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NI201100090A - TETRAHIDROPIRAN SPIRO PYRROLIDINONE AND SUBSTITUTE PIPERIDINONE, THEIR PREPARATION AND THEIR THERAPEUTIC USE. - Google Patents

TETRAHIDROPIRAN SPIRO PYRROLIDINONE AND SUBSTITUTE PIPERIDINONE, THEIR PREPARATION AND THEIR THERAPEUTIC USE.

Info

Publication number
NI201100090A
NI201100090A NI201100090A NI201100090A NI201100090A NI 201100090 A NI201100090 A NI 201100090A NI 201100090 A NI201100090 A NI 201100090A NI 201100090 A NI201100090 A NI 201100090A NI 201100090 A NI201100090 A NI 201100090A
Authority
NI
Nicaragua
Prior art keywords
preparation
tetrahidropiran
piperidinone
substitute
therapeutic use
Prior art date
Application number
NI201100090A
Other languages
Spanish (es)
Inventor
Gao Zhongli
Stefany David
Hartung Ryan
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of NI201100090A publication Critical patent/NI201100090A/en

Links

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invención describe y reivindica una serie de carboxamidas N - fenil - bipirrolidina sustituidas de fórmula (I) donde Rl, R2, m, n y p son como se definió anteriormente en este documento. Más específicamente, los compuestos de esta invención son moduladores de los receptores H3 y, por lo tanto, son útiles como agentes farmacéuticos, especialmente en el tratamiento y/o prevención de una variedad de enfermedades moduladas por los receptores H3, incluyendo enfermedades asociadas con el sistema nervioso lo central. Además, la presente invención también describe métodos para la preparación de carboxamidas N-fenil-bipirrolidina sustituidas e intermedios para ello.The present invention describes and claims a series of substituted N-phenyl-bipyrrolidine carboxamides of formula (I) where Rl, R2, m, n and p are as defined hereinbefore. More specifically, the compounds of this invention are modulators of H3 receptors and are therefore useful as pharmaceutical agents, especially in the treatment and / or prevention of a variety of diseases modulated by H3 receptors, including diseases associated with the central nervous system. Furthermore, the present invention also describes methods for the preparation of substituted N-phenyl-bipyrrolidine carboxamides and intermediates therefor.

NI201100090A 2008-12-05 2011-05-06 TETRAHIDROPIRAN SPIRO PYRROLIDINONE AND SUBSTITUTE PIPERIDINONE, THEIR PREPARATION AND THEIR THERAPEUTIC USE. NI201100090A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12008708P 2008-12-05 2008-12-05
FR0955909 2009-08-28

Publications (1)

Publication Number Publication Date
NI201100090A true NI201100090A (en) 2011-11-03

Family

ID=66221461

Family Applications (1)

Application Number Title Priority Date Filing Date
NI201100090A NI201100090A (en) 2008-12-05 2011-05-06 TETRAHIDROPIRAN SPIRO PYRROLIDINONE AND SUBSTITUTE PIPERIDINONE, THEIR PREPARATION AND THEIR THERAPEUTIC USE.

Country Status (3)

Country Link
BR (1) BRPI0922822A2 (en)
CL (1) CL2011001330A1 (en)
NI (1) NI201100090A (en)

Also Published As

Publication number Publication date
CL2011001330A1 (en) 2011-08-26
BRPI0922822A2 (en) 2020-08-04

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