MC2096A1
(fr)
*
|
1989-02-23 |
1991-02-15 |
Hoffmann La Roche |
Pyrroles substitues
|
GB8904161D0
(en)
*
|
1989-02-23 |
1989-04-05 |
Hoffmann La Roche |
Substituted pyrroles
|
US5380746A
(en)
*
|
1989-05-05 |
1995-01-10 |
Goedecke Aktiengesellschaft |
Bis-(1H-indol-3-YL)-maleinimide derivatives, processes for the preparation thereof and pharmaceutical compositions containing them
|
DE3914764A1
(de)
*
|
1989-05-05 |
1990-11-08 |
Goedecke Ag |
Maleinimid-derivate und deren verwendung als arzneimittel
|
PT93947B
(pt)
*
|
1989-05-05 |
1996-11-29 |
Goedecke Ag |
Processo para a preparacao de novos derivados de maleinimidas e de composicoes farmaceuticas que os contem
|
DE4005969A1
(de)
*
|
1990-02-26 |
1991-08-29 |
Boehringer Mannheim Gmbh |
Neue trisubstituierte pyrrole, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten
|
DE4005970A1
(de)
*
|
1990-02-26 |
1991-08-29 |
Boehringer Mannheim Gmbh |
Neue trisubstituierte maleinimide, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten
|
US5292747A
(en)
*
|
1990-08-07 |
1994-03-08 |
Hoffman-La Roche Inc. |
Substituted pyrroles
|
CA2046801C
(en)
*
|
1990-08-07 |
2002-02-26 |
Peter D. Davis |
Substituted pyrroles
|
GB9123396D0
(en)
*
|
1991-11-04 |
1991-12-18 |
Hoffmann La Roche |
A process for the manufacture of substituted maleimides
|
JPH07504673A
(ja)
*
|
1992-03-20 |
1995-05-25 |
ザ・ウエルカム・ファウンデーション・リミテッド |
抗ウイルス活性を有するインドール誘導体
|
DE4243321A1
(de)
*
|
1992-12-21 |
1994-06-23 |
Goedecke Ag |
Aminosäurederivate von Heterocyclen als PKC-Inhibitoren
|
US5290777A
(en)
*
|
1993-02-24 |
1994-03-01 |
Regents Of The Univ. Of California |
Use for topsentin compounds and pharmaceutical compositions containing same
|
US5721230A
(en)
*
|
1993-05-10 |
1998-02-24 |
Hoffmann-La Roche Inc. |
Substituted pyrroles
|
AU678435B2
(en)
*
|
1993-05-10 |
1997-05-29 |
F. Hoffmann-La Roche Ag |
Substituted pyrroles
|
US5405864A
(en)
*
|
1993-10-15 |
1995-04-11 |
Syntex (U.S.A.) Inc. |
Chemotherapeutic maleimides
|
TW270114B
(no)
*
|
1993-10-22 |
1996-02-11 |
Hoffmann La Roche |
|
US5624949A
(en)
*
|
1993-12-07 |
1997-04-29 |
Eli Lilly And Company |
Protein kinase C inhibitors
|
DK0657458T3
(da)
*
|
1993-12-07 |
2001-10-29 |
Lilly Co Eli |
Inhibitorer af proteinkinase-C
|
US5843935A
(en)
*
|
1993-12-07 |
1998-12-01 |
Eli Lilly And Company |
Protein kinase C inhibitors
|
FI945705A
(fi)
*
|
1993-12-07 |
1996-06-03 |
Lilly Co Eli |
Bisindolyylimaleimidien parannettu synteesi
|
US5541347A
(en)
*
|
1993-12-07 |
1996-07-30 |
Eli Lilly And Company |
Synthesis of bisindolylmaleimides
|
US5723456A
(en)
*
|
1993-12-07 |
1998-03-03 |
Eli Lilly & Company |
Therapeutic treatment for cardiovascular diseases
|
ES2236702T3
(es)
*
|
1993-12-23 |
2005-07-16 |
Eli Lilly And Company |
Inhibidores de la proteina quinasa c.
|
US5545636A
(en)
*
|
1993-12-23 |
1996-08-13 |
Eli Lilly And Company |
Protein kinase C inhibitors
|
AU2771395A
(en)
*
|
1994-06-14 |
1996-01-05 |
Sloan-Kettering Institute For Cancer Research |
Ceramide-activated protein kinase and methods of use of effectors
|
US5481003A
(en)
*
|
1994-06-22 |
1996-01-02 |
Eli Lilly And Company |
Protein kinase C inhibitors
|
US5491242A
(en)
*
|
1994-06-22 |
1996-02-13 |
Eli Lilly And Company |
Protein kinase C inhibitors
|
ES2123873T3
(es)
*
|
1994-08-04 |
1999-01-16 |
Hoffmann La Roche |
Pirrolocarbazol.
|
US5591855A
(en)
*
|
1994-10-14 |
1997-01-07 |
Cephalon, Inc. |
Fused pyrrolocarbazoles
|
US5705511A
(en)
*
|
1994-10-14 |
1998-01-06 |
Cephalon, Inc. |
Fused pyrrolocarbazoles
|
US5475110A
(en)
*
|
1994-10-14 |
1995-12-12 |
Cephalon, Inc. |
Fused Pyrrolocarbazoles
|
US5594009A
(en)
*
|
1994-10-14 |
1997-01-14 |
Cephalon, Inc. |
Fused pyrrolocarbazoles
|
US5559228A
(en)
*
|
1995-03-30 |
1996-09-24 |
Eli Lilly And Company |
Synthesis of bisindolylmaleimides
|
AU6836696A
(en)
*
|
1995-09-05 |
1997-03-27 |
Banyu Pharmaceutical Co., Ltd. |
Antitumor indolopyrrolocarbazole derivatives
|
US5710145A
(en)
*
|
1995-11-20 |
1998-01-20 |
Eli Lilly And Company |
Protein kinase C inhibitor
|
US5616724A
(en)
*
|
1996-02-21 |
1997-04-01 |
Cephalon, Inc. |
Fused pyrrolo[2,3-c]carbazole-6-ones
|
WO1997034890A1
(en)
*
|
1996-03-20 |
1997-09-25 |
Eli Lilly And Company |
Synthesis of indolylmaleimides
|
US6232299B1
(en)
|
1996-05-01 |
2001-05-15 |
Eli Lilly And Company |
Use of protein kinase C inhibitors to enhance the clinical efficacy of oncolytic agents and radiation therapy
|
EP0915698A4
(en)
|
1996-05-01 |
1999-08-11 |
Lilly Co Eli |
TREATMENT PROCEDURE FOR VEGF-RELATED DISEASES
|
UA54427C2
(uk)
*
|
1996-05-01 |
2003-03-17 |
Елі Ліллі Енд Компані |
Спосіб лікування очних захворювань, які пов'язані з фактором васкулярного ендотеліального росту
|
PE91598A1
(es)
*
|
1996-07-29 |
1998-12-24 |
Hoffmann La Roche |
Pirroles sustituidos
|
PE91498A1
(es)
*
|
1996-07-29 |
1998-12-22 |
Hoffmann La Roche |
Pirroles sustituidos
|
PE91698A1
(es)
*
|
1996-07-29 |
1998-12-24 |
Hoffmann La Roche |
Pirroles sustituidos
|
US6093709A
(en)
*
|
1996-08-22 |
2000-07-25 |
Eli Lilly And Company |
Therapeutic treatment for sexual dysfunctions
|
PL331899A1
(en)
*
|
1996-08-23 |
1999-08-16 |
Lilly Co Eli |
Method of obtaining bis-indolyl malimides
|
US5962446A
(en)
*
|
1996-08-30 |
1999-10-05 |
Eli Lilly And Company |
Therapetutic treatment for human T cell lymphotrophic virus type 1 infection
|
US6107327A
(en)
*
|
1996-08-30 |
2000-08-22 |
Eli Lilly And Company |
Therapeutic treatment for HIV infection
|
SE9603284D0
(sv)
*
|
1996-09-10 |
1996-09-10 |
Astra Ab |
New compounds
|
SE9603283D0
(sv)
*
|
1996-09-10 |
1996-09-10 |
Astra Ab |
New compounds
|
TW472045B
(en)
*
|
1996-09-25 |
2002-01-11 |
Astra Ab |
Protein kinase C inhibitor compounds, method for their preparation, pharmaceutical composition thereof and intermediate used for their preparation
|
WO1998018466A2
(en)
*
|
1996-10-31 |
1998-05-07 |
Harbor Branch Oceanographic Institution, Inc. |
Anti-neurogenic inflammatory compounds and compositions and methods of use thereof
|
US5859261A
(en)
*
|
1997-03-20 |
1999-01-12 |
Eli Lilly And Company |
Synthesis of indolylmaleimides
|
US6093740A
(en)
*
|
1997-04-30 |
2000-07-25 |
Eli Lilly And Company |
Therapeutic treatment for skin disorders
|
US6133452A
(en)
*
|
1997-08-22 |
2000-10-17 |
Eli Lilly And Company |
Synthesis of bisindolylmalimides
|
AR017200A1
(es)
|
1997-12-23 |
2001-08-22 |
Astrazeneca Ab |
Compuestos inhibidores de la proteina cinasa c, sales farmaceuticamente aceptables de los mismos, formulaciones farmaceuitcas que los comprenden, usode las mismas y proceso para la sintesis de dichos compuestos
|
EP1057484A4
(en)
*
|
1998-02-23 |
2002-11-20 |
Sagami Chem Res |
INHIBITORS OF CELL DEATH
|
US6103713A
(en)
*
|
1998-03-05 |
2000-08-15 |
Eli Lilly And Company |
Therapeutic treatment for autoimmune diseases
|
US6291446B1
(en)
|
1998-03-05 |
2001-09-18 |
Eli Lilly And Company |
Therapeutic treatment for cytomegalovirus infection
|
US6225301B1
(en)
|
1998-03-05 |
2001-05-01 |
Eli Lilly And Company |
Therapeutic treatment for renal dysfunction
|
US6103712A
(en)
*
|
1998-03-05 |
2000-08-15 |
Eli Lilly And Company |
Therapeutic treatment for asthma
|
SE9800835D0
(sv)
|
1998-03-13 |
1998-03-13 |
Astra Ab |
New Compounds
|
PL195323B1
(pl)
*
|
1998-03-17 |
2007-09-28 |
Hoffmann La Roche |
Podstawione bisindolilomaleimidy do hamowania proliferacji komórek
|
SE9802538D0
(sv)
*
|
1998-07-13 |
1998-07-13 |
Astra Ab |
New pharmaceutically active compounds
|
US6350786B1
(en)
*
|
1998-09-22 |
2002-02-26 |
Hoffmann-La Roche Inc. |
Stable complexes of poorly soluble compounds in ionic polymers
|
EP1119548B1
(en)
*
|
1998-10-08 |
2004-12-08 |
SmithKline Beecham plc |
3-(3-chloro-4-hydroxyphenylamino)-4-(2-nitrophenyl)-1h-pyrrole-2,5-dione as glycogen synthase kinase-3 inhibitor (gsk-3)
|
US6719520B2
(en)
|
1998-10-08 |
2004-04-13 |
Smithkline Beecham Corporation |
Method and compounds
|
GB9828640D0
(en)
*
|
1998-12-23 |
1999-02-17 |
Smithkline Beecham Plc |
Novel method and compounds
|
DK1165558T3
(da)
*
|
1999-03-31 |
2004-02-09 |
Vernalis Ltd |
Pyrimido[6,1-a]isoquinolin-4-on-derivater
|
US6492406B1
(en)
|
1999-05-21 |
2002-12-10 |
Astrazeneca Ab |
Pharmaceutically active compounds
|
US6284783B1
(en)
|
1999-06-09 |
2001-09-04 |
The Uab Research Foundation |
Use of bisindolylmaleimide compounds to induce Fas-mediated apoptosis
|
US6346625B1
(en)
|
1999-06-23 |
2002-02-12 |
Astrazeneca Ab |
Protein kinase inhibitors
|
WO2001013916A1
(fr)
*
|
1999-08-20 |
2001-03-01 |
Sagami Chemical Research Center |
Medicaments inhibant la mort cellulaire
|
US6559164B1
(en)
|
1999-10-12 |
2003-05-06 |
Hoffmann-La Roche Inc. |
Substituted pyrroles suitable for continuous infusion
|
US6313143B1
(en)
*
|
1999-12-16 |
2001-11-06 |
Hoffmann-La Roche Inc. |
Substituted pyrroles
|
US6281356B1
(en)
|
1999-12-22 |
2001-08-28 |
Hoffmann-La Roche Inc. |
Substituted pyrroles
|
GB0008264D0
(en)
*
|
2000-04-04 |
2000-05-24 |
Smithkline Beecham Plc |
Novel method and compounds
|
US6326501B1
(en)
*
|
2000-04-19 |
2001-12-04 |
Hoffmann-La Roche Inc. |
Methylation of indole compounds using dimethyl carbonate
|
US7129250B2
(en)
*
|
2000-05-19 |
2006-10-31 |
Aegera Therapeutics Inc. |
Neuroprotective and anti-proliferative compounds
|
CA2308994A1
(en)
*
|
2000-05-19 |
2001-11-19 |
Aegera Therapeutics Inc. |
Neuroprotective compounds
|
US6353007B1
(en)
*
|
2000-07-13 |
2002-03-05 |
Boehringer Ingelheim Pharmaceuticals, Inc. |
Substituted 1-(4-aminophenyl)indoles and their use as anti-inflammatory agents
|
RU2003104796A
(ru)
*
|
2000-07-27 |
2004-08-20 |
Ф.Хоффманн-Ля Рош Аг (Ch) |
Производные 3-индолил-4-фенил-1н-пиррол-2, 5-диона в качестве ингибиторов гликогенсинтазы-киназы-3 бета
|
US6469179B1
(en)
*
|
2000-10-03 |
2002-10-22 |
Hoffmann-La Roche Inc. |
Amorphous form of cell cycle inhibitor having improved solubility and bioavailability
|
US6482847B2
(en)
*
|
2000-10-03 |
2002-11-19 |
Hoffmann-La Roche Inc. |
Amorphous form of cell cycle inhibitor having improved solubility and bioavailability
|
EP1337527B1
(en)
*
|
2000-11-07 |
2009-10-14 |
Novartis AG |
Indolylmaleimide derivatives as protein kinase c inhibitors
|
US6645970B2
(en)
*
|
2000-11-07 |
2003-11-11 |
Novartis Ag |
Indolylmaleimide derivatives
|
ES2263681T3
(es)
*
|
2000-12-08 |
2006-12-16 |
Ortho-Mcneil Pharmaceutical, Inc. |
Compuestos de pirrolina indazolil-substituidos como inhibidores de la kinasa.
|
US6548531B2
(en)
|
2001-02-09 |
2003-04-15 |
Hoffmann-La Roche Inc. |
Method for cancer therapy
|
DE10109280A1
(de)
*
|
2001-02-26 |
2002-09-05 |
Peter Mayser |
Indolderivate mit inhibitorischer Wirkung auf Proteinkinasen
|
WO2002102373A1
(en)
*
|
2001-06-15 |
2002-12-27 |
F. Hoffmann-La Roche Ag |
Method for administration of cancer therapeutic
|
TWI335221B
(en)
|
2001-09-27 |
2011-01-01 |
Alcon Inc |
Inhibtors of glycogen synthase kinase-3 (gsk-3) for treating glaucoma
|
US20030143185A1
(en)
*
|
2001-10-29 |
2003-07-31 |
Shearwater Corporation |
Polymer conjugates of protein kinase C inhibitors
|
US20030139373A1
(en)
*
|
2001-11-20 |
2003-07-24 |
Breimer Lars Holger |
Method for cancer therapy
|
WO2003076442A1
(en)
*
|
2002-03-05 |
2003-09-18 |
Eli Lilly And Company |
Purine derivatives as kinase inhibitors
|
KR20040091113A
(ko)
*
|
2002-03-08 |
2004-10-27 |
일라이 릴리 앤드 캄파니 |
피롤-2,5-디온 유도체 및 gsk-3 억제제로서 그의 용도
|
PE20040079A1
(es)
|
2002-04-03 |
2004-04-19 |
Novartis Ag |
Derivados de indolilmaleimida
|
EP1900738A3
(en)
*
|
2002-05-08 |
2008-04-09 |
Janssen Pharmaceutica, N.V. |
Substituted pyrroline kinase inhibitors
|
CA2485527A1
(en)
*
|
2002-05-08 |
2003-11-20 |
Janssen Pharmaceutica N.V. |
Substituted pyrroline kinase inhibitors
|
AU2003238874A1
(en)
|
2002-06-05 |
2003-12-22 |
Janssen Pharmaceutica N.V. |
Bisindolyl-maleimid derivatives as kinase inhibitors
|
ES2312785T3
(es)
*
|
2002-06-05 |
2009-03-01 |
Janssen Pharmaceutica Nv |
Pirrolinas sustituidas utiles como inhibidores de quinasa.
|
CA2393720C
(en)
*
|
2002-07-12 |
2010-09-14 |
Eli Lilly And Company |
Crystalline 2,5-dione-3-(1-methyl-1h-indol-3-yl)-4-[1-(pyridin-2-ylmethyl)piperidin-4-yl]-1h-indol-3-yl]-1h-pyrrole mono-hydrochloride
|
US6800655B2
(en)
*
|
2002-08-20 |
2004-10-05 |
Sri International |
Analogs of indole-3-carbinol metabolites as chemotherapeutic and chemopreventive agents
|
GB0303319D0
(en)
*
|
2003-02-13 |
2003-03-19 |
Novartis Ag |
Organic compounds
|
EP1611132A1
(en)
*
|
2003-03-27 |
2006-01-04 |
Janssen Pharmaceutica N.V. |
Substituted pyrroline kinase inhibitors
|
CA2529353A1
(en)
*
|
2003-06-13 |
2005-01-06 |
Janssen Pharmaceutica N.V. |
Substituted indazolyl(indolyl)maleimide derivatives as kinase inhibitors
|
AU2004262927B2
(en)
|
2003-08-08 |
2008-05-22 |
Novartis Ag |
Combinations comprising staurosporines
|
US7648989B2
(en)
*
|
2004-01-19 |
2010-01-19 |
Novartis Ag |
Indolylmaleimide derivatives as PKC inhibitors
|
BRPI0509754A
(pt)
*
|
2004-04-08 |
2007-10-16 |
Novartis Ag |
inibidores de proteìna quinase c para o tratamento de doenças auto-imunes e de rejeição a transplante
|
CA2571421A1
(en)
|
2004-06-24 |
2006-01-05 |
Nicholas Valiante |
Compounds for immunopotentiation
|
CA2589127C
(en)
*
|
2004-12-08 |
2013-02-05 |
Johannes Gutenberg-Universitat Mainz |
3-(indolyl)-4-arylmaleimide derivatives and their use as angiogenesis inhibitors
|
WO2006078421A2
(en)
*
|
2005-01-04 |
2006-07-27 |
The Board Of Trustees Of The Leland Stanford Junior University |
Methods of increasing cerebral blood flow
|
RU2547148C2
(ru)
*
|
2005-02-09 |
2015-04-10 |
Аркьюл, Инк. |
Композиции и способы лечения рака
|
PL1904482T3
(pl)
*
|
2005-07-11 |
2011-06-30 |
Novartis Ag |
Pochodne indolilomaleimidowe
|
WO2007027974A1
(en)
*
|
2005-09-02 |
2007-03-08 |
The Board Of Trustees Of The Leland Stanford Junior University |
Method for reducing risk of and extent of injury due to stroke in hypertensive subjects
|
JP2009508868A
(ja)
|
2005-09-16 |
2009-03-05 |
シェーリング コーポレイション |
テモゾロミドおよびプロテインキナーゼインヒビターを用いる薬学的組成物および方法
|
CA2673368C
(en)
*
|
2006-12-19 |
2014-10-28 |
The Board Of Trustees Of The University Of Illinois |
3-benzofuranyl-4-indolyl maleimides as potent gsk3 inhibitors for neurogenerative disorders
|
EP2392574B1
(en)
*
|
2007-06-22 |
2013-12-18 |
ArQule, Inc. |
Indolyl pyrrolidines for the treatment of cancer
|
JP5425060B2
(ja)
*
|
2007-06-22 |
2014-02-26 |
アークル インコーポレイテッド |
ピロリジノン、ピロリジン−2,5−ジオン、ピロリジンおよびチオスクシンイミド誘導体、癌の治療のための組成物および方法
|
CN101801937A
(zh)
*
|
2007-06-22 |
2010-08-11 |
艾科尔公司 |
喹唑啉酮化合物及其使用方法
|
FR2927075A1
(fr)
*
|
2008-02-04 |
2009-08-07 |
Centre Nat Rech Scient |
Molecules comprenant un squelette bis-(heteroaryl)maleimide, et leur utilisation dans l'inhibition d'enzymes
|
US8304421B2
(en)
*
|
2008-09-30 |
2012-11-06 |
Vanderbilt University |
Indole compounds and their use as radiation sensitizing agents and chemotherapeutic agents
|
EP2343291A1
(en)
*
|
2009-12-18 |
2011-07-13 |
Johannes Gutenberg-Universität Mainz |
3-(Indolyl)- or 3-(Azaindolyl)-4-arylmaleimide compounds and their use in tumor treatment
|
EP2338486A1
(en)
|
2009-12-18 |
2011-06-29 |
Johannes Gutenberg-Universität Mainz |
3-(indolyl)- or 3-(azaindolyl)-4-arylmaleimide derivatives for use in the treatment of colon and gastric adenocarcinoma
|
EP2474541A1
(en)
|
2010-12-23 |
2012-07-11 |
Johannes- Gutenberg-Universität Mainz |
Conjugated 3-(indolyl)- and 3-(azaindolyl)-4-arylmaleimide compounds and their use in tumor treatment
|
GB201111427D0
(en)
*
|
2011-07-05 |
2011-08-17 |
Amakem Nv |
Novel bisindolylmaleimides, pan-pkc inhibitors
|
EP2928465B1
(en)
*
|
2012-12-10 |
2020-11-18 |
Centogene GmbH |
Use of maleimide derivatives for preventing and treating cancer
|
WO2014090398A1
(en)
*
|
2012-12-10 |
2014-06-19 |
Centogene Ag |
Use of maleimide derivatives for preventing and treating leukemia
|
CN103382199A
(zh)
*
|
2013-06-28 |
2013-11-06 |
北京理工大学 |
一种n-烷基-双吲哚马来酰亚胺的制备方法
|
JP2017524739A
(ja)
|
2014-07-17 |
2017-08-31 |
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