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NI200500106A - Derivados de dihidropiranoindol-3,4-diona sustituidos y derivados de 2-hidroxi-metilindol del acido 3-oxoacetico sustituidos como inhibidores del inhibidor del activador de plasminogeno 1 (pai-1). - Google Patents

Derivados de dihidropiranoindol-3,4-diona sustituidos y derivados de 2-hidroxi-metilindol del acido 3-oxoacetico sustituidos como inhibidores del inhibidor del activador de plasminogeno 1 (pai-1).

Info

Publication number
NI200500106A
NI200500106A NI200500106A NI200500106A NI200500106A NI 200500106 A NI200500106 A NI 200500106A NI 200500106 A NI200500106 A NI 200500106A NI 200500106 A NI200500106 A NI 200500106A NI 200500106 A NI200500106 A NI 200500106A
Authority
NI
Nicaragua
Prior art keywords
derivatives
pyridinyl
cycloalkyl
pai
inhibitors
Prior art date
Application number
NI200500106A
Other languages
English (en)
Inventor
Hassan Mahmoud Elokdah
David Zenan Li
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of NI200500106A publication Critical patent/NI200500106A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/22—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an aralkyl radical attached to the ring nitrogen atom

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Endocrinology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Psychiatry (AREA)
  • Reproductive Health (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)

Abstract

Se proveen compuestos de las formulas I y II: en las que X es un metal alcalino o un resto de amina básica; R1 es alquilo, cicloalquilo, -CH2-cicloalquilo, piridinilo, -CH2-piridinilo, fenilo o bencilo, en donde los anillos de estos grupos están opcionalmente sustituidos; R2 es halógeno, alquilo, perfluoroalquilo, alcoxi, cicloalquilo, -C2-cicloalquilo -NH2 o -NO2; R3 es fenilo, bencilo, benciloxi, piridinilo o -CH2-piridinilo, en donde los anillos de estos grupos están opcionalmente sustutidos; o una de sus sales o formas de ésteres farmacéuticamente aceptables, así como composiciones farmacéuticas y métodos que usan estos compuestos como inhibidores del inhibidor del activador del plasminógeno 1 (PAI-1) y como composiciones terapéuticas para tratar condiciones que resultan de trastornos fibrinolíticos tales como trombosis venosa profunda y enfermedad cardiaca coronaria y fibrosis pulmonar.
NI200500106A 2002-12-10 2005-06-09 Derivados de dihidropiranoindol-3,4-diona sustituidos y derivados de 2-hidroxi-metilindol del acido 3-oxoacetico sustituidos como inhibidores del inhibidor del activador de plasminogeno 1 (pai-1). NI200500106A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US43232702P 2002-12-10 2002-12-10

Publications (1)

Publication Number Publication Date
NI200500106A true NI200500106A (es) 2006-02-02

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
NI200500106A NI200500106A (es) 2002-12-10 2005-06-09 Derivados de dihidropiranoindol-3,4-diona sustituidos y derivados de 2-hidroxi-metilindol del acido 3-oxoacetico sustituidos como inhibidores del inhibidor del activador de plasminogeno 1 (pai-1).

Country Status (18)

Country Link
US (2) US7101903B2 (es)
EP (1) EP1569639A2 (es)
JP (1) JP2006514641A (es)
KR (1) KR20050085589A (es)
CN (1) CN1726029A (es)
AU (1) AU2003296322A1 (es)
BR (1) BR0316586A (es)
CA (1) CA2509242A1 (es)
CR (1) CR7865A (es)
EC (1) ECSP055847A (es)
MX (1) MXPA05006281A (es)
NI (1) NI200500106A (es)
NO (1) NO20053340L (es)
NZ (1) NZ540865A (es)
RU (1) RU2337910C2 (es)
UA (1) UA80453C2 (es)
WO (1) WO2004052893A2 (es)
ZA (1) ZA200504723B (es)

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US20050113436A1 (en) 2005-05-26
US7459478B2 (en) 2008-12-02
EP1569639A2 (en) 2005-09-07
BR0316586A (pt) 2005-10-11
ZA200504723B (en) 2007-12-27
ECSP055847A (es) 2005-11-22
KR20050085589A (ko) 2005-08-29
NZ540865A (en) 2008-11-28
NO20053340D0 (no) 2005-07-08
US20060270728A1 (en) 2006-11-30
WO2004052893A3 (en) 2004-08-12
RU2337910C2 (ru) 2008-11-10
UA80453C2 (en) 2007-09-25
CN1726029A (zh) 2006-01-25
US7101903B2 (en) 2006-09-05
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AU2003296322A1 (en) 2004-06-30

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