MY102212A - Cephalosporin salts and injectable compositions. - Google Patents
Cephalosporin salts and injectable compositions.Info
- Publication number
- MY102212A MY102212A MYPI87002279A MYPI19872279A MY102212A MY 102212 A MY102212 A MY 102212A MY PI87002279 A MYPI87002279 A MY PI87002279A MY PI19872279 A MYPI19872279 A MY PI19872279A MY 102212 A MY102212 A MY 102212A
- Authority
- MY
- Malaysia
- Prior art keywords
- salts
- crystalline
- injectable compositions
- zwitterion
- admixture
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
- C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
CRYSTALLINE SULFURIC, DI-NITRIC, MONO-HYDROCHLORIC DI-HYDROCLORIC, AND DI AND SESQUIORTHOSPHOSPHORIC ADDITION SALTS OF 7-<A-(AMINOTHIAZOL-4-YL)-A-(Z)-METHOXYIMINOACETAMIDO>-3-<(1-METHYL-1-PYRROLIDINIO)-METHYL>-3-CEPHEM-4-CARBOXYLATE ARE STABLE EVEN AT ELEVATED TEMPERATURES. THE CRYSTALLINE SURFURIC ACID ADDITION SALT IS MADE BY FORMING AN ADMIXTURE OF (A) AT LEAST ONE MOLAR EQUIVQLENT OF SULFURICACID WITH (B) ZWITTERION IN AN AMOUNT SO AS TO BE PRESENT IN THE ADMIXTURE AT A CONCENTRATION OF GREATER THAN 25 MILLIGRAMS/ML, CAUSING CRYSTALLIZATION, SEPARATING THE CRYSTALS, WASHINGAND DRYING. THE CRYSTALLINE MONOHYDROCHLORIDE, AND ORTHOPHOSPHATE SALTS ARE PREPARED BY DISSOLVING THE ZWITTERION IN THE APPROPRIATE AMOUNT OF ACID, CAUSING CRYSTALLIZATION BY ADDING ACETONE AND ISOLATING THE CRYSTALS. PHYSICAL ADMIXTURES OF THE SALTS WITH CERTAIN BASES IN PROPORTIONS TO GIVE A PH RANGING FROM ABOUT 3.5 TO ABOUT 7 ON DILUTION WITH WATER PROVIDE INJECTABLE COMPOSITIONS ON DILUTION.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US76223585A | 1985-08-05 | 1985-08-05 | |
| GB8618989A GB2179936B (en) | 1985-08-05 | 1986-08-04 | Cephalosporin salts and injectable compositions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MY102212A true MY102212A (en) | 1992-05-15 |
Family
ID=25064475
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MYPI87002279A MY102212A (en) | 1985-08-05 | 1987-09-29 | Cephalosporin salts and injectable compositions. |
Country Status (34)
| Country | Link |
|---|---|
| JP (1) | JPH0615548B2 (en) |
| KR (1) | KR930003121B1 (en) |
| AR (1) | AR243894A1 (en) |
| AT (1) | AT390957B (en) |
| AU (1) | AU597262B2 (en) |
| BE (1) | BE905219A (en) |
| CA (1) | CA1284994C (en) |
| CH (1) | CH675581A5 (en) |
| CS (2) | CS276849B6 (en) |
| CY (1) | CY1614A (en) |
| DD (2) | DD254941A5 (en) |
| DE (1) | DE3626375A1 (en) |
| DK (1) | DK162053C (en) |
| EG (1) | EG18003A (en) |
| ES (1) | ES2002112A6 (en) |
| FI (1) | FI84484C (en) |
| FR (1) | FR2585705B1 (en) |
| GB (1) | GB2179936B (en) |
| GR (1) | GR862055B (en) |
| HK (1) | HK99691A (en) |
| HU (1) | HU196602B (en) |
| IE (1) | IE59222B1 (en) |
| IL (1) | IL79608A (en) |
| IT (1) | IT1197067B (en) |
| LU (2) | LU88574I2 (en) |
| MY (1) | MY102212A (en) |
| NL (1) | NL8601991A (en) |
| OA (1) | OA08672A (en) |
| PT (1) | PT83134B (en) |
| SE (1) | SE469633B (en) |
| SG (1) | SG79791G (en) |
| SU (1) | SU1516013A3 (en) |
| YU (1) | YU45793B (en) |
| ZA (1) | ZA865842B (en) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4883868A (en) * | 1984-12-27 | 1989-11-28 | Banyu Pharmaceutical Co., Ltd. | 7-amino-3-(substituted isoindolinium)methyl-3-cephem derivatives |
| US4959469A (en) * | 1984-12-27 | 1990-09-25 | Banyu Pharmaceutical Company, Ltd. | Crystalline cephalosporin compounds |
| US5244891A (en) * | 1985-08-05 | 1993-09-14 | Bristol-Myers Squibb Company | Injectable compositions of cefepime dihydrochloride hydrate |
| US4910301A (en) * | 1985-08-05 | 1990-03-20 | Bristol-Myers Company | Cefepime cephalosporin salts |
| US4808617A (en) * | 1985-12-18 | 1989-02-28 | Bristol-Myers Company | Lyophilized or precipitated cephalosporin zwitterion and salt combination |
| EP0321562B1 (en) * | 1987-06-25 | 1993-11-24 | Banyu Pharmaceutical Co., Ltd. | Crystalline cephalosporin compounds, process for their preparation, and intermediates for their preparation |
| JPH02101081A (en) * | 1988-10-08 | 1990-04-12 | Meiji Seika Kaisha Ltd | Crystalline dihydrochloride of cephalosporin derivative and production thereof |
| CA2011116C (en) * | 1989-03-06 | 1999-11-16 | Murray A. Kaplan | Lyophilized bmy-28142 dihydrochloride for parenteral use |
| CA2101571A1 (en) * | 1992-09-08 | 1994-03-09 | Elizabeth A. Garofalo | Crystalline dihydrate of a cephalosporin dihydrate salt and injectable compositions thereof |
| EP0638573A1 (en) * | 1993-08-10 | 1995-02-15 | Lucky Ltd. | Crystalline hydrates of cephalosporin and process for preparation thereof |
| EP1699804B1 (en) | 2003-12-23 | 2008-02-06 | Sandoz Gmbh | Process for production of intermediates for use in cefalosporin synthesis |
| WO2008056221A2 (en) * | 2006-11-06 | 2008-05-15 | Orchid Chemicals & Pharmaceuticals Limited | Crystalline sulfate salt of cephalosporin antibiotic |
| DE102012101680A1 (en) * | 2012-02-29 | 2013-08-29 | Aicuris Gmbh & Co. Kg | Pharmaceutical preparation containing an antiviral dihydroquinazoline derivative |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS55151588A (en) * | 1979-05-14 | 1980-11-26 | Takeda Chem Ind Ltd | Preparation of cephalosporin salt crystal |
| US4406899A (en) * | 1982-03-04 | 1983-09-27 | Bristol-Myers Company | Cephalosporins |
| CA1213882A (en) * | 1982-03-04 | 1986-11-12 | Jun Okumura | Cephalosporins |
| US4525473A (en) * | 1983-03-30 | 1985-06-25 | Bristol-Myers Company | Cephalosporins |
| DE3419015A1 (en) * | 1984-05-22 | 1985-11-28 | Bayer Ag, 5090 Leverkusen | METHOD FOR PRODUCING CEPHALOSPORINES |
| GB8424692D0 (en) * | 1984-10-01 | 1984-11-07 | Glaxo Group Ltd | Chemical compounds |
| GB2165245B (en) * | 1984-10-01 | 1988-05-25 | Glaxo Group Ltd | Chemical compounds |
-
1986
- 1986-07-28 CA CA000514766A patent/CA1284994C/en not_active Expired - Lifetime
- 1986-07-28 FR FR8610892A patent/FR2585705B1/en not_active Expired
- 1986-07-29 AR AR86304717A patent/AR243894A1/en active
- 1986-07-30 AU AU60694/86A patent/AU597262B2/en not_active Expired
- 1986-07-31 YU YU137186A patent/YU45793B/en unknown
- 1986-08-01 FI FI863155A patent/FI84484C/en not_active IP Right Cessation
- 1986-08-01 IE IE207886A patent/IE59222B1/en not_active IP Right Cessation
- 1986-08-04 JP JP61183288A patent/JPH0615548B2/en not_active Expired - Lifetime
- 1986-08-04 CH CH3117/86A patent/CH675581A5/de not_active IP Right Cessation
- 1986-08-04 GB GB8618989A patent/GB2179936B/en not_active Expired
- 1986-08-04 LU LU88574C patent/LU88574I2/en unknown
- 1986-08-04 CS CS903570A patent/CS276849B6/en unknown
- 1986-08-04 SE SE8603308A patent/SE469633B/en not_active IP Right Cessation
- 1986-08-04 DK DK371886A patent/DK162053C/en not_active IP Right Cessation
- 1986-08-04 PT PT83134A patent/PT83134B/en unknown
- 1986-08-04 BE BE07217010A patent/BE905219A/en not_active IP Right Cessation
- 1986-08-04 CS CS865827A patent/CS276717B6/en unknown
- 1986-08-04 IT IT21409/86A patent/IT1197067B/en active Protection Beyond IP Right Term
- 1986-08-04 LU LU86540A patent/LU86540A1/en unknown
- 1986-08-04 NL NL8601991A patent/NL8601991A/en not_active Application Discontinuation
- 1986-08-04 DE DE19863626375 patent/DE3626375A1/en not_active Ceased
- 1986-08-04 IL IL79608A patent/IL79608A/en not_active IP Right Cessation
- 1986-08-04 GR GR862055A patent/GR862055B/en unknown
- 1986-08-04 ZA ZA865842A patent/ZA865842B/en unknown
- 1986-08-04 SU SU864027914A patent/SU1516013A3/en active
- 1986-08-05 AT AT0211086A patent/AT390957B/en not_active IP Right Cessation
- 1986-08-05 KR KR1019860006445A patent/KR930003121B1/en not_active IP Right Cessation
- 1986-08-05 ES ES8600872A patent/ES2002112A6/en not_active Expired
- 1986-08-05 HU HU863376A patent/HU196602B/en unknown
- 1986-08-05 OA OA58918A patent/OA08672A/en unknown
- 1986-08-05 DD DD86293433A patent/DD254941A5/en unknown
-
1987
- 1987-09-29 MY MYPI87002279A patent/MY102212A/en unknown
-
1988
- 1988-03-30 DD DD88314213A patent/DD268395A5/en unknown
-
1989
- 1989-08-04 EG EG489/86A patent/EG18003A/en active
-
1991
- 1991-10-02 SG SG797/91A patent/SG79791G/en unknown
- 1991-12-05 HK HK996/91A patent/HK99691A/en not_active IP Right Cessation
-
1992
- 1992-07-10 CY CY1614A patent/CY1614A/en unknown
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