NL300181I2 - N-(pyrroloÖÄ2,3-dÖÜpyrimidine-3-ylacyl)-glutaminezuurderivaten. - Google Patents

N-(pyrroloÖÄ2,3-dÖÜpyrimidine-3-ylacyl)-glutaminezuurderivaten.

Info

Publication number: NL300181I2
Authority: NL; Netherlands
Prior art keywords: ylacyl; pyrrolo; pyrimidine; glutamic acid; acid derivatives
Prior art date: 1989-12-11

Application number

NL300181C

Other languages

English (en)

Other versions

NL300181I1 (nl

Original Assignee

Univ Princeton

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-12-11

Filing date

2005-03-16

Publication date

2005-06-01

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27503964&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NL300181(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1990-05-24 Priority claimed from US07/528,805 external-priority patent/US4996206A/en

2005-03-16 Application filed by Univ Princeton, Lilly Co Eli filed Critical Univ Princeton

2005-05-02 Publication of NL300181I1 publication Critical patent/NL300181I1/nl

2005-06-01 Publication of NL300181I2 publication Critical patent/NL300181I2/nl

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Hematology (AREA)
Oncology (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)

NL300181C 1989-12-11 2005-03-16 N-(pyrroloÖÄ2,3-dÖÜpyrimidine-3-ylacyl)-glutaminezuurderivaten. NL300181I2 (nl)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US44874289A	1989-12-11	1989-12-11
US47965590A	1990-02-08	1990-02-08
US07/528,805 US4996206A (en)	1989-12-11	1990-05-24	N-(pyrrolo[2,3-d]pyrimidin-3-ylacyl)-glutamic acid derivatives
US07/528,155 US5028608A (en)	1989-12-11	1990-05-24	N-(6-Amino-(pyrrolo(2,3-d)pyrimidin-3-ylacyl) )-glutamic acid derivatives

Publications (2)

Publication Number	Publication Date
NL300181I1 NL300181I1 (nl)	2005-05-02
NL300181I2 true NL300181I2 (nl)	2005-06-01

Family

ID=27503964

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NL300181C NL300181I2 (nl)	1989-12-11	2005-03-16	N-(pyrroloÖÄ2,3-dÖÜpyrimidine-3-ylacyl)-glutaminezuurderivaten.

Country Status (22)

Country	Link
EP (1)	EP0432677B1 (nl)
JP (1)	JP3016876B2 (nl)
CN (1)	CN1030608C (nl)
AR (1)	AR245129A1 (nl)
AT (1)	ATE135007T1 (nl)
AU (1)	AU640182B2 (nl)
CA (1)	CA2031890C (nl)
CY (1)	CY2076B1 (nl)
DE (2)	DE69025723T2 (nl)
DK (1)	DK0432677T3 (nl)
ES (1)	ES2084639T4 (nl)
GR (1)	GR3019784T3 (nl)
HK (1)	HK1000920A1 (nl)
HU (1)	HU218483B (nl)
IE (1)	IE904445A1 (nl)
IL (1)	IL96531A (nl)
LU (1)	LU91147I2 (nl)
NL (1)	NL300181I2 (nl)
NZ (1)	NZ236385A (nl)
PT (1)	PT96140B (nl)
RU (1)	RU2057131C9 (nl)
SG (1)	SG48098A1 (nl)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5254687A (en)	1991-12-04	1993-10-19	The Trustees Of Princeton University	Process for the preparation of pyrrolo[2,3-d]pyrimidines
US5235053A (en) *	1992-06-22	1993-08-10	Eli Lilly And Company	Process for the synthesis of 4-hydroxy-5-halopyrrold[2,3-d]pyrimidine intermediates
JP4625637B2 (ja)	2002-02-22	2011-02-02	シャイアエルエルシー	活性物質送達系及び活性物質を保護し投与する方法
CN100344615C (zh) *	2004-11-25	2007-10-24	重庆医药工业研究院有限责任公司	制备N－(吡咯并[2,3－d]嘧啶－5－基)酰基谷氨酸衍生物的方法及中间体
JP5475234B2 (ja)	2005-01-21	2014-04-16	アステックス・セラピューティクス・リミテッド	医薬化合物
KR20090052355A (ko)	2006-08-14	2009-05-25	시코르, 인크.	순도가 높은 페메트렉세드 이산 및 이의 제조 방법
KR101101443B1 (ko)	2006-08-14	2012-01-03	시코르, 인크.	페메트렉세드의 중간체의 제조 방법
EP1943252B1 (en)	2006-08-14	2010-12-22	Sicor, Inc.	Processes for the preparation of lyophilized pharmaceutically acceptable salts of pemetrexed diacid
EP1945645B1 (en)	2006-08-14	2010-12-01	Sicor, Inc.	Crystalline forms of pemetrexed diacid and processes for the preparation thereof
EP2073803B1 (en)	2006-10-12	2018-09-19	Astex Therapeutics Limited	Pharmaceutical combinations
US8883790B2 (en)	2006-10-12	2014-11-11	Astex Therapeutics Limited	Pharmaceutical combinations
CN101417998B (zh)	2007-10-24	2012-10-24	重庆医药工业研究院有限责任公司	一种培美曲塞盐的纯化方法
ES2662824T3 (es) *	2008-06-06	2018-04-09	Boehringer Ingelheim International Gmbh	Combinación farmacéutica
AU2015210337B2 (en) *	2008-06-06	2017-02-02	Boehringer Ingelheim International Gmbh	Pharmaceutical combination
CN101684121B (zh) *	2008-09-22	2013-04-03	重庆医药工业研究院有限责任公司	培美曲塞二酸的新晶型及其制备方法
EP2504341A1 (en)	2009-11-24	2012-10-03	Azad Pharmaceutical Ingredients AG	A new crystalline form of pemetrexed disodium
EP3210629A1 (en)	2012-05-30	2017-08-30	Fresenius Kabi Oncology Ltd	Pharmaceutical composition of pemetrexed
ITRM20120398A1 (it)	2012-08-08	2014-02-09	Berlin Chemie Ag	Procedimento di sintesi pemetrexed e suo sale di lisina.
WO2014167585A1 (en)	2013-04-12	2014-10-16	Actavis Group Ptc Ehf.	Pemetrexed formulation
EP2997031A1 (en)	2013-05-17	2016-03-23	Instytut Farmaceutyczny	Process for the preparation of high purity amorphous pemetrexed disodium and crystalline forms of n-[4-[2-(2-amino-4,7-dihydro-4-oxo-3h-pyrrolo[2,3- d]pyrimidin-5-yl)ethyl]benzoyl]-l-glutamic acid
EP3008064B1 (en)	2013-06-14	2017-11-22	Synthon B.V.	Stable pemetrexed arginine salt and compositions comprising it
WO2015008221A1 (en)	2013-07-16	2015-01-22	Dr. Reddy’S Laboratories Limited	Novel crystalline forms of pemetrexed tromethamine salts
NZ630292A (en)	2013-11-25	2015-02-27	Shilpa Medicare Ltd	Process for crystalline pemetrexed dipotassium salt
SI3206666T1 (sl)	2014-10-16	2020-04-30	Synthon B.V.	Tekoč farmacevtski sestavek, ki obsega pemetreksed
CN104672241B (zh) *	2015-01-29	2018-04-24	王磊	吡咯并[2,3-d]嘧啶类化合物及其用途
FR3037956B1 (fr) *	2015-06-23	2017-08-04	Servier Lab	Nouveaux derives d'acide amine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
SG10201913331VA (en)	2016-03-15	2020-03-30	Oryzon Genomics Sa	Combinations of lsd1 inhibitors for use in the treatment of solid tumors
WO2019046612A1 (en) *	2017-08-31	2019-03-07	Duquesne University Of The Holy Spirit	INHIBITORS OF FIRST-CATEGORY SHMT2 AND MTHFD2 AS ANTI-TUMOR AGENTS
CN110305137A (zh) *	2018-03-20	2019-10-08	鲁南制药集团股份有限公司	一种培美曲塞二钠中间体及其制备方法
CN110305136A (zh) *	2018-03-20	2019-10-08	鲁南制药集团股份有限公司	一种培美曲塞二钠中间体及其制备方法
CN110305134B (zh) *	2018-03-20	2022-02-22	鲁南制药集团股份有限公司	一种培美曲塞二钠中间体及其制备方法
CN110305135B (zh) *	2018-03-20	2022-02-22	鲁南制药集团股份有限公司	一种培美曲塞二钠中间体及其制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4818819A (en) *	1986-10-20	1989-04-04	The Trustees Of Princeton University	Process for the preparation of fused pyridine compounds
NO169490C (no) *	1988-03-24	1992-07-01	Takeda Chemical Industries Ltd	Analogifremgangsmaate for fremstilling av terapeutisk aktive pyrrolopyrimidinderivater
DK172753B1 (da) *	1988-05-25	1999-06-28	Lilly Co Eli	N-(5,6,7,8-tetrahydropyrido[2,3--d]pyrimidin-6-yl-alkanoyl)-glutaminsyrederivater, deres anvendelse, farmaceutiske præparat
US4883799A (en) *	1988-06-29	1989-11-28	The Trustees Of Princeton University	N-(4-(1-hydroxy-3-(5,6,7,8-tetrahydropyrido(2,3,-d)-pyrimidin-6-yl)prop-2-yl)benzoyl)glutamic acid derivatives

1990
- 1990-12-04 IL IL9653190A patent/IL96531A/en active Protection Beyond IP Right Term
- 1990-12-05 AU AU67791/90A patent/AU640182B2/en not_active Expired
- 1990-12-07 NZ NZ236385A patent/NZ236385A/en unknown
- 1990-12-10 SG SG1996007025A patent/SG48098A1/en unknown
- 1990-12-10 AT AT90123671T patent/ATE135007T1/de active
- 1990-12-10 DK DK90123671.1T patent/DK0432677T3/da active
- 1990-12-10 DE DE69025723T patent/DE69025723T2/de not_active Expired - Lifetime
- 1990-12-10 AR AR90318580A patent/AR245129A1/es active
- 1990-12-10 ES ES90123671T patent/ES2084639T4/es not_active Expired - Lifetime
- 1990-12-10 CA CA002031890A patent/CA2031890C/en not_active Expired - Lifetime
- 1990-12-10 HU HU147/90A patent/HU218483B/hu unknown
- 1990-12-10 EP EP90123671A patent/EP0432677B1/en not_active Expired - Lifetime
- 1990-12-10 DE DE200512000012 patent/DE122005000012I2/de active Active
- 1990-12-10 IE IE444590A patent/IE904445A1/en not_active IP Right Cessation
- 1990-12-10 PT PT96140A patent/PT96140B/pt not_active IP Right Cessation
- 1990-12-11 CN CN90110125A patent/CN1030608C/zh not_active Ceased
- 1990-12-11 JP JP2409992A patent/JP3016876B2/ja not_active Expired - Lifetime
1991
- 1991-02-07 RU SU4894454/04A patent/RU2057131C9/ru active Protection Beyond IP Right Term
1996
- 1996-04-29 GR GR960401164T patent/GR3019784T3/el unknown
1997
- 1997-12-22 HK HK97102541A patent/HK1000920A1/xx not_active IP Right Cessation
1998
- 1998-09-11 CY CY9802076A patent/CY2076B1/xx unknown
2005
- 2005-03-14 LU LU91147C patent/LU91147I2/fr unknown
- 2005-03-16 NL NL300181C patent/NL300181I2/nl unknown

Also Published As

Publication number	Publication date
EP0432677B1 (en)	1996-03-06
CN1030608C (zh)	1996-01-03
HU908147D0 (en)	1991-06-28
IE904445A1 (en)	1991-06-19
DK0432677T3 (da)	1996-04-09
IL96531A0 (en)	1991-09-16
GR3019784T3 (en)	1996-07-31
LU91147I2 (fr)	2005-05-17
HU218483B (hu)	2000-09-28
CY2076B1 (en)	1998-09-11
DE69025723T2 (de)	1996-10-31
JPH083166A (ja)	1996-01-09
AU640182B2 (en)	1993-08-19
ATE135007T1 (de)	1996-03-15
CN1055182A (zh)	1991-10-09
HK1000920A1 (en)	1998-05-08
PT96140B (pt)	1997-06-30
NL300181I1 (nl)	2005-05-02
SG48098A1 (en)	1998-04-17
ES2084639T4 (es)	2013-06-11
DE69025723D1 (de)	1996-04-11
RU2057131C9 (ru)	2006-04-10
AU6779190A (en)	1991-06-13
AR245129A1 (es)	1993-12-30
PT96140A (pt)	1991-09-30
DE122005000012I2 (de)	2006-02-09
CA2031890C (en)	2000-07-25
HUT58335A (en)	1992-02-28
JP3016876B2 (ja)	2000-03-06
ES2084639T3 (es)	1996-05-16
CA2031890A1 (en)	1991-06-12
EP0432677A1 (en)	1991-06-19
NZ236385A (en)	1992-05-26
RU2057131C1 (ru)	1996-03-27
DE122005000012I1 (de)	2005-06-23
IL96531A (en)	1995-08-31

Publication	Publication Date	Title
NL300181I2 (nl)	2005-06-01	N-(pyrroloÖÄ2,3-dÖÜpyrimidine-3-ylacyl)-glutaminezuurderivaten.
LV5742B4 (lv)	1996-12-20	3,5-divalizvietoti pirokatehina atvasinajumi
DE59008394D1 (de)	1995-03-16	Aminosäureamid-Derivate.
NO901399D0 (no)	1990-03-27	Aminosyrederivater.
NO903832D0 (no)	1990-09-03	Aminosyrederivater.
NO901033L (no)	1990-09-07	Aminosyrederivater.
DE3763411D1 (de)	1990-08-02	1,2,3,6-tetrahydro-5-nitro-pyrimidin-derivate.
NO885319D0 (no)	1988-11-29	Psykotropiske asykliske amid-derivater.
NO901533L (no)	1990-10-08	Aminosyrederivater.
FI881612A (fi)	1988-10-12	Nya pyrrolidin-2-(1,3-dikarbonyl) -derivat, foerfaranden foer deras framstaellning, dessa innehaollande aemnen saovael som deras anvaendning.
NO883070D0 (no)	1988-07-08	4-aminosubstituerte 1,2-dihydroksynaftalin-derivater.
NO900025L (no)	1990-07-06	Pyrrolylfenyl-substituerte hydroksamsyrederivater.
DE3887281D1 (de)	1994-03-03	1,2,3,4-Tetrahydro-5-nitro-pyrimidin-Derivate.
DK10190A (da)	1990-01-15	1,1-dioxo-cephem-4-carbothiolsyrederivater
DE69122555D1 (de)	1996-11-14	2,4-Dihydroxyadipinsäurederivate
DE3765646D1 (de)	1990-11-29	2,5,6,7-tetranor-4,8-inter-m-phenylen-pgi2-derivate.
FI941149A (fi)	1994-12-22	2,4-diamino-3-hydroksikarboksyylihapon johdannaisia
DE3888097D1 (de)	1994-04-07	1,2,3,4-Tetrahydro-5-nitro-pyrimidin-Derivate.
DE68909873D1 (de)	1993-11-18	1,4-Dihydropyridin-Derivate.
DE3780156D1 (de)	1992-08-06	Herbizide 1,5-diphenyl-1h-1,2,4-triazol-3-carboxamidderivate.
DE69018816D1 (de)	1995-05-24	Aminosäurederivate.
FI880320A0 (fi)	1988-01-25	Foerfarande foer framstaellning av n,n-(dibensohexatrienylen) urinaemnen.
DE58903154D1 (de)	1993-02-11	2,2-difluorcyclopropyl-derivate.
DE59002430D1 (de)	1993-09-30	Cyclopropanoylaminosäureamid-Derivate.
NO901519L (no)	1990-10-05	Aminosyrederivater.