FI792498A - Mercaptoacylderivat av substituerade proliner - Google Patents

Mercaptoacylderivat av substituerade proliner

Info

Publication number: FI792498A
Authority: FI; Finland
Prior art keywords: mercaptoacylderivat; proliner; substituerade; substituerade proliner
Prior art date: 1978-08-11

Application number

FI792498A

Other languages

English (en)

Other versions

FI69834C (fi

FI69834B (fi

Inventor

Miguel A Ondetti

John Krapcho

Original Assignee

Squibb & Sons Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1978-08-11

Filing date

1979-08-10

Publication date

1980-02-12

1979-08-10 Application filed by Squibb & Sons Inc filed Critical Squibb & Sons Inc

1980-02-12 Publication of FI792498A publication Critical patent/FI792498A/fi

1985-12-31 Application granted granted Critical

1985-12-31 Publication of FI69834B publication Critical patent/FI69834B/fi

1986-05-26 Publication of FI69834C publication Critical patent/FI69834C/fi

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pyrrole Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Peptides Or Proteins (AREA)

FI792498A 1978-08-11 1979-08-10 Foerfarande foer framstaellning av terapeutiskt anvaendbara etr- eller tioetermerkaptoacylproliner FI69834C (fi)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US93288378A	1978-08-11	1978-08-11
US93288378		1978-08-11
KR1019790002731A KR830002450B1 (ko)	1978-08-11	1979-08-10	치환 프로린의 메르캅토아실 유도체의 제조방법
KR790002731		1979-08-10

Publications (3)

Publication Number	Publication Date
FI792498A true FI792498A (fi)	1980-02-12
FI69834B FI69834B (fi)	1985-12-31
FI69834C FI69834C (fi)	1986-05-26

Family

ID=26626596

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI792498A FI69834C (fi)	1978-08-11	1979-08-10	Foerfarande foer framstaellning av terapeutiskt anvaendbara etr- eller tioetermerkaptoacylproliner

Country Status (30)

Country	Link
JP (2)	JPS5527199A (fi)
KR (1)	KR830002450B1 (fi)
AR (1)	AR229081A1 (fi)
AT (1)	AT379589B (fi)
AU (1)	AU530690B2 (fi)
BE (1)	BE878191A (fi)
CA (1)	CA1144930A (fi)
CH (1)	CH642064A5 (fi)
CS (1)	CS228118B2 (fi)
DD (1)	DD145749A5 (fi)
DE (1)	DE2932021C2 (fi)
DK (1)	DK154553C (fi)
ES (1)	ES483311A1 (fi)
FI (1)	FI69834C (fi)
FR (1)	FR2435469A1 (fi)
GB (1)	GB2028327B (fi)
GR (1)	GR72420B (fi)
IE (1)	IE48802B1 (fi)
IN (1)	IN152712B (fi)
IT (1)	IT1117782B (fi)
LU (2)	LU81593A1 (fi)
NL (2)	NL193374C (fi)
NZ (1)	NZ191036A (fi)
PH (1)	PH15030A (fi)
PT (1)	PT70049A (fi)
RO (1)	RO78870B (fi)
SE (1)	SE447477B (fi)
SU (1)	SU1066460A3 (fi)
YU (1)	YU41876B (fi)
ZA (1)	ZA793633B (fi)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4483861A (en) *	1978-10-31	1984-11-20	Santen Pharmaceutical Co., Ltd.	Antihypertensive sulfur-containing compounds
CA1132985A (en) *	1978-12-22	1982-10-05	John Krapcho	Ketal and thioketal derivatives of mercaptoacyl prolines
US4347371A (en) *	1978-12-30	1982-08-31	Santen Pharmaceutical Co., Ltd.	Disulfide compounds
US4234489A (en) *	1979-06-25	1980-11-18	E. R. Squibb & Sons, Inc.	Pyroglutamic acid derivatives and analogs
US4288368A (en) *	1979-07-30	1981-09-08	E. R. Squibb & Sons, Inc.	Dithioacylproline derivatives
US4291040A (en) *	1979-10-22	1981-09-22	E. R. Squibb & Sons, Inc.	Mercaptoacyl derivatives of 4-disubstituted prolines and 4-substituted dehydroprolines
US4692458A (en) *	1980-03-05	1987-09-08	University Of Miami	Anti-hypertensive agents
AU542211B2 (en) *	1980-03-07	1985-02-14	Gruppo Lepetit S.P.A.	Mercaptocycloalkyl carbonyl prolines
GB2070586A (en) *	1980-03-21	1981-09-09	Squibb & Sons Inc	Derivatives of Proline or Pipecolic Acid
US4284624A (en)	1980-05-02	1981-08-18	E. R. Squibb & Sons, Inc.	Mixed disulfides
US4390695A (en) *	1980-06-23	1983-06-28	E. R. Squibb & Sons, Inc.	Imido, amido and amino derivatives of mercaptoacyl prolines and pipecolic acids
US4578474A (en) *	1980-06-23	1986-03-25	E. R. Squibb & Sons, Inc.	Imido, amido and amino derivatives of mercaptoacyl prolines and pipecolic acids
US4316905A (en) *	1980-07-01	1982-02-23	E. R. Squibb & Sons, Inc.	Mercaptoacyl derivatives of various 4-substituted prolines
US4332726A (en) *	1980-08-25	1982-06-01	E. R. Squibb & Sons, Inc.	Purification of mercaptoacyl amino acids
US4307110A (en) *	1980-09-12	1981-12-22	E. R. Squibb & Sons, Inc.	Mercaptoacyl derivatives of 3-substituted proline derivatives
US4311705A (en) *	1980-10-06	1982-01-19	E. R. Squibb & Sons, Inc.	Carboxyalkanoyl and hydroxycarbamoylalkanoyl derivatives of substituted prolines
US4312809A (en)	1980-10-31	1982-01-26	E. R. Squibb & Sons, Inc.	Lactam derivatives of mercaptoacylamino acids
US4462943A (en) *	1980-11-24	1984-07-31	E. R. Squibb & Sons, Inc.	Carboxyalkyl amino acid derivatives of various substituted prolines
US4337201A (en) *	1980-12-04	1982-06-29	E. R. Squibb & Sons, Inc.	Phosphinylalkanoyl substituted prolines
US4384123A (en) *	1980-12-04	1983-05-17	E. R. Squibb & Sons, Inc.	Phosphinylalkanoyl substituted prolines
US4374131A (en)	1981-04-27	1983-02-15	E. R. Squibb & Sons, Inc.	Amino and substituted amino phosphinyl-alkanoyl compounds
US4416831A (en)	1981-04-27	1983-11-22	E. R. Squibb & Sons, Inc.	Amino and substituted amino phosphinylalkanoyl compounds
US4416833A (en)	1981-05-04	1983-11-22	E. R. Squibb & Sons, Inc.	Substituted carbonyl phosphinyl-alkanoyl compounds
US4381297A (en)	1981-05-04	1983-04-26	E. R. Squibb & Sons, Inc.	Substituted carbonyl phosphinyl-alkanoyl compounds
US4497953A (en) *	1981-06-01	1985-02-05	E. R. Squibb & Sons, Inc.	Imido, amido and amino derivatives of mercaptoacyl prolines and pipecolic acids
US4377701A (en) *	1981-09-21	1983-03-22	E. R. Squibb & Sons, Inc.	4-Methylene-1-[[(alranoyl or arylcarbonyl)mercapto]acyl]proline and pipecolic acid
US4555506A (en) *	1981-12-24	1985-11-26	E. R. Squibb & Sons, Inc.	Phosphorus containing compounds and use as hypotensives
US4452791A (en) *	1982-03-15	1984-06-05	E. R. Squibb & Sons, Inc.	Aminoalkyl and related substituted phosphinic acid angiotensin converting enzyme inhibitors
US4560680A (en) *	1982-03-15	1985-12-24	E. R. Squibb & Sons, Inc.	Aminoalkyl and related substituted phosphinic acid angiotensin converting enzyme inhibitors
US4616005A (en) *	1982-06-23	1986-10-07	E. R. Squibb & Sons, Inc.	Phosphonyl hydroxyacyl amino acid derivatives as antihypertensives
US4703043A (en) *	1982-06-23	1987-10-27	E. R. Squibb & Sons, Inc.	Phosphonyl hydroxyacyl amino acid derivatives as antihypertensive
US4452790A (en) *	1982-06-23	1984-06-05	E. R. Squibb & Sons, Inc.	Phosphonyl hydroxyacyl amino acid derivatives as antihypertensives
US4567166A (en) *	1982-07-14	1986-01-28	E. R. Squibb & Sons, Inc.	Amino and substituted amino phosphinylalkanoyl compounds useful for treating hypertension
EP0187037A3 (en) *	1984-12-21	1988-03-23	Takeda Chemical Industries, Ltd.	Piperidine derivatives, their production and use
CA2021409A1 (en) *	1989-08-21	1991-02-22	Donald S. Karanewsky	Phosphonate substituted amino or imino acids useful as antihypertensives
JPH05344844A (ja) *	1992-06-12	1993-12-27	Suzumo Kiko Kk	焼おむすびせんべいの製造方法
EP0640594A1 (en)	1993-08-23	1995-03-01	Fujirebio Inc.	Hydantoin derivative as metalloprotease inhibitor
US5435286A (en) *	1994-05-02	1995-07-25	Cummins Engine Company, Inc.	Ball link assembly for vehicle engine drive trains
US7659305B2 (en)	2002-10-31	2010-02-09	Pfizer Inc.	Therapeutic proline derivatives
GB0225379D0 (en) *	2002-10-31	2002-12-11	Pfizer Ltd	Therapeutic proline derivatives
WO2006038119A1 (en) *	2004-10-08	2006-04-13	Warner-Lambert Company Llc	Stereoselective synthesis of n-protected alkoxy prolines
GB0715626D0 (en) *	2007-08-10	2007-09-19	Generics Uk Ltd	Crystalline form of zofenopril calcium
CA2715726C (en) *	2008-02-27	2014-12-02	Vinayak Gore	Novel crystalline forms
US8853421B2 (en)	2008-02-27	2014-10-07	Generics [Uk] Limited	Crystalline forms of zofenopril calcium
SI23949A (sl)	2011-12-19	2013-06-28	Silverstone Pharma	Nove kristalne soli zofenoprila, postopek za njihovo dobivanje in njihova uporaba v terapiji

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2340092A2 (fr) *	1976-02-09	1977-09-02	Roussel Uclaf	Nouveaux derives de l'acide 3-quinoleine carboxylique, leur procede de preparation et leur application comme medicament
AU509899B2 (en) *	1976-02-13	1980-05-29	E.R. Squibb & Sons, Inc.	Proline derivatives and related compounds
US4116962A (en) *	1976-12-03	1978-09-26	E. R. Squibb & Sons, Inc.	Pyrrolidine and piperidine-2-carboxylic acid derivatives
US4113715A (en) *	1977-01-17	1978-09-12	E. R. Squibb & Sons, Inc.	Amino acid derivatives
US4108886A (en) *	1977-03-11	1978-08-22	E. R. Squibb & Sons, Inc.	Thiopropanoylamino acid derivatives
PH15381A (en) *	1978-02-21	1982-12-17	Squibb & Sons Inc	Halogen substituted mercaptoacylamino acids
US4154934A (en) *	1978-08-11	1979-05-15	E. R. Squibb & Sons, Inc.	Mercaptoacylamino derivatives of heterocyclic carboxylic acids

1979
- 1979-07-16 CA CA000331877A patent/CA1144930A/en not_active Expired
- 1979-07-17 NZ NZ191036A patent/NZ191036A/en unknown
- 1979-07-18 GR GR59635A patent/GR72420B/el unknown
- 1979-07-18 IN IN524/DEL/79A patent/IN152712B/en unknown
- 1979-07-18 ZA ZA00793633A patent/ZA793633B/xx unknown
- 1979-07-24 AU AU49190/79A patent/AU530690B2/en not_active Expired
- 1979-07-30 FR FR7919590A patent/FR2435469A1/fr active Granted
- 1979-08-01 PH PH22842A patent/PH15030A/en unknown
- 1979-08-03 IT IT49954/79A patent/IT1117782B/it active Protection Beyond IP Right Term
- 1979-08-07 DE DE2932021A patent/DE2932021C2/de not_active Expired - Lifetime
- 1979-08-07 YU YU1923/79A patent/YU41876B/xx unknown
- 1979-08-08 AT AT0541679A patent/AT379589B/de not_active IP Right Cessation
- 1979-08-09 CS CS795462A patent/CS228118B2/cs unknown
- 1979-08-09 DD DD79214896A patent/DD145749A5/de not_active IP Right Cessation
- 1979-08-10 PT PT70049A patent/PT70049A/pt unknown
- 1979-08-10 DK DK335879A patent/DK154553C/da not_active IP Right Cessation
- 1979-08-10 KR KR1019790002731A patent/KR830002450B1/ko active
- 1979-08-10 NL NL7906120A patent/NL193374C/nl active Protection Beyond IP Right Term
- 1979-08-10 SE SE7906722A patent/SE447477B/sv active Protection Beyond IP Right Term
- 1979-08-10 BE BE0/196688A patent/BE878191A/fr not_active IP Right Cessation
- 1979-08-10 IE IE1544/79A patent/IE48802B1/en active Protection Beyond IP Right Term
- 1979-08-10 FI FI792498A patent/FI69834C/fi not_active IP Right Cessation
- 1979-08-10 LU LU81593A patent/LU81593A1/xx active Protection Beyond IP Right Term
- 1979-08-10 CH CH737579A patent/CH642064A5/de not_active IP Right Cessation
- 1979-08-10 GB GB7927867A patent/GB2028327B/en not_active Expired
- 1979-08-10 ES ES483311A patent/ES483311A1/es not_active Expired
- 1979-08-10 AR AR277678A patent/AR229081A1/es active
- 1979-08-10 RO RO98428A patent/RO78870B/ro unknown
- 1979-08-10 JP JP10272279A patent/JPS5527199A/ja active Granted
- 1979-08-10 SU SU792800304A patent/SU1066460A3/ru active
1988
- 1988-12-21 JP JP63323204A patent/JPH01287069A/ja active Pending
1999
- 1999-06-04 LU LU90403C patent/LU90403I2/fr unknown
- 1999-08-04 NL NL990024C patent/NL990024I1/nl unknown

Also Published As

Publication number	Publication date
CS228118B2 (en)	1984-05-14
DK154553B (da)	1988-11-28
ES483311A1 (es)	1980-04-16
IT7949954A0 (it)	1979-08-03
AR229081A1 (es)	1983-06-15
DE2932021C2 (de)	1994-05-19
BE878191A (fr)	1980-02-11
SE7906722L (sv)	1980-02-12
LU90403I2 (fr)	2000-07-07
SE447477B (sv)	1986-11-17
IN152712B (fi)	1984-03-17
JPS5527199A (en)	1980-02-27
GB2028327A (en)	1980-03-05
ZA793633B (en)	1980-07-30
NL193374B (nl)	1999-04-01
PH15030A (en)	1982-05-13
JPH0134987B2 (fi)	1989-07-21
DK335879A (da)	1980-02-12
RO78870A (ro)	1982-07-06
ATA541679A (de)	1985-06-15
AT379589B (de)	1986-01-27
DE2932021A1 (de)	1980-02-21
GB2028327B (en)	1982-11-24
GR72420B (fi)	1983-11-03
DK154553C (da)	1989-04-17
DD145749A5 (de)	1981-01-07
LU81593A1 (fr)	1979-12-07
SU1066460A3 (ru)	1984-01-07
CH642064A5 (de)	1984-03-30
AU4919079A (en)	1980-02-14
NL7906120A (nl)	1980-02-13
NZ191036A (en)	1984-05-31
KR830002450B1 (ko)	1983-10-26
NL193374C (nl)	1999-08-03
AU530690B2 (en)	1983-07-28
PT70049A (en)	1979-09-01
CA1144930A (en)	1983-04-19
NL990024I2 (nl)	1999-11-01
YU192379A (en)	1983-02-28
IE791544L (en)	1980-02-11
IE48802B1 (en)	1985-05-15
YU41876B (en)	1988-02-29
FI69834C (fi)	1986-05-26
JPH01287069A (ja)	1989-11-17
NL990024I1 (nl)	1999-11-01
KR830001269A (ko)	1983-04-29
RO78870B (ro)	1985-01-30
IT1117782B (it)	1986-02-24
FR2435469A1 (fr)	1980-04-04
FI69834B (fi)	1985-12-31
FR2435469B1 (fi)	1983-02-11

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FI56783B (fi)	1979-12-31	Foerfarande foer tillverkning av tandpetare
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FI781746A (fi)	1979-12-02	Centrifungerande tvaettmaskin av entrumstyp
FI781747A (fi)	1979-12-02	Behandling av vattendispersioner

Legal Events

Date	Code	Title	Description
1994-01-28	FD	Application lapsed
1999-07-02	SPCG	Supplementary protection certificate granted	Spc suppl protection certif: L99 Extension date: 20040810
1999-07-20	ND	Supplementary protection certificate (spc) granted
2004-08-31	MA	Patent expired	Owner name: MENARINI INTERNATIONAL OPERATIONS