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NI201800071A - ISOINDOL COMPOUNDS - Google Patents

ISOINDOL COMPOUNDS

Info

Publication number
NI201800071A
NI201800071A NI201800071A NI201800071A NI201800071A NI 201800071 A NI201800071 A NI 201800071A NI 201800071 A NI201800071 A NI 201800071A NI 201800071 A NI201800071 A NI 201800071A NI 201800071 A NI201800071 A NI 201800071A
Authority
NI
Nicaragua
Prior art keywords
isoindol
compounds
compound
ror
mediated
Prior art date
Application number
NI201800071A
Other languages
Spanish (es)
Inventor
Lever Sarah
Narjes Frank
Ingemar Olsson Roine
Von Berg Stefan
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of NI201800071A publication Critical patent/NI201800071A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/4035—Isoindoles, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/12—Mucolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente memoria proporciona un compuesto de fórmula (I): (I) o una sal farmacéuticamente aceptable del mismo; un procedimiento para preparar un compuesto tal; y al uso de tal compuesto en el tratamiento de una ROR? y o estado de enfermedad / ROR?t mediada.The present specification provides a compound of formula (I): (I) or a pharmaceutically acceptable salt thereof; a process for preparing such a compound; and to the use of such a compound in the treatment of an ROR? and or disease state / ROR? t mediated.

NI201800071A 2015-12-15 2018-06-13 ISOINDOL COMPOUNDS NI201800071A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201562267391P 2015-12-15 2015-12-15

Publications (1)

Publication Number Publication Date
NI201800071A true NI201800071A (en) 2018-10-18

Family

ID=57708552

Family Applications (1)

Application Number Title Priority Date Filing Date
NI201800071A NI201800071A (en) 2015-12-15 2018-06-13 ISOINDOL COMPOUNDS

Country Status (27)

Country Link
US (4) US10011566B2 (en)
EP (1) EP3390396B1 (en)
JP (1) JP6448867B2 (en)
KR (1) KR101947976B1 (en)
CN (1) CN109071516B (en)
AR (1) AR107054A1 (en)
AU (1) AU2016374294B2 (en)
BR (1) BR112018011851A2 (en)
CA (1) CA3007893A1 (en)
CL (1) CL2018001573A1 (en)
CO (1) CO2018005983A2 (en)
CR (1) CR20180328A (en)
DO (1) DOP2018000148A (en)
EA (1) EA034514B1 (en)
ES (1) ES2927631T3 (en)
IL (1) IL259818B (en)
MX (1) MX376029B (en)
MY (1) MY196276A (en)
NI (1) NI201800071A (en)
PE (1) PE20181319A1 (en)
PH (1) PH12018501237A1 (en)
SG (1) SG11201804587QA (en)
SV (1) SV2018005713A (en)
TN (1) TN2018000188A1 (en)
TW (1) TWI728017B (en)
WO (1) WO2017102784A1 (en)
ZA (1) ZA201804618B (en)

Families Citing this family (8)

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KR101947976B1 (en) 2015-12-15 2019-02-13 아스트라제네카 아베 Isoindole compound
EP3638661A1 (en) 2017-06-14 2020-04-22 Astrazeneca AB 2,3-dihydroisoindole-1-carboxamides useful as ror-gamma modulators
WO2020035557A1 (en) * 2018-08-17 2020-02-20 Leo Pharma A/S Novel heteroaromatic modulators of the retinoid-related orphan receptor gamma
WO2020035556A1 (en) * 2018-08-17 2020-02-20 Leo Pharma A/S Novel heteroaromatic modulators of the retinoid-related orphan receptor gamma
CN113666863B (en) * 2020-05-15 2024-06-11 励缔(杭州)医药科技有限公司 Biaryl compounds useful as rory modulators
CA3178650A1 (en) * 2020-05-15 2021-11-18 Yaobang CHENG Aniline compound used as ror.gamma. regulator
KR102422891B1 (en) 2022-01-26 2022-07-20 (주)셀시스템 Integrated solar hot water and battery charging device with AI-based priority control function and charging method using the same
WO2023232870A1 (en) 2022-05-31 2023-12-07 Immunic Ag Rorg/rorgt modulators for the treatment of virus infections like covid-19

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Also Published As

Publication number Publication date
CR20180328A (en) 2018-08-09
WO2017102784A9 (en) 2018-04-05
CO2018005983A2 (en) 2018-06-20
IL259818B (en) 2021-05-31
US11453644B1 (en) 2022-09-27
EA034514B1 (en) 2020-02-14
EP3390396A1 (en) 2018-10-24
SG11201804587QA (en) 2018-06-28
WO2017102784A1 (en) 2017-06-22
AU2016374294A1 (en) 2018-07-19
JP6448867B2 (en) 2019-01-09
CA3007893A1 (en) 2017-06-22
CL2018001573A1 (en) 2018-07-27
TW201738210A (en) 2017-11-01
US10011566B2 (en) 2018-07-03
CN109071516A (en) 2018-12-21
IL259818A (en) 2018-07-31
MX2018007296A (en) 2019-01-10
ES2927631T3 (en) 2022-11-08
US10526286B2 (en) 2020-01-07
MY196276A (en) 2023-03-24
US20170166527A1 (en) 2017-06-15
AU2016374294B2 (en) 2019-06-27
CN109071516B (en) 2021-08-31
DOP2018000148A (en) 2018-07-15
ZA201804618B (en) 2020-09-30
US20200181084A1 (en) 2020-06-11
AR107054A1 (en) 2018-03-14
SV2018005713A (en) 2018-08-08
US20190084934A1 (en) 2019-03-21
PH12018501237A1 (en) 2019-02-18
TWI728017B (en) 2021-05-21
KR20180086269A (en) 2018-07-30
KR101947976B1 (en) 2019-02-13
MX376029B (en) 2025-03-07
BR112018011851A2 (en) 2018-12-04
JP2018537485A (en) 2018-12-20
EP3390396B1 (en) 2022-07-06
US10988445B2 (en) 2021-04-27
PE20181319A1 (en) 2018-08-14
EA201891342A1 (en) 2019-01-31
TN2018000188A1 (en) 2019-10-04

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