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MXPA04007776A - Derivados de sulfonilamino como nuevos inhibidores de histona deacetilasa. - Google Patents

Derivados de sulfonilamino como nuevos inhibidores de histona deacetilasa.

Info

Publication number
MXPA04007776A
MXPA04007776A MXPA04007776A MXPA04007776A MXPA04007776A MX PA04007776 A MXPA04007776 A MX PA04007776A MX PA04007776 A MXPA04007776 A MX PA04007776A MX PA04007776 A MXPA04007776 A MX PA04007776A MX PA04007776 A MXPA04007776 A MX PA04007776A
Authority
MX
Mexico
Prior art keywords
histone deacetylase
sulfonylamino
derivatives
novel inhibitors
novel
Prior art date
Application number
MXPA04007776A
Other languages
English (en)
Inventor
Isabelle Noele Constan Pilatte
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of MXPA04007776A publication Critical patent/MXPA04007776A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/402—1-aryl substituted, e.g. piretanide
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Abstract

Esta invencion comprende los nuevos compuestos de formula (I)(ver formula I)en donde n, m, t, R1, R2, R3, R4, R5 , L, Q, X, Y, Z Y (ver formula) tienen los significados definidos, que tienen actividad enzimatica inhibitoria de histona deacetilasa; su preparacion, composiciones que contienen los mismos y su uso como una medicina.
MXPA04007776A 2002-03-13 2003-03-11 Derivados de sulfonilamino como nuevos inhibidores de histona deacetilasa. MXPA04007776A (es)

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PCT/EP2003/002517 WO2003076401A1 (en) 2002-03-13 2003-03-11 Sulfonylamino-derivatives as novel inhibitors of histone deacetylase

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