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NL7704030A - Werkwijze ter bereiding van bis-quartaire pyridinium-2-aldoxime-zouten. - Google Patents

Werkwijze ter bereiding van bis-quartaire pyridinium-2-aldoxime-zouten.

Info

Publication number
NL7704030A
NL7704030A NL7704030A NL7704030A NL7704030A NL 7704030 A NL7704030 A NL 7704030A NL 7704030 A NL7704030 A NL 7704030A NL 7704030 A NL7704030 A NL 7704030A NL 7704030 A NL7704030 A NL 7704030A
Authority
NL
Netherlands
Prior art keywords
pyridinium
quarter
preparing bis
aldoxime
salts
Prior art date
Application number
NL7704030A
Other languages
English (en)
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of NL7704030A publication Critical patent/NL7704030A/nl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/53—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
NL7704030A 1976-04-14 1977-04-13 Werkwijze ter bereiding van bis-quartaire pyridinium-2-aldoxime-zouten. NL7704030A (nl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19762616481 DE2616481A1 (de) 1976-04-14 1976-04-14 Bis-quartaere pyridinium-2-aldoxim- salze und verfahren zu ihrer herstellung

Publications (1)

Publication Number Publication Date
NL7704030A true NL7704030A (nl) 1977-10-18

Family

ID=5975404

Family Applications (1)

Application Number Title Priority Date Filing Date
NL7704030A NL7704030A (nl) 1976-04-14 1977-04-13 Werkwijze ter bereiding van bis-quartaire pyridinium-2-aldoxime-zouten.

Country Status (16)

Country Link
US (1) US4128651A (nl)
JP (1) JPS52128381A (nl)
AT (1) AT361923B (nl)
BE (1) BE853570A (nl)
CA (1) CA1070307A (nl)
CH (1) CH627745A5 (nl)
DE (1) DE2616481A1 (nl)
DK (1) DK163177A (nl)
ES (1) ES457791A1 (nl)
FR (1) FR2348211A1 (nl)
GB (1) GB1516626A (nl)
IE (1) IE44737B1 (nl)
IL (1) IL51857A (nl)
NL (1) NL7704030A (nl)
SE (1) SE7704240L (nl)
ZA (1) ZA772253B (nl)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4352810A (en) 1979-07-26 1982-10-05 Nederlandse Centrale Organisatie Voor Toegepast-Natuurwetenschappelijkond erzoek 1-Substituted hydroxyiminomethyl-pyridinium salts, with an activity against organophosphate poisonings

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT365410B (de) * 1978-08-31 1982-01-11 Ciba Geigy Ag Mittel zum schutz von kulturpflanzen vor aggressi-ven herbiziden
DE3332272A1 (de) * 1983-09-07 1985-03-21 Bayer Ag, 5090 Leverkusen Herbizide mittel enthaltend metribuzin in kombination mit pyridincarbonsaeureamiden
IL72788A (en) * 1984-08-28 1989-07-31 Israel State Bis quaternary oxy-bis methylene(or trimethylene)bis-n-quinuclidines,pyridines and piperidines,their preparation and antidotes against organophosphorus and carbamate poisoning containing them
US5130438A (en) * 1985-11-20 1992-07-14 The United States Of America As Represented By The Secretary Of The Army Bis-methylene ether pyridinium compound preparation
US5760049A (en) * 1997-02-21 1998-06-02 Synapse Pharmaceuticals International, Inc. Method for controlling tobacco use and alleviating withdrawal symptoms due to cessation of tobacco use
US7414135B2 (en) * 2005-02-17 2008-08-19 Aerojet Fine Chemicals Llc Process for halomethyl ethers of hydroxyiminomethyl quaternary pyridinium salts
US20060247281A1 (en) * 2005-02-17 2006-11-02 Aerojet Fine Chemicals Llc, A Delaware Limited Liability Company Process for halomethyl ethers of hydroxyiminomethyl quaternary pyridinium salts
US8946200B2 (en) * 2006-11-02 2015-02-03 Southwest Research Institute Pharmaceutically active nanosuspensions
US8404850B2 (en) * 2008-03-13 2013-03-26 Southwest Research Institute Bis-quaternary pyridinium-aldoxime salts and treatment of exposure to cholinesterase inhibitors
US8722706B2 (en) * 2008-08-15 2014-05-13 Southwest Research Institute Two phase bioactive formulations of bis-quaternary pyridinium oxime sulfonate salts
US8309134B2 (en) * 2008-10-03 2012-11-13 Southwest Research Institute Modified calcium phosphate nanoparticle formation
US9028873B2 (en) * 2010-02-08 2015-05-12 Southwest Research Institute Nanoparticles for drug delivery to the central nervous system
WO2011142826A1 (en) * 2010-05-12 2011-11-17 Mississipi State University Phenoxyalkyl pyridinium oxime therapeutics for treatment of organophosphate poisoning

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773775A (en) * 1968-08-27 1973-11-20 Merck Patent Gmbh Bis-quaternary pyridinium salts

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4352810A (en) 1979-07-26 1982-10-05 Nederlandse Centrale Organisatie Voor Toegepast-Natuurwetenschappelijkond erzoek 1-Substituted hydroxyiminomethyl-pyridinium salts, with an activity against organophosphate poisonings

Also Published As

Publication number Publication date
ATA257077A (de) 1980-09-15
FR2348211B1 (nl) 1980-04-18
DK163177A (da) 1977-10-15
IE44737L (en) 1977-10-14
DE2616481A1 (de) 1977-11-03
ES457791A1 (es) 1978-08-01
ZA772253B (en) 1978-03-29
IL51857A (en) 1980-05-30
FR2348211A1 (fr) 1977-11-10
JPS52128381A (en) 1977-10-27
SE7704240L (sv) 1977-10-15
GB1516626A (en) 1978-07-05
US4128651A (en) 1978-12-05
AT361923B (de) 1981-04-10
CH627745A5 (de) 1982-01-29
IE44737B1 (en) 1982-03-10
BE853570A (fr) 1977-10-14
IL51857A0 (en) 1977-06-30
CA1070307A (en) 1980-01-22

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Legal Events

Date Code Title Description
BV The patent application has lapsed