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NO172440C - Kjemisk forbindelse - Google Patents

Kjemisk forbindelse

Info

Publication number
NO172440C
NO172440C NO920665A NO920665A NO172440C NO 172440 C NO172440 C NO 172440C NO 920665 A NO920665 A NO 920665A NO 920665 A NO920665 A NO 920665A NO 172440 C NO172440 C NO 172440C
Authority
NO
Norway
Prior art keywords
chemical connection
chemical
connection
Prior art date
Application number
NO920665A
Other languages
English (en)
Other versions
NO172440B (no
NO920665L (no
NO920665D0 (no
Inventor
Mark G Saulnier
Peter D Senter
John F Kadow
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Publication of NO920665L publication Critical patent/NO920665L/no
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Priority to NO920665A priority Critical patent/NO172440C/no
Publication of NO920665D0 publication Critical patent/NO920665D0/no
Publication of NO172440B publication Critical patent/NO172440B/no
Publication of NO172440C publication Critical patent/NO172440C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Mechanical Coupling Of Light Guides (AREA)
  • Cable Accessories (AREA)
NO920665A 1987-08-04 1992-02-20 Kjemisk forbindelse NO172440C (no)

Priority Applications (1)

Application Number Priority Date Filing Date Title
NO920665A NO172440C (no) 1987-08-04 1992-02-20 Kjemisk forbindelse

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US8149387A 1987-08-04 1987-08-04
US07/199,731 US4904768A (en) 1987-08-04 1988-05-27 Epipodophyllotoxin glucoside 4'-phosphate derivatives
NO883299A NO170284C (no) 1987-08-04 1988-07-26 Analogifremgangsmaate til fremstilling av farmakologisk aktive 4'-fo sfatderivater av 4'-demetylepipodofyllotoksinglukosider
NO920665A NO172440C (no) 1987-08-04 1992-02-20 Kjemisk forbindelse

Publications (4)

Publication Number Publication Date
NO920665L NO920665L (no) 1989-02-24
NO920665D0 NO920665D0 (no) 1992-02-20
NO172440B NO172440B (no) 1993-04-13
NO172440C true NO172440C (no) 1993-07-21

Family

ID=26765636

Family Applications (4)

Application Number Title Priority Date Filing Date
NO883299A NO170284C (no) 1987-08-04 1988-07-26 Analogifremgangsmaate til fremstilling av farmakologisk aktive 4'-fo sfatderivater av 4'-demetylepipodofyllotoksinglukosider
NO920277A NO920277D0 (no) 1987-08-04 1992-01-22 Kjemisk forbindelse og fremgangsmaate til fremstilling derav, samt anvendelse av forbindelsen
NO920665A NO172440C (no) 1987-08-04 1992-02-20 Kjemisk forbindelse
NO1998002C NO1998002I1 (no) 1987-08-04 1998-01-14 Etoposide-fosfat

Family Applications Before (2)

Application Number Title Priority Date Filing Date
NO883299A NO170284C (no) 1987-08-04 1988-07-26 Analogifremgangsmaate til fremstilling av farmakologisk aktive 4'-fo sfatderivater av 4'-demetylepipodofyllotoksinglukosider
NO920277A NO920277D0 (no) 1987-08-04 1992-01-22 Kjemisk forbindelse og fremgangsmaate til fremstilling derav, samt anvendelse av forbindelsen

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO1998002C NO1998002I1 (no) 1987-08-04 1998-01-14 Etoposide-fosfat

Country Status (34)

Country Link
US (3) US4904768A (no)
JP (1) JPH0699465B2 (no)
KR (1) KR900006230B1 (no)
CN (1) CN1027169C (no)
AT (1) AT398974B (no)
BE (1) BE1002982A4 (no)
CA (1) CA1310637C (no)
CH (1) CH676716A5 (no)
CY (1) CY1625A (no)
CZ (1) CZ286893B6 (no)
DD (2) DD274423A5 (no)
DE (1) DE3826562A1 (no)
DK (2) DK169344B1 (no)
ES (1) ES2010775A6 (no)
FI (1) FI87790C (no)
FR (1) FR2622193B1 (no)
GB (1) GB2207674B (no)
GR (1) GR1000490B (no)
HK (1) HK6392A (no)
HU (3) HU208147B (no)
IE (1) IE61040B1 (no)
IL (1) IL87290A (no)
IT (1) IT1226825B (no)
LU (2) LU87290A1 (no)
MX (1) MX173843B (no)
MY (1) MY104321A (no)
NL (2) NL192683C (no)
NO (4) NO170284C (no)
NZ (1) NZ225615A (no)
PT (1) PT88186B (no)
SE (1) SE502214C2 (no)
SG (1) SG101291G (no)
SK (1) SK279325B6 (no)
YU (3) YU143688A (no)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
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US5191071A (en) * 1987-08-21 1993-03-02 Novo Nordisk A/S Monoesters of glycosides and a process for enzymatic preparation thereof
US4965348A (en) * 1989-05-19 1990-10-23 Bristol-Myers Company Dimeric epipodophyllotoxin glucoside derivatives
US5036055A (en) * 1989-06-07 1991-07-30 Bristol-Myers Company Acylated derivatives of etoposide
US5066645A (en) * 1989-09-01 1991-11-19 Bristol-Myers Company Epipodophyllotoxin altroside derivatives
US6610299B1 (en) 1989-10-19 2003-08-26 Aventis Pharma Deutschland Gmbh Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
US7241595B2 (en) 1989-10-20 2007-07-10 Sanofi-Aventis Pharma Deutschland Gmbh Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
US6475486B1 (en) 1990-10-18 2002-11-05 Aventis Pharma Deutschland Gmbh Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
US5552154A (en) * 1989-11-06 1996-09-03 The Stehlin Foundation For Cancer Research Method for treating cancer with water-insoluble s-camptothecin of the closed lactone ring form and derivatives thereof
US5034380A (en) * 1989-11-20 1991-07-23 Bristol-Myers Squibb Company Alkoxymethylidene epipodophyllotoxin glucosides
US5081234A (en) * 1990-04-30 1992-01-14 Bristol-Myers Squibb Co. 4'-demethylepipodophyllotoxin glycosides
US4997931A (en) * 1990-06-11 1991-03-05 Bristol-Myers Squibb Company Epipodophyllotoxin glycosides
TW260671B (no) * 1991-04-29 1995-10-21 Bristol Myers Squibb Co
IT1250692B (it) * 1991-07-23 1995-04-21 Procedimento per la preparazione di demetilepipodofillotossina- beta-d-glucosidi.
US5648474A (en) * 1991-10-08 1997-07-15 Bristol-Myers Squibb Crystalline etoposide 4'-phosphate diethanolate
JPH07632B2 (ja) * 1991-12-23 1995-01-11 ブリストル−マイヤーズ スクイブ カンパニー エトポシド４’−ホスフェート二ナトリウム塩の安定な六水和物
US6080751A (en) * 1992-01-14 2000-06-27 The Stehlin Foundation For Cancer Research Method for treating pancreatic cancer in humans with water-insoluble S-camptothecin of the closed lactone ring form and derivatives thereof
JP3061476B2 (ja) * 1992-04-24 2000-07-10 日本化薬株式会社 エトポシド燐酸エステルの製造法
US5459248A (en) * 1993-11-04 1995-10-17 Bristol-Myers Squibb Company Process of preparing etoposide phosphate and etoposide
FR2725990B1 (fr) * 1994-10-21 1997-01-10 Pf Medicament Derives hydrosolubles d'epipodophyllotoxine, leur procede de preparation, leur utilisation a titre de medicament, et leur utilisation destinee aux traitements anticancereux
CA2223484A1 (en) * 1995-06-07 1996-12-19 Thomas Jefferson University Anti-fungal agents and methods of identifying and using the same
CA2247620A1 (en) 1996-04-01 1997-10-09 Epix Medical, Inc. Bioactivated diagnostic imaging contrast agents
US6207673B1 (en) 1997-03-12 2001-03-27 The University Of North Carolina At Chapel Hill Covalent conjugates of topoisomerase I and topoisomerase II inhibitors
WO1999032499A1 (en) * 1997-12-23 1999-07-01 Korea Research Institute Of Chemical Technology 4'-O-DEMETHYL-EPIPODOPHYLLOTOXIN-β-D-GLUCOSIDE ACETAL DERIVATIVES
EP1229934B1 (en) 1999-10-01 2014-03-05 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
US6624317B1 (en) 2000-09-25 2003-09-23 The University Of North Carolina At Chapel Hill Taxoid conjugates as antimitotic and antitumor agents
US6506739B1 (en) 2001-05-01 2003-01-14 Telik, Inc. Bis-(N,N'-bis-(2-haloethyl)amino)phosphoramidates as antitumor agents
CA2464311A1 (en) * 2001-10-26 2003-05-01 Centre National De La Recherche Scientifique Derivatives of etoposide and analogs, and pharmaceutical compositions containing them
EP2281578A3 (en) 2002-07-15 2011-04-13 Board of Regents, The University of Texas System Selected antibodies and duramycin peptides binding to anionic phospholipids and aminophospholipids and their use in treating viral infections and cancer
CA2516056C (en) * 2003-01-06 2012-05-29 Angiochem Inc. Aprotinin and analogs as carriers across the blood-brain barrier
CN100334090C (zh) * 2005-02-02 2007-08-29 南京医科大学 吡啶类鬼臼毒素化合物及其制备方法和在制备杀虫剂中的应用
BRPI0520032A2 (pt) * 2005-02-18 2009-04-14 Angiochem Inc moléculas para transportar um composto através da barreira hematoencefálica
US20090016959A1 (en) * 2005-02-18 2009-01-15 Richard Beliveau Delivery of antibodies to the central nervous system
EP2471555A3 (en) 2005-07-15 2012-10-17 Angiochem Inc. Use of aprotinin polypeptides as carriers in pharmaceutical conjugates
CN100410266C (zh) * 2006-01-11 2008-08-13 重庆华邦制药股份有限公司 鬼臼毒素磷酸酯衍生物的合成方法
JO2660B1 (en) 2006-01-20 2012-06-17 نوفارتيس ايه جي Pi-3 inhibitors and methods of use
PE20070978A1 (es) * 2006-02-14 2007-11-15 Novartis Ag COMPUESTOS HETEROCICLICOS COMO INHIBIDORES DE FOSFATIDILINOSITOL 3-QUINASAS (PI3Ks)
AR060358A1 (es) * 2006-04-06 2008-06-11 Novartis Vaccines & Diagnostic Quinazolinas para la inhibicion de pdk 1
GB0625283D0 (en) * 2006-12-19 2007-01-24 Cyclacel Ltd Combination
US9365634B2 (en) * 2007-05-29 2016-06-14 Angiochem Inc. Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues
US8263644B2 (en) * 2007-09-13 2012-09-11 Bristol-Myers Squibb Company Cytotoxic xanthone compounds
CN101918030B (zh) 2007-11-09 2015-10-14 派瑞格恩医药公司 抗vegf抗体的组合物和方法
BRPI0820722A2 (pt) 2007-12-20 2015-06-16 Novartis Ag Derivados de tiazol usados como inibidores de pi 3 cinases
TR201905480T4 (tr) * 2008-04-18 2019-05-21 Angiochem Inc Paklitaksel, paklitaksel analogları veya paklitaksel konjugatlarının farmasötik bileşimleri ve ilgili preparasyon ve kullanım yöntemleri.
WO2010043047A1 (en) 2008-10-15 2010-04-22 Angiochem Inc. Conjugates of glp-1 agonists and uses thereof
BRPI0920121A2 (pt) 2008-10-15 2019-09-24 Angiochem Inc conjugados de etoposida e doxorubicina para liberação de fármaco
WO2010063122A1 (en) * 2008-12-05 2010-06-10 Angiochem Inc. Conjugates of neurotensin or neurotensin analogs and uses thereof
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US9173891B2 (en) 2009-04-20 2015-11-03 Angiochem, Inc. Treatment of ovarian cancer using an anticancer agent conjugated to an angiopep-2 analog
US8293753B2 (en) 2009-07-02 2012-10-23 Novartis Ag Substituted 2-carboxamide cycloamino ureas
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US9586954B2 (en) 2010-06-22 2017-03-07 Demerx, Inc. N-substituted noribogaine prodrugs
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JP6381523B2 (ja) 2012-05-16 2018-08-29 ノバルティス アーゲー Ｐｉ−３キナーゼ阻害剤の投与レジメン
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CN107921143B (zh) 2015-06-15 2021-11-19 安吉奥开米公司 用于治疗软脑膜癌病的方法
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FR1171314A (fr) * 1955-05-13 1959-01-23 Sandoz Ag Produits de condensation de glucosides avec des composés carbonyliques et leur préparation
NL6613143A (no) * 1965-09-21 1967-03-22
CH464957A (de) * 1965-12-14 1968-11-15 Sandoz Ag Verfahren zur Herstellung eines neuen Glucosids
CH481094A (de) * 1966-12-13 1969-11-15 Sandoz Ag Verfahren zur Herstellung neuer Glucoside
CH514578A (de) * 1968-02-27 1971-10-31 Sandoz Ag Verfahren zur Herstellung von Glucosiden
CH543502A (de) * 1970-11-20 1973-10-31 Sandoz Ag Verfahren zur Herstellung neuer Glucoside
GB1395820A (en) * 1971-06-05 1975-05-29 Villax I Preparation of 21-inorganic esters of corticosteroids and salts thereof
CH589668A5 (en) * 1973-06-07 1977-07-15 Sandoz Ag Cytostatic (4')-demethyl substd. epipodophyllotoxin - prepd. from the corresp. glucopyranoside with (3)-thiophene-carboxaldehyde
FR2397425A1 (fr) * 1977-07-11 1979-02-09 Rhone Poulenc Ind Nouveaux derives de la daunorubicine, leur preparation et les compositions qui les contiennent
EP0111058B1 (en) * 1982-11-26 1987-11-04 Nippon Kayaku Kabushiki Kaisha Process for producing 4'-demethyl-epipodophyllotoxin-beta-d-ethylidene-glucoside and acyl-derivative thereof
US4567253A (en) * 1984-02-03 1986-01-28 Tony Durst 2-Substituted derivatives of podophyllotoxin and etoposide
JPS60208910A (ja) * 1984-03-31 1985-10-21 Green Cross Corp:The 水難溶性薬物・リン脂質複合体の製造方法
JPS60246393A (ja) * 1984-05-22 1985-12-06 Nippon Kayaku Co Ltd エトポシドの新規製造法
US4739046A (en) * 1985-08-19 1988-04-19 Luzio Nicholas R Di Soluble phosphorylated glucan
IL77334A (en) * 1985-12-16 1991-04-15 Univ Bar Ilan Synthesis of 9-epipodophyllotoxin glucoside derivatives and some novel intermediates therefor
US4916217A (en) * 1987-01-08 1990-04-10 Bristol-Myers Company Phosphorus containing derivatives of epipodophyllotoxin
JPS63192793A (ja) * 1987-02-06 1988-08-10 Nippon Kayaku Co Ltd ４′−デメチル−エピポドフイロトキシン誘導体の新規エステル
US4874851A (en) * 1987-07-01 1989-10-17 Bristol-Meyers Company 3',4'-dinitrogen substituted epipodophyllotoxin glucoside derivatives

Also Published As

Publication number Publication date
GR880100512A (en) 1989-05-25
FI87790C (fi) 1993-02-25
GR1000490B (el) 1992-07-30
HUT47303A (en) 1989-02-28
IT1226825B (it) 1991-02-19
HU905862D0 (en) 1991-03-28
DK169344B1 (da) 1994-10-10
NO170284C (no) 1992-09-30
GB2207674B (en) 1991-09-11
IL87290A (en) 1993-01-31
CN1027169C (zh) 1994-12-28
NZ225615A (en) 1991-06-25
NL192683B (no) 1997-08-01
HU208147B (en) 1993-08-30
JPH0699465B2 (ja) 1994-12-07
NO920277L (no) 1989-02-24
GB8818462D0 (en) 1988-09-07
LU90138I2 (fr) 1997-11-26
NL970042I1 (nl) 1998-03-02
DE3826562A1 (de) 1989-02-16
FI87790B (fi) 1992-11-13
ES2010775A6 (es) 1989-12-01
MX173843B (es) 1994-03-30
KR900006230B1 (ko) 1990-08-27
AU2030688A (en) 1989-06-08
SK541288A3 (en) 1998-10-07
NO172440B (no) 1993-04-13
BE1002982A4 (fr) 1991-10-15
AT398974B (de) 1995-02-27
IL87290A0 (en) 1989-01-31
NO920665L (no) 1989-02-24
AU610619B2 (en) 1991-05-23
SE8802815D0 (sv) 1988-08-03
DK434088A (da) 1989-02-05
DK434088D0 (da) 1988-08-03
CA1310637C (en) 1992-11-24
NL192683C (nl) 1997-12-02
IE61040B1 (en) 1994-09-07
US5041424A (en) 1991-08-20
SK279325B6 (sk) 1998-10-07
SE8802815L (sv) 1989-02-05
CY1625A (en) 1992-07-10
NO920665D0 (no) 1992-02-20
NL970042I2 (no) 2005-06-01
MY104321A (en) 1994-03-31
US4904768A (en) 1990-02-27
IE882378L (en) 1989-02-04
FI883596A0 (fi) 1988-08-01
YU10390A (en) 1990-06-30
YU143688A (en) 1990-04-30
FR2622193B1 (fr) 1993-12-17
MX9202851A (es) 1992-06-30
HU211960A9 (en) 1996-01-29
ATA195588A (de) 1994-07-15
USRE35524E (en) 1997-06-03
IT8821535A0 (it) 1988-07-28
HU202547B (en) 1991-03-28
SE502214C2 (sv) 1995-09-18
DE3826562C2 (no) 1993-04-08
DD299067A5 (de) 1992-03-26
CH676716A5 (no) 1991-02-28
KR890003790A (ko) 1989-04-18
NO920277D0 (no) 1992-01-22
LU87290A1 (fr) 1990-02-07
FI883596A (fi) 1989-02-05
DD274423A5 (de) 1989-12-20
NO883299D0 (no) 1988-07-26
CZ541288A3 (cs) 1999-12-15
NO883299L (no) 1989-02-24
PT88186A (pt) 1989-06-30
YU10490A (en) 1990-06-30
FR2622193A1 (fr) 1989-04-28
CN1061225A (zh) 1992-05-20
PT88186B (pt) 1995-07-03
NO170284B (no) 1992-06-22
DK11992D0 (da) 1992-01-31
CZ286893B6 (cs) 2000-07-12
SG101291G (en) 1992-01-17
HK6392A (en) 1992-01-17
NL8801934A (nl) 1989-03-01
DK11992A (da) 1992-01-31
GB2207674A (en) 1989-02-08
NO1998002I1 (no) 1998-01-14
JPH01100188A (ja) 1989-04-18

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