NL192387C - Zuivere silibininederivaten, werkwijze voor de bereiding daarvan en farmaceutisch preparaat dat een dergelijk derivaat bevat. - Google Patents

Zuivere silibininederivaten, werkwijze voor de bereiding daarvan en farmaceutisch preparaat dat een dergelijk derivaat bevat. Download PDF

Info

Publication number: NL192387C
Authority: NL; Netherlands
Prior art keywords: formula; derivatives; ethanol; ethyl acetate; silibinine
Prior art date: 1984-11-22

Application number

NL8503171A

Other languages

English (en)

Dutch (nl)

Other versions

NL8503171A (nl

NL192387B (nl

Original Assignee

Madaus Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-11-22

Filing date

1985-11-18

Publication date

1997-07-04

1985-11-18 Application filed by Madaus Ag filed Critical Madaus Ag

1986-06-16 Publication of NL8503171A publication Critical patent/NL8503171A/nl

1997-03-03 Publication of NL192387B publication Critical patent/NL192387B/xx

1997-07-04 Application granted granted Critical

1997-07-04 Publication of NL192387C publication Critical patent/NL192387C/nl

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Toxicology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Dermatology (AREA)
Gastroenterology & Hepatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Silicon Compounds (AREA)

NL8503171A 1984-11-22 1985-11-18 Zuivere silibininederivaten, werkwijze voor de bereiding daarvan en farmaceutisch preparaat dat een dergelijk derivaat bevat. NL192387C (nl)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE19843442639 DE3442639A1 (de)	1984-11-22	1984-11-22	Flavolignanderivate, verfahren zu deren herstellung und arzneimittel, die diese verbindungen enthalten
DE3442639		1984-11-22

Publications (3)

Publication Number	Publication Date
NL8503171A NL8503171A (nl)	1986-06-16
NL192387B NL192387B (nl)	1997-03-03
NL192387C true NL192387C (nl)	1997-07-04

Family

ID=6250903

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NL8503171A NL192387C (nl)	1984-11-22	1985-11-18	Zuivere silibininederivaten, werkwijze voor de bereiding daarvan en farmaceutisch preparaat dat een dergelijk derivaat bevat.

Country Status (29)

Country	Link
JP (1)	JPS61143377A (de)
KR (1)	KR870001020B1 (de)
AR (1)	AR240931A1 (de)
AT (1)	AT393268B (de)
BE (1)	BE903693A (de)
CA (1)	CA1337124C (de)
CH (1)	CH659473A5 (de)
CS (1)	CS273610B2 (de)
DD (1)	DD259191A1 (de)
DE (1)	DE3442639A1 (de)
DK (1)	DK164865C (de)
EG (1)	EG19424A (de)
ES (1)	ES8609311A1 (de)
FI (1)	FI84064C (de)
FR (1)	FR2573427B1 (de)
GB (1)	GB2167414B (de)
HU (1)	HU195503B (de)
IE (1)	IE58791B1 (de)
IT (1)	IT1190426B (de)
LU (1)	LU86163A1 (de)
MX (1)	MX168415B (de)
NL (1)	NL192387C (de)
NO (1)	NO160205C (de)
PL (1)	PL146890B1 (de)
PT (1)	PT81532B (de)
SE (1)	SE465676B (de)
SU (1)	SU1436875A3 (de)
YU (1)	YU43689B (de)
ZA (1)	ZA858951B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8716918D0 (en) *	1987-07-17	1987-08-26	Inverni Della Beffa Spa	Soluble derivatives of silybin
US5262439A (en) *	1992-04-30	1993-11-16	The Regents Of The University Of California	Soluble analogs of probucol
DK1856085T3 (en) *	2005-03-11	2015-10-05	Howard Florey Inst Pty Ltd	FLAVONOID COMPOUNDS AND APPLICATIONS THEREOF
RU2482844C2 (ru) *	2007-11-15	2013-05-27	Мадаус Гмбх	Силибининовый компонент для лечения гепатита
WO2009062737A1 (en) *	2007-11-15	2009-05-22	Madaus Gmbh	Silibinin component for the treatment of hepatitis
AU2010247716B2 (en) *	2009-05-14	2015-11-05	Madaus Gmbh	Amorphous silibinin for the treatment of viral hepatitis
US20150174213A1 (en)	2012-07-05	2015-06-25	Nutramax Laboratories, Inc.	Compositions comprising sulforaphane or a sulforaphane precursor and ursolic acid
CN103113359B (zh) *	2013-02-22	2016-01-06	西安安健药业有限公司	水飞蓟宾二偏琥珀酸酯及其药用盐
CN103193768B (zh) *	2013-02-22	2016-03-30	西安安健药业有限公司	治疗肝病的水飞蓟宾二偏琥珀酸酯异构体
CN103172622B (zh) *	2013-02-22	2015-11-04	西安安健药业有限公司	水飞蓟宾二偏琥珀酸酯的活性异构体

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE1963318A1 (de) *	1969-12-17	1971-06-24	Schwabe Willmar Gmbh & Co	Silybinhalbester der Bernsteinsaeure und der Phthalsaeure,ihre Salze mit pharmakologisch vertraglichen Basen,Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung von Arzneipraeparaten

1984
- 1984-11-22 DE DE19843442639 patent/DE3442639A1/de active Granted
1985
- 1985-11-11 IE IE280885A patent/IE58791B1/en not_active IP Right Cessation
- 1985-11-13 LU LU86163A patent/LU86163A1/de unknown
- 1985-11-14 YU YU1786/85A patent/YU43689B/xx unknown
- 1985-11-14 AR AR302267A patent/AR240931A1/es active
- 1985-11-15 GB GB08528226A patent/GB2167414B/en not_active Expired
- 1985-11-18 NL NL8503171A patent/NL192387C/nl not_active IP Right Cessation
- 1985-11-18 FI FI854535A patent/FI84064C/fi not_active IP Right Cessation
- 1985-11-19 CH CH4935/85A patent/CH659473A5/de not_active IP Right Cessation
- 1985-11-19 AT AT3371/85A patent/AT393268B/de not_active IP Right Cessation
- 1985-11-20 SE SE8505487A patent/SE465676B/sv not_active IP Right Cessation
- 1985-11-20 DD DD85283042A patent/DD259191A1/de not_active IP Right Cessation
- 1985-11-20 CS CS837885A patent/CS273610B2/cs unknown
- 1985-11-20 CA CA000495804A patent/CA1337124C/en not_active Expired - Fee Related
- 1985-11-21 SU SU853985401A patent/SU1436875A3/ru active
- 1985-11-21 ZA ZA858951A patent/ZA858951B/xx unknown
- 1985-11-21 EG EG74085A patent/EG19424A/xx active
- 1985-11-21 DK DK537785A patent/DK164865C/da not_active IP Right Cessation
- 1985-11-21 NO NO854655A patent/NO160205C/no not_active IP Right Cessation
- 1985-11-21 IT IT22932/85A patent/IT1190426B/it active
- 1985-11-21 PL PL1985256374A patent/PL146890B1/pl unknown
- 1985-11-21 ES ES549116A patent/ES8609311A1/es not_active Expired
- 1985-11-21 HU HU854448A patent/HU195503B/hu not_active IP Right Cessation
- 1985-11-21 PT PT81532A patent/PT81532B/pt not_active IP Right Cessation
- 1985-11-22 KR KR1019850008733A patent/KR870001020B1/ko not_active IP Right Cessation
- 1985-11-22 MX MX009022A patent/MX168415B/es unknown
- 1985-11-22 BE BE2/60850A patent/BE903693A/fr not_active IP Right Cessation
- 1985-11-22 FR FR858517321A patent/FR2573427B1/fr not_active Expired
- 1985-11-22 JP JP60261629A patent/JPS61143377A/ja active Granted

Also Published As

Publication number	Publication date
GB8528226D0 (en)	1985-12-18
JPS61143377A (ja)	1986-07-01
FI854535A0 (fi)	1985-11-18
FR2573427A1 (fr)	1986-05-23
ES549116A0 (es)	1986-09-01
HU195503B (en)	1988-05-30
BE903693A (fr)	1986-05-22
YU43689B (en)	1989-10-31
NO160205B (no)	1988-12-12
SE8505487D0 (sv)	1985-11-20
CA1337124C (en)	1995-09-26
DK164865C (da)	1993-01-18
CS837885A2 (en)	1990-08-14
FI84064C (fi)	1991-10-10
DE3442639C2 (de)	1989-08-10
AR240931A1 (es)	1991-03-27
FR2573427B1 (fr)	1989-03-10
HUT40114A (en)	1986-11-28
YU178685A (en)	1988-02-29
DK164865B (da)	1992-08-31
FI84064B (fi)	1991-06-28
ES8609311A1 (es)	1986-09-01
AR240931A2 (es)	1991-03-27
LU86163A1 (de)	1986-03-24
GB2167414A (en)	1986-05-29
EG19424A (en)	1995-02-28
DE3442639A1 (de)	1986-05-22
DK537785D0 (da)	1985-11-21
JPH0432073B2 (de)	1992-05-28
IT1190426B (it)	1988-02-16
SU1436875A3 (ru)	1988-11-07
NL8503171A (nl)	1986-06-16
KR860004056A (ko)	1986-06-16
ZA858951B (en)	1986-08-27
DK537785A (da)	1986-05-23
NL192387B (nl)	1997-03-03
PT81532A (de)	1985-12-01
CS273610B2 (en)	1991-03-12
CH659473A5 (de)	1987-01-30
SE8505487L (sv)	1986-05-23
AT393268B (de)	1991-09-25
KR870001020B1 (ko)	1987-05-23
PT81532B (pt)	1987-11-11
ATA337185A (de)	1991-02-15
IE58791B1 (en)	1993-11-17
NO854655L (no)	1986-05-23
IT8522932A0 (it)	1985-11-21
PL146890B1 (en)	1989-03-31
SE465676B (sv)	1991-10-14
MX168415B (es)	1993-05-24
DD259191A1 (de)	1988-08-17
PL256374A1 (en)	1986-12-02
GB2167414B (en)	1989-01-11
FI854535A (fi)	1986-05-23
NO160205C (no)	1989-03-22
IE852808L (en)	1986-05-22

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EP0275224B1 (de)	1993-07-21	Phospholipidische Komplexe aus Vitis Vinifera-Extrakten, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische und kosmetische Zusammensetzungen
JP3179494B2 (ja)	2001-06-25	プロブコールの可溶性類似体
NL192387C (nl)	1997-07-04	Zuivere silibininederivaten, werkwijze voor de bereiding daarvan en farmaceutisch preparaat dat een dergelijk derivaat bevat.
HU190774B (en)	1986-11-28	Process for preparing ether derivatives with pharmacological activity
KR0134376B1 (ko)	1998-04-21	면역 억제제로서 유용한 4-퀴놀린 카르복실산 유도체
US3988446A (en)	1976-10-26	Glycerides with anti-inflammatory properties
US5202313A (en)	1993-04-13	Bilobalide derivatives, their applications and formulations containing them
CA2355776C (en)	2008-03-18	Phospholipid complexes of proanthocyanidin a2 as antiatherosclerotic agents
US4046887A (en)	1977-09-06	Glycerides with anti-inflammatory properties
CA2031505C (en)	1999-03-23	Phospholipid derivative
EP1153010A1 (de)	2001-11-14	N-substituierte aminosäuren, pharmazeutische antioxidant-zusammensetzungen die diese enthalten und verfahren zu ihrer anwendung
JP3243879B2 (ja)	2002-01-07	抗高脂血症剤
SI8511786A8 (sl)	1996-06-30	Postopek za pripravo derivatov silibinina
CH665642A5 (fr)	1988-05-31	Derives de l'aminomethyle-6 furo-(3,4-c)-pyridine, leur preparation et compositions therapeutiques en contenant.
JPS6233118A (ja)	1987-02-13	抗炎症剤
WO2000049030A1 (fr)	2000-08-24	Derives de 5-fluorouridine et anticancereux renfermant ces derives comme principe actif
JPH0366685A (ja)	1991-03-22	イミダゾール誘導体及びそれを有効成分として含有する肝臓疾患治療薬

Legal Events

Date	Code	Title	Description
1989-12-01	BA	A request for search or an international-type search has been filed
1990-01-02	BB	A search report has been drawn up
1990-08-01	BC	A request for examination has been filed
1990-08-16	CNR	Transfer of rights (patent application after its laying open for public inspection)	Free format text: MADAUS AKTIENGESELLSCHAFT
2002-08-01	V1	Lapsed because of non-payment of the annual fee	Effective date: 20020601