MXPA03007966A - Inhibidores de transcriptasa reversa sin nucleosido. - Google Patents
Inhibidores de transcriptasa reversa sin nucleosido.Info
- Publication number
- MXPA03007966A MXPA03007966A MXPA03007966A MXPA03007966A MXPA03007966A MX PA03007966 A MXPA03007966 A MX PA03007966A MX PA03007966 A MXPA03007966 A MX PA03007966A MX PA03007966 A MXPA03007966 A MX PA03007966A MX PA03007966 A MXPA03007966 A MX PA03007966A
- Authority
- MX
- Mexico
- Prior art keywords
- alkyl
- cr8ar8b
- cycloalkyl
- reverse transcriptase
- transcriptase inhibitors
- Prior art date
Links
- 229940042402 non-nucleoside reverse transcriptase inhibitor Drugs 0.000 title 1
- 239000002726 nonnucleoside reverse transcriptase inhibitor Substances 0.000 title 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 5
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Enzymes And Modification Thereof (AREA)
- Saccharide Compounds (AREA)
Abstract
Un compuesto de la formula I: en donde A es una cadena de enlace de alquilo de (C1-3); B es O o S; R1 es H, alquilo de (C1-6), halo, CF3, u OR1a, en donde R1a es H, o alquilo de (C1-6); R2 es H o Me; R3 es H o Me; R4 es H, alquilo de (C1-4), cicloalquilo de (C3-4) y alquilo de (C1-4) cicloalquilo de (C3-7); W se selecciona de la formula (i), (ii), o (iii), en donde a) es una de Y que es SO2 y la otra Y es NR5, con la condicion de que ambos no sean lo mismo, en donde R5 es H, alquilo de (C1-6), cicloalquilo de (C3-6), el alquilo estando substituido, COR5o, COOR5p o CONR5pR5q, y cada uno de R8 es H, alquilo de (C1-4), cicloalquilo de (C3-6), o alquilo de (C1-4) -cicloalquilo de (C3-6); o b) E es CR8aR8b en donde R8a y R8b es H, o alquilo y J es CH2; o J es CR8aR8b y E es CH2, y la linea de puntos represente un enlace sencillo; O C) es C (O) y J es CR8aR8b o J es C(O) y E es CR8aR8b y la linea de puntos representa un enlace sencillo; o d) E y J son CR8aRBb y la linea de puntos representa un doble enlace. Los compuestos de la formula I tienen actividad contra el VIH TN y las cepas mutantes dobles.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27804401P | 2001-03-22 | 2001-03-22 | |
| PCT/CA2002/000385 WO2002076982A2 (en) | 2001-03-22 | 2002-03-21 | Non-nucleoside reverse transcriptase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA03007966A true MXPA03007966A (es) | 2004-05-24 |
Family
ID=23063458
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MXPA03007966A MXPA03007966A (es) | 2001-03-22 | 2002-03-21 | Inhibidores de transcriptasa reversa sin nucleosido. |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6716836B2 (es) |
| EP (1) | EP1373267B1 (es) |
| JP (1) | JP4148780B2 (es) |
| AT (1) | ATE288434T1 (es) |
| AU (1) | AU2002247573A1 (es) |
| CA (1) | CA2441996C (es) |
| DE (1) | DE60202853T2 (es) |
| ES (1) | ES2236500T3 (es) |
| MX (1) | MXPA03007966A (es) |
| PT (1) | PT1373267E (es) |
| WO (1) | WO2002076982A2 (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6706706B2 (en) * | 2002-03-27 | 2004-03-16 | Boehringer Ingelheim International Gmbh | Non-nucleoside reverse transcriptase inhibitors |
| US6806265B2 (en) * | 2002-05-16 | 2004-10-19 | Boehringer Ingelheim International Gmbh | Non-nucleoside reverse transcriptase inhibitors |
| JP2006505532A (ja) * | 2002-09-19 | 2006-02-16 | ベーリンガー インゲルハイム （カナダ） リミテッド | 非ヌクレオシド逆転写酵素インヒビター |
| ATE331716T1 (de) * | 2002-09-19 | 2006-07-15 | Boehringer Ingelheim Ca Ltd | Nicht-nukleosidische inhibitoren der reverse transkriptase |
| JP2013149779A (ja) * | 2012-01-19 | 2013-08-01 | Semiconductor Components Industries Llc | 半導体装置 |
| CN110121343B (zh) | 2016-09-12 | 2023-11-03 | 整体健康 | 用作gpr120调节剂的双环化合物 |
| EP3509587B1 (en) | 2016-09-12 | 2023-12-06 | Valo Health, Inc. | Monocyclic compounds useful as gpr120 modulators |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5366972A (en) * | 1989-04-20 | 1994-11-22 | Boehringer Ingelheim Pharmaceuticals, Inc. | 5,11-dihydro-6H-dipyrido(3,2-B:2',3'-E)(1,4)diazepines and their use in the prevention or treatment of HIV infection |
| PL181323B1 (pl) * | 1994-02-18 | 2001-07-31 | Boehringer Ingelheim Pharma | 2-heteroarylo-5,11-dihydro-6H-dipirydo[3,2-b:2’,3'-e][1,4] diazepinyi ich zastosowanie w zapobieganiu i leczeniu zakazen HIV PL PL PL |
| US5705499A (en) | 1995-10-06 | 1998-01-06 | Boehringer Ingelheim Pharmaceuticals, Inc. | 8-arylalkyl- and 8-arylheteroalkyl-5,11-dihydro-6H-dipyrido 3,2-B:2',3'-e! 1!diazepines and their use in the treatment of HIV-1 infection |
| TWI270547B (en) | 2000-06-16 | 2007-01-11 | Boehringer Ingelheim Ca Ltd | Non-nucleoside reverse transcriptase inhibitors |
-
2002
- 2002-03-13 US US10/096,779 patent/US6716836B2/en not_active Expired - Lifetime
- 2002-03-21 AT AT02716563T patent/ATE288434T1/de active
- 2002-03-21 MX MXPA03007966A patent/MXPA03007966A/es unknown
- 2002-03-21 PT PT02716563T patent/PT1373267E/pt unknown
- 2002-03-21 EP EP02716563A patent/EP1373267B1/en not_active Expired - Lifetime
- 2002-03-21 ES ES02716563T patent/ES2236500T3/es not_active Expired - Lifetime
- 2002-03-21 CA CA2441996A patent/CA2441996C/en not_active Expired - Fee Related
- 2002-03-21 AU AU2002247573A patent/AU2002247573A1/en not_active Abandoned
- 2002-03-21 DE DE60202853T patent/DE60202853T2/de not_active Expired - Lifetime
- 2002-03-21 JP JP2002576240A patent/JP4148780B2/ja not_active Expired - Fee Related
- 2002-03-21 WO PCT/CA2002/000385 patent/WO2002076982A2/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| EP1373267B1 (en) | 2005-02-02 |
| WO2002076982A2 (en) | 2002-10-03 |
| ATE288434T1 (de) | 2005-02-15 |
| US6716836B2 (en) | 2004-04-06 |
| WO2002076982A3 (en) | 2002-12-12 |
| CA2441996A1 (en) | 2002-10-03 |
| JP4148780B2 (ja) | 2008-09-10 |
| EP1373267A2 (en) | 2004-01-02 |
| PT1373267E (pt) | 2005-05-31 |
| US20030069226A1 (en) | 2003-04-10 |
| DE60202853D1 (de) | 2005-03-10 |
| JP2004523590A (ja) | 2004-08-05 |
| ES2236500T3 (es) | 2005-07-16 |
| DE60202853T2 (de) | 2006-02-09 |
| AU2002247573A1 (en) | 2002-10-08 |
| CA2441996C (en) | 2011-07-19 |
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