NO173236C - Analogifremgangsmaate for fremstilling av terapeutisk aktive oksaspiro(2.5)oktanderivater - Google Patents
Analogifremgangsmaate for fremstilling av terapeutisk aktive oksaspiro(2.5)oktanderivaterInfo
- Publication number
- NO173236C NO173236C NO893235A NO893235A NO173236C NO 173236 C NO173236 C NO 173236C NO 893235 A NO893235 A NO 893235A NO 893235 A NO893235 A NO 893235A NO 173236 C NO173236 C NO 173236C
- Authority
- NO
- Norway
- Prior art keywords
- alkylcarbamoyl
- alkyl
- hydroxy
- alkenoyl
- oxaspiro
- Prior art date
Links
- VUEWYZJJYGPJDC-UHFFFAOYSA-N 1-oxaspiro[2.5]octane Chemical class C1OC11CCCCC1 VUEWYZJJYGPJDC-UHFFFAOYSA-N 0.000 title abstract 3
- 230000001225 therapeutic effect Effects 0.000 title 1
- 125000005115 alkyl carbamoyl group Chemical group 0.000 abstract 12
- 125000000217 alkyl group Chemical group 0.000 abstract 12
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 6
- 125000003545 alkoxy group Chemical group 0.000 abstract 4
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 3
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- 206010012689 Diabetic retinopathy Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000004681 Psoriasis Diseases 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 230000033115 angiogenesis Effects 0.000 abstract 1
- 125000005116 aryl carbamoyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
- C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
- C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/34—Compounds containing oxirane rings with hydrocarbon radicals, substituted by sulphur, selenium or tellurium atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Furan Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Epoxy Compounds (AREA)
- Photoreceptors In Electrophotography (AREA)
- Polyesters Or Polycarbonates (AREA)
- Dental Preparations (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Seasonings (AREA)
- Cereal-Derived Products (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NO930648A NO174552C (no) | 1988-08-12 | 1993-02-24 | Analogifremgangsmåte for fremstilling av angiogenese-hemmende oksaspiro(2.5)oktanderivater |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB888819258A GB8819258D0 (en) | 1988-08-12 | 1988-08-12 | Oxaspiro(2 5)octane compound |
| GB888819256A GB8819256D0 (en) | 1988-08-12 | 1988-08-12 | Oxaspiro(2 5)octane derivative |
| GB898908029A GB8908029D0 (en) | 1989-04-10 | 1989-04-10 | Oxaspriro(2,5)octane derivative |
| GB898909794A GB8909794D0 (en) | 1989-04-28 | 1989-04-28 | Cyclohexane derivative |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| NO893235D0 NO893235D0 (no) | 1989-08-11 |
| NO893235L NO893235L (no) | 1990-02-13 |
| NO173236B NO173236B (no) | 1993-08-09 |
| NO173236C true NO173236C (no) | 1993-11-17 |
Family
ID=27450157
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO893235A NO173236C (no) | 1988-08-12 | 1989-08-11 | Analogifremgangsmaate for fremstilling av terapeutisk aktive oksaspiro(2.5)oktanderivater |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US5789405A (no) |
| EP (1) | EP0354787B1 (no) |
| JP (2) | JP2773275B2 (no) |
| KR (1) | KR0130765B1 (no) |
| CN (1) | CN1051703C (no) |
| AT (1) | ATE118490T1 (no) |
| AU (1) | AU632056B2 (no) |
| CA (1) | CA1340291C (no) |
| DE (1) | DE68921114T2 (no) |
| DK (1) | DK171987B1 (no) |
| ES (1) | ES2067546T3 (no) |
| FI (1) | FI97805C (no) |
| GR (1) | GR3015382T3 (no) |
| HU (1) | HU211569A9 (no) |
| IE (1) | IE66923B1 (no) |
| IL (1) | IL91250A (no) |
| NO (1) | NO173236C (no) |
| PH (1) | PH26256A (no) |
Families Citing this family (71)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PH26256A (en) * | 1988-08-12 | 1992-04-01 | Fujisawa Pharmaceutical Co | Oxaspiro [2,5] octane derivative |
| JPH0660168B2 (ja) * | 1988-09-01 | 1994-08-10 | 武田薬品工業株式会社 | ０―置換フマギロール誘導体 |
| DE68927904T2 (de) * | 1988-09-01 | 1997-09-04 | Takeda Chemical Industries Ltd | Fumagillol-Derivate |
| JPH0660095B2 (ja) * | 1988-09-01 | 1994-08-10 | 武田薬品工業株式会社 | 血管新生阻害剤 |
| ATE87623T1 (de) * | 1989-03-06 | 1993-04-15 | Takeda Chemical Industries Ltd | 6-epifumagillole, ihre herstellung und ihre verwendung. |
| US5290807A (en) * | 1989-08-10 | 1994-03-01 | Children's Medical Center Corporation | Method for regressing angiogenesis using o-substituted fumagillol derivatives |
| US6017954A (en) * | 1989-08-10 | 2000-01-25 | Children's Medical Center Corp. | Method of treating tumors using O-substituted fumagillol derivatives |
| EP0415294A3 (en) * | 1989-08-31 | 1991-06-12 | Takeda Chemical Industries, Ltd. | Cyclohexanol derivatives, production and use thereof |
| TW282399B (no) * | 1990-05-25 | 1996-08-01 | Takeda Pharm Industry Co Ltd | |
| DE69231457T2 (de) * | 1991-06-21 | 2001-05-23 | Takeda Chemical Industries Ltd | Zyklodextrin-Zusammensetzung enthaltend Fumagillol-Derivate |
| WO1993005777A1 (fr) * | 1991-09-18 | 1993-04-01 | Fujisawa Pharmaceutical Co., Ltd. | Preparation transoculaire |
| DE69311278T2 (de) * | 1992-12-16 | 1997-10-30 | Takeda Chemical Industries Ltd | Stabile pharmazeutische Zubereitung mit Fumagillolderivaten |
| US5710148A (en) * | 1995-03-06 | 1998-01-20 | Senju Pharmaceuticals Co., Ltd. | Corneal opacification inhibitory composition |
| FR2733499B1 (fr) * | 1995-04-27 | 1997-05-30 | Adir | Nouvelles tetrahydropyrano(3,2-d)oxazolones substituees, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| FR2733498B1 (fr) * | 1995-04-27 | 1997-05-30 | Adir | Nouveaux composes cyclohexaniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| US5719167A (en) * | 1995-08-07 | 1998-02-17 | Alcon Laboratories, Inc. | Angiostatic compounds |
| US5798356A (en) * | 1995-08-07 | 1998-08-25 | Alcon Laboratories, Inc. | Angiostatic compounds |
| WO1997013509A1 (en) * | 1995-10-11 | 1997-04-17 | Fujisawa Pharmaceutical Co., Ltd. | Vascular permeation inhibitor |
| WO1998056372A1 (en) | 1997-06-09 | 1998-12-17 | Massachusetts Institute Of Technology | TYPE 2 METHIONINE AMINOPEPTIDASE (MetAP2) INHIBITORS AND USES THEROF |
| WO1999061432A1 (en) * | 1998-05-12 | 1999-12-02 | Biochem Pharma Inc. | Fumagillin analogs and their use as angiogenesis inhibitors |
| KR100357541B1 (ko) * | 1998-05-15 | 2002-10-18 | 주식회사종근당 | 5-데메톡시 푸마질롤 유도체 및 그 제조방법 |
| KR100357542B1 (ko) * | 1998-05-15 | 2002-10-18 | 주식회사종근당 | 푸마질롤 유도체 및 그 제조방법 |
| US6919307B2 (en) * | 2000-11-01 | 2005-07-19 | Praecis Pharmaceuticals, Inc. | Therapeutic agents and methods of use thereof for the modulation of angiogenesis |
| MXPA03003775A (es) * | 2000-11-01 | 2003-07-28 | Praecis Pharm Inc | Peptidos como inhibidores de met-ap2. |
| US7105482B2 (en) | 2000-11-01 | 2006-09-12 | Praecis Pharmaceuticals, Inc. | Methionine aminopeptidase-2 inhibitors and methods of use thereof |
| US6548477B1 (en) * | 2000-11-01 | 2003-04-15 | Praecis Pharmaceuticals Inc. | Therapeutic agents and methods of use thereof for the modulation of angiogenesis |
| JP2007537147A (ja) * | 2003-12-29 | 2007-12-20 | プレーシス ファーマスーティカルズ インコーポレイテッド | メチオニンアミノペプチダーゼ−２のインヒビターおよびその使用 |
| JP2009505924A (ja) * | 2006-01-24 | 2009-02-12 | ゴス インターナショナル アメリカス インコーポレイテッド | ラップ平坦化装置を備える折丁ホッパ |
| CA2706914A1 (en) | 2007-11-28 | 2009-06-11 | Mersana Therapeutics, Inc. | Biocompatible biodegradable fumagillin analog conjugates |
| EP2317845A4 (en) * | 2008-07-18 | 2011-11-09 | Zafgen Inc | METHOD FOR TREATING AN OVERWEIGHT OR FATABLE PERSON |
| WO2010065877A2 (en) | 2008-12-04 | 2010-06-10 | Zafgen Corporation | Methods of treating an overweight or obese subject |
| US8642650B2 (en) | 2008-12-04 | 2014-02-04 | Zafgen, Inc. | Methods of treating an overweight or obese subject |
| JP2012528240A (ja) | 2009-05-28 | 2012-11-12 | メルサナ セラピューティックス， インコーポレイテッド | 可変速度放出リンカーを含むポリアル−薬物コンジュゲート |
| AU2010303270A1 (en) | 2009-10-09 | 2012-05-03 | Zafgen Corporation | Sulphone compounds for use in the treatment of obesity |
| US8772333B2 (en) | 2010-01-08 | 2014-07-08 | Zafgen, Inc. | Fumigillol type compounds and methods of making and using same |
| WO2011085198A1 (en) | 2010-01-08 | 2011-07-14 | Zafgen Corporation | Metap-2 inhibitor for use in treating benign prostatic hypertrophy (bph) |
| US20130266578A1 (en) | 2010-04-07 | 2013-10-10 | Thomas E. Hughes | Methods of treating an overweight subject |
| US9266896B2 (en) | 2010-07-22 | 2016-02-23 | Zafgen, Inc. | Tricyclic compounds and methods of making and using same |
| PH12013500934A1 (en) | 2010-11-09 | 2022-10-24 | Zafgen Inc | Crystalline solids of a metap-2 inhibitor and methods of making and using same |
| WO2012075020A1 (en) | 2010-11-29 | 2012-06-07 | Zafgen Corporation | Treatment of obesity using non-daily administration of 6 - 0 - (4 - dimethylaminoethoxy) cinnamoyl fumagillol |
| MX344238B (es) | 2011-01-26 | 2016-12-07 | Zafgen Inc | Compuestos de tetrazol y métodos para preparar y usar los mismos. |
| MX342257B (es) | 2011-03-08 | 2016-09-21 | Zafgen Inc | Derivados y análogos de oxaspiro [2.5] octano. |
| EP2705030B1 (en) | 2011-05-06 | 2016-07-27 | Zafgen, Inc. | Partially saturated tricyclic compounds and methods of making and using same |
| MX343688B (es) | 2011-05-06 | 2016-11-16 | Zafgen Inc | Compuestos tricíclicos de sulfonamida y pirazolo y métodos para su fabricación y uso. |
| US9187494B2 (en) | 2011-05-06 | 2015-11-17 | Zafgen, Inc. | Aryl-substituted tricyclic sulfonamides as methionyl aminopeptidase 2 modulators |
| JP5926374B2 (ja) | 2011-06-10 | 2016-05-25 | メルサナ セラピューティクス，インコーポレイティド | タンパク質−高分子−薬剤コンジュゲート |
| EP2763671A2 (en) | 2011-10-03 | 2014-08-13 | Zafgen, Inc. | Methods of treating age related disorders |
| JP6035347B2 (ja) | 2012-01-18 | 2016-11-30 | ザフゲン，インコーポレイテッド | 三環式スルホンアミド化合物ならびにその作製および使用方法 |
| AU2013209719A1 (en) | 2012-01-18 | 2014-08-07 | Zafgen, Inc. | Tricyclic sulfone compounds and methods of making and using same |
| AU2013259760A1 (en) | 2012-05-07 | 2014-11-20 | Zafgen, Inc. | Polymorphic salt of the oxalate salt of 6-O-(4-dimethylaminoethoxy) cinnamoyl fumagillol and methods of making and using same |
| CN104363905A (zh) | 2012-05-08 | 2015-02-18 | 扎夫根股份有限公司 | 用metap2抑制剂治疗下丘脑性肥胖 |
| BR112014027981A2 (pt) * | 2012-05-09 | 2017-06-27 | Zafgen Inc | compostos do tipo fumagilol e métodos de produção e utilização dos mesmos |
| CA2890344A1 (en) | 2012-11-05 | 2014-05-08 | Zafgen, Inc. | Tricyclic compounds for use in the treatment and/or control of obesity |
| BR112015010225A2 (pt) | 2012-11-05 | 2017-07-11 | Zafgen Inc | compostos tricíclicos e seus métodos de produção e utilização |
| EA028367B1 (ru) | 2012-11-05 | 2017-11-30 | Зафджен, Инк. | Способы лечения заболеваний печени |
| AU2013359506B2 (en) | 2012-12-10 | 2018-05-24 | Mersana Therapeutics, Inc. | Protein-polymer-drug conjugates |
| EP2931316B1 (en) | 2012-12-12 | 2019-02-20 | Mersana Therapeutics, Inc. | Hydroxyl-polymer-drug-protein conjugates |
| US9597309B2 (en) | 2013-03-14 | 2017-03-21 | Zafgen, Inc. | Methods of treating renal disease and other disorders |
| IL245009B (en) | 2013-10-11 | 2022-08-01 | Asana Biosciences Llc | Protein-polymer-drug conjugates |
| JP6420331B2 (ja) | 2013-10-11 | 2018-11-07 | メルサナ セラピューティクス，インコーポレイティド | タンパク質−高分子−薬剤コンジュゲート |
| TW201636342A (zh) | 2014-12-19 | 2016-10-16 | 武田藥品工業有限公司 | 煙黴醇衍生物 |
| AR105671A1 (es) | 2015-08-11 | 2017-10-25 | Zafgen Inc | Compuestos heterocíclicos de fumagillol y sus métodos de elaboración y uso |
| CN106432255A (zh) | 2015-08-11 | 2017-02-22 | 扎夫根公司 | 烟曲霉素醇螺环化合物和制备和使用其的方法 |
| US11135307B2 (en) | 2016-11-23 | 2021-10-05 | Mersana Therapeutics, Inc. | Peptide-containing linkers for antibody-drug conjugates |
| EP3641826B1 (en) | 2017-06-22 | 2023-12-06 | Mersana Therapeutics, Inc. | Methods of producing drug-carrying polymer scaffolds and protein-polymer-drug conjugates |
| CN108530375B (zh) * | 2018-05-29 | 2020-04-21 | 南京药石科技股份有限公司 | 4-氧杂-7-氮杂螺[2.5]辛烷或其盐的中间体及制备方法 |
| CA3117050A1 (en) | 2018-10-29 | 2020-05-07 | Mersana Therapeutics, Inc. | Cysteine engineered antibody-drug conjugates with peptide-containing linkers |
| US20250129033A1 (en) * | 2022-02-16 | 2025-04-24 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Metap2 inhibitors and uses thereof |
| JP2025524727A (ja) | 2022-07-15 | 2025-07-30 | フィアン セラピューティクス エルティーディー | Ｃｄｃｐ１と結合する抗体薬物複合体及びその使用 |
| WO2024040009A2 (en) * | 2022-08-17 | 2024-02-22 | Primetime Life Sciences, Llc | Inhibitors of methionine aminopeptidase-2 and methods of preparation and uses thereof |
| WO2025149667A1 (en) | 2024-01-12 | 2025-07-17 | Pheon Therapeutics Ltd | Antibody drug conjugates and uses thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0629278B2 (ja) * | 1985-06-26 | 1994-04-20 | 藤沢薬品工業株式会社 | オキサスピロオクタン化合物 |
| PH26256A (en) * | 1988-08-12 | 1992-04-01 | Fujisawa Pharmaceutical Co | Oxaspiro [2,5] octane derivative |
| DE68927904T2 (de) * | 1988-09-01 | 1997-09-04 | Takeda Chemical Industries Ltd | Fumagillol-Derivate |
| CA1329771C (en) * | 1988-09-01 | 1994-05-24 | Shoji Kishimoto | Angiogenesis inhibitory agent |
| JPH0660168B2 (ja) * | 1988-09-01 | 1994-08-10 | 武田薬品工業株式会社 | ０―置換フマギロール誘導体 |
| ATE87623T1 (de) * | 1989-03-06 | 1993-04-15 | Takeda Chemical Industries Ltd | 6-epifumagillole, ihre herstellung und ihre verwendung. |
-
1989
- 1989-08-01 PH PH39029A patent/PH26256A/en unknown
- 1989-08-02 IE IE250589A patent/IE66923B1/en not_active IP Right Cessation
- 1989-08-07 JP JP1204257A patent/JP2773275B2/ja not_active Expired - Lifetime
- 1989-08-08 IL IL9125089A patent/IL91250A/en not_active IP Right Cessation
- 1989-08-09 AU AU39453/89A patent/AU632056B2/en not_active Ceased
- 1989-08-09 DE DE68921114T patent/DE68921114T2/de not_active Expired - Fee Related
- 1989-08-09 AT AT89308113T patent/ATE118490T1/de not_active IP Right Cessation
- 1989-08-09 DK DK390989A patent/DK171987B1/da not_active IP Right Cessation
- 1989-08-09 EP EP89308113A patent/EP0354787B1/en not_active Expired - Lifetime
- 1989-08-09 ES ES89308113T patent/ES2067546T3/es not_active Expired - Lifetime
- 1989-08-10 CA CA000607998A patent/CA1340291C/en not_active Expired - Fee Related
- 1989-08-11 FI FI893794A patent/FI97805C/fi not_active IP Right Cessation
- 1989-08-11 CN CN93104924A patent/CN1051703C/zh not_active Expired - Fee Related
- 1989-08-11 KR KR1019890011591A patent/KR0130765B1/ko not_active Expired - Fee Related
- 1989-08-11 NO NO893235A patent/NO173236C/no unknown
-
1991
- 1991-06-05 US US07/711,420 patent/US5789405A/en not_active Expired - Fee Related
-
1994
- 1994-08-05 US US08/287,589 patent/US5767293A/en not_active Expired - Fee Related
-
1995
- 1995-03-13 GR GR950400533T patent/GR3015382T3/el unknown
- 1995-06-22 HU HU95P/P00365P patent/HU211569A9/hu unknown
-
1996
- 1996-03-25 JP JP8067849A patent/JP2970524B2/ja not_active Expired - Fee Related
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