NO841158L - Fremgangsmaate for fremstilling av 2-azetidin-4-substituerte forbindelser - Google Patents

Fremgangsmaate for fremstilling av 2-azetidin-4-substituerte forbindelser

Info

Publication number: NO841158L
Authority: NO; Norway
Prior art keywords: azetidin; procedure; preparation; substituted compounds; substituted
Prior art date: 1983-03-25

Application number

NO841158A

Other languages

English (en)

Other versions

NO158740B (no

NO158740C (no

Inventor

Toshinari Tamura

Hidenori Iwamoto

Makoto Yoshida

Minoru Yamamoto

Original Assignee

Yamanouchi Pharma Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-03-25

Filing date

1984-03-23

Publication date

1984-09-26

1983-03-25 Priority claimed from JP58048989A external-priority patent/JPS59225182A/ja

1983-11-25 Priority claimed from JP58221470A external-priority patent/JPS60115578A/ja

1983-11-25 Priority claimed from JP58221469A external-priority patent/JPS60115577A/ja

1984-03-23 Application filed by Yamanouchi Pharma Co Ltd filed Critical Yamanouchi Pharma Co Ltd

1984-09-26 Publication of NO841158L publication Critical patent/NO841158L/no

1987-01-23 Priority to NO870289A priority Critical patent/NO167662C/no

1988-07-18 Publication of NO158740B publication Critical patent/NO158740B/no

1988-10-26 Publication of NO158740C publication Critical patent/NO158740C/no

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C07K5/06147—Dipeptides with the first amino acid being heterocyclic and His-amino acid; Derivatives thereof

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

NO841158A 1983-03-25 1984-03-23 Analogifremgangsmaate ved fremstilling av terapeutisk aktive 4-substituerte 2-azetidinonforbindelser. NO158740C (no)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
NO870289A NO167662C (no)	1983-03-25	1987-01-23	4-substituerte-2-azetidinonforbindelser.

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
JP58048989A JPS59225182A (ja)	1983-03-25	1983-03-25	２−アゼチジノン−４−カルボン酸の誘導体
JP58221470A JPS60115578A (ja)	1983-11-25	1983-11-25	２−アゼチジノン−４−置換化合物
JP58221469A JPS60115577A (ja)	1983-11-25	1983-11-25	２−アゼチジノン−４−置換体

Publications (3)

Publication Number	Publication Date
NO841158L true NO841158L (no)	1984-09-26
NO158740B NO158740B (no)	1988-07-18
NO158740C NO158740C (no)	1988-10-26

Family

ID=27293483

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO841158A NO158740C (no)	1983-03-25	1984-03-23	Analogifremgangsmaate ved fremstilling av terapeutisk aktive 4-substituerte 2-azetidinonforbindelser.

Country Status (8)

Country	Link
US (3)	US4564609A (no)
EP (1)	EP0123444B1 (no)
KR (3)	KR870000357B1 (no)
CA (1)	CA1256650A (no)
DE (1)	DE3476399D1 (no)
DK (1)	DK164684A (no)
ES (4)	ES530960A0 (no)
NO (1)	NO158740C (no)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
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US4719207A (en) *	1984-06-25	1988-01-12	Yamanouchi Pharmaceutical Co., Ltd.	CNS active substituted azetidinone compounds
JPS6253994A (ja)	1985-05-09	1987-03-09	Yamanouchi Pharmaceut Co Ltd	１−置換シリル−４−オキソ−２−アゼチジンカルボン酸低級アルキルエステル
ZA868957B (en) *	1985-12-06	1987-07-29	Yamanouchi Pharma Co Ltd	Crystals of nalpha-(((s)-4-oxo-2-azetidinyl)carbonyl)-l-histidyl-l-prolinamide and process for producing the crystals
US5686420A (en) *	1987-06-05	1997-11-11	Georgetown University	Thyrotropin-releasing hormone analogs and method of use
US5151497A (en) *	1989-02-21	1992-09-29	Japan Tobacco Inc.	Histidyl peptide derivatives
DK437289D0 (da) *	1989-09-04	1989-09-04	Hans Bundgaard	Prodrug derivatives of thyrotropin-releasing hormone (trh)
IT1249728B (it) *	1991-11-06	1995-03-09	Sigma Tau Ind Farmaceuti	Derivati delle prolinammide quali attivatori della memoria e dei processi di apprendimento e composizioni farmaceutiche che li contengono
WO1998050032A1 (en) *	1997-05-09	1998-11-12	Smithkline Beecham Corporation	BETA-LACTAM INHIBITORS OF CoA-IT
US20020151502A1 (en) *	1997-10-09	2002-10-17	Albert Sattin	Tri-peptides for neurological and neurobehavior applications
US7202279B1 (en) *	1998-02-11	2007-04-10	Georgetown University	Cyclic dipeptides and azetidinone compounds and their use in treating CNS injury and neurodegenerative disorders
EP1300155A1 (en) *	2000-07-11	2003-04-09	Shionogi & Co., Ltd.	Enteric preparations containing physiologically active peptides
KR100557268B1 (ko)	2000-08-31	2006-03-07	시오노기세이야쿠가부시키가이샤	파킨슨씨병 치료제
US6982251B2 (en) *	2000-12-20	2006-01-03	Schering Corporation	Substituted 2-azetidinones useful as hypocholesterolemic agents
CN100522159C (zh) *	2001-01-26	2009-08-05	先灵公司	取代的氮杂环丁烷酮化合物在制备治疗谷甾醇血症的药物中的应用
US20060287254A1 (en) *	2001-01-26	2006-12-21	Schering Corporation	Use of substituted azetidinone compounds for the treatment of sitosterolemia
ES2296894T3 (es) *	2001-01-26	2008-05-01	Schering Corporation	Combinaciones de ezetimiba con aspirina para tratar estados vasculares.
WO2002058733A2 (en) *	2001-01-26	2002-08-01	Schering Corporation	Combinations of bile acid sequestrant(s) and sterol absorption inhibitor(s) and treatments for vascular indications
US7071181B2 (en) *	2001-01-26	2006-07-04	Schering Corporation	Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors
DK1385548T3 (da) *	2001-01-26	2007-09-10	Schering Corp	Kombinationer af sterolabsorptionsinhibitor(er) med (et eller flere) kardiovaskulære midler til behandling af vaskulære tilstande
EP1353695A2 (en) *	2001-01-26	2003-10-22	Schering Corporation	Combinations of nicotinic acid and derivatives thereof and sterol absorption inhibitor(s) and treatments for vascular indications
RS20100015A (en) *	2001-01-26	2010-12-31	Schering Corporation	Combination of receptor activator activated by fenofibrate peroxisome-proliferator (ppar) with sterol absorption inhibitor ezetimibe for vascular indications
CA2447884A1 (en) *	2001-05-25	2002-12-05	Schering Corporation	Use of azetidinone substituted derivatives in the treatment of alzheimer's disease
US20030119808A1 (en) *	2001-09-21	2003-06-26	Schering Corporation	Methods of treating or preventing cardiovascular conditions while preventing or minimizing muscular degeneration side effects
US7053080B2 (en) *	2001-09-21	2006-05-30	Schering Corporation	Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors
US7056906B2 (en) *	2001-09-21	2006-06-06	Schering Corporation	Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women
MXPA04002572A (es) *	2001-09-21	2004-05-31	Schering Corp	Metodos para el tratamiento o prevencion de inflamacion vascular usando inhibidores de absorcion de esterol.
WO2003026643A2 (en) *	2001-09-21	2003-04-03	Schering Corporation	Treatment of xanthoma with azetidinone derivatives as sterol absorption inhibitors
EP1560579A1 (en) *	2002-11-06	2005-08-10	Schering Corporation	Cholesterol absorption inhibitors for the treatment of autoimmune disorders
DE602004018617D1 (de) *	2003-03-07	2009-02-05	Schering Corp	Substituierte azetidinon-derivate, deren pharmazeutische formulierungen und deren verwendung zur behandlung von hypercholesterolemia
EP1606287B1 (en) *	2003-03-07	2013-10-02	Merck Sharp & Dohme Corp.	Substituted azetidinone compounds, formulations and uses thereof for the treatment of hypercholesterolemia
MXPA05009503A (es)	2003-03-07	2005-10-18	Schering Corp	Compuestos de azetidinona sustituidos, formulaciones y usos de los mismos para el tratamiento de hipercolesterolemia.
US7459442B2 (en) *	2003-03-07	2008-12-02	Schering Corporation	Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
JP2007510659A (ja) *	2003-11-05	2007-04-26	シェーリング　コーポレイション	脂質調節剤および置換アゼチジノンの組み合わせならびに血管状態の処置
US7462595B2 (en) *	2004-09-17	2008-12-09	Prange Jr Arthur Jergen	Methods for treating cancer-related fatigue
KR101137503B1 (ko) *	2009-07-14	2012-04-20	웰이앤씨 주식회사	고분자 고체 지지체를 이용한 히스티딜-프롤린아미드 유도체의 제조 방법
TWI648001B (zh) *	2013-08-16	2019-01-21	洛斯阿拉莫斯國家安全有限責任公司	用於改良植物性能之化合物及方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3959248A (en) *	1974-04-03	1976-05-25	Merck & Co., Inc.	Analogs of thyrotropin-releasing hormone
GB1523598A (en) *	1975-03-08	1978-09-06	Reckitt & Colmann Prod Ltd	Tripeptides
US4271164A (en) *	1979-04-16	1981-06-02	Warner-Lambert Company	6-Substituted-arylpyrido[2,3-d]pyrimidin-7-amines and derivatives
HU180926B (en) *	1979-06-28	1983-05-30	Richter Gedeon Vegyeszet	Process for preparing trh analogues,tripeptide amides infectives on the central nerve sysrhem
US4328134A (en) *	1980-05-06	1982-05-04	Schally Andrew Victor	Anorexigenic peptides
US4426378A (en) *	1981-04-09	1984-01-17	The United States Of America As Represented By The Secretary Of The Army	Thyrotropin releasing hormone in therapy of shock and as a central nervous system stimulant

1984
- 1984-03-15 CA CA000449641A patent/CA1256650A/en not_active Expired
- 1984-03-23 DK DK164684A patent/DK164684A/da not_active Application Discontinuation
- 1984-03-23 NO NO841158A patent/NO158740C/no unknown
- 1984-03-23 KR KR1019840001506A patent/KR870000357B1/ko not_active IP Right Cessation
- 1984-03-23 ES ES530960A patent/ES530960A0/es active Granted
- 1984-03-23 US US06/592,866 patent/US4564609A/en not_active Expired - Fee Related
- 1984-03-26 EP EP84302016A patent/EP0123444B1/en not_active Expired
- 1984-03-26 DE DE8484302016T patent/DE3476399D1/de not_active Expired
1985
- 1985-06-14 ES ES85544234A patent/ES8604209A1/es not_active Expired
- 1985-06-14 ES ES544235A patent/ES8604208A1/es not_active Expired
- 1985-06-14 ES ES544236A patent/ES8604136A1/es not_active Expired
- 1985-10-07 US US06/785,169 patent/US4636567A/en not_active Expired - Fee Related
- 1985-10-07 US US06/785,168 patent/US4610821A/en not_active Expired - Fee Related
1987
- 1987-01-20 KR KR1019870000409A patent/KR890002105B1/ko not_active IP Right Cessation
- 1987-01-20 KR KR1019870000408A patent/KR890002104B1/ko not_active IP Right Cessation

Also Published As

Publication number	Publication date
DK164684A (da)	1984-09-26
DE3476399D1 (en)	1989-03-02
KR890002104B1 (ko)	1989-06-19
ES8604209A1 (es)	1986-01-16
ES544234A0 (es)	1986-01-16
EP0123444A1 (en)	1984-10-31
ES8604136A1 (es)	1986-01-16
DK164684D0 (da)	1984-03-23
KR880009550A (ko)	1988-09-15
ES8600279A1 (es)	1985-10-01
NO158740B (no)	1988-07-18
KR870000357B1 (ko)	1987-03-05
ES544236A0 (es)	1986-01-16
EP0123444B1 (en)	1989-01-25
KR890002105B1 (ko)	1989-06-19
KR840008021A (ko)	1984-12-12
US4636567A (en)	1987-01-13
KR880009549A (ko)	1988-09-15
US4610821A (en)	1986-09-09
ES544235A0 (es)	1986-01-16
ES530960A0 (es)	1985-10-01
ES8604208A1 (es)	1986-01-16
CA1256650A (en)	1989-06-27
US4564609A (en)	1986-01-14
NO158740C (no)	1988-10-26

Publication	Publication Date	Title
NO841158L (no)	1984-09-26	Fremgangsmaate for fremstilling av 2-azetidin-4-substituerte forbindelser
NO843956L (no)	1985-04-09	Fremgangsmaate for fremstilling av karboksyalkenamido-cefalosporiner
RO90861A (ro)	1987-04-30	Procedeu pentru prepararea etielnglicolului
NO833705L (no)	1984-04-16	Fremgangsmaate for fremstilling av fenyl-piperidin-propanol-forbindelser.
NO851524L (no)	1985-10-18	Fremgangsmaate for fremstilling av fenetanolamin-forbindelser
NO844710L (no)	1985-05-29	Fremgangsmaate for fremstilling av hoeyrent protein
NO844388L (no)	1985-06-24	Fremgangsmaate for fremstilling av aminoeteralkoholer
RO86213A (ro)	1985-03-15	Procedeu pentru prepararea izobutenei
NO814065L (no)	1982-06-01	Fremgansmaate for fremstilling av imidazolylfenylamidiner
NO845162L (no)	1985-07-01	Fremgangsmaate for fremstilling av alkalimetallsalter
NO844631L (no)	1985-05-28	Fremgangsmaate for fremstilling av tremasse
NO845207L (no)	1985-06-24	Fremgangsmaate for fremstilling av diaminopolyalkenyletere
NO843055L (no)	1985-01-30	Fremgangsmaate ved fremstilling av cephalosporinderivater
NO170019C (no)	1992-09-02	Fremgangsmaate for fremstilling av deglucoteicoplanin (antibiotikum l 17392)
NO842868L (no)	1985-01-15	Framgangsmaate for framstilling av alkoholer
NO823637L (no)	1983-05-04	Fremgangsmaate for fremstilling av eburnamoninderivater
FI840478A0 (fi)	1984-02-06	Foerfarande foer framstaellning av blodtryckssaenkande n-piperazinylalkanoylanilider
NO169126C (no)	1992-05-13	Fremgangsmaate for fremstilling av n-formyl-alfa-aspartyl-fenylalanin
NO832830L (no)	1984-02-07	Fremgangsmaate for fremstilling av alfa-arylalkansyrer
NO833531L (no)	1984-04-02	Fremgangsmaate for fremstilling av 7-substituerte-3-vinyl-3-cefem-forbindelser
TR22146A (tr)	1986-08-17	Difloropiridin bilesiklerinin hazirlanmasi
NO172547C (no)	1993-08-04	Fremgangsmaate til fremstilling av nalfa-acetyl-eglin b og -c
NO840865L (no)	1984-09-10	Fremgangsmaate til fremstilling av carbapenemderivater
NO830176L (no)	1983-07-29	Fremgangsmaate for fremstilling av ultrarent toriumfluorid
NO813814L (no)	1982-05-14	Fremgangsmaate for fremstilling av monoalkyletere av hydrokinonforbindelser