NO142081B - Nye funksjonelle derivater av nikotinamid-adenin-dinukleotid - Google Patents
Nye funksjonelle derivater av nikotinamid-adenin-dinukleotid Download PDFInfo
- Publication number
- NO142081B NO142081B NO751510A NO751510A NO142081B NO 142081 B NO142081 B NO 142081B NO 751510 A NO751510 A NO 751510A NO 751510 A NO751510 A NO 751510A NO 142081 B NO142081 B NO 142081B
- Authority
- NO
- Norway
- Prior art keywords
- ointment
- functional derivatives
- new functional
- adenin dinucleotide
- nicotinamide
- Prior art date
Links
- GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 title 1
- 229930024421 Adenine Natural products 0.000 title 1
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical class NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 title 1
- 239000002674 ointment Substances 0.000 claims description 16
- 239000002245 particle Substances 0.000 claims description 10
- 239000004033 plastic Substances 0.000 claims description 6
- 229920003023 plastic Polymers 0.000 claims description 6
- 230000037072 sun protection Effects 0.000 claims description 5
- 239000000463 material Substances 0.000 claims description 4
- 239000004793 Polystyrene Substances 0.000 claims description 2
- 229920002223 polystyrene Polymers 0.000 claims description 2
- 239000012798 spherical particle Substances 0.000 claims 2
- CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 claims 1
- 230000000694 effects Effects 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 239000004160 Ammonium persulphate Substances 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- ROOXNKNUYICQNP-UHFFFAOYSA-N ammonium persulfate Chemical compound [NH4+].[NH4+].[O-]S(=O)(=O)OOS([O-])(=O)=O ROOXNKNUYICQNP-UHFFFAOYSA-N 0.000 description 2
- 235000019395 ammonium persulphate Nutrition 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 241000416162 Astragalus gummifer Species 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 description 1
- 206010042496 Sunburn Diseases 0.000 description 1
- 229920001615 Tragacanth Polymers 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 238000000862 absorption spectrum Methods 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 1
- 239000002685 polymerization catalyst Substances 0.000 description 1
- 239000004926 polymethyl methacrylate Substances 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
- C07H19/207—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids the phosphoric or polyphosphoric acids being esterified by a further hydroxylic compound, e.g. flavine adenine dinucleotide or nicotinamide-adenine dinucleotide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/48—Compounds containing oxirane rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Description
Solbeskyttelsessalve.
Foreliggende oppfinnelse vedrører en
solbeskyttelsessalve.
Kjente salver av denne art baserer sin
effekt på ingredienser i salvene, som evner
å absorbere visse deler av sollyset. I mange
tilfelle fremkaller sådanne ingredienser
imidlertid allergiske reaksjoner hos føl-somme personer, og oppfinnelsen har til
formål å skaffe en solbeskyttelsessalve som
ikke inneholder noen stoffer som påvirker
huden, men som allikevel gir en effektiv
beskyttelse mot solens stråler.
Dette oppnås ifølge oppfinnelsen ved
at solbeskyttelsessalven inneholder sfæriske
partikler av vevsvennlig hårdt plastmateriale, f. eks. polymethyl-metakrylat eller
polystyren med en partikkelstørrelse mellom 0,25 og 2,5
Dette plastmateriale har intet absorp-sjonsspektrum innenfor det ultrafiolette
område, men det har .allikevel vist seg at
salven gir en fullstendig beskyttelse mot
solens stråler. Effekten oppstår som følge
av den totalref leksjon som de mange små
partikler bevirker. Grunnen til at partikkel-størrelsen bør være større enn 0,25 \ i, er
at mindre partikler kan trenge så dypt ned
i huden at de bevirker irritasjon og igjen-tetning av porene. Partikkelstørrelsen bør
på den annen side være så liten som mulig,
fordi den beste refleksjon oppnås med små
partikler som helst bør være av én og samme størrelse. Små partikler har god ved-heftningsevne selv uten å være oppslam-met i spesielle oljer eller kremer. Med en
hård plast menes en plast med myknings-punkt over 40° C.
Det er selvsagt mulig i plastmaterialet
å inkorporere stoffer som har ultrafiolett-absorpsjonsevne og således ytterligere for-sterker effekten, likesom man til en salve ifølge oppfinnelsen ikan sette konvensjonel-le dermatologisk virkende preparater.
Eksempel:
I en 1 liters kolbe med omrører, tiltoake-strømskjøler og termometer chargeres 300 g vann og 3 g sorbitolmonostearat. Derpå tilsettes polymerisasjonskatalysatoren ammoniumpersulfat 0,1 g, og når denne har oppløst seg i vannet, tilsettes 100 g methyl-metakrylat. Reaksj onsblandingen varmes under omrøring opptil 75° C og holdes på denne temperatur i 2,5 timer, hvorunder ytterligere 0,1 g ammoniumpersulfat tilfø-res. Den ferdige emulsjon inntørkes ved 60° C til en kake av relativt løs beskaffenhet. Av dette produkt blandes så 50 g i en salve-rivemaskin med 1 g tragantpulver oppløst i 20 g glycerin og 75 g vann. Etter egalise-ring fåes et produkt som har en for en salve egnet konsistens.
En undersøkelse med elektronmikro-skop har vist at alle salvens faste partikler er nesten fullstendig sfæriske og har en diameter som ligger mellom 0,5 og 0,8 \ i.
Salven er blitt prøvet på personer som har vært særlig følsomme for sollys, og det har da vist seg at der oppnås en fullstendig beskyttelsesvirkning selv om salven er på-ført i et så tynt lag at den ikke kan sees. På personer med normal følsomhet for sollys har anvendelsen av salven den effekt at de ikke får den naturlige solbrenthet.
Claims (2)
1. Solbeskyttelsessalve, karakterisert ved at den inneholder sfæriske partikler av vevsvennlig hårdt plastmateriale, f. eks. polyrhethylmetakrylat eller polystyren med en partikkelstørrelse på mellom 0,25 og 2,5 ,u.
2. Salve ifølge påstand 1, karakterisert ved at de sfæriske partikler i hovedsaken er av én og samme størrelse.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT22105/74A IT1017564B (it) | 1974-04-30 | 1974-04-30 | Processo per la preparazione di derivati adeninici funzionalizza ti e prodotti cosi ottenuti |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO751510L NO751510L (no) | 1975-10-31 |
| NO142081B true NO142081B (no) | 1980-03-17 |
| NO142081C NO142081C (no) | 1980-06-25 |
Family
ID=11191560
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO751510A NO142081C (no) | 1974-04-30 | 1975-04-28 | Nye funksjonelle derivater av nikotinamid-adenin-dinukleotid |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US4008363A (no) |
| JP (1) | JPS5324960B2 (no) |
| BE (1) | BE828259A (no) |
| CA (1) | CA1058169A (no) |
| CH (1) | CH618169A5 (no) |
| CS (1) | CS199583B2 (no) |
| DD (1) | DD119789A5 (no) |
| DE (1) | DE2519063A1 (no) |
| DK (1) | DK140696B (no) |
| FR (1) | FR2269530B1 (no) |
| GB (1) | GB1510534A (no) |
| HU (1) | HU171512B (no) |
| IL (1) | IL47141A (no) |
| IT (1) | IT1017564B (no) |
| LU (1) | LU72340A1 (no) |
| NL (1) | NL7505121A (no) |
| NO (1) | NO142081C (no) |
| SE (1) | SE419551B (no) |
| YU (1) | YU79875A (no) |
| ZA (1) | ZA751831B (no) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1039756B (it) * | 1975-07-10 | 1979-12-10 | Snam Progetti | Procedimento per migliopare l at tivita di enzimi ossidoriduttasici inglobati in strutture filamentose |
| IT1065294B (it) * | 1976-12-23 | 1985-02-25 | Snam Progetti | Procedimento per la preparazione di fibre a struttura porosa,fibre porose cosi'ottenute e impieghi delle stesse |
| DE2841414C2 (de) * | 1978-09-22 | 1980-04-03 | Gesellschaft Fuer Biotechnologische Forschung Mbh (Gbf), 3300 Braunschweig | Verfahren zur Herstellung von an Makromoleküle gebundenen, ein Adeninringsystem enthaltenden Koenzymen |
| JPS5564599A (en) * | 1978-11-08 | 1980-05-15 | Unitika Ltd | Adenosine triphosphate derivative |
| US4711955A (en) * | 1981-04-17 | 1987-12-08 | Yale University | Modified nucleotides and methods of preparing and using same |
| DE3728772A1 (de) * | 1987-08-28 | 1989-03-09 | Hoechst Ag | Enzymreaktor mit polymerfixiertem cofaktor |
| US5569650A (en) * | 1993-06-11 | 1996-10-29 | Sloan-Kettering Institute For Cancer Research | C-nucleoside isosters of analogs thereof and pharmaceutical compositions |
| AU2277201A (en) * | 1999-12-17 | 2001-06-25 | Ariad Pharmaceuticals, Inc. | Novel purines |
| IL150062A0 (en) * | 1999-12-17 | 2002-12-01 | Ariad Pharma Inc | Proton pump inhibitors |
| EP1259520B1 (en) * | 1999-12-17 | 2006-05-24 | Ariad Pharmaceuticals, Inc. | Novel purines |
| US20030228621A1 (en) * | 2002-05-24 | 2003-12-11 | Yong Qin | Common ligand universal enzyme assay and compositions for use therein |
| US20050065171A1 (en) * | 2003-06-25 | 2005-03-24 | Shakespeare William C. | Substituted purine derivatives |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3287352A (en) * | 1964-10-12 | 1966-11-22 | Upjohn Co | Nu6-(2-hydroxyethyl) tubercidin and process therefor |
| DE1545645A1 (de) * | 1965-12-06 | 1969-08-21 | Boehringer Mannheim Gmbh | Verfahren zur Herstellung von disubstituierten Adenosin-Derivaten |
-
1974
- 1974-04-30 IT IT22105/74A patent/IT1017564B/it active
-
1975
- 1975-03-24 ZA ZA00751831A patent/ZA751831B/xx unknown
- 1975-03-27 CS CS752123A patent/CS199583B2/cs unknown
- 1975-03-28 YU YU00798/75A patent/YU79875A/xx unknown
- 1975-04-09 GB GB14711/75A patent/GB1510534A/en not_active Expired
- 1975-04-22 FR FR7512541A patent/FR2269530B1/fr not_active Expired
- 1975-04-22 CH CH512075A patent/CH618169A5/it not_active IP Right Cessation
- 1975-04-22 IL IL47141A patent/IL47141A/xx unknown
- 1975-04-23 BE BE155664A patent/BE828259A/xx not_active IP Right Cessation
- 1975-04-23 LU LU72340A patent/LU72340A1/xx unknown
- 1975-04-24 HU HU75SA00002783A patent/HU171512B/hu unknown
- 1975-04-25 SE SE7504842A patent/SE419551B/xx unknown
- 1975-04-28 NO NO751510A patent/NO142081C/no unknown
- 1975-04-28 JP JP5085175A patent/JPS5324960B2/ja not_active Expired
- 1975-04-28 DD DD185736A patent/DD119789A5/xx unknown
- 1975-04-29 DK DK186175AA patent/DK140696B/da unknown
- 1975-04-29 NL NL7505121A patent/NL7505121A/xx unknown
- 1975-04-29 US US05/572,653 patent/US4008363A/en not_active Expired - Lifetime
- 1975-04-29 DE DE19752519063 patent/DE2519063A1/de not_active Withdrawn
- 1975-04-30 CA CA225,889A patent/CA1058169A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| CA1058169A (en) | 1979-07-10 |
| JPS50149697A (no) | 1975-11-29 |
| IL47141A (en) | 1978-08-31 |
| ZA751831B (en) | 1976-06-30 |
| JPS5324960B2 (no) | 1978-07-24 |
| CH618169A5 (no) | 1980-07-15 |
| DK140696B (da) | 1979-10-29 |
| YU79875A (en) | 1982-02-28 |
| IT1017564B (it) | 1977-08-10 |
| IL47141A0 (en) | 1975-06-25 |
| DK186175A (no) | 1975-10-31 |
| NO142081C (no) | 1980-06-25 |
| LU72340A1 (no) | 1975-08-20 |
| BE828259A (fr) | 1975-08-18 |
| CS199583B2 (en) | 1980-07-31 |
| FR2269530B1 (no) | 1977-04-15 |
| DE2519063A1 (de) | 1975-11-20 |
| US4008363A (en) | 1977-02-15 |
| SE7504842L (sv) | 1975-10-31 |
| DK140696C (no) | 1980-05-05 |
| FR2269530A1 (no) | 1975-11-28 |
| SE419551B (sv) | 1981-08-10 |
| AU8020675A (en) | 1976-10-21 |
| DD119789A5 (no) | 1976-05-12 |
| NL7505121A (nl) | 1975-11-03 |
| GB1510534A (en) | 1978-05-10 |
| HU171512B (hu) | 1978-01-28 |
| NO751510L (no) | 1975-10-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NO142081B (no) | Nye funksjonelle derivater av nikotinamid-adenin-dinukleotid | |
| Crider et al. | Electrodermal lability as a personality dimension. | |
| US3177120A (en) | Stable cosmetic preparations containing dihydroxy acetone | |
| JP6495655B2 (ja) | 美容方法 | |
| DE1948990A1 (de) | Mittel zur oertlichen Behandlung der Haut | |
| CN110420266A (zh) | 一种三椒祛痘除螨剂 | |
| CN112641687A (zh) | 美白组合物、制备方法及用途 | |
| US5049376A (en) | Cosmetic powder bar composition and process for making same | |
| CN113041190A (zh) | 抗氧化组合物、制备方法及用途 | |
| CN104117088A (zh) | 一种用于伤口愈合的液体伤口敷料及其制备方法 | |
| CN107982072A (zh) | 一种含石墨烯的水性眼线液及制备方法 | |
| KR20210019315A (ko) | 클로렐라 추출물을 유효성분으로 포함하는 자외선 차단 효과를 갖는 입술용 화장료 조성물 | |
| Staricco | Qualitative and quantitative data on melanocytes in human epidermis treated with thorium X | |
| CN108888570A (zh) | 一种耐盐性能好的温和乳化剂 | |
| CH642537A5 (en) | Cosmetic sunscreen product | |
| ATE20065T1 (de) | Heterocyclische verbindungen, herstellung dieser verbindungen, kosmetische mittel, die diese verbindungen als wirkstoffe enthalten, sowie verwendung dieser mittel zur pflege des haares oder der haut. | |
| JP6198082B2 (ja) | アレルギーを抑制する海ブドウ抽出物、その調製方法及び応用 | |
| CN111870549A (zh) | 一种清洁能源眼影及其制备方法 | |
| US2418695A (en) | Ultraviolet light filter composition | |
| CN113081924A (zh) | 抗氧化组合物、制备方法及用途 | |
| CN102274229A (zh) | 一种治疗皮炎的外用药物及其制法 | |
| CN111700820A (zh) | 一种护肤组合物、精华液及其制备方法和面膜 | |
| CN106265377B (zh) | 一种具有防腐活性的组合物及其制备方法和应用 | |
| JPS5948808B2 (ja) | 化粧料 | |
| Ippen | The photoprotective effect and pharmaceutical properties of 5-fluorouracil ointment |