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AR037880A1 - Derivados de benzodifuranimidazolina y benzofuranimidazolina y su uso para el tratamiento de glaucoma - Google Patents

Derivados de benzodifuranimidazolina y benzofuranimidazolina y su uso para el tratamiento de glaucoma

Info

Publication number
AR037880A1
AR037880A1 ARP020104911A ARP020104911A AR037880A1 AR 037880 A1 AR037880 A1 AR 037880A1 AR P020104911 A ARP020104911 A AR P020104911A AR P020104911 A ARP020104911 A AR P020104911A AR 037880 A1 AR037880 A1 AR 037880A1
Authority
AR
Argentina
Prior art keywords
alkyl
derivatives
link
benzofuranimidazolina
benzodifuranimidazolina
Prior art date
Application number
ARP020104911A
Other languages
English (en)
Original Assignee
Alcon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alcon Inc filed Critical Alcon Inc
Publication of AR037880A1 publication Critical patent/AR037880A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente proporciona derivados de benzodifuran imidazolina y derivados de benzofuran imidazolina para la disminución de la presión intraocular y para proporcionar neuroprotección ocular. Reivindicación 1: Un compuesto de la fórmula (1)en donde A, B y D se seleccionan en forma independiente entre ya sea N o C, con la condición de que por lo menos uno de A, B o D es N; E es C o N; R es H o alquilo C1-4; R2 y R3 son de forma independiente, H, alquilo C1-3, alquenilo C2-3, o R2 y R3 tomados juntos pueden formar un anillo de 5 ó 6 miembros; X es hidrógeno, halógeno, alquilo C1-4 o CF3; y el enlace delinea de puntos puede ser un enlace simple o un enlace doble; y sales farmacéuticamente aceptables y solvatos.
ARP020104911A 2001-12-20 2002-12-17 Derivados de benzodifuranimidazolina y benzofuranimidazolina y su uso para el tratamiento de glaucoma AR037880A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US34337801P 2001-12-20 2001-12-20

Publications (1)

Publication Number Publication Date
AR037880A1 true AR037880A1 (es) 2004-12-09

Family

ID=23345873

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP020104911A AR037880A1 (es) 2001-12-20 2002-12-17 Derivados de benzodifuranimidazolina y benzofuranimidazolina y su uso para el tratamiento de glaucoma

Country Status (13)

Country Link
US (1) US7208512B2 (es)
EP (1) EP1455780A4 (es)
JP (1) JP2005513103A (es)
KR (1) KR20040068315A (es)
CN (1) CN1268334C (es)
AR (1) AR037880A1 (es)
AU (1) AU2002353088B2 (es)
BR (1) BR0215172A (es)
CA (1) CA2469904A1 (es)
MX (1) MXPA04006029A (es)
TW (1) TW593302B (es)
WO (1) WO2003053436A1 (es)
ZA (1) ZA200404473B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6960579B1 (en) 1998-05-19 2005-11-01 Alcon Manufacturing, Ltd. Serotonergic 5HT7 receptor compounds for treating ocular and CNS disorders
TW593302B (en) 2001-12-20 2004-06-21 Alcon Inc Novel benzodifuranimidazoline and benzofuranimidazoline derivatives and their use for the treatment of glaucoma
BR0316775A (pt) 2002-12-13 2005-11-01 Alcon Inc Novos análogos de benzopirano e seu uso para o tratamento de glaucoma
WO2005053688A1 (en) * 2003-11-26 2005-06-16 Alcon, Inc. Substituted furo[2,3-g] indazoles for the treatment of glaucoma
US7129257B1 (en) 2003-12-15 2006-10-31 Alcon, Inc. Pyrazolo[3,4- e]benzoxazoles for the treatment of glaucoma
US7338972B1 (en) 2003-12-15 2008-03-04 Alcon, Inc. Substituted 1-alkylamino-1H-indazoles for the treatment of glaucoma
AR046890A1 (es) 2003-12-15 2005-12-28 Alcon Inc [1,4] oxazino [2,3-g] indazoles sustituidos para el tratamiento del glaucoma.
WO2006062839A1 (en) 2004-12-08 2006-06-15 Alcon, Inc. Use of dioxindoindazoles and dioxoloindazoles for treating glaucoma
TW200744567A (en) * 2005-09-23 2007-12-16 Alcon Inc Phenylethylamine analogs and their use for treating glaucoma
US20070293475A1 (en) * 2006-06-20 2007-12-20 Alcon Manufacturing Ltd. Aryl and heteroaryl tetrahydrobenzazepine derivatives and their use for treating glaucoma

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TW334423B (en) * 1993-10-22 1998-06-21 Hoffmann La Roche Tricyclic 1-aminoethylpyrrole-derivatives
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US5902815A (en) * 1996-09-03 1999-05-11 Washington University Use of 5HT-2A serotonin agonists to prevent adverse effects of NMDA receptor hypofunction
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BR9910590A (pt) 1998-05-19 2001-01-23 Alcon Lab Inc Composto, processo para diminuir iop, para melhorar o fluxo sanguìneo para a extremidade do nervo óptico e a retina, e para tratar doenças retinais, composições para diminuir iop, para melhorar o fluxo sanguìneo para a extremidade do nervo óptico e a retina, e para tratar doenças retinais, processo e composição para prover neuroproteção para a extremidade do nervo óptico ou a retina, e, processo para tratar pessoas sofrendo de distúrbios do sono, depressão, esquizofrenia, ansiedade, distúrbios rìtmicos circadianos e hipertensão centralmente e perifericamente mediada
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Also Published As

Publication number Publication date
US7208512B2 (en) 2007-04-24
JP2005513103A (ja) 2005-05-12
US20060009503A1 (en) 2006-01-12
ZA200404473B (en) 2005-06-07
CN1606441A (zh) 2005-04-13
AU2002353088B2 (en) 2006-09-21
CN1268334C (zh) 2006-08-09
EP1455780A1 (en) 2004-09-15
KR20040068315A (ko) 2004-07-30
AU2002353088A1 (en) 2003-07-09
MXPA04006029A (es) 2004-09-27
CA2469904A1 (en) 2003-07-03
WO2003053436A1 (en) 2003-07-03
TW200301257A (en) 2003-07-01
BR0215172A (pt) 2004-10-19
TW593302B (en) 2004-06-21
EP1455780A4 (en) 2005-04-06

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