NI201100094A - PIPERIDINE SPIRO PYRROLIDINONE AND PIPERIDINONE SUBSTITUTED, THEIR PREPARATION AND THEIR THERAPEUTIC USE. - Google Patents
PIPERIDINE SPIRO PYRROLIDINONE AND PIPERIDINONE SUBSTITUTED, THEIR PREPARATION AND THEIR THERAPEUTIC USE.Info
- Publication number
- NI201100094A NI201100094A NI201100094A NI201100094A NI201100094A NI 201100094 A NI201100094 A NI 201100094A NI 201100094 A NI201100094 A NI 201100094A NI 201100094 A NI201100094 A NI 201100094A NI 201100094 A NI201100094 A NI 201100094A
- Authority
- NI
- Nicaragua
- Prior art keywords
- substituted
- preparation
- piperidinone
- therapeutic use
- piperidine spiro
- Prior art date
Links
- KWKQMOUOQABFCZ-UHFFFAOYSA-N 2,6-diazaspiro[4.5]decan-1-one Chemical group O=C1NCCC11NCCCC1 KWKQMOUOQABFCZ-UHFFFAOYSA-N 0.000 title 1
- XUWHAWMETYGRKB-UHFFFAOYSA-N piperidin-2-one Chemical group O=C1CCCCN1 XUWHAWMETYGRKB-UHFFFAOYSA-N 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- 102000004384 Histamine H3 receptors Human genes 0.000 abstract 2
- 108090000981 Histamine H3 receptors Proteins 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- KFIOZBMCNUODPK-UHFFFAOYSA-N n-phenyl-1-pyrrolidin-1-ylpyrrolidine-2-carboxamide Chemical class C1CCN(N2CCCC2)C1C(=O)NC1=CC=CC=C1 KFIOZBMCNUODPK-UHFFFAOYSA-N 0.000 abstract 2
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000000543 intermediate Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008177 pharmaceutical agent Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
La presente invención describe y reivindica una serie de carboxamidas N-fenil-bipirrolidina sustituidas de fórmula (I). Donde R1, R2, R3, m, n y p son como se describen en el presente documento. Más específicamente, los compuestos de esta invención son moduladores de los receptores H3 y, por lo tanto, son útiles como agentes farmacéuticos, especialmente en el tratamiento y/o prevención de una variedad de enfermedades moduladas por los receptores H3, incluyendo enfermedades asociadas con el sistema nervioso central. Además, la presente invención también describe métodos para la preparación de carboxamidas N-fenil-bipirrolidina sustituidas e intermedios para ello.The present invention describes and claims a series of substituted N-phenyl-bipyrrolidine carboxamides of formula (I). Where R1, R2, R3, m, n and p are as described herein. More specifically, the compounds of this invention are modulators of H3 receptors and therefore are useful as pharmaceutical agents, especially in the treatment and / or prevention of a variety of diseases modulated by H3 receptors, including diseases associated with the Central Nervous System. Furthermore, the present invention also describes methods for the preparation of substituted N-phenyl-bipyrrolidine carboxamides and intermediates therefor.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12008808P | 2008-12-05 | 2008-12-05 | |
| FR0955431 | 2009-07-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NI201100094A true NI201100094A (en) | 2011-11-03 |
Family
ID=66221462
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NI201100094A NI201100094A (en) | 2008-12-05 | 2011-05-10 | PIPERIDINE SPIRO PYRROLIDINONE AND PIPERIDINONE SUBSTITUTED, THEIR PREPARATION AND THEIR THERAPEUTIC USE. |
Country Status (3)
| Country | Link |
|---|---|
| BR (1) | BRPI0922843A2 (en) |
| CL (1) | CL2011001328A1 (en) |
| NI (1) | NI201100094A (en) |
-
2009
- 2009-12-04 BR BRPI0922843A patent/BRPI0922843A2/en not_active Application Discontinuation
-
2011
- 2011-05-10 NI NI201100094A patent/NI201100094A/en unknown
- 2011-06-03 CL CL2011001328A patent/CL2011001328A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CL2011001328A1 (en) | 2011-08-26 |
| BRPI0922843A2 (en) | 2019-09-03 |
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