NI201700060A - Agonistas parciales del receptor de insulina - Google Patents
Agonistas parciales del receptor de insulinaInfo
- Publication number
- NI201700060A NI201700060A NI201700060A NI201700060A NI201700060A NI 201700060 A NI201700060 A NI 201700060A NI 201700060 A NI201700060 A NI 201700060A NI 201700060 A NI201700060 A NI 201700060A NI 201700060 A NI201700060 A NI 201700060A
- Authority
- NI
- Nicaragua
- Prior art keywords
- insulin receptor
- receptor agonists
- partial insulin
- partial
- insulin
- Prior art date
Links
- 229940127519 Insulin Receptor Agonists Drugs 0.000 title 1
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical class N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 2
- 102000003746 Insulin Receptor Human genes 0.000 abstract 1
- 108010001127 Insulin Receptor Proteins 0.000 abstract 1
- 239000000539 dimer Substances 0.000 abstract 1
- 239000004026 insulin derivative Chemical class 0.000 abstract 1
- 108010033606 insulin dimers Proteins 0.000 abstract 1
- 239000004031 partial agonist Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Organic Chemistry (AREA)
- Endocrinology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Abstract
Se divulgan dimeros de insulina y dimeros de análogo de insulina que actúan como agonistas parciales en el receptor de insulina.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462082857P | 2014-11-21 | 2014-11-21 | |
| US201562242503P | 2015-10-16 | 2015-10-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NI201700060A true NI201700060A (es) | 2017-07-18 |
Family
ID=54838417
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NI201700060A NI201700060A (es) | 2014-11-21 | 2017-05-19 | Agonistas parciales del receptor de insulina |
Country Status (26)
| Country | Link |
|---|---|
| US (4) | US20170355743A1 (es) |
| EP (4) | EP3666792B1 (es) |
| JP (5) | JP6484337B2 (es) |
| KR (2) | KR102049647B1 (es) |
| CN (2) | CN112494656B (es) |
| AR (1) | AR102712A1 (es) |
| AU (3) | AU2015349890B2 (es) |
| CA (2) | CA2966765C (es) |
| CL (3) | CL2017001288A1 (es) |
| CO (1) | CO2017004976A2 (es) |
| CR (1) | CR20170208A (es) |
| DO (1) | DOP2017000124A (es) |
| EA (1) | EA036714B1 (es) |
| ES (2) | ES3004386T3 (es) |
| GT (1) | GT201700104A (es) |
| IL (1) | IL252257A0 (es) |
| MX (3) | MX2017006651A (es) |
| NI (1) | NI201700060A (es) |
| PE (1) | PE20170957A1 (es) |
| PH (1) | PH12017500935A1 (es) |
| SG (4) | SG10201809428UA (es) |
| SV (1) | SV2017005445A (es) |
| TN (1) | TN2017000178A1 (es) |
| TW (1) | TW201625673A (es) |
| WO (1) | WO2016081670A2 (es) |
| ZA (1) | ZA201703238B (es) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK3177612T3 (da) | 2014-08-04 | 2022-05-16 | Nuevolution As | Eventuelt fusionerede heterocyclylsubstituerede derivater af pyrimidin, der er anvendelige til behandling af inflammatoriske, metaboliske, onkologiske og autoimmune sygdomme |
| KR102049647B1 (ko) * | 2014-11-21 | 2019-11-29 | 머크 샤프 앤드 돔 코포레이션 | 인슐린 수용체 부분 효능제 |
| AR105616A1 (es) | 2015-05-07 | 2017-10-25 | Lilly Co Eli | Proteínas de fusión |
| US10953076B2 (en) | 2016-05-24 | 2021-03-23 | Merck Sharp & Dohme Corp. | Insulin receptor partial agonists and GLP-1 analogues |
| EP3463413A4 (en) * | 2016-05-25 | 2020-03-04 | Merck Sharp & Dohme Corp. | Insulin receptor partial agonists |
| JP7022746B2 (ja) * | 2016-10-24 | 2022-02-18 | ノヴォ ノルディスク アー／エス | インスリン製剤のためのバイオアッセイ |
| EP3668892A1 (en) | 2017-08-17 | 2020-06-24 | Novo Nordisk A/S | Novel acylated insulin analogues and uses thereof |
| US11168141B2 (en) | 2018-08-02 | 2021-11-09 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating dystrophinopathies |
| US12097263B2 (en) | 2018-08-02 | 2024-09-24 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating myotonic dystrophy |
| US12018087B2 (en) | 2018-08-02 | 2024-06-25 | Dyne Therapeutics, Inc. | Muscle-targeting complexes comprising an anti-transferrin receptor antibody linked to an oligonucleotide and methods of delivering oligonucleotide to a subject |
| WO2020028864A1 (en) | 2018-08-02 | 2020-02-06 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating facioscapulohumeral muscular dystrophy |
| CA3108282A1 (en) | 2018-08-02 | 2020-02-06 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating dystrophinopathies |
| US11911484B2 (en) | 2018-08-02 | 2024-02-27 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating myotonic dystrophy |
| CN112898172B (zh) * | 2019-12-04 | 2022-05-31 | 中国科学院大连化学物理研究所 | 可被羧肽酶酶解的双亲和功能团化合物的合成方法 |
| JP2021098692A (ja) | 2019-12-20 | 2021-07-01 | ヌエヴォリューション・アクティーゼルスカブＮｕｅｖｏｌｕｔｉｏｎ Ａ／Ｓ | 核内受容体に対して活性の化合物 |
| WO2021198956A1 (en) | 2020-03-31 | 2021-10-07 | Nuevolution A/S | Compounds active towards nuclear receptors |
| JP2023519603A (ja) | 2020-03-31 | 2023-05-11 | ヌエヴォリューション・アクティーゼルスカブ | 核内受容体に対して活性な化合物 |
| US20230310551A1 (en) * | 2020-08-26 | 2023-10-05 | Merck Sharp & Dohme Llc | Insulin receptor partial agonists |
| US20250051416A1 (en) * | 2020-08-26 | 2025-02-13 | Merck Sharp & Dohme Llc | Insulin receptor partial agonists |
| EP4208173A1 (en) * | 2020-09-03 | 2023-07-12 | Dyne Therapeutics, Inc. | Methods of preparing protein-oligonucleotide complexes |
| CN116457015A (zh) * | 2020-09-03 | 2023-07-18 | 达因疗法公司 | 制备蛋白质-寡核苷酸复合物的方法 |
| WO2022055877A2 (en) * | 2020-09-09 | 2022-03-17 | Merck Sharp & Dohme Corp. | Insulin receptor partial agonists |
| US11771776B2 (en) | 2021-07-09 | 2023-10-03 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating dystrophinopathies |
| US11648318B2 (en) | 2021-07-09 | 2023-05-16 | Dyne Therapeutics, Inc. | Anti-transferrin receptor (TFR) antibody and uses thereof |
| US11969475B2 (en) | 2021-07-09 | 2024-04-30 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating facioscapulohumeral muscular dystrophy |
| US11638761B2 (en) | 2021-07-09 | 2023-05-02 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating Facioscapulohumeral muscular dystrophy |
| KR20240035825A (ko) | 2021-07-09 | 2024-03-18 | 다인 세라퓨틱스, 인크. | 디스트로핀병증을 치료하기 위한 근육 표적화 복합체 및 제제 |
| US11633498B2 (en) | 2021-07-09 | 2023-04-25 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating myotonic dystrophy |
| CN119183457A (zh) | 2022-04-15 | 2024-12-24 | 达因疗法公司 | 用于治疗强直性肌营养不良的肌肉靶向复合物和制剂 |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1381273A (en) * | 1971-01-28 | 1975-01-22 | Nat Res Dev | Insulin derivatives |
| US3907763A (en) | 1972-03-01 | 1975-09-23 | Bayer Ag | Insulin derivatives crosslinked by a dicarboxylic acid moiety |
| PH25772A (en) | 1985-08-30 | 1991-10-18 | Novo Industri As | Insulin analogues, process for their preparation |
| US5514646A (en) | 1989-02-09 | 1996-05-07 | Chance; Ronald E. | Insulin analogs modified at position 29 of the B chain |
| US5304473A (en) | 1991-06-11 | 1994-04-19 | Eli Lilly And Company | A-C-B proinsulin, method of manufacturing and using same, and intermediates in insulin production |
| AU1272295A (en) | 1993-12-17 | 1995-07-03 | Novo Nordisk A/S | Proinsulin-like compounds |
| AU5724996A (en) | 1995-05-05 | 1996-11-21 | Eli Lilly And Company | Single chain insulin with high bioactivity |
| WO1999063932A2 (en) * | 1998-06-08 | 1999-12-16 | Advanced Medicine, Inc. | Multibinding agents that modulate the 5-ht transporter |
| DE19908041A1 (de) * | 1999-02-24 | 2000-08-31 | Hoecker Hartwig | Kovalent verbrückte Insulindimere |
| KR100449454B1 (ko) | 2000-10-02 | 2004-09-21 | 이현철 | 단일사슬 인슐린 유도체의 유전자를 포함하는 당뇨병치료용 벡터 |
| WO2002067969A2 (en) | 2001-02-21 | 2002-09-06 | Medtronic Minimed, Inc. | Stabilized insulin formulations |
| US7105314B2 (en) | 2001-04-02 | 2006-09-12 | Novo Nordisk A/S | Method for making human insulin precursors |
| EP2226316B1 (en) | 2002-05-30 | 2016-01-13 | The Scripps Research Institute | Copper-catalysed ligation of azides and acetylenes |
| KR100507796B1 (ko) | 2003-04-03 | 2005-08-17 | 한미약품 주식회사 | 생체내 반감기가 증가된 ｐｅｇ-생리활성 폴리펩티드 동종이량체 결합체 및 이의 제조방법 |
| AU2004295023A1 (en) | 2003-12-03 | 2005-06-16 | Novo Nordisk A/S | Single-chain insulin |
| US20090197800A1 (en) | 2004-10-27 | 2009-08-06 | Novo Nordisk A/S | Insulin Receptor Binding Peptides with Non-Insulin Gene Activation Profiles and Uses Thereof |
| WO2006050262A2 (en) | 2004-11-01 | 2006-05-11 | The Regents Of The University Of California | Compositions and methods for modification of biomolecules |
| JP2008533100A (ja) | 2005-03-18 | 2008-08-21 | ノボ ノルディスク アクティーゼルスカブ | Ｐｅｇ化された単鎖インスリン |
| EP1991575A1 (en) | 2006-02-21 | 2008-11-19 | Novo Nordisk A/S | Single-chain insulin analogues and pharmaceutical formulations thereof |
| US20090069215A1 (en) | 2006-03-13 | 2009-03-12 | Novo Nordisk A/S | Acylated Single Chain Insulin |
| JP2009530243A (ja) | 2006-03-13 | 2009-08-27 | ノボ・ノルデイスク・エー／エス | アシル化単鎖インスリン |
| WO2007104736A2 (en) | 2006-03-13 | 2007-09-20 | Novo Nordisk A/S | Acylated single chain insulin |
| WO2007104734A1 (en) | 2006-03-13 | 2007-09-20 | Novo Nordisk A/S | Acylated single chain insulin |
| JP5256199B2 (ja) | 2006-08-07 | 2013-08-07 | テヴァ バイオファーマシューティカルズ ユーエスエー，インコーポレーティッド | アルブミン−インスリン融合タンパク質 |
| WO2008145721A2 (en) * | 2007-06-01 | 2008-12-04 | Novo Nordisk A/S | N-terminal modification of polypeptides for protection against degradation by aminopeptidases |
| EP2249853A4 (en) | 2008-01-30 | 2012-12-26 | Univ Indiana Res & Tech Corp | ESTER BASED PEPTIDE PRODRUGS |
| CA2722168A1 (en) | 2008-04-22 | 2009-10-29 | Case Western Reserve University | Isoform-specific insulin analogues |
| TWI394580B (zh) * | 2008-04-28 | 2013-05-01 | Halozyme Inc | 超快起作用胰島素組成物 |
| EP3228320B1 (de) * | 2008-10-17 | 2019-12-18 | Sanofi-Aventis Deutschland GmbH | Kombination von einem insulin und einem glp-1-agonisten |
| CN102245624B (zh) | 2008-12-19 | 2016-08-10 | 印第安纳大学研究及科技有限公司 | 基于酰胺的胰岛素前药 |
| AU2009335712B2 (en) | 2008-12-19 | 2015-09-17 | Indiana University Research And Technology Corporation | Insulin analogs |
| WO2011059895A1 (en) | 2009-11-11 | 2011-05-19 | Quest Diagnostics Investments Incorporated | Hexa mutations |
| AU2011268327B2 (en) * | 2010-06-16 | 2016-02-25 | Indiana University Research And Technology Corporation | Single chain insulin agonists exhibiting high activity at the insulin receptor |
| US8255297B2 (en) | 2010-07-20 | 2012-08-28 | Facebook, Inc. | Creation, redemption, and accounting in a virtual currency system |
| WO2012049307A2 (en) | 2010-10-15 | 2012-04-19 | Novo Nordisk A/S | Novel n-terminally modified insulin derivatives |
| CN104010652A (zh) * | 2011-10-27 | 2014-08-27 | 卡斯西部储备大学 | 超浓缩的速效胰岛素类似物制剂 |
| WO2014052451A2 (en) * | 2012-09-26 | 2014-04-03 | Indiana University Research And Technology Corporation | Insulin analog dimers |
| US20160067212A1 (en) | 2013-03-15 | 2016-03-10 | Universite De Geneve | Use of insulin signaling antagonists, optionally in combination of transfection of non-beta cells, for inducing insulin production |
| CN105792852B (zh) * | 2013-10-04 | 2019-12-10 | 默沙东公司 | 葡萄糖响应性的胰岛素缀合物 |
| US10758636B2 (en) * | 2013-11-12 | 2020-09-01 | Centre For Probe Development And Commercialization | Residualizing linkers and uses thereof |
| MX369656B (es) | 2014-01-20 | 2019-11-15 | Hanmi Pharm Ind Co Ltd | Insulina de accion prolongada y uso de la misma. |
| KR102049647B1 (ko) | 2014-11-21 | 2019-11-29 | 머크 샤프 앤드 돔 코포레이션 | 인슐린 수용체 부분 효능제 |
-
2015
- 2015-11-19 KR KR1020177016516A patent/KR102049647B1/ko active Active
- 2015-11-19 AR ARP150103770A patent/AR102712A1/es unknown
- 2015-11-19 AU AU2015349890A patent/AU2015349890B2/en active Active
- 2015-11-19 CN CN202011335828.4A patent/CN112494656B/zh active Active
- 2015-11-19 CA CA2966765A patent/CA2966765C/en active Active
- 2015-11-19 EP EP19211801.6A patent/EP3666792B1/en active Active
- 2015-11-19 EP EP15807730.5A patent/EP3221343B1/en active Active
- 2015-11-19 PH PH12017500935A patent/PH12017500935A1/en unknown
- 2015-11-19 ES ES19211801T patent/ES3004386T3/es active Active
- 2015-11-19 TN TN2017000178A patent/TN2017000178A1/en unknown
- 2015-11-19 CR CR20170208A patent/CR20170208A/es unknown
- 2015-11-19 SG SG10201809428UA patent/SG10201809428UA/en unknown
- 2015-11-19 JP JP2017526961A patent/JP6484337B2/ja active Active
- 2015-11-19 EA EA201791117A patent/EA036714B1/ru unknown
- 2015-11-19 TW TW104138282A patent/TW201625673A/zh unknown
- 2015-11-19 MX MX2017006651A patent/MX2017006651A/es unknown
- 2015-11-19 SG SG11201704064TA patent/SG11201704064TA/en unknown
- 2015-11-19 EP EP19211799.2A patent/EP3660041B1/en active Active
- 2015-11-19 SG SG10201809427SA patent/SG10201809427SA/en unknown
- 2015-11-19 CA CA3014641A patent/CA3014641C/en active Active
- 2015-11-19 SG SG10201809457YA patent/SG10201809457YA/en unknown
- 2015-11-19 EP EP19211793.5A patent/EP3660040B1/en active Active
- 2015-11-19 KR KR1020197016746A patent/KR102101136B1/ko active Active
- 2015-11-19 US US15/527,363 patent/US20170355743A1/en not_active Abandoned
- 2015-11-19 US US14/945,461 patent/US10017556B2/en active Active
- 2015-11-19 WO PCT/US2015/061445 patent/WO2016081670A2/en active Application Filing
- 2015-11-19 CN CN201580074165.6A patent/CN108064173B/zh active Active
- 2015-11-19 ES ES19211799T patent/ES2946247T3/es active Active
- 2015-11-19 PE PE2017000888A patent/PE20170957A1/es unknown
-
2017
- 2017-05-10 ZA ZA2017/03238A patent/ZA201703238B/en unknown
- 2017-05-11 IL IL252257A patent/IL252257A0/en unknown
- 2017-05-18 CL CL2017001288A patent/CL2017001288A1/es unknown
- 2017-05-18 CO CONC2017/0004976A patent/CO2017004976A2/es unknown
- 2017-05-19 NI NI201700060A patent/NI201700060A/es unknown
- 2017-05-19 MX MX2020014120A patent/MX2020014120A/es unknown
- 2017-05-19 SV SV2017005445A patent/SV2017005445A/es unknown
- 2017-05-19 DO DO2017000124A patent/DOP2017000124A/es unknown
- 2017-05-19 GT GT201700104A patent/GT201700104A/es unknown
- 2017-05-19 MX MX2020014121A patent/MX2020014121A/es unknown
-
2018
- 2018-06-13 US US16/007,046 patent/US10183981B2/en active Active
- 2018-07-31 AU AU2018211208A patent/AU2018211208B2/en active Active
- 2018-07-31 AU AU2018211207A patent/AU2018211207B2/en active Active
- 2018-09-28 JP JP2018183315A patent/JP6943825B2/ja active Active
- 2018-09-28 JP JP2018183314A patent/JP2019014734A/ja not_active Withdrawn
- 2018-09-28 JP JP2018183316A patent/JP6703068B2/ja active Active
- 2018-11-26 US US16/199,774 patent/US10800827B2/en active Active
-
2019
- 2019-04-26 CL CL2019001144A patent/CL2019001144A1/es unknown
- 2019-04-26 CL CL2019001143A patent/CL2019001143A1/es unknown
- 2019-11-12 JP JP2019204409A patent/JP6931033B2/ja active Active
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NI201700060A (es) | Agonistas parciales del receptor de insulina | |
| UY36179A (es) | Derivados de exendina-4 como agonistas selectivos del receptor de glucagón | |
| BR112017012364A2 (pt) | pré-tratamento rápido. | |
| IN2015DE00625A (es) | ||
| ES2914082T8 (es) | Procedimiento de generación de progenitores de células T | |
| FR3023171B1 (fr) | Autoinjecteur. | |
| FR3023170B1 (fr) | Autoinjecteur. | |
| ECSP17039183A (es) | Agonistas parciales del receptor de insulina | |
| EA201991576A1 (ru) | Частичные агонисты инсулинового рецептора | |
| GT201700043S (es) | Pico para lavaplatos | |
| TN2014000468A1 (fr) | اختراع الة للف شباك مراكب الصيد البحري و تسهيل تحويلها من المركب الى رصيف الميناء ثم ارجاعها للمركب بعد القيام بعملية ترقيعها | |
| TN2014000355A1 (fr) | طريقة مبتكرة لتوفير الاضاءة العامة و المنزلية | |
| ES1119305Y (es) | Lámpara de mesa | |
| TN2014000377A1 (fr) | طائرة كهربائية كاتمة للصوت | |
| GT201400039S (es) | Diseño de bici-motocicleta | |
| ITCE20140004U1 (it) | Salvabimbi del dr. cirillo | |
| TN2014000384A1 (fr) | نظام صوتي ذكي وآمن | |
| CR20140455S (es) | Grua de portico | |
| ES1106783Y (es) | Mesa de cultivo | |
| CL2014003446S1 (es) | Mesa. | |
| CR20140458S (es) | Grúa de pórtico | |
| TN2014000388A1 (fr) | منظومة فيزيائية متجانسة كهربائية ميكانيكية مغناطيسية لتوليد الطاقة الكهربائية الحرة الايكولوجية المضاعفة | |
| TN2014000354A1 (fr) | جهاز مبتكر لتلقيح النخيل | |
| GT201400051S (es) | Escúter o motoneta | |
| TH1501006949A (th) | องค์ประกอบที่มีเอทิลีนเป็นองค์ประกอบหลัก |