[go: up one dir, main page]

NO152216C - Analogifremgangsmaate til fremstilling av terapeutisk anvendbare substituerte 2-(2-benzimidazolyl)-pyridiner - Google Patents

Analogifremgangsmaate til fremstilling av terapeutisk anvendbare substituerte 2-(2-benzimidazolyl)-pyridiner

Info

Publication number
NO152216C
NO152216C NO791227A NO791227A NO152216C NO 152216 C NO152216 C NO 152216C NO 791227 A NO791227 A NO 791227A NO 791227 A NO791227 A NO 791227A NO 152216 C NO152216 C NO 152216C
Authority
NO
Norway
Prior art keywords
pyridines
benzimidazolyl
preparation
therapeutically used
used substituted
Prior art date
Application number
NO791227A
Other languages
English (en)
Norwegian (no)
Other versions
NO791227L (no
NO152216B (no
Inventor
Ulf Krister Junggren
Sven Erik Sjoestrand
Original Assignee
Haessle Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=20334608&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO152216(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Haessle Ab filed Critical Haessle Ab
Publication of NO791227L publication Critical patent/NO791227L/no
Publication of NO152216B publication Critical patent/NO152216B/no
Publication of NO152216C publication Critical patent/NO152216C/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
NO791227A 1978-04-14 1979-04-10 Analogifremgangsmaate til fremstilling av terapeutisk anvendbare substituerte 2-(2-benzimidazolyl)-pyridiner NO152216C (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE7804231A SE7804231L (sv) 1978-04-14 1978-04-14 Magsyrasekretionsmedel

Publications (3)

Publication Number Publication Date
NO791227L NO791227L (no) 1979-10-16
NO152216B NO152216B (no) 1985-05-13
NO152216C true NO152216C (no) 1985-08-21

Family

ID=20334608

Family Applications (5)

Application Number Title Priority Date Filing Date
NO791227A NO152216C (no) 1978-04-14 1979-04-10 Analogifremgangsmaate til fremstilling av terapeutisk anvendbare substituerte 2-(2-benzimidazolyl)-pyridiner
NO840112A NO152785C (no) 1978-04-14 1984-01-12 Mellomprodukter til bruk ved fremstilling av substituerte 2-(2-benzimidazoylyl)-pyridiner.
NO1994027C NO1994027I1 (no) 1978-04-14 1994-12-21 Omeprazol
NO1995006C NO1995006I1 (no) 1978-04-14 1995-06-14 Omeprazole/ 5-metoksy-2-[[(4-metoksy-3,5-dimetyl-2-pyridinyl)metyl]sulfinyl]-1H-benzimidazol
NO1995005C NO1995005I1 (no) 1978-04-14 1995-06-14 Omeprazole/ 5-metoksy-2-[[(4-metoksy-3,5-dimetyl-2-pyridinyl)metyl]sulfinyl]-1H-benzimidazol

Family Applications After (4)

Application Number Title Priority Date Filing Date
NO840112A NO152785C (no) 1978-04-14 1984-01-12 Mellomprodukter til bruk ved fremstilling av substituerte 2-(2-benzimidazoylyl)-pyridiner.
NO1994027C NO1994027I1 (no) 1978-04-14 1994-12-21 Omeprazol
NO1995006C NO1995006I1 (no) 1978-04-14 1995-06-14 Omeprazole/ 5-metoksy-2-[[(4-metoksy-3,5-dimetyl-2-pyridinyl)metyl]sulfinyl]-1H-benzimidazol
NO1995005C NO1995005I1 (no) 1978-04-14 1995-06-14 Omeprazole/ 5-metoksy-2-[[(4-metoksy-3,5-dimetyl-2-pyridinyl)metyl]sulfinyl]-1H-benzimidazol

Country Status (25)

Country Link
US (3) US4255431A (fr)
EP (1) EP0005129B1 (fr)
JP (2) JPS6034956B2 (fr)
AT (2) AT374471B (fr)
BG (1) BG61492B2 (fr)
CA (1) CA1127158A (fr)
CS (1) CS261851B2 (fr)
CY (1) CY1232A (fr)
DD (1) DD142882A5 (fr)
DE (1) DE2960293D1 (fr)
DK (1) DK150510C (fr)
FI (1) FI65067C (fr)
HK (1) HK15284A (fr)
HU (1) HU179022B (fr)
IE (1) IE48370B1 (fr)
LT (1) LT2274B (fr)
LU (2) LU88307I2 (fr)
MY (1) MY8500074A (fr)
NL (2) NL930075I2 (fr)
NO (5) NO152216C (fr)
NZ (1) NZ190203A (fr)
SE (1) SE7804231L (fr)
SG (1) SG63383G (fr)
SU (4) SU895292A3 (fr)
ZA (1) ZA791586B (fr)

Families Citing this family (372)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4359465A (en) * 1980-07-28 1982-11-16 The Upjohn Company Methods for treating gastrointestinal inflammation
CH644116A5 (de) * 1980-08-21 1984-07-13 Hoffmann La Roche Imidazolderivate.
IL66340A (en) * 1981-08-13 1986-08-31 Haessle Ab Pharmaceutical compositions comprising pyridylmethyl-thiobenzimidazole derivatives,certain such novel derivatives and their preparation
ZA828136B (en) * 1981-11-05 1983-09-28 Byk Gulden Lomberg Chem Fab Substituted benzimidazoles,a process for their preparation,their use,and medicaments containing them
US4472409A (en) * 1981-11-05 1984-09-18 Byk Gulden Lomberg Chemische Fabrik Gesellschaft Mit Beschrankter Haftung 2-Pyridylmethyl thio(sulfinyl)benzimidazoles with gastric acid secretion inhibiting effects
DE3216843C2 (de) * 1982-05-05 1986-10-23 Ludwig Heumann & Co GmbH, 8500 Nürnberg 3-Thiomethyl-pyridin-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
SE8204879D0 (sv) * 1982-08-26 1982-08-26 Haessle Ab Novel chemical intermediates
SE8300736D0 (sv) * 1983-02-11 1983-02-11 Haessle Ab Novel pharmacologically active compounds
SE8301182D0 (sv) * 1983-03-04 1983-03-04 Haessle Ab Novel compounds
HU193408B (en) * 1983-05-03 1987-10-28 Byk Gulden Lomberg Chem Fqb Process for production of new tree-cycle compounds
HU195220B (en) * 1983-05-03 1988-04-28 Byk Gulden Lomberg Chem Fqb Process for production of new fluor-alkoxi-benzimidasole-derivatives and medical compositions containig them
CA1259070A (fr) * 1983-07-01 1989-09-05 Upjohn Company (The) Derives de substitution de 2-¬noyaux condenses (3,4- 4,5-, 5,6-)-pyridylalcoylenesulfinyl|- benzimidazoles
US5077407A (en) * 1983-07-01 1991-12-31 The Upjohn Company Substituted 2-[monoannelated (3,4-,4,5-, and 5,6-) pyridylalkylenesulfinyl]benzimidazoles
DE3333314A1 (de) * 1983-09-15 1985-03-28 Hoechst Ag, 6230 Frankfurt Substituierte pyrido(1,2-c)imidazo(1,2-a)benzimidazole, verfahren zu ihrer herstellung, ihre verwendung sowie pharmazeutische praeparate auf basis dieser verbindungen
US4663347A (en) 1983-10-31 1987-05-05 Merck Frosst Canada, Inc. Benzofuran 2-carboxylic acid esters useful as inhibitors of leukotriene biosynthesis
US4575554A (en) * 1983-12-05 1986-03-11 The Upjohn Company Substituted 2-pyridylmethylthio- and sulfinyl-benzimidazoles as gastric antisecretory agents
ZW4585A1 (en) * 1984-04-19 1985-11-20 Hoffmann La Roche Imidazole derivatives
SE8403179D0 (sv) * 1984-06-13 1984-06-13 Haessle Ab New compounds
IL75400A (en) * 1984-06-16 1988-10-31 Byk Gulden Lomberg Chem Fab Dialkoxypyridine methyl(sulfinyl or sulfonyl)benzimidazoles,processes for the preparation thereof and pharmaceutical compositions containing the same
EP0174717B1 (fr) * 1984-07-06 1992-01-22 FISONS plc Benzimidazoles, et leur préparation, formulation et application comme inhibiteur de sécrétion d'acide gastrique
SE8404065D0 (sv) * 1984-08-10 1984-08-10 Haessle Ab Novel biologically active compounds
JPS6150979A (ja) * 1984-08-16 1986-03-13 Takeda Chem Ind Ltd ピリジン誘導体およびその製造法
JPS6150978A (ja) * 1984-08-16 1986-03-13 Takeda Chem Ind Ltd ピリジン誘導体およびその製造法
US4619997A (en) * 1984-09-06 1986-10-28 The Upjohn Company Substituted 2-pyridylmethylthio and sulfinyl-benzimidazoles as gastric antisecretory agents
KR890000387B1 (ko) * 1984-09-24 1989-03-16 디 엎존 캄파니 2-(피리딜알켄술 피닐)벤즈 이미드아졸류의 n-치환 유도체의 제조방법
SE8405588D0 (sv) * 1984-11-08 1984-11-08 Haessle Ab New compounds
EP0187977B1 (fr) * 1984-12-18 1990-08-29 Otsuka Pharmaceutical Co., Ltd. Dérivés de tétrahydroquinoline, leur procédé de préparation et compositions anti-ulcère gastrique les contenant
FI861772A (fi) * 1985-05-07 1986-11-08 Chemie Linz Ag Nya tieno(2,3-d)imidazolderivat och foerfarande for deras framstaellning.
US5869513A (en) * 1985-05-24 1999-02-09 G. D. Searle & Co. 2- (1H-benzimidazol-2-ylsulfinyl)methyl!benzenamines
AU5768886A (en) 1985-05-24 1986-11-27 G.D. Searle & Co. 2-((1-h-benzimidazol-2-ylsulfinyl)methyl)benzenamines
CA1309557C (fr) 1985-06-18 1992-10-27 Robert N. Young Antagonistes de leucotrienes
US4738975A (en) * 1985-07-02 1988-04-19 Takeda Chemical Industries, Ltd. Pyridine derivatives, and use as anti-ulcer agents
AR243167A1 (es) 1985-08-24 1993-07-30 Hoechst Ag Procedimiento para la preparacion de toluidinas sustituidas.
JPS6261978A (ja) * 1985-09-12 1987-03-18 Otsuka Pharmaceut Co Ltd 5−フルオロ−1h−ベンズイミダゾ−ル誘導体
SE8505112D0 (sv) * 1985-10-29 1985-10-29 Haessle Ab Novel pharmacological compounds
US5433959A (en) * 1986-02-13 1995-07-18 Takeda Chemical Industries, Ltd. Stabilized pharmaceutical composition
CA1327010C (fr) * 1986-02-13 1994-02-15 Tadashi Makino Compositions pharmaceutiques contenant un compose anti-ulcereux de type benzimidazole et sa production
US6749864B2 (en) * 1986-02-13 2004-06-15 Takeda Chemical Industries, Ltd. Stabilized pharmaceutical composition
DE3777855D1 (de) 1986-02-20 1992-05-07 Hoechst Ag Substituierte thienoimidazol-derivate, verfahren zu ihrer herstellung, sie enthaltende pharmazeutische zubereitungen und ihre verwendung als magensaeuresekretionshemmer.
WO1987005296A1 (fr) * 1986-03-07 1987-09-11 Pfizer Inc. 2-[(2-pyridyl)methylsulfinyl]thienoimidazoles et composes apparentes utilises en tant qu'agents de traitement ou de prevention des ulceres
EP0239306B1 (fr) 1986-03-27 1993-06-02 Merck Frosst Canada Inc. Esters de tétrahydrocarbazoles
GB2189698A (en) 1986-04-30 1987-11-04 Haessle Ab Coated omeprazole tablets
GB2189699A (en) * 1986-04-30 1987-11-04 Haessle Ab Coated acid-labile medicaments
US4687775A (en) * 1986-07-17 1987-08-18 G. D. Searle & Co. 2-[(Imidazo[1,2-a]pyridinylmethyl)sulfinyl]-1H-benzimidazoles
US4772619A (en) * 1986-07-17 1988-09-20 G. D. Searle & Co. [(1H-benzimidazol-2-ylsulfinyl)methyl]-2-pyridinamines
US4721718A (en) * 1986-08-18 1988-01-26 G. D. Searle & Co. 2-[(imidazo[1,2-a]pyridin-3-ylmethyl)sulfinyl]-1H-benzimidazoles useful in the treatment and prevention of ulcers
CA1256109A (fr) * 1986-09-10 1989-06-20 Franz Rovenszky Methode de preparation de derives de 4,5-dihydro- oxazoles
SE8604566D0 (sv) * 1986-10-27 1986-10-27 Haessle Ab Novel compunds
FI90544C (fi) * 1986-11-13 1994-02-25 Eisai Co Ltd Menetelmä lääkeaineina käyttökelpoisten 2-pyridin-2-yyli-metyylitio- ja sulfinyyli-1H-bensimidatsolijohdannaisten valmistamiseksi
ATE103912T1 (de) * 1986-11-13 1994-04-15 Eisai Co Ltd Pyridin-derivate, deren pharmazeutische zusammenstellungen, deren anwendung fuer die herstellung von arzneimitteln mit therapeutischem oder vorbeugendem wert und verfahren zu deren herstellung.
NZ222495A (en) 1986-11-21 1991-04-26 Haessle Ab Benzimidazole derivatives and pharmaceutical compositions
SE8604998D0 (sv) 1986-11-21 1986-11-21 Haessle Ab Novel pharmacological compounds
DE3639926A1 (de) * 1986-11-22 1988-06-01 Hoechst Ag Substituierte thienoimidazoltoluidin-derivate, verfahren zu ihrer herstellung, sie enthaltende pharmazeutische zubereitungen und ihre verwendung als magensaeuresekretionshemmer
FI91754C (fi) * 1986-12-02 1994-08-10 Tanabe Seiyaku Co Analogiamenetelmä lääkeaineena käyttökelpoisen imidatsolijohdannaisen valmistamiseksi
JPS63230633A (ja) * 1987-03-19 1988-09-27 Nippon Chemiphar Co Ltd 胃腸の細胞保護剤
DE3719783A1 (de) * 1987-06-13 1988-12-22 Hoechst Ag Verfahren zur herstellung von 5-phenylsulfinyl-1h-2-(methoxycarbonylamino)- benzimidazol
JP2718945B2 (ja) * 1987-06-17 1998-02-25 エーザイ株式会社 ピリジン誘導体及びそれを含有する潰瘍治療剤
FI96860C (fi) * 1987-06-17 1996-09-10 Eisai Co Ltd Analogiamenetelmä lääkeaineena käytettävän pyridiinijohdannaisen valmistamiseksi
DE3723327A1 (de) * 1987-07-15 1989-02-02 Hoechst Ag Substituierte thienoimidazol-derivate, verfahren zu ihrer herstellung, sie enthaltende pharmazeutische zubereitungen und ihre verwendung als magensaeuresekretionshemmer, magenschutzmittel sowie als medikament gegen intestinale entzuendungen
DK171989B1 (da) * 1987-08-04 1997-09-08 Takeda Chemical Industries Ltd Fremgangsmåde til fremstilling af 2-(2-pyridylmethylsulfinyl)-benzimidazoler
US5124158A (en) * 1988-06-30 1992-06-23 The Upjohn Company Transdermal antisecretory agents for gastrointestinal disease
US5223515A (en) * 1988-08-18 1993-06-29 Takeda Chemical Industries, Ltd. Injectable solution containing a pyridyl methylsulfinylbenzimidazole
KR900701270A (ko) * 1988-08-23 1990-12-01 안데르스 베딘 피리디닐메틸(술피닐 또는 티오)벤즈이미다졸을 사용한 인체 눈의 녹내장 및 관련 장해의 치료 방법
US5075323A (en) * 1988-08-24 1991-12-24 Aktiebolaget Hassle Compounds including omeprazole in the treatment of glaucoma
US5175286A (en) * 1988-09-20 1992-12-29 Hisamitsu Pharmaceutical Co., Inc. Dibenz[b,e]oxepin derivatives
AT391693B (de) * 1988-11-15 1990-11-12 Cl Pharma Verfahren zur herstellung von 3-5-dimethyl-4methoxypyridinderivaten sowie neues zwischenprodukt hierfuer
EG19302A (en) * 1988-12-22 1994-11-30 Haessle Ab Compound with gastric acid inhibitory effect and process for its preparation
SE8804628D0 (sv) 1988-12-22 1988-12-22 Ab Haessle New compounds
SE8804629D0 (sv) 1988-12-22 1988-12-22 Ab Haessle New therapeutically active compounds
JP2694361B2 (ja) * 1989-02-09 1997-12-24 アストラ アクチエボラグ 抗菌剤
GB2239453A (en) * 1989-11-27 1991-07-03 Haessle Ab Omeprazole
US5049674A (en) * 1989-12-20 1991-09-17 Aktiebolaget Hassle Therapeutically active fluoro substituted benzimidazoles
US5274099A (en) * 1989-12-20 1993-12-28 Aktiebolaget Hassle Therapeutically active fluoro substituted benzimidazoles
US4965269A (en) * 1989-12-20 1990-10-23 Ab Hassle Therapeutically active chloro substituted benzimidazoles
KR930000861B1 (ko) * 1990-02-27 1993-02-08 한미약품공업 주식회사 오메프라졸 직장투여 조성물
KR100206150B1 (ko) 1990-04-04 1999-07-01 로버트 피. 블랙버언 항-에이치씨브이 항체에 대한 면역분석용 씨형 간염 바이러스(에이치디브이)항원의 조합체
SE9002043D0 (sv) * 1990-06-07 1990-06-07 Astra Ab Improved method for synthesis
SE9002206D0 (sv) 1990-06-20 1990-06-20 Haessle Ab New compounds
CA2083606C (fr) * 1990-06-20 2001-08-21 Arne Elof Brandstrom Derives de dialcoxypyridinylbenzimidazole; methode de preparation et utilisation en pharmacie
US5061805A (en) * 1990-08-10 1991-10-29 Reilly Industries, Inc. Process for preparing 2-methyl-3,5-dialkylpyridines by dealkylation with sulfur
CA2052698A1 (fr) * 1990-10-11 1992-04-12 Roger G. Berlin Traitement des ulceres peptiques
EP0480716A1 (fr) 1990-10-12 1992-04-15 Merck Frosst Canada Inc. Acides hydroxyalkylquinoliniques saturés comme antagonistes de leukotriène
DE69132082T2 (de) * 1990-10-17 2000-08-31 Takeda Chemical Industries, Ltd. Pyridin-Derivate, Verfahren zu deren Herstellung und Anwendung
ES2026761A6 (es) * 1990-10-31 1992-05-01 Genesis Para La Investigacion Procedimiento de obtencion del omeprazol.
NZ244301A (en) * 1991-09-20 1994-08-26 Merck & Co Inc Preparation of 2-pyridylmethylsulphinylbenzimidazole and pyridoimidazole derivatives from the corresponding sulphenyl compounds
FR2692146B1 (fr) * 1992-06-16 1995-06-02 Ethypharm Sa Compositions stables de microgranules d'omeprazole gastro-protégés et leur procédé d'obtention.
WO1994001107A1 (fr) * 1992-07-08 1994-01-20 Monsanto Company Benzimidazoles utilises pour le traitement des ulceres de l'estomac chez le porc
US5589491A (en) * 1992-07-28 1996-12-31 Astra Aktiebolag Injection and injection kit containing omeprazole and its analogs
SE9301830D0 (sv) 1993-05-28 1993-05-28 Ab Astra New compounds
US6875872B1 (en) 1993-05-28 2005-04-05 Astrazeneca Compounds
SE9302395D0 (sv) * 1993-07-09 1993-07-09 Ab Astra New pharmaceutical formulation
SE9302396D0 (sv) * 1993-07-09 1993-07-09 Ab Astra A novel compound form
US5410054A (en) * 1993-07-20 1995-04-25 Merck Frosst Canada, Inc. Heteroaryl quinolines as inhibitors of leukotriene biosynthesis
TW280770B (fr) 1993-10-15 1996-07-11 Takeda Pharm Industry Co Ltd
EP0729957A4 (fr) * 1993-10-29 1996-12-27 Yoshitomi Pharmaceutical Compose de pyridine et son utilisation en tant que remede
US5502195A (en) * 1993-11-04 1996-03-26 Slemon; Clarke Sulfoxide-carboxylate intermediates of omeprazole and lansoprazole
US5374730A (en) * 1993-11-04 1994-12-20 Torcan Chemical Ltd. Preparation of omeprazole and lansoprazole
KR0142815B1 (ko) * 1994-12-02 1998-07-15 정도언 신규한 5-피롤릴-6-할로게노-2피리딜메틸설피닐벤즈이미다졸 유도체
KR0179401B1 (ko) * 1994-02-28 1999-03-20 송택선 신규한 5-피롤릴-2-피리딜메틸설피닐벤즈이미다졸 유도체
AU2395095A (en) * 1994-04-29 1995-11-29 G.D. Searle & Co. Method of using (h+/k+) atpase inhibitors as antiviral agents
DK0723436T3 (da) 1994-07-08 2001-11-26 Astrazeneca Ab Tabletteret flerenhedsdoseringsform
SE9402431D0 (sv) * 1994-07-08 1994-07-08 Astra Ab New tablet formulation
SE504459C2 (sv) * 1994-07-15 1997-02-17 Astra Ab Förfarande för framställning av substituerade sulfoxider
GB9423968D0 (en) * 1994-11-28 1995-01-11 Astra Ab Resolution
GB9423970D0 (en) * 1994-11-28 1995-01-11 Astra Ab Oxidation
SE9500422D0 (sv) * 1995-02-06 1995-02-06 Astra Ab New oral pharmaceutical dosage forms
SE9500478D0 (sv) * 1995-02-09 1995-02-09 Astra Ab New pharmaceutical formulation and process
JP3015702B2 (ja) * 1995-02-21 2000-03-06 株式会社アラクス イミダゾール誘導体及びそれらの薬剤として許容される酸付加塩及びその製造法並びにそれらを有効成分とする抗潰瘍剤
JP3046924B2 (ja) * 1995-03-27 2000-05-29 株式会社アラクス イミダゾリン誘導体又はそれらの可能な互変異性体及びそれらの製造方法並びにそれらを有効成分とする創傷治療薬
US5708017A (en) * 1995-04-04 1998-01-13 Merck & Co., Inc. Stable, ready-to-use pharmaceutical paste composition containing proton pump inhibitors
HRP960232A2 (en) * 1995-07-03 1998-02-28 Astra Ab A process for the optical purification of compounds
US5686588A (en) * 1995-08-16 1997-11-11 Yoo; Seo Hong Amine acid salt compounds and process for the production thereof
US5824339A (en) * 1995-09-08 1998-10-20 Takeda Chemical Industries, Ltd Effervescent composition and its production
DK1092434T3 (da) * 1995-09-21 2004-07-26 Pharma Pass Ii Llc Hidtil ukendt sammensætning indeholdende lansoprazol og fremgangsmåde til fremstilling deraf
SE521100C2 (sv) * 1995-12-15 2003-09-30 Astra Ab Förfarande för framställning av en bensimidazolförening
KR970032861A (ko) * 1995-12-29 1997-07-22 김준웅 헬리코박터 피로리 제거용 약제 투여방법
US6489346B1 (en) 1996-01-04 2002-12-03 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
US6699885B2 (en) * 1996-01-04 2004-03-02 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and methods of using same
US6645988B2 (en) * 1996-01-04 2003-11-11 Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
US5840737A (en) * 1996-01-04 1998-11-24 The Curators Of The University Of Missouri Omeprazole solution and method for using same
US20050054682A1 (en) * 1996-01-04 2005-03-10 Phillips Jeffrey O. Pharmaceutical compositions comprising substituted benzimidazoles and methods of using same
SE9600070D0 (sv) 1996-01-08 1996-01-08 Astra Ab New oral pharmaceutical dosage forms
WO1997029103A2 (fr) * 1996-02-06 1997-08-14 Pdi-Research Laboratories, Inc. Synthese de derives de la pyridine du type omeprazole et intermediaires correspondants
US6623759B2 (en) 1996-06-28 2003-09-23 Astrazeneca Ab Stable drug form for oral administration with benzimidazole derivatives as active ingredient and process for the preparation thereof
US5625069A (en) * 1996-07-22 1997-04-29 Development Center For Biotechnology Process for preparing 2-cyano-3,5-dimethyl-4-methoxypyridine
US6599927B2 (en) 1996-10-11 2003-07-29 Astrazeneca Ab Use of an H+, K+-ATPase inhibitor in the treatment of Widal's Syndrome
TW385306B (en) * 1996-11-14 2000-03-21 Takeda Chemical Industries Ltd Method for producing crystals of benzimidazole derivatives
SE510666C2 (sv) * 1996-12-20 1999-06-14 Astra Ab Nya Kristallmodifikationer
CA2204580A1 (fr) * 1997-05-06 1998-11-06 Michel Zoghbi Synthese de derives de la pyridine utiles en pharmacie
US6437139B1 (en) 1997-05-06 2002-08-20 Pdi-Research Laboratories, Inc. Synthesis of pharmaceutically useful pyridine derivatives
KR100463031B1 (ko) * 1997-05-26 2005-04-06 동아제약주식회사 5-메톡시-2-[3,5-디메틸-4-메톡시피리딜메틸)설피닐]-1h-벤즈이미다졸의신규제조방법
SE9702000D0 (sv) * 1997-05-28 1997-05-28 Astra Ab New pharmaceutical formulation
US6747155B2 (en) 1997-05-30 2004-06-08 Astrazeneca Ab Process
SE510650C2 (sv) 1997-05-30 1999-06-14 Astra Ab Ny förening
WO1998054172A1 (fr) * 1997-05-30 1998-12-03 Dr. Reddy's Research Foundation Nouveaux benzimidazoles utilises comme agents antiulcereux, leur procede de preparation et compositions pharmaceutiques les contenant
SE510643C2 (sv) 1997-06-27 1999-06-14 Astra Ab Termodynamiskt stabil omeprazol natrium form B
KR100570104B1 (ko) * 1997-07-11 2006-04-11 에자이 가부시키가이샤 피리딘 유도체의 제조방법
SI9700186B (sl) * 1997-07-14 2006-10-31 Lek, Tovarna Farmacevtskih In Kemicnih Izdelkov, D.D. Nova farmacevtska oblika z nadzorovanim sproscanjem zdravilnih ucinkovin
SI1003554T1 (en) 1997-07-25 2005-04-30 Altana Pharma Ag Proton pump inhibitor in therapeutic combination with antibacterial substances
US6296876B1 (en) 1997-10-06 2001-10-02 Isa Odidi Pharmaceutical formulations for acid labile substances
US7230014B1 (en) 1997-10-14 2007-06-12 Eisai Co., Ltd. Pharmaceutical formulation comprising glycine as a stabilizer
US6096340A (en) * 1997-11-14 2000-08-01 Andrx Pharmaceuticals, Inc. Omeprazole formulation
SE9704183D0 (sv) 1997-11-14 1997-11-14 Astra Ab New process
US6174548B1 (en) 1998-08-28 2001-01-16 Andrx Pharmaceuticals, Inc. Omeprazole formulation
ES2362418T3 (es) 1997-12-08 2011-07-05 Nycomed Gmbh Nueva forma de supositorio que comprende un compuesto activo ácido-lábil.
DE19754324A1 (de) * 1997-12-08 1999-06-10 Byk Gulden Lomberg Chem Fab Neue Darreichungsform enthaltend einen säurelabilen Wirkstoff
SE9704869D0 (sv) * 1997-12-22 1997-12-22 Astra Ab New pharmaceutical formulaton II
SE9704870D0 (sv) 1997-12-22 1997-12-22 Astra Ab New pharmaceutical formulation I
US6159968A (en) * 1998-01-15 2000-12-12 University Of Cincinnati Activation of chloride channels for correction of defective chloride transport
US6197962B1 (en) 1998-01-26 2001-03-06 Kuraray Co., Ltd. Method for producing 2-sulfonylpyridine derivatives and method for producing 2-{[(2-pyridyl)methyl]thio}-1H-benzimidazole derivatives
US6350876B2 (en) 1998-01-26 2002-02-26 Kuraray Co., Ltd. 4-chloro-3,5-dimethyl-2-sulfonyl pyridines
IT1299198B1 (it) 1998-03-05 2000-02-29 Nicox Sa Sali nitrati di farmaci antiulcera
ATE348601T1 (de) 1998-05-18 2007-01-15 Takeda Pharmaceutical Im munde zerfallende tablette enthaltend ein benzimidazole
US6303787B1 (en) 1998-05-27 2001-10-16 Natco Pharma Limited Intermediates and an improved process for the preparation of Omeprazole employing the said intermediates
ZA9810765B (en) * 1998-05-28 1999-08-06 Ranbaxy Lab Ltd Stable oral pharmaceutical composition containing a substituted pyridylsulfinyl benzimidazole.
WO2000000474A1 (fr) * 1998-06-26 2000-01-06 Russinsky Limited Blocs constitutifs de pyrimidine utilises comme intermediaires dans la synthese de composes pharmaceutiquement actifs
SI20019A (sl) 1998-07-13 2000-02-29 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Izboljšan postopek sinteze 5-metoksi -2-/(4-metoksi-3,5-dimetil-2-piridil)metil/ sulfinil-1H-benzimidazola
NZ510180A (en) * 1998-08-10 2002-11-26 Univ California Prodrugs of the pyridyl-methylsulphonyl-benzimidazole type proton pump inhibitors
US6093734A (en) * 1998-08-10 2000-07-25 Partnership Of Michael E. Garst, George Sachs, And Jai Moo Shin Prodrugs of proton pump inhibitors
US6166213A (en) * 1998-08-11 2000-12-26 Merck & Co., Inc. Omeprazole process and compositions thereof
US6191148B1 (en) * 1998-08-11 2001-02-20 Merck & Co., Inc. Omerazole process and compositions thereof
US7041313B1 (en) 1998-08-12 2006-05-09 Altana Pharma Ag Oral administration form for pyridin-2-ylmethylsulfinyl-1H-benzimidazoles
DE19843413C1 (de) * 1998-08-18 2000-03-30 Byk Gulden Lomberg Chem Fab Neue Salzform von Pantoprazol
US6733778B1 (en) 1999-08-27 2004-05-11 Andrx Pharmaceuticals, Inc. Omeprazole formulation
SE9803772D0 (sv) 1998-11-05 1998-11-05 Astra Ab Pharmaceutical formulation
AU1054899A (en) * 1998-11-06 2000-05-29 Dong-A Pharmaceutical Co., Ltd. Method of preparing sulfide derivatives
IL142703A (en) * 1998-11-10 2006-04-10 Astrazeneca Ab Crystalline form of omeprazole
UA72748C2 (en) * 1998-11-10 2005-04-15 Astrazeneca Ab A novel crystalline form of omeprazole
JP3926936B2 (ja) 1998-11-16 2007-06-06 エーザイ・アール・アンド・ディー・マネジメント株式会社 スルホキシド誘導体・アセトン錯体およびその製造法
SE9900274D0 (sv) * 1999-01-28 1999-01-28 Astra Ab New compound
US6852739B1 (en) 1999-02-26 2005-02-08 Nitromed Inc. Methods using proton pump inhibitors and nitric oxide donors
TWI243672B (en) 1999-06-01 2005-11-21 Astrazeneca Ab New use of compounds as antibacterial agents
CA2376202C (fr) 1999-06-07 2008-11-18 Byk Gulden Lomberg Chemische Fabrik Gmbh Preparation et forme galenique comprenant un compose actif acido-labile
IL130602A0 (en) 1999-06-22 2000-06-01 Dexcel Ltd Stable benzimidazole formulation
US6555139B2 (en) 1999-06-28 2003-04-29 Wockhardt Europe Limited Preparation of micron-size pharmaceutical particles by microfluidization
US6245913B1 (en) 1999-06-30 2001-06-12 Wockhardt Europe Limited Synthetic procedure for 5-methoxy-2-[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methylthio]-IH-benzimidazole hydrochloride and its conversion to omeprazole
US6268385B1 (en) 1999-08-26 2001-07-31 Robert R. Whittle Dry blend pharmaceutical formulations
CA2382838A1 (fr) * 1999-08-26 2001-03-01 Frederick D. Sancilio Mesure spectroscopique raman par transformee de fourier du rapport isomerique de l'omeprazole dans une composition
EP1595879A3 (fr) * 1999-08-26 2010-01-27 aaiPharma Inc. Composés de benzimidazole substitués par un alkoxy, préparations pharmaceutiques contenant ces derniers, et procédés d'utilisation
US6369087B1 (en) 1999-08-26 2002-04-09 Robert R. Whittle Alkoxy substituted benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same
US6316020B1 (en) 1999-08-26 2001-11-13 Robert R. Whittle Pharmaceutical formulations
US6262086B1 (en) 1999-08-26 2001-07-17 Robert R. Whittle Pharmaceutical unit dosage form
SI20974A (sl) * 1999-08-26 2003-02-28 Aaipharma, Inc. Alkoksi substituirane benzimidazolne spojine, farmacevtski pripravki, ki jih vsebujejo ter metode za njihovo uporabo
US6326384B1 (en) 1999-08-26 2001-12-04 Robert R. Whittle Dry blend pharmaceutical unit dosage form
US6780880B1 (en) 1999-08-26 2004-08-24 Robert R. Whittle FT-Raman spectroscopic measurement
US6312712B1 (en) 1999-08-26 2001-11-06 Robert R. Whittle Method of improving bioavailability
US6262085B1 (en) * 1999-08-26 2001-07-17 Robert R. Whittle Alkoxy substituted Benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same
US6312723B1 (en) 1999-08-26 2001-11-06 Robert R. Whittle Pharmaceutical unit dosage form
US6228400B1 (en) 1999-09-28 2001-05-08 Carlsbad Technology, Inc. Orally administered pharmaceutical formulations of benzimidazole derivatives and the method of preparing the same
SE9903831D0 (sv) 1999-10-22 1999-10-22 Astra Ab Formulation of substituted benzimidazoles
DE19951960C2 (de) * 1999-10-28 2002-06-27 Gruenenthal Gmbh Verfahren zur Herstellung als Ulkustherapeutika geeigneter Benzimidazol-Derivate
CA2290893C (fr) 1999-11-16 2007-05-01 Bernard Charles Sherman Omeprazole de magnesium
DE19959419A1 (de) 1999-12-09 2001-06-21 Ratiopharm Gmbh Stabile galenische Zubereitungen umfassend ein Benzimidazol und Verfahren zu ihrer Herstellung
AU2277201A (en) * 1999-12-17 2001-06-25 Ariad Pharmaceuticals, Inc. Novel purines
US6787342B2 (en) 2000-02-16 2004-09-07 Merial Limited Paste formulations
SE0000774D0 (sv) 2000-03-08 2000-03-08 Astrazeneca Ab New formulation
SE0000773D0 (sv) * 2000-03-08 2000-03-08 Astrazeneca Ab New formulation
US6306435B1 (en) 2000-06-26 2001-10-23 Yung Shin Pharmaceutical Industrial Co. Ltd. Oral pharmaceutical preparation embedded in an oily matrix and methods of making the same
SE0002476D0 (sv) 2000-06-30 2000-06-30 Astrazeneca Ab New compounds
US6544556B1 (en) 2000-09-11 2003-04-08 Andrx Corporation Pharmaceutical formulations containing a non-steroidal antiinflammatory drug and a proton pump inhibitor
WO2002026210A2 (fr) * 2000-09-29 2002-04-04 Geneva Pharmaceuticals Inc. Formulation d'inhibiteur de la pompe à protons
SI1341524T1 (sl) 2000-12-07 2012-02-29 Nycomed Gmbh Farmacevtski pripravek v obliki paste, ki obsega kislinsko labilno učinkovino
AU2002221939A1 (en) 2000-12-07 2002-06-18 Byk Gulden Lomberg Chemische Fabrik G.M.B.H. Rapidly disintegrating tablet comprising an acid-labile active ingredient
CN100528232C (zh) 2000-12-07 2009-08-19 尼科梅德有限责任公司 包含酸不稳定活性成分的混悬液形式的药物制剂
CN1781918A (zh) 2001-02-02 2006-06-07 特瓦制药工业有限公司 制备硫酯化合物的方法
US6645946B1 (en) 2001-03-27 2003-11-11 Pro-Pharmaceuticals, Inc. Delivery of a therapeutic agent in a formulation for reduced toxicity
SE0101379D0 (sv) * 2001-04-18 2001-04-18 Diabact Ab Komposition som hämmar utsöndring av magsyra
SI20875A (sl) * 2001-04-25 2002-10-31 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Kristalna oblika omeprazola
US6926907B2 (en) * 2001-06-01 2005-08-09 Pozen Inc. Pharmaceutical compositions for the coordinated delivery of NSAIDs
US8206741B2 (en) 2001-06-01 2012-06-26 Pozen Inc. Pharmaceutical compositions for the coordinated delivery of NSAIDs
DE10140492A1 (de) 2001-08-17 2003-08-14 Gruenenthal Gmbh Hydrate von gegebenenfalls substituierten 2-(2-Pyridinyl)methylthio-1H-benzimidazolen und Verfahren zu ihrer Herstellung
SE0102993D0 (sv) 2001-09-07 2001-09-07 Astrazeneca Ab New self emulsifying drug delivery system
CN1243749C (zh) * 2001-09-18 2006-03-01 泽里新药工业株式会社 苯并咪唑衍生物
US8101209B2 (en) 2001-10-09 2012-01-24 Flamel Technologies Microparticulate oral galenical form for the delayed and controlled release of pharmaceutical active principles
ES2392960T3 (es) 2001-10-17 2012-12-17 Takeda Pharmaceutical Company Limited Gránulos que contienen gran cantidad de compuesto químico inestable en medio ácido
US7855082B1 (en) 2001-10-31 2010-12-21 Astrazeneca Ab Raman spectroscopic method for determining the ratio of 5-methoxy and 6-methoxy isomers of omeprazole
JP2005521662A (ja) * 2002-01-25 2005-07-21 サンタラス インコーポレイティッド プロトンポンプ阻害剤の経粘膜送達
ATE363480T1 (de) * 2002-03-05 2007-06-15 Astrazeneca Ab Alkylammoniumsalze von omeprazol und esomeprazol
DE60325709D1 (de) 2002-04-09 2009-02-26 Flamel Tech Sa Orale wässrige suspension, mikrokapseln enthaltend, zur kontrollierten freisetzung von wirkstoffen
PT1492531E (pt) 2002-04-09 2008-12-10 Flamel Tech Sa Formulação farmacêutica oral sob a forma de suspensão aquosa de microcápsulas que permite a libertação modificada de amoxicilina
US20030228363A1 (en) * 2002-06-07 2003-12-11 Patel Mahendra R. Stabilized pharmaceutical compositons containing benzimidazole compounds
US20040034078A1 (en) * 2002-06-14 2004-02-19 Agouron Pharmaceuticals, Inc. Benzimidazole inhibitors of poly(ADP-ribosyl) polymerase
MXPA05000657A (es) * 2002-07-19 2005-08-19 Winston Pharmaceuticals Llc Profarmacos de los inhibidores de bomba de protones.
TW200410955A (en) 2002-07-29 2004-07-01 Altana Pharma Ag Novel salt of (S)-PANTOPRAZOLE
JP4634144B2 (ja) * 2002-08-01 2011-02-16 ニコックス エスエー ニトロソ化プロトンポンプ阻害剤、組成物および使用方法
SE0203065D0 (sv) 2002-10-16 2002-10-16 Diabact Ab Gastric acid secretion inhibiting composition
MY148805A (en) 2002-10-16 2013-05-31 Takeda Pharmaceutical Controlled release preparation
EP2596791B1 (fr) 2002-10-16 2015-04-01 Takeda Pharmaceutical Company Limited Préparations solides stables
SE0203092D0 (en) * 2002-10-18 2002-10-18 Astrazeneca Ab Method for the synthesis of a benzimidazole compound
FR2845915B1 (fr) 2002-10-21 2006-06-23 Negma Gild Utilisation du tenatoprazole pour le traitement du reflux gastro-oesophagien
US20040235903A1 (en) * 2002-10-22 2004-11-25 Khanna Mahavir Singh Amorphous form of esomeprazole salts
DE10254167A1 (de) 2002-11-20 2004-06-09 Icon Genetics Ag Verfahren zur Kontrolle von zellulären Prozessen in Pflanzen
MXPA05005762A (es) 2002-12-06 2005-08-16 Altana Pharma Ag Procedimiento para preparar compuestos activos opticamente puros.
KR101169471B1 (ko) 2002-12-06 2012-07-30 니코메드 게엠베하 (s)-판토프라졸의 제조 방법
FR2848555B1 (fr) 2002-12-16 2006-07-28 Negma Gild Enantiomere(-)du tenatoprazole et son application en therapeutique
AU2003303240A1 (en) * 2002-12-19 2004-07-14 Eva Pharmaceutical Industries Ltd. Solid states of pantoprazole sodium, processes for preparing them and processes for preparing known pantoprazole sodium hydrates
US20040166162A1 (en) * 2003-01-24 2004-08-26 Robert Niecestro Novel pharmaceutical formulation containing a proton pump inhibitor and an antacid
WO2004073654A2 (fr) * 2003-02-20 2004-09-02 Santarus, Inc. Liberation immediate d'un complexe antacide d'omeprazole presentant une nouvelle formulation pour une elimination rapide et prolongee d'acide gastrique
US20040185119A1 (en) * 2003-02-26 2004-09-23 Theuer Richard C. Method and compositions for treating gastric hyperacidity while diminishing the likelihood of producing vitamin deficiency
CA2518999A1 (fr) * 2003-03-12 2004-09-23 Teva Pharmaceutical Industries Ltd Formes solides cristallines et amorphes de pantoprazole et procedes de preparation de ces formes
JP4355703B2 (ja) * 2003-03-13 2009-11-04 エーザイ・アール・アンド・ディー・マネジメント株式会社 歯ぎしりの予防剤または治療剤
US20040185092A1 (en) * 2003-03-18 2004-09-23 Yih Ming Hsiao Pharmaceutical preparations of omeprazole and/or clarithromycin for oral use
US20060281782A1 (en) * 2003-03-28 2006-12-14 Avraham Cohen Method for the enantioselective preparation of sulphoxide derivatives
FR2852956B1 (fr) * 2003-03-28 2006-08-04 Negma Gild Procede de preparation enantioselective de derives de sulfoxydes
PE20050150A1 (es) 2003-05-08 2005-03-22 Altana Pharma Ag Una forma de dosificacion que contiene (s)-pantoprazol como ingrediente activo
CL2004000983A1 (es) 2003-05-08 2005-03-04 Altana Pharma Ag Composicion farmaceutica oral en forma de tableta que comprende a pantoprazol magnetico dihidratado, en donde la forma de tableta esta compuesto por un nucleo, una capa intermedia y una capa exterior; y uso de la composicion farmaceutica en ulceras y
US7524837B2 (en) * 2003-05-12 2009-04-28 Janssen Pharmaceutica N.V. Benzotriazapinone salts and methods for using same
CA2528993A1 (fr) * 2003-06-10 2004-12-23 Teva Pharmaceutical Industries Ltd. Procede de preparation de benzimidazoles 2-[(pyridinyl)methyl]sulfinyle substitues et nouveau derives chlorures de pantoprazole
EP2112920B1 (fr) 2003-06-26 2018-07-25 Intellipharmaceutics Corp. Capsules contenant un inhibiteur de la pompe a protons comprenant des unites secondaires differemment structurees permettant une liberation retardee de l'ingredient actif
WO2005016917A1 (fr) * 2003-07-15 2005-02-24 Allergan, Inc. Procede de preparation de promedicaments isomeriquement purs d'inhibiteurs de la pompe a protons
JP2006528182A (ja) * 2003-07-18 2006-12-14 サンタラス インコーポレイティッド 薬学的製剤および酸に起因する消化器疾患の治療法
EP1648416A4 (fr) * 2003-07-18 2012-03-28 Santarus Inc Formulations pharmaceutiques utilisees pour inhiber une secretion acide et procede de fabrication associe
US8993599B2 (en) 2003-07-18 2015-03-31 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
MXPA06002443A (es) * 2003-09-03 2006-08-31 Agi Therapeutics Ltd Formulaciones inhibidoras de la bomba de protones y metodos para preparar y utilizar tales formulaciones.
SE0302381D0 (sv) 2003-09-04 2003-09-04 Astrazeneca Ab New salts I
SE0302382D0 (sv) 2003-09-04 2003-09-04 Astrazeneca Ab New salts II
TWI372066B (en) 2003-10-01 2012-09-11 Wyeth Corp Pantoprazole multiparticulate formulations
US20060241037A1 (en) * 2003-10-03 2006-10-26 Allergan Inc. Compositions comprising trefoil factor family peptides and/or mucoadhesives and proton pump ihhibitor prodrugs
US20050075371A1 (en) * 2003-10-03 2005-04-07 Allergan, Inc. Methods and compositions for the oral administration of prodrugs of proton pump inhibitors
ES2357430T3 (es) * 2003-10-24 2011-04-26 Immunaid Pty Ltd Método de terapia.
US20070292498A1 (en) * 2003-11-05 2007-12-20 Warren Hall Combinations of proton pump inhibitors, sleep aids, buffers and pain relievers
WO2005077936A1 (fr) 2004-02-11 2005-08-25 Ulkar Kimya Sanayii Ve Ticaret A.S. Sulfoxydes pyridine benzimidazole d'une grande purete
US20070161679A1 (en) * 2004-02-18 2007-07-12 Allergan, Inc. Method and compositions for the intravenous administration of compounds related to proton pump inhibitors
BRPI0507784A (pt) * 2004-02-18 2007-07-17 Allergan Inc métodos e composições para a administração de pró-fármacos de inibidores da bomba de prótons
SE0400410D0 (sv) 2004-02-20 2004-02-20 Astrazeneca Ab New compounds
US20080287502A1 (en) * 2004-03-30 2008-11-20 Dermatrends, Inc. Transdermal Administration of Proton Pump Inhibitors
ATE437869T1 (de) 2004-04-28 2009-08-15 Hetero Drugs Ltd Verfahren zur herstellung von pyridinylmethyl-1h- benzimidazolverbindungen in enantiomerenangereicherter form oder als einzelne enantiomere
US8815916B2 (en) 2004-05-25 2014-08-26 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US8906940B2 (en) 2004-05-25 2014-12-09 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
PT1748998E (pt) 2004-05-28 2010-03-24 Hetero Drugs Ltd Novo processo de síntese estereoselectiva de sulfóxidos de benzimidazol
US20050267157A1 (en) * 2004-05-28 2005-12-01 David White Magnesium-S-omeprazole
CA2568652A1 (fr) * 2004-06-02 2005-12-15 Altana Pharma Ag Procede permettant la preparation de composes pyridin-2-yl-methyl-sulfinyl-1h-benzimidazol
US8394409B2 (en) 2004-07-01 2013-03-12 Intellipharmaceutics Corp. Controlled extended drug release technology
US20060024362A1 (en) 2004-07-29 2006-02-02 Pawan Seth Composition comprising a benzimidazole and process for its manufacture
US10624858B2 (en) 2004-08-23 2020-04-21 Intellipharmaceutics Corp Controlled release composition using transition coating, and method of preparing same
EP1790647B1 (fr) 2004-09-13 2013-05-08 Takeda Pharmaceutical Company Limited Procede destines a produire un compose oxyde
US8541026B2 (en) 2004-09-24 2013-09-24 Abbvie Inc. Sustained release formulations of opioid and nonopioid analgesics
KR20070109985A (ko) 2004-11-22 2007-11-15 아나디스 리미티드 생물활성 조성물
EP1830823A2 (fr) 2004-12-23 2007-09-12 Ranbaxy Laboratories Limited Compositions orales stables de benzimidazoles et leur procede de preparation
EP1845982A2 (fr) * 2005-02-02 2007-10-24 Ranbaxy Laboratories Limited Compositions de benzimidazole orales stables preparees par un procede de stratification non aqueux
US8871273B2 (en) 2005-02-25 2014-10-28 Takeda Pharmaceutical Company Limited Method for producing granules
US7981908B2 (en) 2005-05-11 2011-07-19 Vecta, Ltd. Compositions and methods for inhibiting gastric acid secretion
US7803817B2 (en) 2005-05-11 2010-09-28 Vecta, Ltd. Composition and methods for inhibiting gastric acid secretion
US7563812B2 (en) 2005-06-15 2009-07-21 Hetero Drugs Limited Amorphous esomeprazole hydrate
CA2613875C (fr) 2005-07-04 2018-09-25 Ramu Krishnan Medicament ou composes pharmaceutiques ameliores et preparation associee
EP1904064A4 (fr) * 2005-07-07 2009-12-02 Reddys Lab Ltd Dr Omeprazole de forme b
US7601737B2 (en) 2005-07-26 2009-10-13 Nycomed Gmbh Isotopically substituted proton pump inhibitors
CN102134232B (zh) * 2005-07-26 2012-11-21 奈科明有限责任公司 同位素取代的质子泵抑制剂
TWI410409B (zh) * 2005-07-26 2013-10-01 Takeda Gmbh 同位素取代之潘托拉唑(pantoprazole)
CA2624179A1 (fr) * 2005-10-06 2007-04-12 Auspex Pharmaceuticals, Inc. Inhibiteurs deuteries d'atpase h+,k+ gastrique ayant des proprietes therapeutiques renforcees
US7576219B2 (en) 2005-10-26 2009-08-18 Hanmi Pharm. Co., Ltd Crystalline S-omeprazole strontium hydrate, method for preparing same, and pharmaceutical composition containing same
AU2006323245B2 (en) 2005-12-05 2011-03-03 Astrazeneca Ab New process for the preparation of esomeprazole non-salt form
EP1801110A1 (fr) 2005-12-22 2007-06-27 KRKA, tovarna zdravil, d.d., Novo mesto Sel d'arginine d'ésoméprazole
US10064828B1 (en) 2005-12-23 2018-09-04 Intellipharmaceutics Corp. Pulsed extended-pulsed and extended-pulsed pulsed drug delivery systems
AU2006331373B2 (en) 2005-12-28 2011-06-02 Union Quimico Farmaceutica, S.A. A process for the preparation of the (S)-enantiomer of omeprazole
CA2634232C (fr) 2005-12-28 2013-08-20 Takeda Pharmaceutical Company Limited Procede de production de preparation solide se desintegrant dans la cavite orale
EP2007360B1 (fr) * 2006-04-03 2014-11-26 Isa Odidi Dispositif d'administration à libération commandée comprenant un enrobage organosol
US10960077B2 (en) 2006-05-12 2021-03-30 Intellipharmaceutics Corp. Abuse and alcohol resistant drug composition
US7786309B2 (en) 2006-06-09 2010-08-31 Apotex Pharmachem Inc. Process for the preparation of esomeprazole and salts thereof
US7863330B2 (en) 2006-06-14 2011-01-04 Rottapharm S.P.A. Deloxiglumide and proton pump inhibitor combination in the treatment of gastrointestinal disorders
JP5474541B2 (ja) 2006-07-25 2014-04-16 ベクタ・リミテッド 小さいジカルボン酸の誘導体と組み合わせてppiを用いる胃酸分泌を阻害する組成物および方法
US20100317689A1 (en) * 2006-09-19 2010-12-16 Garst Michael E Prodrugs of proton pump inhibitors including the 1h-imidazo[4,5-b] pyridine moiety
US20090092658A1 (en) * 2007-10-05 2009-04-09 Santarus, Inc. Novel formulations of proton pump inhibitors and methods of using these formulations
GB2459393B (en) 2006-10-05 2010-09-08 Santarus Inc Novel capsule formulation for the proton pump inhibitor omeprazole
CA2667682A1 (fr) 2006-10-27 2008-05-15 The Curators Of The University Of Missouri Compositions comprenant des agents d'inhibition de la pompe a protons labiles d'acide, au moins un autre agent pharmaceutiquement actif et leurs procedes d'utilisation
EP2478894A3 (fr) 2006-12-22 2012-12-19 Ironwood Pharmaceuticals, Inc. Compositions permettant de traiter des troubles oesophagiens
EP1947099A1 (fr) 2007-01-18 2008-07-23 LEK Pharmaceuticals D.D. Procédé pour l'élimination de solvant des sels d'oméprazole
WO2008092939A2 (fr) 2007-01-31 2008-08-07 Krka, Tovarna Zdravil, D.D., Novo Mesto Procédé de préparation d'oméprazole optiquement pur
US20080194307A1 (en) * 2007-02-13 2008-08-14 Jeff Sanger Sports-based game of chance
EP2186807B1 (fr) 2007-02-21 2015-01-07 Cipla Limited Procédé pour la préparation de ésoméprazole magnésium dihydraté
CN101631768A (zh) * 2007-03-15 2010-01-20 太阳医药高级研究有限公司 新型前药
US8492551B2 (en) * 2007-06-07 2013-07-23 Aurobindo Pharma. Ltd. Process for preparing an optically active proton pump inhibitor
WO2009010937A1 (fr) * 2007-07-17 2009-01-22 Ranbaxy Laboratories Limited Procédé de préparation de pantoprazole sodique.
WO2009066317A2 (fr) * 2007-08-20 2009-05-28 Macleods Pharmaceuticals Limited Procédé de préparation de pantoprazole sodique
EP2195309A4 (fr) 2007-10-08 2013-04-24 Hetero Drugs Ltd Polymorphes de sels de l'ésoméprazole
CN101450939B (zh) * 2007-12-05 2013-06-19 沈阳药科大学 新型苯并咪唑类化合物
WO2009105568A1 (fr) 2008-02-20 2009-08-27 The Curators Of The University Of Missouri Composition comprenant une combinaison d'oméprazole et de lansoprazole, et un agent tampon, et ses méthodes d'utilisation
US8911787B2 (en) 2008-02-26 2014-12-16 Ranbaxy Laboratories Limited Stable oral benzimidazole compositions and process of preparation thereof
WO2009129301A2 (fr) * 2008-04-15 2009-10-22 Schering Corporation Compositions pharmaceutiques orales dans une dispersion solide moléculaire
PE20091778A1 (es) * 2008-04-15 2009-11-13 Schering Corp Composiciones de alta densidad que contienen posaconazol y formulaciones que lo comprenden
KR101044880B1 (ko) * 2008-06-12 2011-06-28 일양약품주식회사 항궤양제 화합물의 합성에 유용한 중간체의 제조방법
EP2147918A1 (fr) 2008-07-21 2010-01-27 LEK Pharmaceuticals D.D. Procédé de préparation de magnésium d'oméprazole S dans une forme stable
CH699302B1 (de) * 2008-08-11 2012-03-15 Mepha Gmbh Orale pharmazeutische Formulierung für Omeprazol, enthaltend eine spezifische Trennschicht.
CN102209529A (zh) 2008-09-09 2011-10-05 阿斯利康(瑞典)有限公司 将药物组合物递送至有需要的患者的方法
WO2010042785A1 (fr) * 2008-10-10 2010-04-15 Celtaxsys, Inc. Procédé d’induction d’un chimiotactisme négatif
EP2264024A1 (fr) 2008-10-14 2010-12-22 LEK Pharmaceuticals d.d. Procédé de préparation d'inhibiteurs de la pompe à protons énantiomériquement enrichis
WO2010134099A1 (fr) 2009-05-21 2010-11-25 Cadila Healthcare Limited Procédé de préparation dans un récipient unique d'oméprazole
EP2435825B8 (fr) 2009-05-27 2015-09-02 Biotempus Limited Procédés de traitement de maladies
CN102638978A (zh) * 2009-06-25 2012-08-15 波曾公司 用于治疗需要阿司匹林治疗之患者的方法
JP2012531409A (ja) 2009-06-25 2012-12-10 アストラゼネカ・アクチエボラーグ Nsaid関連潰瘍を発症するリスクがある患者の処置方法
WO2011058569A1 (fr) 2009-11-12 2011-05-19 Hetero Research Foundation Procédé de dédoublement de l'oméprazole
WO2011080500A2 (fr) 2009-12-29 2011-07-07 Orexo Ab Nouvelle forme pharmaceutique destinée au traitement de troubles liés à l'acide gastrique
WO2011080501A2 (fr) 2009-12-29 2011-07-07 Orexo Ab Nouvelle forme pharmaceutique destinée au traitement de troubles liés à l'acide gastrique
WO2011080502A2 (fr) 2009-12-29 2011-07-07 Orexo Ab Nouvelle forme pharmaceutique destinée au traitement de troubles liés à l'acide gastrique
EP2345408A3 (fr) 2010-01-08 2012-02-29 Dr. Reddy's Laboratories Ltd. Formulations de médicament labiles acides
CN102140099A (zh) 2010-02-02 2011-08-03 山东轩竹医药科技有限公司 新的吡啶衍生物
US9623622B2 (en) 2010-02-24 2017-04-18 Michael Baines Packaging materials and methods
US20130156720A1 (en) 2010-08-27 2013-06-20 Ironwood Pharmaceuticals, Inc. Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders
US9233103B2 (en) 2011-03-25 2016-01-12 Takeda Pharmaceuticals U.S.A., Inc. Methods for treating heartburn, gastric bleeding or hemorrhage in patients receiving clopidogrel therapy
JP6011982B2 (ja) 2011-08-26 2016-10-25 国立大学法人名古屋大学 骨形成促進剤及びその用途
RS66326B1 (sr) 2011-09-09 2025-01-31 Merck Sharp & Dohme Llc Ceftolozan/tazobaktam za lečenje intrapulmonalnih infekcija
WO2013081566A1 (fr) 2011-11-25 2013-06-06 Mahmut Bilgic Formulation comprenant du benzimidazole
EP2601947A1 (fr) 2011-12-05 2013-06-12 Abo Bakr Mohammed Ali Al-Mehdar Combinaison à dose fixe pour le traitement de maladies associées à Hélicobacter pylori
EA028049B1 (ru) 2011-12-28 2017-10-31 Поузен Инк. Улучшенные композиции и способы доставки омепразола и ацетилсалициловой кислоты
CN102584792B (zh) * 2012-01-06 2014-06-11 南京优科生物医药研究有限公司 制备高纯度的埃索美拉唑盐的方法
WO2013108068A1 (fr) 2012-01-21 2013-07-25 Jubilant Life Sciences Limited Procédé de préparation de 2-pyridinylméthylsulfinylbenzimidazoles, leurs analogues et énantiomères optiquement actifs
US8809314B1 (en) 2012-09-07 2014-08-19 Cubist Pharmacueticals, Inc. Cephalosporin compound
US8476425B1 (en) 2012-09-27 2013-07-02 Cubist Pharmaceuticals, Inc. Tazobactam arginine compositions
EA201591338A1 (ru) 2013-01-15 2016-01-29 Айронвуд Фармасьютикалз, Инк. Гастроретентивная лекарственная форма секвестранта желчных кислот с замедленным высвобождением для перорального применения
US20140274990A1 (en) 2013-03-15 2014-09-18 Cubist Pharmaceuticals, Inc. Ceftolozane pharmaceutical compositions
US9872906B2 (en) 2013-03-15 2018-01-23 Merck Sharp & Dohme Corp. Ceftolozane antibiotic compositions
NZ700372A (en) 2013-03-15 2016-01-29 Merck Sharp & Dohme Ceftolozane antibiotic compositions
GB201306720D0 (en) 2013-04-12 2013-05-29 Special Products Ltd Formulation
US10376496B2 (en) 2013-09-09 2019-08-13 Merck, Sharp & Dohme Corp. Treating infections with ceftolozane/tazobactam in subjects having impaired renal function
US20150094293A1 (en) 2013-09-27 2015-04-02 Calixa Therapeutics, Inc. Solid forms of ceftolozane
US9457011B2 (en) 2014-02-25 2016-10-04 Muslim D. Shahid Compositions and methods for the treatment of acid-related gastrointestinal disorders containing a dithiolane compound and a gastric acid secretion inhibitor
FR3018812A1 (fr) 2014-03-21 2015-09-25 Minakem Nouvelle phase intermediaire de la forme a du sel de magnesium dihydrate d'un enantiomere de l'omeprazole
WO2015155281A1 (fr) 2014-04-11 2015-10-15 Sanovel Ilac Sanayi Ve Ticaret A.S. Combinaisons pharmaceutiques de dabigatran et d'inhibiteurs de la pompe à protons
EP2929885A1 (fr) 2014-04-11 2015-10-14 Sanovel Ilac Sanayi ve Ticaret A.S. Combinaisons pharmaceutiques de rivaroxaban et d'inhibiteurs de la pompe à protons
CN104045627A (zh) * 2014-05-21 2014-09-17 丽珠医药集团股份有限公司 一种奥美拉唑纯化方法
WO2015195684A2 (fr) 2014-06-16 2015-12-23 University Of Rochester Agents anti-cicatrices formés de petites molécules
US20180015118A1 (en) 2015-02-03 2018-01-18 Ironwood Pharmaceuticals, Inc. Methods of treating upper gastrointestinal disorders in ppi refractory gerd
EP3288556A4 (fr) 2015-04-29 2018-09-19 Dexcel Pharma Technologies Ltd. Compositions à désintégration par voie orale
US10736855B2 (en) 2016-02-25 2020-08-11 Dexcel Pharma Technologies Ltd. Compositions comprising proton pump inhibitors
US10076494B2 (en) 2016-06-16 2018-09-18 Dexcel Pharma Technologies Ltd. Stable orally disintegrating pharmaceutical compositions
KR102419769B1 (ko) * 2016-08-11 2022-07-13 아다미스 파마슈티칼스 코포레이션 약물 조성물
EP3292862A1 (fr) 2016-09-07 2018-03-14 Sandoz Ag Formulations d'oméprazole
IL307576B1 (en) * 2016-09-14 2025-02-01 Yufeng Jane Tseng History of new modified benzimidazoles as D-amino acid oxidase (DAAO) inhibitors
US11564910B2 (en) 2017-12-08 2023-01-31 Adamis Pharmaceuticals Corporation Drug compositions
CN110317164B (zh) * 2019-07-06 2022-08-19 抚州三和医药化工有限公司 一种奥美拉唑中间体的制备方法
CA3208983A1 (fr) 2021-01-29 2022-08-04 Abbvie Inc. Procedes d'administration d'elagolix
WO2024075017A1 (fr) 2022-10-04 2024-04-11 Zabirnyk Arsenii Inhibition de calcification de valve aortique

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1234058A (fr) * 1968-10-21 1971-06-03
US4045564A (en) * 1974-02-18 1977-08-30 Ab Hassle Benzimidazole derivatives useful as gastric acid secretion inhibitors
SE418966B (sv) * 1974-02-18 1981-07-06 Haessle Ab Analogiforfarande for framstellning av foreningar med magsyrasekretionsinhiberande verkan
SE416649B (sv) * 1974-05-16 1981-01-26 Haessle Ab Forfarande for framstellning av foreningar som paverkar magsyrasekretionen
IN148930B (fr) * 1977-09-19 1981-07-25 Hoffmann La Roche

Also Published As

Publication number Publication date
SG63383G (en) 1984-07-27
NO152785B (no) 1985-08-12
HK15284A (en) 1984-03-02
JPS54141783A (en) 1979-11-05
US4508905A (en) 1985-04-02
NL930074I2 (nl) 1994-02-16
SU878196A3 (ru) 1981-10-30
HU179022B (en) 1982-08-28
NO1994027I1 (no) 1994-12-21
NO791227L (no) 1979-10-16
US4337257A (en) 1982-06-29
JPS6034956B2 (ja) 1985-08-12
IE48370B1 (en) 1984-12-26
DK151179A (da) 1979-10-15
EP0005129B1 (fr) 1981-04-29
NO1995005I1 (no) 1995-06-14
ATA273279A (de) 1983-09-15
EP0005129A1 (fr) 1979-10-31
IE790785L (en) 1979-10-14
NO1995006I1 (no) 1995-06-14
CS261851B2 (en) 1989-02-10
SU873880A3 (ru) 1981-10-15
FI65067C (fi) 1984-03-12
JPS58192880A (ja) 1983-11-10
SU895292A3 (ru) 1981-12-30
SE7804231L (sv) 1979-10-15
NL930075I1 (nl) 1993-09-16
LT2274B (lt) 1993-12-15
CA1127158A (fr) 1982-07-06
FI791219A (fi) 1979-10-15
NO840112L (no) 1979-10-16
AU4602779A (en) 1979-10-18
NL930075I2 (nl) 1994-02-16
ZA791586B (en) 1980-04-30
CY1232A (en) 1984-06-29
AT374471B (de) 1984-04-25
LU88307I2 (fr) 1994-05-04
ATA290483A (de) 1989-08-15
CS254979A2 (en) 1988-07-15
AU529654B2 (en) 1983-06-16
FI65067B (fi) 1983-11-30
JPS6353191B2 (fr) 1988-10-21
SU873879A3 (ru) 1981-10-15
DD142882A5 (de) 1980-07-16
MY8500074A (en) 1985-12-31
NL930074I1 (nl) 1993-09-16
US4255431A (en) 1981-03-10
BG61492B2 (bg) 1997-09-30
DE2960293D1 (en) 1981-08-06
NZ190203A (en) 1984-03-16
DK150510C (da) 1987-12-07
LU88305I2 (fr) 1994-05-04
DK150510B (da) 1987-03-16
NO152785C (no) 1985-11-20
AT389995B (de) 1990-02-26
NO152216B (no) 1985-05-13

Similar Documents

Publication Publication Date Title
NO152216C (no) Analogifremgangsmaate til fremstilling av terapeutisk anvendbare substituerte 2-(2-benzimidazolyl)-pyridiner
NO144420C (no) Analogifremgangsmaate for fremstilling av terapeutisk virksomme hydroksansyrer
NO154058C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive n-heterocyklyl-4-piperidinaminer.
NO151588C (no) Analogifremgangsmaate ved fremstilling av terapeutisk aktive n2-arylsulfonyl-l-argininamid-derivater
NO154522C (no) Analogifremgangsmaate for fremstilling av terapeutisk virksomme kinolinderivater.
NO794069L (no) Fremgangsmaate ved fremstilling av terapeutisk virksomme imidayolderivater.
NO151201C (no) Fremgangsmaate for fremstilling av terapeutisk virksomme antigenderivater
NO152255C (no) Analogifremgangsmaate for fremstilling av terapeutisk virksomme imidazolylvinylethere
NO151500C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive tiazoloksamsyre-derivater
FI790019A (fi) Foerfarande foer framstaellning av 4-(61-metoxi-21-naftyl)butan-2-on med antiinflammatorisk aktivitet
NO150605C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive pyridinyl-aminoalkyletere
NO150202C (no) Analogifremgangsmaate til fremstilling av nye terapeutisk virksomme n-oksacyklyl-alkyl-piperidyl-diazaforbindelser
NO151288C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive indolokinolizindiner
NO146356C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive alkanolaminderivater
NO151285C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive di-o-n-alkyl-glycerolderivater
SE7907985L (sv) Forfarande for framstellning av etanol ur cellulosa
NO152787C (no) Analogifremgangsmaate ved fremstilling av terapeutisk aktive fenyl-kinolizidiner.
NO146863C (no) Analogifremgangsmaate til fremstilling av terapeutisk aktive alkyltiofenoksyalkylaminer
NO151008C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive nitroforbindelser
NO152254C (no) Fremgangsmaate til fremstilling av karbazolderivater
NO147310C (no) Fremgangsmaate for fremstilling av substituerte antitumorantracykliner
NO791599L (no) Fremgangsmaate for fremstilling av dibenzyletere
NO147273C (no) Analogifremgangsmaate til fremstilling av terapeutisk aktive cykloheksadien-derivater
NO791199L (no) Fremgangsmaate til fremstilling av terapeutisk virksomme forbindelser
NO150606C (no) Analogifremgangsmaate ved fremstilling av terapeutisk virksomme substituerte kromoner