HUT41802A - Process for producing salts of cephalosporins and injection compositions containing them - Google Patents

Process for producing salts of cephalosporins and injection compositions containing them

Info

Publication number: HUT41802A
Authority: HU; Hungary
Prior art keywords: cephalosporins; compositions containing; injection compositions; producing salts; salts
Prior art date: 1985-08-05

Application number

HU863376A

Other languages

Hungarian (hu)

Other versions

HU196602B (en

Inventor

Murray Kaplan

Thomas W Hudima

Robert A Lipper

Original Assignee

Bristol Myers Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-08-05

Filing date

1986-08-05

Publication date

1987-05-28

1986-08-05 Application filed by Bristol Myers Co filed Critical Bristol Myers Co

1987-05-28 Publication of HUT41802A publication Critical patent/HUT41802A/en

1988-12-28 Publication of HU196602B publication Critical patent/HU196602B/en

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
- C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Cephalosporin Compounds (AREA)
Medicinal Preparation (AREA)

HU863376A 1985-08-05 1986-08-05 Process for producing acid-addition salts of 7-square brackets open alpha-(aminothiazol-4-yl)-alpha-/z/-methoxy-imino-acetamido square brackets closed -3-square brackets open (1-methyl-1-pyrrolidino)-methyl square brackets closed -3-cefem-4-carboxilate, as well as dry mixtures thereof formed with bases and suitable for producing injectable solutions HU196602B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US76223585A	1985-08-05	1985-08-05

Publications (2)

Publication Number	Publication Date
HUT41802A true HUT41802A (en)	1987-05-28
HU196602B HU196602B (en)	1988-12-28

Family

ID=25064475

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HU863376A HU196602B (en)	1985-08-05	1986-08-05	Process for producing acid-addition salts of 7-square brackets open alpha-(aminothiazol-4-yl)-alpha-/z/-methoxy-imino-acetamido square brackets closed -3-square brackets open (1-methyl-1-pyrrolidino)-methyl square brackets closed -3-cefem-4-carboxilate, as well as dry mixtures thereof formed with bases and suitable for producing injectable solutions

Country Status (34)

Country	Link
JP (1)	JPH0615548B2 (en)
KR (1)	KR930003121B1 (en)
AR (1)	AR243894A1 (en)
AT (1)	AT390957B (en)
AU (1)	AU597262B2 (en)
BE (1)	BE905219A (en)
CA (1)	CA1284994C (en)
CH (1)	CH675581A5 (en)
CS (2)	CS276849B6 (en)
CY (1)	CY1614A (en)
DD (2)	DD254941A5 (en)
DE (1)	DE3626375A1 (en)
DK (1)	DK162053C (en)
EG (1)	EG18003A (en)
ES (1)	ES2002112A6 (en)
FI (1)	FI84484C (en)
FR (1)	FR2585705B1 (en)
GB (1)	GB2179936B (en)
GR (1)	GR862055B (en)
HK (1)	HK99691A (en)
HU (1)	HU196602B (en)
IE (1)	IE59222B1 (en)
IL (1)	IL79608A (en)
IT (1)	IT1197067B (en)
LU (2)	LU88574I2 (en)
MY (1)	MY102212A (en)
NL (1)	NL8601991A (en)
OA (1)	OA08672A (en)
PT (1)	PT83134B (en)
SE (1)	SE469633B (en)
SG (1)	SG79791G (en)
SU (1)	SU1516013A3 (en)
YU (1)	YU45793B (en)
ZA (1)	ZA865842B (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4883868A (en) *	1984-12-27	1989-11-28	Banyu Pharmaceutical Co., Ltd.	7-amino-3-(substituted isoindolinium)methyl-3-cephem derivatives
US4959469A (en) *	1984-12-27	1990-09-25	Banyu Pharmaceutical Company, Ltd.	Crystalline cephalosporin compounds
US5244891A (en) *	1985-08-05	1993-09-14	Bristol-Myers Squibb Company	Injectable compositions of cefepime dihydrochloride hydrate
US4910301A (en) *	1985-08-05	1990-03-20	Bristol-Myers Company	Cefepime cephalosporin salts
US4808617A (en) *	1985-12-18	1989-02-28	Bristol-Myers Company	Lyophilized or precipitated cephalosporin zwitterion and salt combination
EP0321562B1 (en) *	1987-06-25	1993-11-24	Banyu Pharmaceutical Co., Ltd.	Crystalline cephalosporin compounds, process for their preparation, and intermediates for their preparation
JPH02101081A (en) *	1988-10-08	1990-04-12	Meiji Seika Kaisha Ltd	Crystalline dihydrochloride of cephalosporin derivative and production thereof
CA2011116C (en) *	1989-03-06	1999-11-16	Murray A. Kaplan	Lyophilized bmy-28142 dihydrochloride for parenteral use
CA2101571A1 (en) *	1992-09-08	1994-03-09	Elizabeth A. Garofalo	Crystalline dihydrate of a cephalosporin dihydrate salt and injectable compositions thereof
EP0638573A1 (en) *	1993-08-10	1995-02-15	Lucky Ltd.	Crystalline hydrates of cephalosporin and process for preparation thereof
EP1699804B1 (en)	2003-12-23	2008-02-06	Sandoz Gmbh	Process for production of intermediates for use in cefalosporin synthesis
WO2008056221A2 (en) *	2006-11-06	2008-05-15	Orchid Chemicals & Pharmaceuticals Limited	Crystalline sulfate salt of cephalosporin antibiotic
DE102012101680A1 (en) *	2012-02-29	2013-08-29	Aicuris Gmbh & Co. Kg	Pharmaceutical preparation containing an antiviral dihydroquinazoline derivative

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS55151588A (en) *	1979-05-14	1980-11-26	Takeda Chem Ind Ltd	Preparation of cephalosporin salt crystal
US4406899A (en) *	1982-03-04	1983-09-27	Bristol-Myers Company	Cephalosporins
CA1213882A (en) *	1982-03-04	1986-11-12	Jun Okumura	Cephalosporins
US4525473A (en) *	1983-03-30	1985-06-25	Bristol-Myers Company	Cephalosporins
DE3419015A1 (en) *	1984-05-22	1985-11-28	Bayer Ag, 5090 Leverkusen	METHOD FOR PRODUCING CEPHALOSPORINES
GB8424692D0 (en) *	1984-10-01	1984-11-07	Glaxo Group Ltd	Chemical compounds
GB2165245B (en) *	1984-10-01	1988-05-25	Glaxo Group Ltd	Chemical compounds

1986
- 1986-07-28 CA CA000514766A patent/CA1284994C/en not_active Expired - Lifetime
- 1986-07-28 FR FR8610892A patent/FR2585705B1/en not_active Expired
- 1986-07-29 AR AR86304717A patent/AR243894A1/en active
- 1986-07-30 AU AU60694/86A patent/AU597262B2/en not_active Expired
- 1986-07-31 YU YU137186A patent/YU45793B/en unknown
- 1986-08-01 FI FI863155A patent/FI84484C/en not_active IP Right Cessation
- 1986-08-01 IE IE207886A patent/IE59222B1/en not_active IP Right Cessation
- 1986-08-04 JP JP61183288A patent/JPH0615548B2/en not_active Expired - Lifetime
- 1986-08-04 CH CH3117/86A patent/CH675581A5/de not_active IP Right Cessation
- 1986-08-04 GB GB8618989A patent/GB2179936B/en not_active Expired
- 1986-08-04 LU LU88574C patent/LU88574I2/en unknown
- 1986-08-04 CS CS903570A patent/CS276849B6/en unknown
- 1986-08-04 SE SE8603308A patent/SE469633B/en not_active IP Right Cessation
- 1986-08-04 DK DK371886A patent/DK162053C/en not_active IP Right Cessation
- 1986-08-04 PT PT83134A patent/PT83134B/en unknown
- 1986-08-04 BE BE07217010A patent/BE905219A/en not_active IP Right Cessation
- 1986-08-04 CS CS865827A patent/CS276717B6/en unknown
- 1986-08-04 IT IT21409/86A patent/IT1197067B/en active Protection Beyond IP Right Term
- 1986-08-04 LU LU86540A patent/LU86540A1/en unknown
- 1986-08-04 NL NL8601991A patent/NL8601991A/en not_active Application Discontinuation
- 1986-08-04 DE DE19863626375 patent/DE3626375A1/en not_active Ceased
- 1986-08-04 IL IL79608A patent/IL79608A/en not_active IP Right Cessation
- 1986-08-04 GR GR862055A patent/GR862055B/en unknown
- 1986-08-04 ZA ZA865842A patent/ZA865842B/en unknown
- 1986-08-04 SU SU864027914A patent/SU1516013A3/en active
- 1986-08-05 AT AT0211086A patent/AT390957B/en not_active IP Right Cessation
- 1986-08-05 KR KR1019860006445A patent/KR930003121B1/en not_active IP Right Cessation
- 1986-08-05 ES ES8600872A patent/ES2002112A6/en not_active Expired
- 1986-08-05 HU HU863376A patent/HU196602B/en unknown
- 1986-08-05 OA OA58918A patent/OA08672A/en unknown
- 1986-08-05 DD DD86293433A patent/DD254941A5/en unknown
1987
- 1987-09-29 MY MYPI87002279A patent/MY102212A/en unknown
1988
- 1988-03-30 DD DD88314213A patent/DD268395A5/en unknown
1989
- 1989-08-04 EG EG489/86A patent/EG18003A/en active
1991
- 1991-10-02 SG SG797/91A patent/SG79791G/en unknown
- 1991-12-05 HK HK996/91A patent/HK99691A/en not_active IP Right Cessation
1992
- 1992-07-10 CY CY1614A patent/CY1614A/en unknown

Also Published As

Publication number	Publication date
DD268395A5 (en)	1989-05-31
CA1284994C (en)	1991-06-18
ATA211086A (en)	1990-01-15
DK162053C (en)	1992-02-10
FI84484C (en)	1991-12-10
AT390957B (en)	1990-07-25
IE862078L (en)	1987-02-05
JPS62103090A (en)	1987-05-13
BE905219A (en)	1987-02-04
GR862055B (en)	1986-12-24
IT8621409A0 (en)	1986-08-04
IL79608A0 (en)	1986-11-30
CY1614A (en)	1992-07-10
AU597262B2 (en)	1990-05-31
SE8603308D0 (en)	1986-08-04
NL8601991A (en)	1987-03-02
LU86540A1 (en)	1987-03-06
GB2179936A (en)	1987-03-18
ZA865842B (en)	1987-04-29
FI863155A0 (en)	1986-08-01
AR243894A1 (en)	1993-09-30
PT83134B (en)	1989-07-31
EG18003A (en)	1991-08-30
CS276717B6 (en)	1992-08-12
IT1197067B (en)	1988-11-25
DK371886A (en)	1987-02-06
PT83134A (en)	1986-09-01
FI84484B (en)	1991-08-30
IT8621409A1 (en)	1988-02-04
ES2002112A6 (en)	1988-07-16
DK162053B (en)	1991-09-09
YU137186A (en)	1987-12-31
IE59222B1 (en)	1994-01-26
DK371886D0 (en)	1986-08-04
SE469633B (en)	1993-08-09
CS276849B6 (en)	1992-08-12
FI863155A (en)	1987-02-06
SU1516013A3 (en)	1989-10-15
OA08672A (en)	1989-03-31
FR2585705B1 (en)	1989-01-13
DD254941A5 (en)	1988-03-16
CH675581A5 (en)	1990-10-15
IL79608A (en)	1991-07-18
DE3626375A1 (en)	1987-02-12
HK99691A (en)	1991-12-13
SG79791G (en)	1991-11-15
LU88574I2 (en)	1995-03-01
KR880002530A (en)	1988-05-09
JPH0615548B2 (en)	1994-03-02
YU45793B (en)	1992-07-20
MY102212A (en)	1992-05-15
KR930003121B1 (en)	1993-04-19
SE8603308L (en)	1987-02-06
GB2179936B (en)	1989-04-26
GB8618989D0 (en)	1986-09-17
AU6069486A (en)	1987-02-12
HU196602B (en)	1988-12-28
FR2585705A1 (en)	1987-02-06

Publication	Publication Date	Title
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YU20886A (en)	1988-04-30	Process for producing derivatives of cephem
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HUT39746A (en)	1986-10-29	Process for producing cephalosporin derivatives and pharmaceutical compositions containing them
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HUT39142A (en)	1986-08-28	Process for producing naphtyl-analogues of mevalolactone and derivatives and pharmaceutical compositions containing them
HUT42455A (en)	1987-07-28	Process for production of derivatives of 5-substituated amino-piramidin and medical compositions containing thereof
HUT43785A (en)	1987-12-28	Process for production of medical compounds containing dibenzicyclohetodiene applicable against insuffuciency of liver
HUT41762A (en)	1987-05-28	Process for producing thieno-benzo-pyranes, -thiopyranes and naphtothiophenes and pharmaceutical compositions containing them
HUT38646A (en)	1986-06-30	Process for production of derivatives of spirohydantion and preparatives containing thereof
HUT50764A (en)	1990-03-28	Process for production of new substituated 1-aryl-sulphonil-2-pirro-lidinones and medical compositions containing them

Legal Events

Date	Code	Title	Description
1990-06-28	HU90	Patent valid on 900628