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NL990024I1 - Anti-hypertensieve mercaptoacylderivaten van gesubstitueerde prolinen en farmaceutische preparaten. - Google Patents

Anti-hypertensieve mercaptoacylderivaten van gesubstitueerde prolinen en farmaceutische preparaten.

Info

Publication number
NL990024I1
NL990024I1 NL990024C NL990024C NL990024I1 NL 990024 I1 NL990024 I1 NL 990024I1 NL 990024 C NL990024 C NL 990024C NL 990024 C NL990024 C NL 990024C NL 990024 I1 NL990024 I1 NL 990024I1
Authority
NL
Netherlands
Prior art keywords
hypertensive
pharmaceutical preparations
substituted prolines
mercaptoacyl derivatives
mercaptoacyl
Prior art date
Application number
NL990024C
Other languages
English (en)
Other versions
NL990024I2 (nl
Original Assignee
Menarini Internat Operations
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Menarini Internat Operations filed Critical Menarini Internat Operations
Publication of NL990024I2 publication Critical patent/NL990024I2/nl
Publication of NL990024I1 publication Critical patent/NL990024I1/nl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12Oxygen or sulfur atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00Thiocarboxylic acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
NL990024C 1978-08-11 1999-08-04 Anti-hypertensieve mercaptoacylderivaten van gesubstitueerde prolinen en farmaceutische preparaten. NL990024I1 (nl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US93288378A 1978-08-11 1978-08-11
KR1019790002731A KR830002450B1 (ko) 1978-08-11 1979-08-10 치환 프로린의 메르캅토아실 유도체의 제조방법

Publications (2)

Publication Number Publication Date
NL990024I2 NL990024I2 (nl) 1999-11-01
NL990024I1 true NL990024I1 (nl) 1999-11-01

Family

ID=26626596

Family Applications (2)

Application Number Title Priority Date Filing Date
NL7906120A NL193374C (nl) 1978-08-11 1979-08-10 Anti-hypertensieve mercaptoacylderivaten van gesubstitueerde prolinen en farmaceutische preparaten.
NL990024C NL990024I1 (nl) 1978-08-11 1999-08-04 Anti-hypertensieve mercaptoacylderivaten van gesubstitueerde prolinen en farmaceutische preparaten.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
NL7906120A NL193374C (nl) 1978-08-11 1979-08-10 Anti-hypertensieve mercaptoacylderivaten van gesubstitueerde prolinen en farmaceutische preparaten.

Country Status (30)

Country Link
JP (2) JPS5527199A (nl)
KR (1) KR830002450B1 (nl)
AR (1) AR229081A1 (nl)
AT (1) AT379589B (nl)
AU (1) AU530690B2 (nl)
BE (1) BE878191A (nl)
CA (1) CA1144930A (nl)
CH (1) CH642064A5 (nl)
CS (1) CS228118B2 (nl)
DD (1) DD145749A5 (nl)
DE (1) DE2932021C2 (nl)
DK (1) DK154553C (nl)
ES (1) ES483311A1 (nl)
FI (1) FI69834C (nl)
FR (1) FR2435469A1 (nl)
GB (1) GB2028327B (nl)
GR (1) GR72420B (nl)
IE (1) IE48802B1 (nl)
IN (1) IN152712B (nl)
IT (1) IT1117782B (nl)
LU (2) LU81593A1 (nl)
NL (2) NL193374C (nl)
NZ (1) NZ191036A (nl)
PH (1) PH15030A (nl)
PT (1) PT70049A (nl)
RO (1) RO78870B (nl)
SE (1) SE447477B (nl)
SU (1) SU1066460A3 (nl)
YU (1) YU41876B (nl)
ZA (1) ZA793633B (nl)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4483861A (en) * 1978-10-31 1984-11-20 Santen Pharmaceutical Co., Ltd. Antihypertensive sulfur-containing compounds
CA1132985A (en) * 1978-12-22 1982-10-05 John Krapcho Ketal and thioketal derivatives of mercaptoacyl prolines
US4347371A (en) * 1978-12-30 1982-08-31 Santen Pharmaceutical Co., Ltd. Disulfide compounds
US4234489A (en) * 1979-06-25 1980-11-18 E. R. Squibb & Sons, Inc. Pyroglutamic acid derivatives and analogs
US4288368A (en) * 1979-07-30 1981-09-08 E. R. Squibb & Sons, Inc. Dithioacylproline derivatives
US4291040A (en) * 1979-10-22 1981-09-22 E. R. Squibb & Sons, Inc. Mercaptoacyl derivatives of 4-disubstituted prolines and 4-substituted dehydroprolines
US4692458A (en) * 1980-03-05 1987-09-08 University Of Miami Anti-hypertensive agents
AU542211B2 (en) * 1980-03-07 1985-02-14 Gruppo Lepetit S.P.A. Mercaptocycloalkyl carbonyl prolines
GB2070586A (en) * 1980-03-21 1981-09-09 Squibb & Sons Inc Derivatives of Proline or Pipecolic Acid
US4284624A (en) 1980-05-02 1981-08-18 E. R. Squibb & Sons, Inc. Mixed disulfides
US4390695A (en) * 1980-06-23 1983-06-28 E. R. Squibb & Sons, Inc. Imido, amido and amino derivatives of mercaptoacyl prolines and pipecolic acids
US4578474A (en) * 1980-06-23 1986-03-25 E. R. Squibb & Sons, Inc. Imido, amido and amino derivatives of mercaptoacyl prolines and pipecolic acids
US4316905A (en) * 1980-07-01 1982-02-23 E. R. Squibb & Sons, Inc. Mercaptoacyl derivatives of various 4-substituted prolines
US4332726A (en) * 1980-08-25 1982-06-01 E. R. Squibb & Sons, Inc. Purification of mercaptoacyl amino acids
US4307110A (en) * 1980-09-12 1981-12-22 E. R. Squibb & Sons, Inc. Mercaptoacyl derivatives of 3-substituted proline derivatives
US4311705A (en) * 1980-10-06 1982-01-19 E. R. Squibb & Sons, Inc. Carboxyalkanoyl and hydroxycarbamoylalkanoyl derivatives of substituted prolines
US4312809A (en) 1980-10-31 1982-01-26 E. R. Squibb & Sons, Inc. Lactam derivatives of mercaptoacylamino acids
US4462943A (en) * 1980-11-24 1984-07-31 E. R. Squibb & Sons, Inc. Carboxyalkyl amino acid derivatives of various substituted prolines
US4337201A (en) * 1980-12-04 1982-06-29 E. R. Squibb & Sons, Inc. Phosphinylalkanoyl substituted prolines
US4384123A (en) * 1980-12-04 1983-05-17 E. R. Squibb & Sons, Inc. Phosphinylalkanoyl substituted prolines
US4374131A (en) 1981-04-27 1983-02-15 E. R. Squibb & Sons, Inc. Amino and substituted amino phosphinyl-alkanoyl compounds
US4416831A (en) 1981-04-27 1983-11-22 E. R. Squibb & Sons, Inc. Amino and substituted amino phosphinylalkanoyl compounds
US4416833A (en) 1981-05-04 1983-11-22 E. R. Squibb & Sons, Inc. Substituted carbonyl phosphinyl-alkanoyl compounds
US4381297A (en) 1981-05-04 1983-04-26 E. R. Squibb & Sons, Inc. Substituted carbonyl phosphinyl-alkanoyl compounds
US4497953A (en) * 1981-06-01 1985-02-05 E. R. Squibb & Sons, Inc. Imido, amido and amino derivatives of mercaptoacyl prolines and pipecolic acids
US4377701A (en) * 1981-09-21 1983-03-22 E. R. Squibb & Sons, Inc. 4-Methylene-1-[[(alranoyl or arylcarbonyl)mercapto]acyl]proline and pipecolic acid
US4555506A (en) * 1981-12-24 1985-11-26 E. R. Squibb & Sons, Inc. Phosphorus containing compounds and use as hypotensives
US4452791A (en) * 1982-03-15 1984-06-05 E. R. Squibb & Sons, Inc. Aminoalkyl and related substituted phosphinic acid angiotensin converting enzyme inhibitors
US4560680A (en) * 1982-03-15 1985-12-24 E. R. Squibb & Sons, Inc. Aminoalkyl and related substituted phosphinic acid angiotensin converting enzyme inhibitors
US4616005A (en) * 1982-06-23 1986-10-07 E. R. Squibb & Sons, Inc. Phosphonyl hydroxyacyl amino acid derivatives as antihypertensives
US4703043A (en) * 1982-06-23 1987-10-27 E. R. Squibb & Sons, Inc. Phosphonyl hydroxyacyl amino acid derivatives as antihypertensive
US4452790A (en) * 1982-06-23 1984-06-05 E. R. Squibb & Sons, Inc. Phosphonyl hydroxyacyl amino acid derivatives as antihypertensives
US4567166A (en) * 1982-07-14 1986-01-28 E. R. Squibb & Sons, Inc. Amino and substituted amino phosphinylalkanoyl compounds useful for treating hypertension
EP0187037A3 (en) * 1984-12-21 1988-03-23 Takeda Chemical Industries, Ltd. Piperidine derivatives, their production and use
CA2021409A1 (en) * 1989-08-21 1991-02-22 Donald S. Karanewsky Phosphonate substituted amino or imino acids useful as antihypertensives
JPH05344844A (ja) * 1992-06-12 1993-12-27 Suzumo Kiko Kk 焼おむすびせんべいの製造方法
EP0640594A1 (en) 1993-08-23 1995-03-01 Fujirebio Inc. Hydantoin derivative as metalloprotease inhibitor
US5435286A (en) * 1994-05-02 1995-07-25 Cummins Engine Company, Inc. Ball link assembly for vehicle engine drive trains
US7659305B2 (en) 2002-10-31 2010-02-09 Pfizer Inc. Therapeutic proline derivatives
GB0225379D0 (en) * 2002-10-31 2002-12-11 Pfizer Ltd Therapeutic proline derivatives
WO2006038119A1 (en) * 2004-10-08 2006-04-13 Warner-Lambert Company Llc Stereoselective synthesis of n-protected alkoxy prolines
GB0715626D0 (en) * 2007-08-10 2007-09-19 Generics Uk Ltd Crystalline form of zofenopril calcium
CA2715726C (en) * 2008-02-27 2014-12-02 Vinayak Gore Novel crystalline forms
US8853421B2 (en) 2008-02-27 2014-10-07 Generics [Uk] Limited Crystalline forms of zofenopril calcium
SI23949A (sl) 2011-12-19 2013-06-28 Silverstone Pharma Nove kristalne soli zofenoprila, postopek za njihovo dobivanje in njihova uporaba v terapiji

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2340092A2 (fr) * 1976-02-09 1977-09-02 Roussel Uclaf Nouveaux derives de l'acide 3-quinoleine carboxylique, leur procede de preparation et leur application comme medicament
AU509899B2 (en) * 1976-02-13 1980-05-29 E.R. Squibb & Sons, Inc. Proline derivatives and related compounds
US4116962A (en) * 1976-12-03 1978-09-26 E. R. Squibb & Sons, Inc. Pyrrolidine and piperidine-2-carboxylic acid derivatives
US4113715A (en) * 1977-01-17 1978-09-12 E. R. Squibb & Sons, Inc. Amino acid derivatives
US4108886A (en) * 1977-03-11 1978-08-22 E. R. Squibb & Sons, Inc. Thiopropanoylamino acid derivatives
PH15381A (en) * 1978-02-21 1982-12-17 Squibb & Sons Inc Halogen substituted mercaptoacylamino acids
US4154934A (en) * 1978-08-11 1979-05-15 E. R. Squibb & Sons, Inc. Mercaptoacylamino derivatives of heterocyclic carboxylic acids

Also Published As

Publication number Publication date
CS228118B2 (en) 1984-05-14
DK154553B (da) 1988-11-28
ES483311A1 (es) 1980-04-16
IT7949954A0 (it) 1979-08-03
AR229081A1 (es) 1983-06-15
DE2932021C2 (de) 1994-05-19
BE878191A (fr) 1980-02-11
SE7906722L (sv) 1980-02-12
LU90403I2 (fr) 2000-07-07
SE447477B (sv) 1986-11-17
IN152712B (nl) 1984-03-17
JPS5527199A (en) 1980-02-27
GB2028327A (en) 1980-03-05
ZA793633B (en) 1980-07-30
NL193374B (nl) 1999-04-01
PH15030A (en) 1982-05-13
JPH0134987B2 (nl) 1989-07-21
DK335879A (da) 1980-02-12
RO78870A (ro) 1982-07-06
ATA541679A (de) 1985-06-15
AT379589B (de) 1986-01-27
DE2932021A1 (de) 1980-02-21
GB2028327B (en) 1982-11-24
GR72420B (nl) 1983-11-03
DK154553C (da) 1989-04-17
DD145749A5 (de) 1981-01-07
LU81593A1 (fr) 1979-12-07
SU1066460A3 (ru) 1984-01-07
CH642064A5 (de) 1984-03-30
AU4919079A (en) 1980-02-14
NL7906120A (nl) 1980-02-13
NZ191036A (en) 1984-05-31
KR830002450B1 (ko) 1983-10-26
NL193374C (nl) 1999-08-03
AU530690B2 (en) 1983-07-28
PT70049A (en) 1979-09-01
CA1144930A (en) 1983-04-19
NL990024I2 (nl) 1999-11-01
YU192379A (en) 1983-02-28
IE791544L (en) 1980-02-11
IE48802B1 (en) 1985-05-15
YU41876B (en) 1988-02-29
FI69834C (fi) 1986-05-26
JPH01287069A (ja) 1989-11-17
KR830001269A (ko) 1983-04-29
RO78870B (ro) 1985-01-30
IT1117782B (it) 1986-02-24
FR2435469A1 (fr) 1980-04-04
FI792498A (fi) 1980-02-12
FI69834B (fi) 1985-12-31
FR2435469B1 (nl) 1983-02-11

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