H. Lundbeck A/S Eljárás citalopram előállítására
SK14512002A3 (sk) 2000-03-14 2003-03-04 H. Lundbeck A/S Spôsob výroby citalopramu, medziprodukt a citalopram výrobený týmto spôsobom
BR0109180A (pt) * 2000-03-16 2003-05-27 Lundbeck & Co As H Método para a preparação de 5-ciano-1-(4-fluorofenil) -1,3- diidroisobenzofuranos e composição farmacêutica de antidepressivo
AR032455A1 (es) 2000-05-12 2003-11-12 Lundbeck & Co As H Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
CA2383963A1 (en) * 2000-07-06 2002-01-17 Eva Bolzonella Method for the preparation of citalopram
FI20011622L (fi) * 2000-08-18 2002-02-19 Lundbeck & Co As H Menetelmä sitalopraamin valmistamiseksi
TR200201166T1 (tr) * 2000-12-22 2002-10-21 H.Lundbecks A/S Saf sitalopram hazırlanması için yöntem
EP1181272B1 (en) * 2000-12-28 2002-08-28 H. Lundbeck A/S Process for the preparation of pure citalopram
EP1355897A1 (en) 2001-01-30 2003-10-29 Orion Corporation Fermion Process for the preparation of 1-(3-dimethylaminopropyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile
GB0105627D0 (en) * 2001-03-07 2001-04-25 Cipla Ltd Preparation of phthalanes
EP1370545A4 (en) * 2001-03-09 2005-03-16 Ranbaxy Lab Ltd PROCESS FOR THE PREPARATION OF CITALOPRAM
US6967259B2 (en) * 2001-09-24 2005-11-22 Pharmachem Technologies Limited Process for the preparation of Citalopram intermediate
WO2003057132A2 (en) * 2002-01-07 2003-07-17 Sun Pharmaceutical Industries Limited Process for the preparation of 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)- 1,3-dihydro-5-isobenzofuran carbonitrile
AR040970A1 (es) 2002-08-12 2005-04-27 Lundbeck & Co As H Metodo para la separacion de intermediarios que pueden ser utilizados para la preparacion de escitalopram
US20050154052A1 (en) * 2003-03-24 2005-07-14 Hetero Drugs Limited Novel crystalline forms of (s)-citalopram oxalate
US7019153B2 (en) 2003-06-10 2006-03-28 Sun Pharmaceutical Industries Limited Process for hydrogenolysis of [1-(3-dimethylamino)propyl)]-1-(4-fluorophenyl)-1,3-dihydro-5-halo-isobenzofuran acetamido-3-substituted-3-cephem-4-carboxylic acid
TWI339651B (en) 2004-02-12 2011-04-01 Lundbeck & Co As H Method for the separation of intermediates which may be used for the preparation of escitalopram
EP1797060A2 (en) 2004-08-23 2007-06-20 Sun Pharmaceutical Industries Limited "process for preparation of citalopram and enantiomers"
TWI358407B (en) 2005-06-22 2012-02-21 Lundbeck & Co As H Crystalline base of escitalopram and orodispersibl
US7834201B2 (en) 2005-06-22 2010-11-16 H. Lundbeck A/S Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base
EP2017271A1 (en) 2007-07-06 2009-01-21 Aurobindo Pharma Limited Process for the preparation of escitalopram
CN114763343A (zh) * 2021-01-14 2022-07-19 浙江华海药业股份有限公司 一种西酞普兰或s-西酞普兰的纯化方法

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1143702A (no) * 1965-03-18
GB1526331A (en) * 1976-01-14 1978-09-27 Kefalas As Phthalanes
GB8419963D0 (en) * 1984-08-06 1984-09-12 Lundbeck & Co As H Intermediate compound and method
GB8814057D0 (en) * 1988-06-14 1988-07-20 Lundbeck & Co As H New enantiomers & their isolation
US5296507A (en) * 1990-09-06 1994-03-22 H.Lundbeck A/S Treatment of cerbrovascular disorders
DK213290D0 (da) * 1990-09-06 1990-09-06 Lundbeck & Co As H Treatment of cerebrovascular disorders
DE19626659A1 (de) * 1996-07-03 1998-01-08 Basf Ag Verfahren zur Herstellung von Phthaliden
DE19627697A1 (de) * 1996-07-10 1998-01-15 Basf Ag Verfahren zur Herstellung von Phthaliden
NZ501737A (en) * 1997-07-08 2001-10-26 H Method for the preparation of citalopram using Grignard reagent 4-halogen-fluorophenyl and 3-halogen-N,N-dimethyl-propylamine
UA62985C2 (en) * 1997-11-10 2004-01-15 Lunnbeck As H A method for the preparation of citalopram
DE1042310T1 (de) * 1997-11-11 2001-04-19 Lundbeck & Co As H Verfahren zur herstellung von citaloprame
PL199423B1 (pl) * 1998-10-20 2008-09-30 Lundbeck & Co As H Sposób wytwarzania citalopramu
PT1140886E (pt) * 1998-12-23 2003-08-29 Lundbeck & Co As H Metodo para a preparacao de 5- cianoftalida
AR022329A1 (es) * 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
DE69907037T3 (de) * 1999-04-14 2010-02-18 H. Lundbeck A/S Verfahren zur herstellung von citalopram
ITMI991579A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
CH692421A5 (de) * 1999-10-25 2002-06-14 Lundbeck & Co As H Verfahren zur Herstellung von Citalopram.
AR026063A1 (es) * 1999-11-01 2002-12-26 Lundbeck & Co As H Metodo para la preparacion de 5-carboxiftalida.
IES20010143A2 (en) * 2000-02-24 2001-07-25 Lundbeck & Co As H Method for the preparation of citalopram
FR2805812A1 (fr) * 2000-02-24 2001-09-07 Lundbeck & Co As H Procede de preparation du citalopram
FI20011622L (fi) * 2000-08-18 2002-02-19 Lundbeck & Co As H Menetelmä sitalopraamin valmistamiseksi
TR200201166T1 (tr) * 2000-12-22 2002-10-21 H.Lundbecks A/S Saf sitalopram hazırlanması için yöntem
EP1181272B1 (en) * 2000-12-28 2002-08-28 H. Lundbeck A/S Process for the preparation of pure citalopram

Also Published As

Publication number Publication date
SE0100193L (sv) 2001-04-25
PL346237A1 (en) 2002-01-28
ATA904199A (de) 2002-05-15
ITMI991581A0 (it) 1999-07-15
AU1374500A (en) 2000-03-27
JP2002526386A (ja) 2002-08-20
WO2000013648A2 (en) 2000-03-16
HUP0103235A2 (hu) 2002-01-28
UA63034C2 (en) 2004-01-15
CZ292198B6 (cs) 2003-08-13
DE19983487C1 (de) 2002-07-25
GB2354239A (en) 2001-03-21
GB0101504D0 (en) 2001-03-07
SK285813B6 (sk) 2007-08-02
WO2000013648A3 (en) 2000-07-13
DE69906389T2 (de) 2003-10-30
JP3447267B2 (ja) 2003-09-16
AT409961B (de) 2002-12-27
PL205579B1 (pl) 2010-05-31
US20020077353A1 (en) 2002-06-20
EP1159274A2 (en) 2001-12-05
SK18402001A3 (sk) 2002-06-04
PT1159274E (pt) 2003-08-29
IL145959A (en) 2007-07-24
DK1159274T3 (da) 2003-07-21
IS2343B (is) 2008-02-15
CA2475401A1 (en) 2000-12-25
KR20020012204A (ko) 2002-02-15
US20090088469A1 (en) 2009-04-02
AR020863A1 (es) 2002-05-29
BR9917368B1 (pt) 2010-02-09
WO2000013648A8 (en) 2000-05-11
CZ2001320A3 (en) 2001-05-16
TR200103702T2 (tr) 2002-06-21
IS5861A (is) 2001-02-23
GB2357761A (en) 2001-07-04
SE0100193D0 (sv) 2001-01-24
AT4365U1 (de) 2001-06-25
GB0105182D0 (en) 2001-04-18
FI108641B (fi) 2002-02-28
HK1049002A1 (en) 2003-04-25
ES2189699A1 (es) 2003-07-01
CA2290127C (en) 2005-01-25
KR100491368B1 (ko) 2005-05-24
ATE235478T1 (de) 2003-04-15
BG65574B1 (bg) 2009-01-30
MXPA01010989A (es) 2002-06-04
AU2001100440A4 (en) 2001-11-01
CN1502616A (zh) 2004-06-09
CN1367786A (zh) 2002-09-04
ZA200108854B (en) 2002-08-28
ES2194545T3 (es) 2003-11-16
HK1049002B (zh) 2004-12-31
BR9917368A (pt) 2002-03-05
CN1140521C (zh) 2004-03-03
HUP0103235A3 (en) 2003-01-28
CH691305A5 (de) 2001-06-29
GB2357761B (en) 2001-09-05
CA2290127A1 (en) 2000-12-25
SI1159274T1 (en) 2003-10-31
EA002560B1 (ru) 2002-06-27
ITMI991581A1 (it) 2001-01-15
NO20010319D0 (no) 2001-01-19
EA200101072A1 (ru) 2002-02-28
NZ514979A (en) 2004-01-30
FI20010155L (fi) 2001-02-09
GB2354239B (en) 2001-06-06
DK200100060A (da) 2001-04-10
EP1159274B1 (en) 2003-03-26
BG106191A (en) 2002-08-30
AU2001100440B4 (en) 2002-01-24
IL145959A0 (en) 2002-07-25
DE69906389D1 (de) 2003-04-30
WO2000013648B1 (en) 2001-03-15
NO328542B1 (no) 2010-03-15
SE516690C2 (sv) 2002-02-12

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Representative=s name: PLOUGMANN & VINGTOFT, POSTBOKS 1003 SENTRUM, 0104

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