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MXPA05007848A - Derivados de arilalquilcarbamatos, su preparacion y su aplicacion en terapeutica. - Google Patents

Derivados de arilalquilcarbamatos, su preparacion y su aplicacion en terapeutica.

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Publication number
MXPA05007848A
MXPA05007848A MXPA05007848A MXPA05007848A MXPA05007848A MX PA05007848 A MXPA05007848 A MX PA05007848A MX PA05007848 A MXPA05007848 A MX PA05007848A MX PA05007848 A MXPA05007848 A MX PA05007848A MX PA05007848 A MXPA05007848 A MX PA05007848A
Authority
MX
Mexico
Prior art keywords
alkyl
cycloalkyl
therapy
alkylene
optionally substituted
Prior art date
Application number
MXPA05007848A
Other languages
English (en)
Inventor
Ravet Antoine
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of MXPA05007848A publication Critical patent/MXPA05007848A/es

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    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/12—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
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    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
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    • A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
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Abstract

Compuesto que responde a la formula general (I): en la cual n representa un numero entero que va de 1 a 7; A se elige entre uno o varios grupos X, Y y/o Z; X representa un grupo alquileno-C1-2 eventualmente substituido por uno o varios grupos alquilo-C1-12, cicloalquilo-C3-7 o cicloalquilo-C3-7-alquileno-C1-6; y representa un grupo alquenileno-C2 eventualmente substituido por uno o varios grupos alquilo-C1-12, cicloalquilo-C3-7, o cicloalquilo-C3-7-alquileno-C1-6; Z representa un grupo cicloalquilo-C3-7, de formula (II), (III), m representa un numero entero que va de 1 a 5; p y q representan numeros enteros y se definen de forma tal que p+q sea un numero que vaya de 1 a 5; R1 representa un atomo de hidrogeno, de halogeno o un grupo hidroxilo, ciano, nitro, alquilo-C1-4, alcoxi-C1-4, tioalquilo-C1-4, fluoroalquilo-C1-4, fluoroalcoxi-C1-4, fluorotioalquilo-C1-4; R2 representa un atomo de hidrogeno, de halogeno o un grupo ciano, nitro, hidroxilo, alquilo-C1-4, alcoxi-C1-4, tioalquilo- C1-4, fluoroalquilo- C1-4, fluoroalcoxi- C1-4, fluorotioalquilo- C1-4,o un grupo de tipo arilo o heteroarilo eventualmente substituido por uno o varios substituyentes; R3 representa un grupo de formula general CHR4CONHR5 en la cual R4 representa un atomo de hidrogeno o un grupo alquilo-C1-3 y R5 representa un atomo de hidrogeno o un grupo alquilo-C1-3, cicloalquilo-C3-5-, cicloalquilo-C3-7-alquileno-C1-6, en estado de base, de sal de adicion con un acido, de hidrato o de solvato. Para aplicacion en terapeutica.
MXPA05007848A 2003-01-23 2004-01-22 Derivados de arilalquilcarbamatos, su preparacion y su aplicacion en terapeutica. MXPA05007848A (es)

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FR0300704A FR2850377B1 (fr) 2003-01-23 2003-01-23 Derives d'arylalkylcarbamates, leur preparation et leur application en therapeutique
PCT/FR2004/000139 WO2004067498A2 (fr) 2003-01-23 2004-01-22 Derives d’ arylalkylcarbamates, leur preparation et leur application en therapeutique

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Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2864080B1 (fr) * 2003-12-23 2006-02-03 Sanofi Synthelabo Derives de 1-piperazine-et-1-homopiperazine-carboxylates, leur preparation et leur application en therapeutique
FR2865205B1 (fr) 2004-01-16 2006-02-24 Sanofi Synthelabo Derives de type aryloxyalkylcarbamates, leur preparation et leur application en therapeutique
FR2866885B1 (fr) * 2004-02-26 2007-08-31 Sanofi Synthelabo Derives de piperidinylalkylcarbamates, leur prepation et leur application en therapeutique
FR2866886B1 (fr) * 2004-02-26 2007-08-31 Sanofi Synthelabo Derives d'aryl-et d'heteroaryl-akylcarbamates, leur preparation et leur application en therapeutique
FR2866884B1 (fr) * 2004-02-26 2007-08-31 Sanofi Synthelabo Derives d'aryl-et d'heteroaryl-piperidinecarboxylates, leur preparation et leur application en therapeutique
DE102004039326A1 (de) * 2004-08-12 2006-02-16 Abbott Gmbh & Co. Kg Neue medizinische Verwendungen und Verfahren
PL2937341T3 (pl) * 2004-12-30 2017-11-30 Janssen Pharmaceutica N.V. Pochodne fenyloamidowe kwasu 4-(benzylo)-piperazyno-1-karboksylowego oraz związki powiązane, jako modulatory hydrolazy amidu kwasu tłuszczowego (FAAH) do leczenia lęku, bólu i innych schorzeń
US20070155707A1 (en) * 2005-12-29 2007-07-05 Kadmus Pharmaceuticals, Inc. Ionizable inhibitors of fatty acid amide hydrolase
US20080089845A1 (en) * 2006-09-07 2008-04-17 N.V. Organon Methods for determining effective doses of fatty acid amide hydrolase inhibitors in vivo
US20090099240A1 (en) * 2006-10-02 2009-04-16 N.V. Organon Methods for treating energy metabolism disorders by inhibiting fatty acid amide hydrolase activity
EP2096915A1 (en) * 2006-11-20 2009-09-09 N.V. Organon Metabolically-stabilized inhibitors of fatty acid amide hydrolase
US8124605B2 (en) * 2007-07-06 2012-02-28 Kinex Pharmaceuticals, Llc Compositions and methods for modulating a kinase cascade
TW200948805A (en) * 2008-03-07 2009-12-01 Sigma Tau Ind Farmaceuti Enol carbamate derivatives as modulators of fatty acid amide hydrolase
CN101537006B (zh) * 2008-03-18 2012-06-06 中国科学院上海药物研究所 哒嗪酮类化合物在制备抗肿瘤药物中的用途
UA108233C2 (uk) 2010-05-03 2015-04-10 Модулятори активності гідролази амідів жирних кислот
CN103153946B (zh) * 2010-07-28 2015-11-25 加利福尼亚大学董事会 外周限制性 faah 抑制剂
WO2013028570A2 (en) 2011-08-19 2013-02-28 The Regents Of The University Of California Meta-substituted biphenyl peripherally restricted faah inhibitors
EP2890680B1 (en) 2012-08-30 2018-02-28 Athenex, Inc. N-(3-fluorobenzyl)-2-(5-(4-morpholinophenyl)pyridin-2-yl) acetamide as protein tyrosine kinase modulators
EP3988540A1 (en) 2014-04-07 2022-04-27 The Regents of the University of California Inhibitors of fatty acid amide hydrolase (faah) enzyme with improved oral bioavailability and their use as medicaments
IL283183B2 (en) * 2018-11-20 2025-05-01 Bayer Ag Alpha2-Adrenoceptor Subtype 2 (ALPHA-2C) Antagonists for the Treatment of Sleep Apnea
CN118515624B (zh) * 2024-04-29 2025-01-24 聊城金歌合成材料有限公司 一种含三氟甲基多取代恶唑烷-4-酮的合成方法及应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2909467A (en) * 1958-07-09 1959-10-20 Us Vitamin Pharm Corp 3-(d-alpha-methylphenethyl)-5-methyl-1, 3-oxazolidine-2, 4-dione
IT649883A (es) * 1960-05-24
US3742022A (en) * 1967-05-08 1973-06-26 A Verbiscar Carbamate esters of physiologically active ph enenthylamines
DE3003653A1 (de) * 1980-02-01 1981-08-06 Hoechst Ag, 6000 Frankfurt Verfahren zur herstellung von n-substituierten oxazolindionen-(2,4)
JP2616989B2 (ja) * 1989-04-03 1997-06-04 株式会社トクヤマ ２，４―オキサゾリジンジオン化合物
EP0545478A1 (en) * 1991-12-03 1993-06-09 MERCK SHARP & DOHME LTD. Heterocyclic compounds as tachykinin antagonists
GB9210744D0 (en) * 1992-05-20 1992-07-08 Pfizer Ltd Antiviral peptides
US6462054B1 (en) * 2000-03-27 2002-10-08 The Scripps Research Institute Inhibitors of fatty acid amide hydrolase
IL158300A0 (en) * 2001-04-27 2004-05-12 Bristol Myers Squibb Co Bisarylimidazol derivatives and pharmaceutical compositions containing the same
WO2003065989A2 (en) * 2002-02-08 2003-08-14 Bristol-Myers Squibb Company (oxime)carbamoyl fatty acid amide hydrolase inhibitors

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CA2511941A1 (en) 2004-08-12
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DE602004026826D1 (de) 2010-06-10
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JP2006517218A (ja) 2006-07-20
FR2850377B1 (fr) 2009-02-20
TWI330628B (en) 2010-09-21
BRPI0406901A (pt) 2005-12-13
CN101058564A (zh) 2007-10-24
AU2004207657B2 (en) 2010-09-16
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JP4617292B2 (ja) 2011-01-19
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