NL8402833A - Hydrogel met in microfase afgescheiden gebieden voor de gecontroleerde afgifte van biologisch actieve materialen. - Google Patents

Hydrogel met in microfase afgescheiden gebieden voor de gecontroleerde afgifte van biologisch actieve materialen. Download PDF

Info

Publication number: NL8402833A
Authority: NL; Netherlands
Prior art keywords: water; insoluble; copolymer; soluble; biologically active
Prior art date: 1983-09-15

Application number

NL8402833A

Other languages

English (en)

Dutch (nl)

Original Assignee

Kendall & Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-09-15

Filing date

1984-09-14

Publication date

1985-04-01

1984-09-14 Application filed by Kendall & Co filed Critical Kendall & Co

1985-04-01 Publication of NL8402833A publication Critical patent/NL8402833A/nl

Links

239000000017 hydrogel Substances 0.000 title description 51
239000011149 active material Substances 0.000 title description 5
239000000203 mixture Substances 0.000 claims description 81
229920001577 copolymer Polymers 0.000 claims description 79
239000000178 monomer Substances 0.000 claims description 47
239000013543 active substance Substances 0.000 claims description 41
239000003814 drug Substances 0.000 claims description 33
239000003795 chemical substances by application Substances 0.000 claims description 30
229940079593 drug Drugs 0.000 claims description 27
238000013270 controlled release Methods 0.000 claims description 21
239000002253 acid Substances 0.000 claims description 19
229920002554 vinyl polymer Polymers 0.000 claims description 17
230000002209 hydrophobic effect Effects 0.000 claims description 16
229920002959 polymer blend Polymers 0.000 claims description 15
229920001519 homopolymer Polymers 0.000 claims description 12
239000012528 membrane Substances 0.000 claims description 8
238000013268 sustained release Methods 0.000 claims description 5
239000012730 sustained-release form Substances 0.000 claims description 5
VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 claims 1
239000005977 Ethylene Substances 0.000 claims 1
229920006395 saturated elastomer Polymers 0.000 claims 1
JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 description 24
RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 description 16
229920000642 polymer Polymers 0.000 description 16
229960000890 hydrocortisone Drugs 0.000 description 12
SOGAXMICEFXMKE-UHFFFAOYSA-N Butylmethacrylate Chemical compound CCCCOC(=O)C(C)=C SOGAXMICEFXMKE-UHFFFAOYSA-N 0.000 description 8
229960003387 progesterone Drugs 0.000 description 8
239000000186 progesterone Substances 0.000 description 8
SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 7
NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 7
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
239000011159 matrix material Substances 0.000 description 6
150000003431 steroids Chemical class 0.000 description 6
WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 5
210000004379 membrane Anatomy 0.000 description 5
239000000126 substance Substances 0.000 description 5
229920002818 (Hydroxyethyl)methacrylate Polymers 0.000 description 4
WOBHKFSMXKNTIM-UHFFFAOYSA-N Hydroxyethyl methacrylate Chemical compound CC(=C)C(=O)OCCO WOBHKFSMXKNTIM-UHFFFAOYSA-N 0.000 description 4
PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 4
238000012377 drug delivery Methods 0.000 description 4
239000000463 material Substances 0.000 description 4
FQPSGWSUVKBHSU-UHFFFAOYSA-N methacrylamide Chemical group CC(=C)C(N)=O FQPSGWSUVKBHSU-UHFFFAOYSA-N 0.000 description 4
LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 description 3
230000002378 acidificating effect Effects 0.000 description 3
150000001875 compounds Chemical class 0.000 description 3
238000004132 cross linking Methods 0.000 description 3
MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 description 3
238000009826 distribution Methods 0.000 description 3
-1 polyethylene, ethylene-vinyl acetate Polymers 0.000 description 3
239000002904 solvent Substances 0.000 description 3
125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 3
QRIMLDXJAPZHJE-UHFFFAOYSA-N 2,3-dihydroxypropyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCC(O)CO QRIMLDXJAPZHJE-UHFFFAOYSA-N 0.000 description 2
OLQFXOWPTQTLDP-UHFFFAOYSA-N 2-(2-hydroxyethoxy)ethyl 2-methylprop-2-enoate Chemical group CC(=C)C(=O)OCCOCCO OLQFXOWPTQTLDP-UHFFFAOYSA-N 0.000 description 2
MZGMQAMKOBOIDR-UHFFFAOYSA-N 2-[2-(2-hydroxyethoxy)ethoxy]ethyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCCOCCOCCO MZGMQAMKOBOIDR-UHFFFAOYSA-N 0.000 description 2
NLHHRLWOUZZQLW-UHFFFAOYSA-N Acrylonitrile Chemical compound C=CC#N NLHHRLWOUZZQLW-UHFFFAOYSA-N 0.000 description 2
KAKZBPTYRLMSJV-UHFFFAOYSA-N Butadiene Chemical compound C=CC=C KAKZBPTYRLMSJV-UHFFFAOYSA-N 0.000 description 2
ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 description 2
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 description 2
VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 description 2
BZHJMEDXRYGGRV-UHFFFAOYSA-N Vinyl chloride Chemical compound ClC=C BZHJMEDXRYGGRV-UHFFFAOYSA-N 0.000 description 2
125000000217 alkyl group Chemical group 0.000 description 2
239000003242 anti bacterial agent Substances 0.000 description 2
229940088710 antibiotic agent Drugs 0.000 description 2
239000012736 aqueous medium Substances 0.000 description 2
229910052799 carbon Inorganic materials 0.000 description 2
125000004432 carbon atom Chemical group C* 0.000 description 2
239000003433 contraceptive agent Substances 0.000 description 2
238000013267 controlled drug release Methods 0.000 description 2
239000000599 controlled substance Substances 0.000 description 2
229920006037 cross link polymer Polymers 0.000 description 2
238000009792 diffusion process Methods 0.000 description 2
125000005670 ethenylalkyl group Chemical group 0.000 description 2
239000000796 flavoring agent Substances 0.000 description 2
235000019634 flavors Nutrition 0.000 description 2
239000003205 fragrance Substances 0.000 description 2
239000000417 fungicide Substances 0.000 description 2
239000002917 insecticide Substances 0.000 description 2
239000007788 liquid Substances 0.000 description 2
238000005192 partition Methods 0.000 description 2
239000004014 plasticizer Substances 0.000 description 2
229940124597 therapeutic agent Drugs 0.000 description 2
229920001169 thermoplastic Polymers 0.000 description 2
ORKBYCQJWQBPFG-WOMZHKBXSA-N (8r,9s,10r,13s,14s,17r)-13-ethyl-17-ethynyl-17-hydroxy-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one;(8r,9s,13s,14s,17r)-17-ethynyl-13-methyl-7,8,9,11,12,14,15,16-octahydro-6h-cyclopenta[a]phenanthrene-3,17-diol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1.O=C1CC[C@@H]2[C@H]3CC[C@](CC)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 ORKBYCQJWQBPFG-WOMZHKBXSA-N 0.000 description 1
HQGPZXPTJWUDQR-UHFFFAOYSA-N 1-ethenyl-5-methylpyrrolidin-2-one Chemical compound CC1CCC(=O)N1C=C HQGPZXPTJWUDQR-UHFFFAOYSA-N 0.000 description 1
JWYVGKFDLWWQJX-UHFFFAOYSA-N 1-ethenylazepan-2-one Chemical compound C=CN1CCCCCC1=O JWYVGKFDLWWQJX-UHFFFAOYSA-N 0.000 description 1
PBGPBHYPCGDFEZ-UHFFFAOYSA-N 1-ethenylpiperidin-2-one Chemical compound C=CN1CCCCC1=O PBGPBHYPCGDFEZ-UHFFFAOYSA-N 0.000 description 1
DAVVKEZTUOGEAK-UHFFFAOYSA-N 2-(2-methoxyethoxy)ethyl 2-methylprop-2-enoate Chemical compound COCCOCCOC(=O)C(C)=C DAVVKEZTUOGEAK-UHFFFAOYSA-N 0.000 description 1
PRAMZQXXPOLCIY-UHFFFAOYSA-N 2-(2-methylprop-2-enoyloxy)ethanesulfonic acid Chemical compound CC(=C)C(=O)OCCS(O)(=O)=O PRAMZQXXPOLCIY-UHFFFAOYSA-N 0.000 description 1
OEPOKWHJYJXUGD-UHFFFAOYSA-N 2-(3-phenylmethoxyphenyl)-1,3-thiazole-4-carbaldehyde Chemical compound O=CC1=CSC(C=2C=C(OCC=3C=CC=CC=3)C=CC=2)=N1 OEPOKWHJYJXUGD-UHFFFAOYSA-N 0.000 description 1
229920000536 2-Acrylamido-2-methylpropane sulfonic acid Polymers 0.000 description 1
GOXQRTZXKQZDDN-UHFFFAOYSA-N 2-Ethylhexyl acrylate Chemical compound CCCCC(CC)COC(=O)C=C GOXQRTZXKQZDDN-UHFFFAOYSA-N 0.000 description 1
XNWFRZJHXBZDAG-UHFFFAOYSA-N 2-METHOXYETHANOL Chemical compound COCCO XNWFRZJHXBZDAG-UHFFFAOYSA-N 0.000 description 1
XHZPRMZZQOIPDS-UHFFFAOYSA-N 2-Methyl-2-[(1-oxo-2-propenyl)amino]-1-propanesulfonic acid Chemical compound OS(=O)(=O)CC(C)(C)NC(=O)C=C XHZPRMZZQOIPDS-UHFFFAOYSA-N 0.000 description 1
YXYJVFYWCLAXHO-UHFFFAOYSA-N 2-methoxyethyl 2-methylprop-2-enoate Chemical compound COCCOC(=O)C(C)=C YXYJVFYWCLAXHO-UHFFFAOYSA-N 0.000 description 1
GKGOIYMLPJJVQI-UHFFFAOYSA-N 4-ethenylbenzenesulfonamide Chemical compound NS(=O)(=O)C1=CC=C(C=C)C=C1 GKGOIYMLPJJVQI-UHFFFAOYSA-N 0.000 description 1
HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical group NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 description 1
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
229920002307 Dextran Polymers 0.000 description 1
KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 description 1
240000002024 Gossypium herbaceum Species 0.000 description 1
235000004341 Gossypium herbaceum Nutrition 0.000 description 1
CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 description 1
SNIOPGDIGTZGOP-UHFFFAOYSA-N Nitroglycerin Chemical compound [O-][N+](=O)OCC(O[N+]([O-])=O)CO[N+]([O-])=O SNIOPGDIGTZGOP-UHFFFAOYSA-N 0.000 description 1
239000000006 Nitroglycerin Substances 0.000 description 1
229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 1
229920002125 Sokalan® Polymers 0.000 description 1
QHOPXUFELLHKAS-UHFFFAOYSA-N Thespesin Natural products CC(C)c1c(O)c(O)c2C(O)Oc3c(c(C)cc1c23)-c1c2OC(O)c3c(O)c(O)c(C(C)C)c(cc1C)c23 QHOPXUFELLHKAS-UHFFFAOYSA-N 0.000 description 1
XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
241000607479 Yersinia pestis Species 0.000 description 1
238000010521 absorption reaction Methods 0.000 description 1
230000002411 adverse Effects 0.000 description 1
125000005250 alkyl acrylate group Chemical group 0.000 description 1
125000005907 alkyl ester group Chemical group 0.000 description 1
230000004071 biological effect Effects 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
229920001400 block copolymer Polymers 0.000 description 1
239000002775 capsule Substances 0.000 description 1
239000004202 carbamide Substances 0.000 description 1
125000002843 carboxylic acid group Chemical group 0.000 description 1
239000012876 carrier material Substances 0.000 description 1
230000015556 catabolic process Effects 0.000 description 1
229940124558 contraceptive agent Drugs 0.000 description 1
LDHQCZJRKDOVOX-NSCUHMNNSA-N crotonic acid Chemical compound C\C=C\C(O)=O LDHQCZJRKDOVOX-NSCUHMNNSA-N 0.000 description 1
230000003247 decreasing effect Effects 0.000 description 1
238000006731 degradation reaction Methods 0.000 description 1
150000001993 dienes Chemical class 0.000 description 1
238000010790 dilution Methods 0.000 description 1
239000012895 dilution Substances 0.000 description 1
ZMXDDKWLCZADIW-UHFFFAOYSA-N dimethylformamide Substances CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 1
238000004090 dissolution Methods 0.000 description 1
238000001647 drug administration Methods 0.000 description 1
230000000694 effects Effects 0.000 description 1
229960003276 erythromycin Drugs 0.000 description 1
AWMFUEJKWXESNL-JZBHMOKNSA-N erythromycin estolate Chemical compound CCCCCCCCCCCCOS(O)(=O)=O.O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)OC(=O)CC)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 AWMFUEJKWXESNL-JZBHMOKNSA-N 0.000 description 1
229960003203 erythromycin estolate Drugs 0.000 description 1
MEGHWIAOTJPCHQ-UHFFFAOYSA-N ethenyl butanoate Chemical compound CCCC(=O)OC=C MEGHWIAOTJPCHQ-UHFFFAOYSA-N 0.000 description 1
239000005038 ethylene vinyl acetate Substances 0.000 description 1
238000001704 evaporation Methods 0.000 description 1
230000008020 evaporation Effects 0.000 description 1
238000001125 extrusion Methods 0.000 description 1
150000002222 fluorine compounds Chemical class 0.000 description 1
238000009472 formulation Methods 0.000 description 1
235000011187 glycerol Nutrition 0.000 description 1
229960003711 glyceryl trinitrate Drugs 0.000 description 1
229920000578 graft copolymer Polymers 0.000 description 1
239000004009 herbicide Substances 0.000 description 1
229920001477 hydrophilic polymer Polymers 0.000 description 1
238000010348 incorporation Methods 0.000 description 1
239000004615 ingredient Substances 0.000 description 1
238000002347 injection Methods 0.000 description 1
239000007924 injection Substances 0.000 description 1
239000002198 insoluble material Substances 0.000 description 1
230000003993 interaction Effects 0.000 description 1
238000001990 intravenous administration Methods 0.000 description 1
150000002634 lipophilic molecules Chemical class 0.000 description 1
VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
239000011976 maleic acid Substances 0.000 description 1
229940126601 medicinal product Drugs 0.000 description 1
239000002609 medium Substances 0.000 description 1
230000004060 metabolic process Effects 0.000 description 1
238000000034 method Methods 0.000 description 1
238000000465 moulding Methods 0.000 description 1
210000002200 mouth mucosa Anatomy 0.000 description 1
229940088644 n,n-dimethylacrylamide Drugs 0.000 description 1
YLGYACDQVQQZSW-UHFFFAOYSA-N n,n-dimethylprop-2-enamide Chemical compound CN(C)C(=O)C=C YLGYACDQVQQZSW-UHFFFAOYSA-N 0.000 description 1
229940087419 nonoxynol-9 Drugs 0.000 description 1
229920004918 nonoxynol-9 Polymers 0.000 description 1
210000000056 organ Anatomy 0.000 description 1
239000012188 paraffin wax Substances 0.000 description 1
230000035699 permeability Effects 0.000 description 1
ABLZXFCXXLZCGV-UHFFFAOYSA-N phosphonic acid group Chemical group P(O)(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 description 1
239000000049 pigment Substances 0.000 description 1
229920000233 poly(alkylene oxides) Polymers 0.000 description 1
229920001490 poly(butyl methacrylate) polymer Polymers 0.000 description 1
229920002338 polyhydroxyethylmethacrylate Polymers 0.000 description 1
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
239000001267 polyvinylpyrrolidone Substances 0.000 description 1
238000002360 preparation method Methods 0.000 description 1
238000003825 pressing Methods 0.000 description 1
239000011541 reaction mixture Substances 0.000 description 1
230000028327 secretion Effects 0.000 description 1
150000003384 small molecules Chemical class 0.000 description 1
239000007787 solid Substances 0.000 description 1
239000000243 solution Substances 0.000 description 1
238000003756 stirring Methods 0.000 description 1
239000000758 substrate Substances 0.000 description 1
125000000542 sulfonic acid group Chemical group 0.000 description 1
FBWNMEQMRUMQSO-UHFFFAOYSA-N tergitol NP-9 Chemical compound CCCCCCCCCC1=CC=C(OCCOCCOCCOCCOCCOCCOCCOCCOCCO)C=C1 FBWNMEQMRUMQSO-UHFFFAOYSA-N 0.000 description 1
239000004416 thermosoftening plastic Substances 0.000 description 1
230000036962 time dependent Effects 0.000 description 1
210000001519 tissue Anatomy 0.000 description 1
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
LDHQCZJRKDOVOX-UHFFFAOYSA-N trans-crotonic acid Natural products CC=CC(O)=O LDHQCZJRKDOVOX-UHFFFAOYSA-N 0.000 description 1
238000000870 ultraviolet spectroscopy Methods 0.000 description 1
229920003169 water-soluble polymer Polymers 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L39/00—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Compositions of derivatives of such polymers
- C08L39/04—Homopolymers or copolymers of monomers containing heterocyclic rings having nitrogen as ring member
- C08L39/06—Homopolymers or copolymers of N-vinyl-pyrrolidones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L57/00—Compositions of unspecified polymers obtained by reactions only involving carbon-to-carbon unsaturated bonds

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Polymers & Plastics (AREA)
Organic Chemistry (AREA)
Inorganic Chemistry (AREA)
Medicinal Preparation (AREA)
Compositions Of Macromolecular Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

NL8402833A 1983-09-15 1984-09-14 Hydrogel met in microfase afgescheiden gebieden voor de gecontroleerde afgifte van biologisch actieve materialen. NL8402833A (nl)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US53264383A	1983-09-15	1983-09-15
US53264383		1983-09-15
US06/606,794 US4693887A (en)	1983-09-15	1984-05-03	Microphase separated hydrogels for controlled release of bioactive materials
US60679484		1984-05-03

Publications (1)

Publication Number	Publication Date
NL8402833A true NL8402833A (nl)	1985-04-01

Family

ID=27063895

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NL8402833A NL8402833A (nl)	1983-09-15	1984-09-14	Hydrogel met in microfase afgescheiden gebieden voor de gecontroleerde afgifte van biologisch actieve materialen.

Country Status (18)

Country	Link
US (1)	US4693887A (de)
AT (1)	ATA290884A (de)
AU (1)	AU577056B2 (de)
BE (1)	BE900581A (de)
BR (1)	BR8404409A (de)
CA (1)	CA1232201A (de)
CH (1)	CH666415A5 (de)
DE (1)	DE3432573A1 (de)
DK (1)	DK410984A (de)
ES (1)	ES8607357A1 (de)
FR (1)	FR2551976B1 (de)
GB (2)	GB2147002B (de)
IT (1)	IT1178430B (de)
NL (1)	NL8402833A (de)
NO (1)	NO843650L (de)
NZ (1)	NZ209323A (de)
PT (1)	PT79192B (de)
SE (1)	SE461502B (de)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
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1984
- 1984-05-03 US US06/606,794 patent/US4693887A/en not_active Expired - Fee Related
- 1984-08-22 AU AU32268/84A patent/AU577056B2/en not_active Ceased
- 1984-08-23 NZ NZ209323A patent/NZ209323A/en unknown
- 1984-08-28 DK DK410984A patent/DK410984A/da not_active Application Discontinuation
- 1984-09-04 BR BR8404409A patent/BR8404409A/pt unknown
- 1984-09-05 DE DE19843432573 patent/DE3432573A1/de not_active Withdrawn
- 1984-09-10 FR FR8413866A patent/FR2551976B1/fr not_active Expired
- 1984-09-11 AT AT842908A patent/ATA290884A/de not_active Application Discontinuation
- 1984-09-11 PT PT79192A patent/PT79192B/pt not_active IP Right Cessation
- 1984-09-12 SE SE8404568A patent/SE461502B/sv not_active IP Right Cessation
- 1984-09-13 IT IT8448836A patent/IT1178430B/it active
- 1984-09-14 ES ES535923A patent/ES8607357A1/es not_active Expired
- 1984-09-14 BE BE0/213653A patent/BE900581A/fr not_active IP Right Cessation
- 1984-09-14 CH CH4417/84A patent/CH666415A5/de not_active IP Right Cessation
- 1984-09-14 NO NO843650A patent/NO843650L/no unknown
- 1984-09-14 CA CA000463168A patent/CA1232201A/en not_active Expired
- 1984-09-14 NL NL8402833A patent/NL8402833A/nl not_active Application Discontinuation
- 1984-09-17 GB GB08423416A patent/GB2147002B/en not_active Expired
1986
- 1986-08-19 GB GB08620117A patent/GB2177708A/en not_active Withdrawn

Also Published As

Publication number	Publication date
BE900581A (fr)	1985-03-14
NZ209323A (en)	1987-04-30
CA1232201A (en)	1988-02-02
AU3226884A (en)	1985-03-21
AU577056B2 (en)	1988-09-15
GB8423416D0 (en)	1984-10-24
SE461502B (sv)	1990-02-26
IT8448836A1 (it)	1986-03-13
CH666415A5 (de)	1988-07-29
PT79192A (en)	1984-10-01
SE8404568L (sv)	1985-03-16
GB2177708A (en)	1987-01-28
SE8404568D0 (sv)	1984-09-12
US4693887A (en)	1987-09-15
IT1178430B (it)	1987-09-09
NO843650L (no)	1985-03-18
FR2551976B1 (fr)	1988-06-10
DK410984A (da)	1985-03-16
IT8448836A0 (it)	1984-09-13
ATA290884A (de)	1991-07-15
BR8404409A (pt)	1985-07-30
ES8607357A1 (es)	1986-05-16
GB8620117D0 (en)	1986-10-01
DK410984D0 (da)	1984-08-28
DE3432573A1 (de)	1985-04-18
GB2147002A (en)	1985-05-01
PT79192B (en)	1986-08-14
FR2551976A1 (fr)	1985-03-22
ES535923A0 (es)	1986-05-16
GB2147002B (en)	1987-11-11

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EP0219208B1 (de)	1992-06-24	Ein Aminosäurepolymer enthaltende Zusammensetzung mit verzögerter Abgabe
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US7811605B2 (en)	2010-10-12	Method of formation of shape-retentive aggregates of gel particles and their uses
WO2005099667A2 (en)	2005-10-27	Drug delivery compositions
EP0564537A1 (de)	1993-10-13	Stabile suspenionszusammensetzungen für die kontrollierte freigabe von pharmazeutischen verbindungen
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KR0136211B1 (ko)	1998-04-25	친수성 고분자 물질을 함유하는 소수성 고분자 매트릭스를 이용한 경구용 약물 전달 체계
Kiser	2008	Bioresponsive Vaginal Delivery Systems

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Date	Code	Title	Description
1990-03-16	CNR	Transfer of rights (patent application after its laying open for public inspection)	Free format text: MANUFACTURERS HANOVER TRUST COMPANY
1991-11-01	BV	The patent application has lapsed