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MXPA04006029A - Derivados novedosos de benzofuranimidazolina y benzodifuranimidazolina y su uso para el tratamiento de glaucoma. - Google Patents

Derivados novedosos de benzofuranimidazolina y benzodifuranimidazolina y su uso para el tratamiento de glaucoma.

Info

Publication number
MXPA04006029A
MXPA04006029A MXPA04006029A MXPA04006029A MXPA04006029A MX PA04006029 A MXPA04006029 A MX PA04006029A MX PA04006029 A MXPA04006029 A MX PA04006029A MX PA04006029 A MXPA04006029 A MX PA04006029A MX PA04006029 A MXPA04006029 A MX PA04006029A
Authority
MX
Mexico
Prior art keywords
derivatives
benzofuranimidazoline
benzodifuranimidazoline
glaucoma
novel
Prior art date
Application number
MXPA04006029A
Other languages
English (en)
Inventor
Mark R Hellberg
Original Assignee
Alcon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alcon Inc filed Critical Alcon Inc
Publication of MXPA04006029A publication Critical patent/MXPA04006029A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invencion proporciona derivados de benzodifurano imidazolina y derivados de benzofuran imidazolina para reducir la presion intraocular y proporcionar una neuroproteccion ocular.
MXPA04006029A 2001-12-20 2002-12-09 Derivados novedosos de benzofuranimidazolina y benzodifuranimidazolina y su uso para el tratamiento de glaucoma. MXPA04006029A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34337801P 2001-12-20 2001-12-20
PCT/US2002/039316 WO2003053436A1 (en) 2001-12-20 2002-12-09 Novel benzodifuranimidazoline and benzofuranimidazoline derivatives and their use for the treatment of glaucoma

Publications (1)

Publication Number Publication Date
MXPA04006029A true MXPA04006029A (es) 2004-09-27

Family

ID=23345873

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA04006029A MXPA04006029A (es) 2001-12-20 2002-12-09 Derivados novedosos de benzofuranimidazolina y benzodifuranimidazolina y su uso para el tratamiento de glaucoma.

Country Status (13)

Country Link
US (1) US7208512B2 (es)
EP (1) EP1455780A4 (es)
JP (1) JP2005513103A (es)
KR (1) KR20040068315A (es)
CN (1) CN1268334C (es)
AR (1) AR037880A1 (es)
AU (1) AU2002353088B2 (es)
BR (1) BR0215172A (es)
CA (1) CA2469904A1 (es)
MX (1) MXPA04006029A (es)
TW (1) TW593302B (es)
WO (1) WO2003053436A1 (es)
ZA (1) ZA200404473B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6960579B1 (en) 1998-05-19 2005-11-01 Alcon Manufacturing, Ltd. Serotonergic 5HT7 receptor compounds for treating ocular and CNS disorders
TW593302B (en) 2001-12-20 2004-06-21 Alcon Inc Novel benzodifuranimidazoline and benzofuranimidazoline derivatives and their use for the treatment of glaucoma
WO2004054572A2 (en) 2002-12-13 2004-07-01 Alcon, Inc. Novel benzopyran analogs and their use for the treatment of glaucoma
US7476687B2 (en) * 2003-11-26 2009-01-13 Alcon, Inc. Substituted furo[2,3-g]indazoles for the treatment of glaucoma
AR046890A1 (es) 2003-12-15 2005-12-28 Alcon Inc [1,4] oxazino [2,3-g] indazoles sustituidos para el tratamiento del glaucoma.
US7129257B1 (en) 2003-12-15 2006-10-31 Alcon, Inc. Pyrazolo[3,4- e]benzoxazoles for the treatment of glaucoma
US7338972B1 (en) 2003-12-15 2008-03-04 Alcon, Inc. Substituted 1-alkylamino-1H-indazoles for the treatment of glaucoma
WO2006062839A1 (en) 2004-12-08 2006-06-15 Alcon, Inc. Use of dioxindoindazoles and dioxoloindazoles for treating glaucoma
TW200744567A (en) * 2005-09-23 2007-12-16 Alcon Inc Phenylethylamine analogs and their use for treating glaucoma
WO2007149728A2 (en) * 2006-06-20 2007-12-27 Alcon Research, Ltd. Aryl and heteroaryl tetrahydrobenzazepine derivatives and their use for treating glaucoma

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ES323985A1 (es) 1966-02-26 1966-12-16 Blade Pique Juan Procedimiento para la obtenciën de derivados del imidazol
US5011846A (en) * 1988-02-23 1991-04-30 Merrell Dow Pharmaceuticals Inc. Medicament compositions derived from quinolizine and quinolizinone and methods of use thereof
AU7124691A (en) * 1990-02-27 1991-08-29 Ciba-Geigy Ag Benzofurans
EP1293525A3 (en) 1990-06-26 2005-09-07 AorTech Biomaterials Pty Ltd Polyurethane or polyurethan-urea elastomeric compositions
US5578612A (en) * 1990-10-15 1996-11-26 Pfizer Inc. Indole derivatives
DK0593513T3 (da) * 1991-06-21 1999-07-05 Smithkline Beecham Plc Tryptaminanaloger, deres syntese og deres anvendelse som 5-HT,-lignende eller 5-HT2-receptoragonister
GB9216380D0 (en) * 1992-07-31 1992-09-16 Glaxo Group Ltd Medicaments
US5290781A (en) * 1993-01-05 1994-03-01 Iolab Corporation Ketaneserinol as an agent to reduce intraocular pressure
US5891131A (en) * 1993-02-01 1999-04-06 Arizona Board Of Regents Method and apparatus for automated simulation and design of corneal refractive procedures
TW270114B (es) * 1993-10-22 1996-02-11 Hoffmann La Roche
TW334423B (en) * 1993-10-22 1998-06-21 Hoffmann La Roche Tricyclic 1-aminoethylpyrrole-derivatives
US5538974A (en) * 1994-01-27 1996-07-23 Senju Pharamceutical Co., Ltd. Ophthalmic composition for lowering intraocular pressure
US5652272A (en) * 1994-03-18 1997-07-29 Senju Pharmaceutical Co., Ltd. Ophthalmic preparations for reducing intraocular pressure
TW403738B (en) * 1994-08-12 2000-09-01 Hoffmann La Roche Tricyclic pyrazole derivatives
US5874477A (en) * 1994-08-12 1999-02-23 The University Of Hawaii Method of treatment for malaria utilizing serotonin receptor ligands
US5998467A (en) 1995-10-25 1999-12-07 Mitsubishi Chemical Corporation Medicine for oculopathy
AU2340997A (en) 1996-03-27 1997-10-17 Merck & Co., Inc. A method for inhibiting clot formation
US5902815A (en) * 1996-09-03 1999-05-11 Washington University Use of 5HT-2A serotonin agonists to prevent adverse effects of NMDA receptor hypofunction
AU4249297A (en) 1996-10-31 1998-05-22 Alcon Laboratories, Inc. Opthalmological compositions containing serotonin 5-ht1a receptor agonist and their use in the treatment of glaucoma
GB9700899D0 (en) 1997-01-17 1997-03-05 Smithkline Beecham Plc Novel treatment
EP1071701A4 (en) * 1998-04-14 2004-04-21 Arena Pharm Inc NON-ENDOGENOUS FORMS CONSTITUTING ACTIVITY OF HUMAN SEROTONIN RECEPTORS AND THEIR SMALL MODULATING MOLECULES
CA2332505A1 (en) 1998-05-19 1999-11-25 Alcon Laboratories, Inc. Serotonergic 5ht7 receptor compounds for treating ocular and cns disorders
GB9819035D0 (en) 1998-09-01 1998-10-28 Cerebrus Res Ltd Chemical compounds VII
GB9819033D0 (en) 1998-09-01 1998-10-28 Cerebrus Ltd Chemical compounds VI
EP1112106B1 (en) * 1998-09-18 2005-11-23 Alcon Manufacturing Ltd. Serotonergic 5ht2 agonists for treating glaucoma
BR9916326A (pt) 1998-12-17 2001-10-02 American Home Prod Derivados de 2,3,4,4a-tetrahidro-1h-pirazino(1,2-a)quinoxalin-5-(6h) ona sendo agonistas de 5ht2c
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AU2001219185A1 (en) * 2000-03-17 2001-10-03 Alcon, Inc. 2-acylaminobenzimidazole derivatives for treating glaucoma
JP2003528085A (ja) 2000-03-17 2003-09-24 アルコン，インコーポレイティド 緑内障治療のための６−ヒドロキシ・インダゾール誘導体
AU1603401A (en) 2000-03-17 2001-10-03 Alcon Universal Ltd Pyranoindoles for treating glaucoma
AU1607101A (en) 2000-03-17 2001-10-03 Alcon Universal Ltd 5HT<sub>2</sub> agonists for controlling IOP and treating glaucoma
MXPA02008825A (es) 2000-03-17 2004-10-15 Alcon Inc Derivados 5-hidroxi indazol para tratamiento de glaucoma.
US6806285B1 (en) * 2000-03-17 2004-10-19 Alcon, Inc. 5-Hydroxyl indole derivatives for treating glaucoma
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WO2002098400A1 (en) 2001-06-01 2002-12-12 Alcon, Inc. Novel arylaminopropane analogues and their use for the treatment of glaucoma
PL366636A1 (en) * 2001-06-01 2005-02-07 Alcon, Inc. Pyranoindazoles and their use for the treatment of glaucoma
US6884816B2 (en) * 2001-08-31 2005-04-26 Alcon, Inc. Hydroxy substituted fused naphthyl-azoles and fused indeno-azoles and their use for the treatment of glaucoma
CA2469663A1 (en) 2001-12-14 2003-06-26 Alcon, Inc. Aminoalkyl-benzofuran-5-ol compounds for the treatment of glaucoma
AU2002364711A1 (en) 2001-12-14 2003-06-30 Alcon, Inc. Substituted 5-hydroxy-indole compounds for the treatment of glaucoma
TW593302B (en) 2001-12-20 2004-06-21 Alcon Inc Novel benzodifuranimidazoline and benzofuranimidazoline derivatives and their use for the treatment of glaucoma
CN1678302A (zh) 2002-08-30 2005-10-05 爱尔康公司 取代的5－苯并二氢吡喃－5－基－乙胺化合物及其在治疗青光眼中的用途
US20060106106A1 (en) 2002-09-24 2006-05-18 Glennon Richard A Beta-hydroxyphenylalkylamines and their use for treating glaucoma
WO2004054572A2 (en) 2002-12-13 2004-07-01 Alcon, Inc. Novel benzopyran analogs and their use for the treatment of glaucoma
WO2004058725A1 (en) 2002-12-23 2004-07-15 Alcon, Inc. 1-alkyl-3-aminoindazoles

Also Published As

Publication number Publication date
AU2002353088A1 (en) 2003-07-09
CA2469904A1 (en) 2003-07-03
TW593302B (en) 2004-06-21
BR0215172A (pt) 2004-10-19
EP1455780A1 (en) 2004-09-15
WO2003053436A1 (en) 2003-07-03
TW200301257A (en) 2003-07-01
CN1268334C (zh) 2006-08-09
AU2002353088B2 (en) 2006-09-21
US20060009503A1 (en) 2006-01-12
CN1606441A (zh) 2005-04-13
AR037880A1 (es) 2004-12-09
EP1455780A4 (en) 2005-04-06
US7208512B2 (en) 2007-04-24
JP2005513103A (ja) 2005-05-12
KR20040068315A (ko) 2004-07-30
ZA200404473B (en) 2005-06-07

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