NO176019C - Analogifremgangsmåte for fremstilling av terapeutisk aktive 6-substituert-heksahydrobenz(cd)indoler samt mellomprodukter for disse - Google Patents

Analogifremgangsmåte for fremstilling av terapeutisk aktive 6-substituert-heksahydrobenz(cd)indoler samt mellomprodukter for disse

Info

Publication number: NO176019C
Authority: NO; Norway
Prior art keywords: hexahydrobenz; indoles; intermediates; substituted; preparation
Prior art date: 1990-08-15

Application number

NO913158A

Other languages

English (en)

Other versions

NO913158D0 (no

NO176019B (no

NO913158L (no

Inventor

Michael Edward Flaugh

Michael John Martinelli

John Mehnert Schaus

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-08-15

Filing date

1991-08-13

Publication date

1995-01-18

1991-08-13 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

1991-08-13 Publication of NO913158D0 publication Critical patent/NO913158D0/no

1992-02-17 Publication of NO913158L publication Critical patent/NO913158L/no

1994-10-10 Publication of NO176019B publication Critical patent/NO176019B/no

1995-01-18 Publication of NO176019C publication Critical patent/NO176019C/no

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/90—Benzo [c, d] indoles; Hydrogenated benzo [c, d] indoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Pain & Pain Management (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Addiction (AREA)
Urology & Nephrology (AREA)
Otolaryngology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

NO913158A 1990-08-15 1991-08-13 Analogifremgangsmåte for fremstilling av terapeutisk aktive 6-substituert-heksahydrobenz(cd)indoler samt mellomprodukter for disse NO176019C (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US56798790A	1990-08-15	1990-08-15
US07/725,177 US5229410A (en)	1990-08-15	1991-07-03	6-substituted-hexahydrobenz[cd]indoles

Publications (4)

Publication Number	Publication Date
NO913158D0 NO913158D0 (no)	1991-08-13
NO913158L NO913158L (no)	1992-02-17
NO176019B NO176019B (no)	1994-10-10
NO176019C true NO176019C (no)	1995-01-18

Family

ID=27074631

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO913158A NO176019C (no)	1990-08-15	1991-08-13	Analogifremgangsmåte for fremstilling av terapeutisk aktive 6-substituert-heksahydrobenz(cd)indoler samt mellomprodukter for disse

Country Status (17)

Country	Link
US (1)	US5229410A (no)
EP (1)	EP0471569A1 (no)
JP (1)	JPH04230664A (no)
KR (1)	KR920004346A (no)
CN (1)	CN1058962A (no)
AU (1)	AU648331B2 (no)
BR (1)	BR9103479A (no)
CS (1)	CS249591A3 (no)
FI (1)	FI913834A (no)
HU (1)	HUT59095A (no)
IE (1)	IE912879A1 (no)
IL (1)	IL99149A0 (no)
MX (1)	MX9100644A (no)
NO (1)	NO176019C (no)
NZ (1)	NZ239334A (no)
PT (1)	PT98639A (no)
YU (1)	YU140391A (no)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5204340A (en) *	1989-04-11	1993-04-20	Eli Lilly And Company	Tetrahydrobenz(c,d)indole serotonin agonists
ATE149480T1 (de) *	1990-08-15	1997-03-15	Lilly Co Eli	Ring-substituierte 2-amino-1,2,3,4-tetra- hydronaphthaline, 3-aminochromane und 3- aminothiochromane
US5654324A (en) *	1991-03-28	1997-08-05	Eli Lilly And Company	6-heterocyclic-4-amino-1,2,2A,3,4,5-hexahydrobenz[cd]indoles
US5364856A (en) *	1991-03-28	1994-11-15	Eli Lilly And Company	6-heterocyclic-4-amino-1,3,4,5-tetrahydrobenz[CD]indoles
US5347013A (en) *	1991-03-28	1994-09-13	Eli Lilly And Company	6-heterocyclic-4-amino-1,2,2a,3,4,5-hexahydrobenz[cd]indoles
US5292766A (en) *	1992-03-25	1994-03-08	Eli Lilly And Company	Method for improving primary memory and/or learning
US5385928A (en) *	1994-05-18	1995-01-31	Eli Lilly And Company	Tetrahydrobenz [CD] indazoles, compositions and use
AU7112198A (en)	1997-04-15	1998-11-11	Massachusetts Institute Of Technology	Synthesis and application of vapor grafted porous materials
KR20050043568A (ko) *	2003-11-06	2005-05-11	김상현	두족류 연체동물 포획용 분할형 인공패각

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE517732C (de) *	1927-10-27	1931-02-09	Then Rudolf	Faerbekufe mit einem drehbaren, trommelartigen Rahmen fuer die auf aus-wechselbaren Faerbestoecken aufgehaengten Waren, insbesondere Struempfe
BE542760A (no) *	1954-11-12
US3194811A (en) *	1963-09-05	1965-07-13	Merck & Co Inc	Aroyl-benzindolyl acids
BE755270A (fr) *	1969-08-27	1971-02-25	Sandoz Sa	Nouveaux derives du benzo(cd)indole, leur preparation et medicaments contenant ces derives
FI206974A (no) *	1973-07-16	1975-01-17	Sandoz Ag
US4110339A (en) *	1977-11-25	1978-08-29	Eli Lilly And Company	4-(Di-n-propyl)amino-1,3,4,5-tetrahydrobenz[cd]indole
FR2522658A1 (fr) *	1982-03-05	1983-09-09	Roussel Uclaf	Application a titre de medicaments de derives du trans 4-amino benz (c,d) indol-5-ol ainsi que de leurs sels, compositions les renfermant, nouveaux derives et leur procede de preparation
DE3346573A1 (de) *	1983-12-23	1985-07-04	Troponwerke GmbH & Co KG, 5000 Köln	1,3,4,5-tetrahydrobenz(c,d)indole, ein verfahren zu ihrer herstellung und ihre verwendung
US4983622A (en) *	1984-02-06	1991-01-08	Eli Lilly And Company	6-substituted-4-dialkylaminotetrahydrobenz(c,d)indoles
IL74222A (en) *	1984-02-06	1988-07-31	Lilly Co Eli	6-substituted-4-dialkylamino tetrahydrobenz(c,d)indoles,their preparation and pharmaceutical compositions comprising them
US4576959A (en) *	1984-02-06	1986-03-18	Eli Lilly And Company	6-Substituted-4-dialkylaminotetrahydrobenz[c,d]indoles
CA1266482A1 (en) *	1984-05-24	1990-03-06	Carl Kaiser	6-oxygenated-1,3,4,5-tetrahydrobenz(cd)indol-4-amines
DE3525564A1 (de) *	1985-07-15	1987-02-05	Schering Ag	Tricyclische verbindungen mit indolstruktur, verfahren zu ihrer herstellung und deren verwendung als arzneimittel
US4745126A (en) *	1987-03-12	1988-05-17	Eli Lilly And Company	Method of treating anxiety with tetrahydrobenz[c,d]indole-6-carboxamides
DE3718892A1 (de) *	1987-06-05	1988-12-22	Bayer Ag	Polyhydrobenz(c,d)indol-sulfonamide
US5039820A (en) *	1990-02-26	1991-08-13	Eli Lilly And Company	4-amino-6-iodo-hexahydrobenz(cd)indoles
IL97308A (en) *	1990-02-26	1996-10-31	Lilly Co Eli	Xahydrobenz [DC] Induced indoles in position 6, their preparation process and pharmaceutical preparations containing them
US5096908A (en) *	1990-05-04	1992-03-17	Eli Lilly And Company	Method of inhibiting gastric acid secretion
US5229409A (en) *	1990-08-15	1993-07-20	Eli Lilly And Company	6-substituted-tetrahydrobenz[cd]indoles
ZA917355B (en) *	1990-09-17	1992-08-26	Agouron Pharma	Antiproliferative substituted naphthalene compounds

1991
- 1991-07-03 US US07/725,177 patent/US5229410A/en not_active Expired - Fee Related
- 1991-08-09 NZ NZ239334A patent/NZ239334A/xx unknown
- 1991-08-09 IL IL99149A patent/IL99149A0/xx unknown
- 1991-08-12 CS CS912495A patent/CS249591A3/cs unknown
- 1991-08-12 PT PT98639A patent/PT98639A/pt not_active Application Discontinuation
- 1991-08-13 AU AU82407/91A patent/AU648331B2/en not_active Ceased
- 1991-08-13 KR KR1019910013966A patent/KR920004346A/ko not_active Application Discontinuation
- 1991-08-13 NO NO913158A patent/NO176019C/no unknown
- 1991-08-13 MX MX9100644A patent/MX9100644A/es unknown
- 1991-08-13 FI FI913834A patent/FI913834A/fi not_active Application Discontinuation
- 1991-08-14 BR BR919103479A patent/BR9103479A/pt not_active Application Discontinuation
- 1991-08-14 YU YU140391A patent/YU140391A/sh unknown
- 1991-08-14 HU HU912707A patent/HUT59095A/hu unknown
- 1991-08-14 CN CN91105627A patent/CN1058962A/zh active Pending
- 1991-08-14 EP EP91307509A patent/EP0471569A1/en not_active Withdrawn
- 1991-08-14 IE IE287991A patent/IE912879A1/en unknown
- 1991-08-14 JP JP3204238A patent/JPH04230664A/ja not_active Withdrawn

Also Published As

Publication number	Publication date
YU140391A (sh)	1994-06-10
FI913834A (fi)	1992-02-16
NO913158D0 (no)	1991-08-13
CN1058962A (zh)	1992-02-26
HUT59095A (en)	1992-04-28
JPH04230664A (ja)	1992-08-19
HU912707D0 (en)	1992-01-28
IE912879A1 (en)	1992-02-26
AU8240791A (en)	1992-02-20
BR9103479A (pt)	1992-05-12
CS249591A3 (en)	1992-03-18
MX9100644A (es)	1992-04-01
US5229410A (en)	1993-07-20
IL99149A0 (en)	1992-07-15
KR920004346A (ko)	1992-03-27
PT98639A (pt)	1992-06-30
NO176019B (no)	1994-10-10
NZ239334A (en)	1993-05-26
EP0471569A1 (en)	1992-02-19
FI913834A0 (fi)	1991-08-13
AU648331B2 (en)	1994-04-21
NO913158L (no)	1992-02-17

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NO176019C (no)	1995-01-18	Analogifremgangsmåte for fremstilling av terapeutisk aktive 6-substituert-heksahydrobenz(cd)indoler samt mellomprodukter for disse
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FI911701A (fi)	1991-10-11	Menetelmä terapeuttisesti käyttökelpoisten 2-substituoitujen alkyyli-3-karboksikarbapeneemien valmistamiseksi
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