NL9000917A - Farmaceutisch preparaat met endoproteolytische activiteit; werkwijze voor endoproteolytische processing van (precursor) eiwitten en voor de (micro) biologische bereiding van eiwitten. - Google Patents

Farmaceutisch preparaat met endoproteolytische activiteit; werkwijze voor endoproteolytische processing van (precursor) eiwitten en voor de (micro) biologische bereiding van eiwitten. Download PDF

Info

Publication number: NL9000917A
Authority: NL; Netherlands
Prior art keywords: furin; enzyme; protein; fragment; derivative
Prior art date: 1989-10-25

Application number

NL9000917A

Other languages

English (en)

Dutch (nl)

Original Assignee

Holland Biotechnology

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-10-25

Filing date

1990-04-18

Publication date

1991-05-16

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26646599&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NL9000917(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1989-10-25 Priority claimed from NL8902651A external-priority patent/NL8902651A/nl

1990-04-18 Application filed by Holland Biotechnology filed Critical Holland Biotechnology

1990-04-18 Priority to NL9000917A priority Critical patent/NL9000917A/nl

1990-10-12 Priority to DE69029663T priority patent/DE69029663T3/de

1990-10-12 Priority to US07/849,420 priority patent/US5989856A/en

1990-10-12 Priority to ES90915837T priority patent/ES2099714T5/es

1990-10-12 Priority to AT90915837T priority patent/ATE147437T1/de

1990-10-12 Priority to EP98200913A priority patent/EP0885956A1/de

1990-10-12 Priority to CA002069929A priority patent/CA2069929C/en

1990-10-12 Priority to PCT/NL1990/000151 priority patent/WO1991006314A2/en

1990-10-12 Priority to JP51489590A priority patent/JP3191111B2/ja

1990-10-12 Priority to EP90915837A priority patent/EP0497828B2/de

1990-10-12 Priority to AU66132/90A priority patent/AU6613290A/en

1990-10-12 Priority to DK90915837T priority patent/DK0497828T4/da

1990-10-12 Priority to EP95202272A priority patent/EP0693286A1/de

1991-05-16 Publication of NL9000917A publication Critical patent/NL9000917A/nl

1992-04-24 Priority to NO19921611A priority patent/NO311895B1/no

1992-04-24 Priority to FI921847A priority patent/FI105348B/fi

1997-04-02 Priority to GR970400685T priority patent/GR3023013T3/el

1997-05-29 Priority to US08/865,203 priority patent/US5935815A/en

1997-10-22 Priority to US08/955,424 priority patent/US6274365B1/en

1999-02-19 Priority to US09/253,854 priority patent/US6132717A/en

2000-12-15 Priority to JP2000381776A priority patent/JP3270760B2/ja

Links

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CWCXERYKLSEGEZ-KDKHKZEGSA-N procalcitonin Chemical compound C([C@@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)NCC(O)=O)[C@@H](C)O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCSC)NC(=O)[C@H]1NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)CNC(=O)[C@@H](N)CSSC1)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 CWCXERYKLSEGEZ-KDKHKZEGSA-N 0.000 description 1
108090000765 processed proteins & peptides Proteins 0.000 description 1
102000004196 processed proteins & peptides Human genes 0.000 description 1
108010001670 prosomatostatin Proteins 0.000 description 1
GGYTXJNZMFRSLX-UHFFFAOYSA-N prosomatostatin Chemical compound C1CCC(C(=O)NC(CCCNC(N)=N)C(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NC(CCCCN)C(=O)NC(C)C(=O)NCC(=O)NC2C(NC(CCCCN)C(=O)NC(CC(N)=O)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C4=CC=CC=C4NC=3)C(=O)NC(CCCCN)C(=O)NC(C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(C(=O)NC(CO)C(=O)NC(CSSC2)C(O)=O)C(C)O)C(C)O)=O)N1C(=O)C(C)NC(=O)C(CCSC)NC(=O)C(C)NC(=O)C1CCCN1C(=O)C(CC(N)=O)NC(=O)C(CO)NC(=O)C(CC(N)=O)NC(=O)C(C)NC(=O)C(N)CO GGYTXJNZMFRSLX-UHFFFAOYSA-N 0.000 description 1
229960000856 protein c Drugs 0.000 description 1
108020001580 protein domains Proteins 0.000 description 1
230000007026 protein scission Effects 0.000 description 1
238000000163 radioactive labelling Methods 0.000 description 1
230000001105 regulatory effect Effects 0.000 description 1
108091008146 restriction endonucleases Proteins 0.000 description 1
230000000717 retained effect Effects 0.000 description 1
238000012163 sequencing technique Methods 0.000 description 1
210000002966 serum Anatomy 0.000 description 1
239000007974 sodium acetate buffer Substances 0.000 description 1
210000000952 spleen Anatomy 0.000 description 1
230000000087 stabilizing effect Effects 0.000 description 1
101150000003 subB gene Proteins 0.000 description 1
101150063279 subC gene Proteins 0.000 description 1
239000000126 substance Substances 0.000 description 1
238000006467 substitution reaction Methods 0.000 description 1
229960004072 thrombin Drugs 0.000 description 1
210000001541 thymus gland Anatomy 0.000 description 1
230000009261 transgenic effect Effects 0.000 description 1
230000014616 translation Effects 0.000 description 1
239000012588 trypsin Substances 0.000 description 1
210000004881 tumor cell Anatomy 0.000 description 1
239000000439 tumor marker Substances 0.000 description 1
230000002227 vasoactive effect Effects 0.000 description 1
238000002424 x-ray crystallography Methods 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6454—Dibasic site splicing serine proteases, e.g. kexin (3.4.21.61); furin (3.4.21.75) and other proprotein convertases
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/82—Translation products from oncogenes
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/58—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi
- C12N9/62—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi from Aspergillus
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/06—Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
- C07K2319/23—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a GST-tag
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/60—Fusion polypeptide containing spectroscopic/fluorescent detection, e.g. green fluorescent protein [GFP]

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Zoology (AREA)
Bioinformatics & Cheminformatics (AREA)
Molecular Biology (AREA)
Wood Science & Technology (AREA)
Medicinal Chemistry (AREA)
Biochemistry (AREA)
Biomedical Technology (AREA)
Biotechnology (AREA)
General Engineering & Computer Science (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Microbiology (AREA)
Biophysics (AREA)
Immunology (AREA)
Gastroenterology & Hepatology (AREA)
Veterinary Medicine (AREA)
Oncology (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Physics & Mathematics (AREA)
Mycology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Plant Pathology (AREA)
Hematology (AREA)
Toxicology (AREA)
Epidemiology (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Enzymes And Modification Thereof (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

NL9000917A 1989-10-25 1990-04-18 Farmaceutisch preparaat met endoproteolytische activiteit; werkwijze voor endoproteolytische processing van (precursor) eiwitten en voor de (micro) biologische bereiding van eiwitten. NL9000917A (nl)

Priority Applications (20)

Application Number	Priority Date	Filing Date	Title
NL9000917A NL9000917A (nl)	1989-10-25	1990-04-18	Farmaceutisch preparaat met endoproteolytische activiteit; werkwijze voor endoproteolytische processing van (precursor) eiwitten en voor de (micro) biologische bereiding van eiwitten.
DK90915837T DK0497828T4 (da)	1989-10-25	1990-10-12	Fremgangsmåde til endoproteolytisk behandling af (forstadie)proteiner og til (mikro)biologisk produktion af proteiner.
EP95202272A EP0693286A1 (de)	1989-10-25	1990-10-12	Furin enthaltende pharmazeutische Zusammensetzung
EP90915837A EP0497828B2 (de)	1989-10-25	1990-10-12	Verfahren zur endoproteolytischen bearbeitung von (vorläufer)proteinen und zur (mikro)biologischen herstellung
AU66132/90A AU6613290A (en)	1989-10-25	1990-10-12	Pharmaceutical composition having an endoproteolytic activity; a process for endoproteolytically processing (precursor) proteins and for the (micro)biological production of proteins
ES90915837T ES2099714T5 (es)	1989-10-25	1990-10-12	Procedimiento de tratamiento endoproteolitico de las proteinas (precursores) y de produccion microbiologica de proteinas.
AT90915837T ATE147437T1 (de)	1989-10-25	1990-10-12	Verfahren zur endoproteolytischen bearbeitung von (vorläufer)proteinen und zur (mikro)biologischen herstellung
EP98200913A EP0885956A1 (de)	1989-10-25	1990-10-12	Pharmazeutische Zusammensetzungen mit endoproteolytischer Aktivität, Verfahren zur endoproteolytischen Bearbeitung von (vorläufer)Proteinen und zur (Mikro)biologischen Herstellung von Proteinen
CA002069929A CA2069929C (en)	1989-10-25	1990-10-12	Pharmaceutical composition having an endoproteolytic activity; a process for endoproteolytically processing (precursor) proteins and for the (micro)biological production of proteins
PCT/NL1990/000151 WO1991006314A2 (en)	1989-10-25	1990-10-12	Pharmaceutical composition having an endoproteolytic activity; a process for endoproteolytically processing (precursor) proteins and for the (micro)biological production of proteins
JP51489590A JP3191111B2 (ja)	1989-10-25	1990-10-12	（前駆体）タンパクのエンドタンパク分解的プロセシングのための方法
DE69029663T DE69029663T3 (de)	1989-10-25	1990-10-12	Verfahren zur endoproteolytischen bearbeitung von (vorläufer)proteinen und zur (mikro)biologischen herstellung
US07/849,420 US5989856A (en)	1989-10-25	1990-10-12	Pharmaceutical composition having an endoproteolytic activity; a process for endoproteolytically processing (precursor) proteins and for the (micro)biological production of proteins
FI921847A FI105348B (fi)	1989-10-25	1992-04-24	Menetelmä proteiinien käsittelemiseksi endoproteolyyttisesti sekä menetelmä proteiinien valmistamiseksi (mikro)biologisesti
NO19921611A NO311895B1 (no)	1989-10-25	1992-04-24	Anvendelse av furin eller furinlignende enzym for spalting av et protein, fremgangsmåte for mikrobiologisk fremstilling av etprotein og pattedyrcelle som omfatter DNA som koder for enzymet
GR970400685T GR3023013T3 (en)	1989-10-25	1997-04-02	A process for endoproteolytically processing (precursor) proteins and for the (micro)biological production of proteins
US08/865,203 US5935815A (en)	1989-10-25	1997-05-29	Process for micro biological production of proteins
US08/955,424 US6274365B1 (en)	1989-10-25	1997-10-22	Pharmaceutical composition having an endoproteolytic activity
US09/253,854 US6132717A (en)	1989-10-25	1999-02-19	Method for treating mammals having a deficiency in endoprotease
JP2000381776A JP3270760B2 (ja)	1989-10-25	2000-12-15	フリンによるタンパクの微生物的生産方法及びその生産のための細胞

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
NL8902651A NL8902651A (nl)	1989-10-25	1989-10-25	Farmaceutisch preparaat met endoproteolytische activiteit; werkwijze voor endoproteolytische processing van eiwitten.
NL8902651		1989-10-25
NL9000917		1990-04-18
NL9000917A NL9000917A (nl)	1989-10-25	1990-04-18	Farmaceutisch preparaat met endoproteolytische activiteit; werkwijze voor endoproteolytische processing van (precursor) eiwitten en voor de (micro) biologische bereiding van eiwitten.

Publications (1)

Publication Number	Publication Date
NL9000917A true NL9000917A (nl)	1991-05-16

Family

ID=26646599

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NL9000917A NL9000917A (nl)	1989-10-25	1990-04-18	Farmaceutisch preparaat met endoproteolytische activiteit; werkwijze voor endoproteolytische processing van (precursor) eiwitten en voor de (micro) biologische bereiding van eiwitten.

Country Status (13)

Country	Link
US (1)	US5989856A (de)
EP (3)	EP0693286A1 (de)
JP (2)	JP3191111B2 (de)
AT (1)	ATE147437T1 (de)
AU (1)	AU6613290A (de)
CA (1)	CA2069929C (de)
DE (1)	DE69029663T3 (de)
DK (1)	DK0497828T4 (de)
ES (1)	ES2099714T5 (de)
FI (1)	FI105348B (de)
GR (1)	GR3023013T3 (de)
NL (1)	NL9000917A (de)
WO (1)	WO1991006314A2 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5935815A (en) *	1989-10-25	1999-08-10	Katholieke Universiteit Leuven	Process for micro biological production of proteins
CA2096418C (en) *	1990-11-26	2001-11-20	Philip J. Barr	Expression of pace in host cells and methods of use thereof
US6348327B1 (en)	1991-12-06	2002-02-19	Genentech, Inc.	Non-endocrine animal host cells capable of expressing variant proinsulin and processing the same to form active, mature insulin and methods of culturing such cells
DK52293D0 (de) *	1993-05-05	1993-05-05	Novo Nordisk As
US6005077A (en) *	1995-11-10	1999-12-21	Immuno Aktiengesellschaft	Use of von willebrand factor and pharmaceutical formulation
AT404838B (de)	1995-11-24	1999-03-25	Immuno Ag	Herstellung von proteinen aus pro-proteinen durch fusionsproteine abgeleitet von furin oder furinanalogen
US6596526B1 (en)	2000-06-09	2003-07-22	Baxter Aktiengesellschaft	Furin polypeptides with improved characteristics
EP1756275A1 (de) *	2004-04-23	2007-02-28	Novozymes A/S	Verfahren zur gewinnung reifer protease durch enzymatische verdauung
JP5485873B2 (ja) *	2007-05-22	2014-05-07	バクスター・インターナショナル・インコーポレイテッド	ヒトフューリンのための予備的な精製方法
BR122019022434B8 (pt)	2007-12-27	2021-07-27	Baxalta GmbH	método para cultivar células de mamífero que secretam proteína heteróloga em um sobrenadante de cultura celular
WO2009088713A1 (en)	2007-12-31	2009-07-16	Baxter International Inc.	Substantially animal protein-free recombinant furin and methods for producing same
EP2569005A1 (de)	2010-05-12	2013-03-20	INSERM - Institut National de la Santé et de la Recherche Médicale	Furin und biologisch aktive derivate davon zur verwendung bei der vorbeugung oder behandlung einer entzündungskrankheit
BR112013030880B1 (pt)	2011-06-02	2022-04-12	Takeda Pharmaceutical Company Limited	Composição aquosa estabilizada de furina recombinante

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0246709A1 (de) *	1986-05-20	1987-11-25	Stichting Katholieke Universiteit	Rekombinantes DNS, komplementäre DNS, Protein, Antikörper und Verfahren zum Nachweis von Tumorzellen
CA1340740C (en) *	1987-12-08	1999-09-14	Eileen R. Mulvihill	Co-expression in eukaryotic cells

1990
- 1990-04-18 NL NL9000917A patent/NL9000917A/nl not_active Application Discontinuation
- 1990-10-12 CA CA002069929A patent/CA2069929C/en not_active Expired - Lifetime
- 1990-10-12 US US07/849,420 patent/US5989856A/en not_active Expired - Lifetime
- 1990-10-12 AU AU66132/90A patent/AU6613290A/en not_active Abandoned
- 1990-10-12 EP EP95202272A patent/EP0693286A1/de not_active Withdrawn
- 1990-10-12 DK DK90915837T patent/DK0497828T4/da active
- 1990-10-12 JP JP51489590A patent/JP3191111B2/ja not_active Expired - Lifetime
- 1990-10-12 DE DE69029663T patent/DE69029663T3/de not_active Expired - Lifetime
- 1990-10-12 EP EP98200913A patent/EP0885956A1/de not_active Withdrawn
- 1990-10-12 WO PCT/NL1990/000151 patent/WO1991006314A2/en active IP Right Grant
- 1990-10-12 ES ES90915837T patent/ES2099714T5/es not_active Expired - Lifetime
- 1990-10-12 AT AT90915837T patent/ATE147437T1/de not_active IP Right Cessation
- 1990-10-12 EP EP90915837A patent/EP0497828B2/de not_active Expired - Lifetime
1992
- 1992-04-24 FI FI921847A patent/FI105348B/fi active
1997
- 1997-04-02 GR GR970400685T patent/GR3023013T3/el unknown
2000
- 2000-12-15 JP JP2000381776A patent/JP3270760B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
FI921847L (fi)	1992-04-24
DE69029663D1 (de)	1997-02-20
ES2099714T5 (es)	2008-04-01
ATE147437T1 (de)	1997-01-15
CA2069929A1 (en)	1991-04-26
JP3191111B2 (ja)	2001-07-23
JPH05504051A (ja)	1993-07-01
DK0497828T4 (da)	2008-02-04
EP0497828B1 (de)	1997-01-08
ES2099714T3 (es)	1997-06-01
EP0497828A1 (de)	1992-08-12
DE69029663T3 (de)	2008-05-21
WO1991006314A2 (en)	1991-05-16
US5989856A (en)	1999-11-23
FI105348B (fi)	2000-07-31
GR3023013T3 (en)	1997-07-30
DE69029663T2 (de)	1997-09-04
EP0693286A1 (de)	1996-01-24
DK0497828T3 (da)	1997-07-07
FI921847A0 (fi)	1992-04-24
CA2069929C (en)	2002-08-27
JP2001238683A (ja)	2001-09-04
EP0497828B2 (de)	2007-10-03
JP3270760B2 (ja)	2002-04-02
AU6613290A (en)	1991-05-31
EP0885956A1 (de)	1998-12-23
WO1991006314A3 (en)	1991-09-05

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