NO158376C - Analogifremgangsmaate for fremstilling av terapeutisk virksomme rooperolforbindelser. - Google Patents
Analogifremgangsmaate for fremstilling av terapeutisk virksomme rooperolforbindelser.Info
- Publication number
- NO158376C NO158376C NO842604A NO842604A NO158376C NO 158376 C NO158376 C NO 158376C NO 842604 A NO842604 A NO 842604A NO 842604 A NO842604 A NO 842604A NO 158376 C NO158376 C NO 158376C
- Authority
- NO
- Norway
- Prior art keywords
- rooperol
- compounds
- preparation
- therapeutically effective
- analogy procedure
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C15/00—Cyclic hydrocarbons containing only six-membered aromatic rings as cyclic parts
- C07C15/40—Cyclic hydrocarbons containing only six-membered aromatic rings as cyclic parts substituted by unsaturated carbon radicals
- C07C15/42—Cyclic hydrocarbons containing only six-membered aromatic rings as cyclic parts substituted by unsaturated carbon radicals monocyclic
- C07C15/48—Cyclic hydrocarbons containing only six-membered aromatic rings as cyclic parts substituted by unsaturated carbon radicals monocyclic the hydrocarbon substituent containing a carbon-to-carbon triple bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C15/00—Cyclic hydrocarbons containing only six-membered aromatic rings as cyclic parts
- C07C15/40—Cyclic hydrocarbons containing only six-membered aromatic rings as cyclic parts substituted by unsaturated carbon radicals
- C07C15/50—Cyclic hydrocarbons containing only six-membered aromatic rings as cyclic parts substituted by unsaturated carbon radicals polycyclic non-condensed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
- C07C33/04—Acyclic alcohols with carbon-to-carbon triple bonds
- C07C33/042—Acyclic alcohols with carbon-to-carbon triple bonds with only one triple bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
- C07C33/04—Acyclic alcohols with carbon-to-carbon triple bonds
- C07C33/048—Acyclic alcohols with carbon-to-carbon triple bonds with double and triple bonds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
- C07C33/18—Monohydroxylic alcohols containing only six-membered aromatic rings as cyclic part
- C07C33/20—Monohydroxylic alcohols containing only six-membered aromatic rings as cyclic part monocyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
- C07C33/28—Alcohols containing only six-membered aromatic rings as cyclic part with unsaturation outside the aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
- C07C33/40—Halogenated unsaturated alcohols
- C07C33/46—Halogenated unsaturated alcohols containing only six-membered aromatic rings as cyclic parts
- C07C33/48—Halogenated unsaturated alcohols containing only six-membered aromatic rings as cyclic parts with unsaturation outside the aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
- C07C33/40—Halogenated unsaturated alcohols
- C07C33/46—Halogenated unsaturated alcohols containing only six-membered aromatic rings as cyclic parts
- C07C33/48—Halogenated unsaturated alcohols containing only six-membered aromatic rings as cyclic parts with unsaturation outside the aromatic rings
- C07C33/486—Polycyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
- C07C39/205—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic, containing only six-membered aromatic rings as cyclic parts with unsaturation outside the rings
- C07C39/21—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic, containing only six-membered aromatic rings as cyclic parts with unsaturation outside the rings with at least one hydroxy group on a non-condensed ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
- C07C43/215—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring having unsaturation outside the six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
- C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D233/24—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/04—Compounds containing oxirane rings containing only hydrogen and carbon atoms in addition to the ring oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/40—Radicals substituted by oxygen atoms
- C07D307/42—Singly bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
- C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Furan Compounds (AREA)
- Epoxy Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Saccharide Compounds (AREA)
- Pyrane Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB838317850A GB8317850D0 (en) | 1983-06-30 | 1983-06-30 | Rooperol and its derivatives |
Publications (3)
Publication Number | Publication Date |
---|---|
NO842604L NO842604L (no) | 1985-01-02 |
NO158376B NO158376B (no) | 1988-05-24 |
NO158376C true NO158376C (no) | 1988-08-31 |
Family
ID=10545081
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO842604A NO158376C (no) | 1983-06-30 | 1984-06-27 | Analogifremgangsmaate for fremstilling av terapeutisk virksomme rooperolforbindelser. |
Country Status (18)
Country | Link |
---|---|
US (1) | US4644085A (no) |
EP (1) | EP0130829B1 (no) |
JP (1) | JPS60105637A (no) |
AR (1) | AR242017A1 (no) |
AT (1) | ATE27599T1 (no) |
AU (1) | AU569529B2 (no) |
CA (1) | CA1293735C (no) |
DE (1) | DE3464050D1 (no) |
DK (1) | DK322984A (no) |
ES (1) | ES8608462A1 (no) |
GB (1) | GB8317850D0 (no) |
GR (1) | GR79540B (no) |
IE (1) | IE57563B1 (no) |
IL (1) | IL72239A (no) |
NO (1) | NO158376C (no) |
NZ (1) | NZ208694A (no) |
PT (1) | PT78819B (no) |
ZA (1) | ZA844983B (no) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8317850D0 (en) * | 1983-06-30 | 1983-08-03 | Roecar Holdings Nv | Rooperol and its derivatives |
FR2576897B1 (fr) * | 1985-02-01 | 1987-02-27 | Centre Nat Rech Scient | Nouveaux derives epoxydiques, leur preparation et leur application, notamment comme medicaments antitumoraux |
ATE61329T1 (de) * | 1985-06-19 | 1991-03-15 | Rooperol Na Nv | Verfahren zur herstellung von rooperol, hypoxosid und deren derivaten. |
US4956502A (en) * | 1985-06-19 | 1990-09-11 | Rooperol (N.A.) Nv | Process for the preparation of rooperol derivative |
AU667564B2 (en) * | 1992-09-07 | 1996-03-28 | Virostat (Na) Nv | Method of treating viral infections |
US5569649A (en) * | 1994-06-14 | 1996-10-29 | Phytopharm (Na) N.V. | Anti-inflammatory treatment method |
CN104513137B (zh) * | 2014-12-22 | 2016-05-04 | 陕西师范大学 | 一种1,5-烯炔醇类化合物及其合成方法和应用 |
CN109704926B (zh) * | 2019-01-29 | 2022-02-08 | 南京工业大学 | 抗癌活性分子骨架1,4-烯炔类化合物及其制备方法与应用 |
WO2023036995A1 (en) * | 2021-09-13 | 2023-03-16 | Centre National De La Recherche Scientifique | Alkynylcarbinols with high cytotoxicity |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE750532A (fr) * | 1969-05-26 | 1970-10-16 | Lilly Co Eli | Nouveaux diethynylcarbinols substitues |
US3922266A (en) * | 1972-06-28 | 1975-11-25 | Sumitomo Chemical Co | Aryl ketones and production thereof |
US4224244A (en) * | 1973-03-30 | 1980-09-23 | Hoffmann-La Roche Inc. | 9-Phenyl 5,6-dimethyl-nona-2,4,6,8 tetraenal or tetraenol derivatives |
IT1022545B (it) * | 1973-10-01 | 1978-04-20 | Hoffmann La Roche | Procedimento per fabricare etinilcarbinoli |
US4055575A (en) * | 1975-03-20 | 1977-10-25 | Scm Corporation | Synthesis of dehydrophytol and vitamin E |
US4162265A (en) * | 1978-09-27 | 1979-07-24 | The United States Of America As Represented By The Secretary Of The Air Force | Aromatic enyne compounds and their synthesis |
US4223172A (en) * | 1978-12-07 | 1980-09-16 | Gulf Research & Development Company | Process for the preparation of bromoarylacetylene and aryldiacetylene precursors |
CH642936A5 (de) * | 1979-10-19 | 1984-05-15 | Hoffmann La Roche | Aethinylierung alpha,beta-ungesaettigter ketone. |
US4345084A (en) * | 1981-06-29 | 1982-08-17 | Hoffmann-La Roche Inc. | Unsaturated eicosanoic acids |
IE54837B1 (en) * | 1982-04-19 | 1990-02-28 | Roecar Holdings Nv | Extract of plants of the family of hypoxidaceae for treatment of cancer |
GB2120650A (en) * | 1982-04-19 | 1983-12-07 | Roecar Holdings Nv | Rooperol derivatives |
GB8317850D0 (en) * | 1983-06-30 | 1983-08-03 | Roecar Holdings Nv | Rooperol and its derivatives |
-
1983
- 1983-06-30 GB GB838317850A patent/GB8317850D0/en active Pending
-
1984
- 1984-06-26 CA CA000457433A patent/CA1293735C/en not_active Expired - Fee Related
- 1984-06-27 AU AU29921/84A patent/AU569529B2/en not_active Ceased
- 1984-06-27 IL IL72239A patent/IL72239A/xx unknown
- 1984-06-27 NO NO842604A patent/NO158376C/no unknown
- 1984-06-28 NZ NZ208694A patent/NZ208694A/xx unknown
- 1984-06-29 ZA ZA844983A patent/ZA844983B/xx unknown
- 1984-06-29 PT PT78819A patent/PT78819B/pt not_active IP Right Cessation
- 1984-06-29 EP EP84304498A patent/EP0130829B1/en not_active Expired
- 1984-06-29 AR AR84297018A patent/AR242017A1/es active
- 1984-06-29 DK DK322984A patent/DK322984A/da not_active Application Discontinuation
- 1984-06-29 ES ES533884A patent/ES8608462A1/es not_active Expired
- 1984-06-29 AT AT84304498T patent/ATE27599T1/de not_active IP Right Cessation
- 1984-06-29 IE IE1653/84A patent/IE57563B1/en not_active IP Right Cessation
- 1984-06-29 DE DE8484304498T patent/DE3464050D1/de not_active Expired
- 1984-06-29 GR GR75155A patent/GR79540B/el unknown
- 1984-06-30 JP JP59136404A patent/JPS60105637A/ja active Pending
-
1985
- 1985-06-04 US US06/740,969 patent/US4644085A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
AU2992184A (en) | 1985-01-03 |
ZA844983B (en) | 1985-02-27 |
ES533884A0 (es) | 1986-04-01 |
PT78819A (en) | 1984-07-01 |
AU569529B2 (en) | 1988-02-04 |
EP0130829A3 (en) | 1985-03-06 |
IE57563B1 (en) | 1992-12-16 |
DE3464050D1 (en) | 1987-07-09 |
DK322984D0 (da) | 1984-06-29 |
ES8608462A1 (es) | 1986-04-01 |
NO158376B (no) | 1988-05-24 |
GR79540B (no) | 1984-10-30 |
NO842604L (no) | 1985-01-02 |
IE841653L (en) | 1984-12-30 |
GB8317850D0 (en) | 1983-08-03 |
JPS60105637A (ja) | 1985-06-11 |
PT78819B (en) | 1986-06-18 |
AR242017A1 (es) | 1993-02-26 |
EP0130829B1 (en) | 1987-06-03 |
IL72239A (en) | 1989-07-31 |
IL72239A0 (en) | 1984-10-31 |
NZ208694A (en) | 1988-09-29 |
ATE27599T1 (de) | 1987-06-15 |
CA1293735C (en) | 1991-12-31 |
EP0130829A2 (en) | 1985-01-09 |
DK322984A (da) | 1984-12-31 |
US4644085A (en) | 1987-02-17 |
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