MXPA03010373A - Naphtothiazine positive allosteric ampa receptor modulators (paarm). - Google Patents
Naphtothiazine positive allosteric ampa receptor modulators (paarm).Info
- Publication number
- MXPA03010373A MXPA03010373A MXPA03010373A MXPA03010373A MXPA03010373A MX PA03010373 A MXPA03010373 A MX PA03010373A MX PA03010373 A MXPA03010373 A MX PA03010373A MX PA03010373 A MXPA03010373 A MX PA03010373A MX PA03010373 A MXPA03010373 A MX PA03010373A
- Authority
- MX
- Mexico
- Prior art keywords
- receptor modulators
- paarm
- naphtothiazine
- positive allosteric
- ampa receptor
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/02—1,2-Thiazines; Hydrogenated 1,2-thiazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Abstract
The present invention relates to new positive allosteric AMPA-receptor modulators of general formula (I), wherein R1, R2, R3, R4 and R5 may have the meanings given in the specification and claims, processes for preparing them and the use thereof as pharmaceutical compositions.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10123952A DE10123952A1 (en) | 2001-05-17 | 2001-05-17 | New naphtho-1,2-thiazine compounds, useful as neuroprotectants for treating e.g. epilepsy or Alzheimer's disease, are allosteric modulators of AMPA receptors |
| PCT/EP2002/005338 WO2002100411A1 (en) | 2001-05-17 | 2002-05-15 | Naphtothiazine positive allosteric ampa receptor modulators (paarm) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA03010373A true MXPA03010373A (en) | 2004-03-16 |
Family
ID=7685080
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MXPA03010373A MXPA03010373A (en) | 2001-05-17 | 2002-05-15 | Naphtothiazine positive allosteric ampa receptor modulators (paarm). |
Country Status (26)
| Country | Link |
|---|---|
| EP (1) | EP1404340A1 (en) |
| JP (1) | JP2004529980A (en) |
| KR (1) | KR20040007572A (en) |
| CN (1) | CN1533278A (en) |
| AR (1) | AR036332A1 (en) |
| BG (1) | BG108324A (en) |
| BR (1) | BR0209796A (en) |
| CA (1) | CA2449189A1 (en) |
| CO (1) | CO5550460A2 (en) |
| CZ (1) | CZ20033112A3 (en) |
| DE (1) | DE10123952A1 (en) |
| EA (1) | EA006608B1 (en) |
| EC (1) | ECSP034852A (en) |
| EE (1) | EE200300566A (en) |
| HR (1) | HRP20030933A2 (en) |
| HU (1) | HUP0401273A3 (en) |
| IL (1) | IL158642A0 (en) |
| MX (1) | MXPA03010373A (en) |
| NO (1) | NO20035088L (en) |
| NZ (1) | NZ530154A (en) |
| PL (1) | PL364053A1 (en) |
| SK (1) | SK14222003A3 (en) |
| UY (1) | UY27290A1 (en) |
| WO (1) | WO2002100411A1 (en) |
| YU (1) | YU90403A (en) |
| ZA (1) | ZA200308466B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2061471A4 (en) * | 2006-08-31 | 2012-02-01 | Univ Alberta | METHOD OF INHIBITING RESPIRATORY DEPRESSION IN WHICH AMPA RECEPTORS ARE POSITIVE ALLOSTERIC MODULATORS |
| CN111518058B (en) * | 2020-05-29 | 2021-03-09 | 四川大学华西医院 | Oxathiazine compound and application thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU4345297A (en) * | 1996-09-17 | 1998-04-14 | Regents Of The University Of California, The | Benzothiadiazide derivatives and their use as allosteric up-modulators of the ampa receptor |
| EP1090000A4 (en) * | 1998-06-25 | 2002-11-27 | Merck & Co Inc | Naphtho 1,8-de]thiasin-2-yl methyl carbapenem antibacterials |
| DE10004572A1 (en) * | 2000-02-02 | 2001-08-09 | Boehringer Ingelheim Pharma | New positive allosteric AMPA receptor modulators (PAARM), processes for their production and their use as medicines |
-
2001
- 2001-05-17 DE DE10123952A patent/DE10123952A1/en not_active Withdrawn
-
2002
- 2002-05-15 SK SK1422-2003A patent/SK14222003A3/en unknown
- 2002-05-15 MX MXPA03010373A patent/MXPA03010373A/en unknown
- 2002-05-15 BR BR0209796-6A patent/BR0209796A/en not_active Expired - Fee Related
- 2002-05-15 CN CNA028100832A patent/CN1533278A/en active Pending
- 2002-05-15 IL IL15864202A patent/IL158642A0/en unknown
- 2002-05-15 EA EA200301167A patent/EA006608B1/en not_active IP Right Cessation
- 2002-05-15 CA CA002449189A patent/CA2449189A1/en not_active Abandoned
- 2002-05-15 NZ NZ530154A patent/NZ530154A/en unknown
- 2002-05-15 HU HU0401273A patent/HUP0401273A3/en unknown
- 2002-05-15 PL PL02364053A patent/PL364053A1/en not_active Application Discontinuation
- 2002-05-15 CZ CZ20033112A patent/CZ20033112A3/en unknown
- 2002-05-15 JP JP2003503232A patent/JP2004529980A/en not_active Abandoned
- 2002-05-15 EP EP02750931A patent/EP1404340A1/en not_active Withdrawn
- 2002-05-15 UY UY27290A patent/UY27290A1/en not_active Application Discontinuation
- 2002-05-15 EE EEP200300566A patent/EE200300566A/en unknown
- 2002-05-15 YU YU90403A patent/YU90403A/en unknown
- 2002-05-15 WO PCT/EP2002/005338 patent/WO2002100411A1/en not_active Application Discontinuation
- 2002-05-15 KR KR10-2003-7014965A patent/KR20040007572A/en not_active Application Discontinuation
- 2002-05-17 AR ARP020101827A patent/AR036332A1/en not_active Suspension/Interruption
-
2003
- 2003-10-30 ZA ZA200308466A patent/ZA200308466B/en unknown
- 2003-11-07 BG BG108324A patent/BG108324A/en active Pending
- 2003-11-14 HR HR20030933A patent/HRP20030933A2/en not_active Application Discontinuation
- 2003-11-14 NO NO20035088A patent/NO20035088L/en not_active Application Discontinuation
- 2003-11-17 EC EC2003004852A patent/ECSP034852A/en unknown
- 2003-12-01 CO CO03105591A patent/CO5550460A2/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2004529980A (en) | 2004-09-30 |
| DE10123952A1 (en) | 2002-11-21 |
| CN1533278A (en) | 2004-09-29 |
| NO20035088D0 (en) | 2003-11-14 |
| EE200300566A (en) | 2004-02-16 |
| EP1404340A1 (en) | 2004-04-07 |
| KR20040007572A (en) | 2004-01-24 |
| NO20035088L (en) | 2003-11-14 |
| YU90403A (en) | 2006-05-25 |
| UY27290A1 (en) | 2002-12-31 |
| HUP0401273A2 (en) | 2004-10-28 |
| NZ530154A (en) | 2005-09-30 |
| PL364053A1 (en) | 2004-12-13 |
| AR036332A1 (en) | 2004-09-01 |
| HUP0401273A3 (en) | 2006-11-28 |
| ECSP034852A (en) | 2003-12-24 |
| WO2002100411A1 (en) | 2002-12-19 |
| ZA200308466B (en) | 2004-05-24 |
| BG108324A (en) | 2004-12-30 |
| EA200301167A1 (en) | 2004-06-24 |
| CZ20033112A3 (en) | 2004-03-17 |
| SK14222003A3 (en) | 2004-05-04 |
| EA006608B1 (en) | 2006-02-24 |
| HRP20030933A2 (en) | 2004-04-30 |
| CA2449189A1 (en) | 2002-12-19 |
| IL158642A0 (en) | 2004-05-12 |
| CO5550460A2 (en) | 2005-08-31 |
| BR0209796A (en) | 2004-06-01 |
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