MXPA03001945A - Tetrahidroindazoles sustituidos con arilo y su uso como ligandos para el receptor gaba-a. - Google Patents
Tetrahidroindazoles sustituidos con arilo y su uso como ligandos para el receptor gaba-a.Info
- Publication number
- MXPA03001945A MXPA03001945A MXPA03001945A MXPA03001945A MXPA03001945A MX PA03001945 A MXPA03001945 A MX PA03001945A MX PA03001945 A MXPA03001945 A MX PA03001945A MX PA03001945 A MXPA03001945 A MX PA03001945A MX PA03001945 A MXPA03001945 A MX PA03001945A
- Authority
- MX
- Mexico
- Prior art keywords
- tetrahydroindazols
- ligandos
- arilo
- gaba
- receiver
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70571—Assays involving receptors, cell surface antigens or cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23025600P | 2000-09-06 | 2000-09-06 | |
| PCT/US2001/027676 WO2002020492A1 (en) | 2000-09-06 | 2001-09-06 | Aryl substituted tetrahydroindazoles and their use as ligands for the gaba-a receptor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA03001945A true MXPA03001945A (es) | 2003-09-10 |
Family
ID=22864511
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MXPA03001945A MXPA03001945A (es) | 2000-09-06 | 2001-09-06 | Tetrahidroindazoles sustituidos con arilo y su uso como ligandos para el receptor gaba-a. |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6656941B2 (es) |
| EP (1) | EP1315703A1 (es) |
| JP (1) | JP2004508359A (es) |
| AU (1) | AU2001287114A1 (es) |
| BR (1) | BR0113697A (es) |
| CA (1) | CA2419966A1 (es) |
| MX (1) | MXPA03001945A (es) |
| WO (1) | WO2002020492A1 (es) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004525937A (ja) | 2001-03-27 | 2004-08-26 | ニューロジェン コーポレイション | （オキソ−ピラゾロ［１，５ａ］ピリミジン−２−イル）アルキル−カルボキサミド |
| EP1472252A1 (en) | 2002-02-07 | 2004-11-03 | Neurogen Corporation | Substituted fused pyrazolecarboxylic acid arylamides and related compounds |
| ATE456558T1 (de) | 2003-08-14 | 2010-02-15 | Hoffmann La Roche | Gabanerge modulatoren |
| WO2005090268A1 (en) * | 2004-03-18 | 2005-09-29 | Suntory Limited | Radiolabeled 3-[3-(benzoyl-amido)benzyloxy]aspartic acid derivative and method of producing the same |
| FR2870239B1 (fr) * | 2004-05-11 | 2006-06-16 | Sanofi Synthelabo | Derives de carbamate de 2h- ou 3h-benzo[e]indazol-1-yle, leur preparation et leur application en therapeutique. |
| SI2074123T1 (sl) * | 2006-10-16 | 2013-03-29 | Bionomics Limited | Nove anksiolitične spojine |
| US10954231B2 (en) | 2006-10-16 | 2021-03-23 | Bionomics Limited | Anxiolytic compounds |
| GB0808832D0 (en) | 2008-05-15 | 2008-06-18 | Ge Healthcare Ltd | Biomarkers for depression |
| KR101260697B1 (ko) * | 2011-01-03 | 2013-05-10 | 한국식품연구원 | 플로로글루시놀 또는 플로로탄닌을 포함하는 가바 ａ형-벤조다이아제핀 수용체 활성용 조성물 및 불안 완화, 경련 개선, 진정 작용, 및 수면 유도 및 개선용 조성물 |
| EP2681198A4 (en) | 2011-03-02 | 2014-09-03 | Bionomics Ltd | NEW LITTLE MOLECULES AS THERAPIES |
| US9133188B2 (en) | 2011-05-12 | 2015-09-15 | Bionomics Limited | Methods for preparing naphthyridines |
| US20150374705A1 (en) | 2012-02-14 | 2015-12-31 | Shanghai Institues for Biological Sciences | Substances for treatment or relief of pain |
| KR20150041651A (ko) * | 2012-08-10 | 2015-04-16 | 에프. 호프만-라 로슈 아게 | 피라졸 카복스아미드 화합물, 조성물 및 사용 방법 |
| KR101899546B1 (ko) | 2017-05-11 | 2018-09-17 | 한국식품연구원 | 플로로글루시놀을 유효성분으로 하는 수면 장애 개선, 예방 또는 치료용 조성물, 또는 gaba a 수용체 효능제의 내성 억제 또는 부작용 경감용 조성물 |
| UY38979A (es) | 2019-12-06 | 2021-07-30 | Vertex Pharma | Tetrahidrofuranos sustituidos como moduladores de canales de sodio |
| CA3200234A1 (en) | 2020-11-25 | 2022-06-02 | Daryl C. Drummond | Lipid nanoparticles for delivery of nucleic acids, and related methods of use |
| EP4347031A1 (en) | 2021-06-04 | 2024-04-10 | Vertex Pharmaceuticals Incorporated | N-(hydroxyalkyl (hetero)aryl) tetrahydrofuran carboxamides as modulators of sodium channels |
| IL312348A (en) | 2021-10-29 | 2024-06-01 | Arcus Biosciences Inc | HIF-2ALPHA inhibitors and methods of using it |
| CN115252749A (zh) * | 2022-03-26 | 2022-11-01 | 吉林大学 | 附子理中制剂作为抗抑郁靶向药物的应用 |
| KR20250031230A (ko) | 2022-05-25 | 2025-03-06 | 아카제라 메디신즈, 인크. | 핵산 전달을 위한 지질 나노입자 및 이의 사용 방법 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5804686A (en) * | 1996-01-19 | 1998-09-08 | Neurogen Corporation | fused pyrrolecarboxamides; a new class of GABA brain receptor ligands |
| DK1030838T3 (da) * | 1997-11-13 | 2003-02-24 | Pfizer Prod Inc | Fremgangsmåde til syntese af pyrrolamider |
| GB9900222D0 (en) * | 1999-01-06 | 1999-02-24 | Merck Sharp & Dohme | Therapeutic compounds |
| DE60035498T2 (de) * | 1999-05-07 | 2008-03-13 | Neurogen Corp., Branford | Screening-verfahren von gaba-modulierenden verbindungen für bestimmte pharmakologische wirkungen |
| GB9911802D0 (en) * | 1999-05-20 | 1999-07-21 | Merck Sharp & Dohme | Therapeutic combination |
| MXPA02001709A (es) | 1999-08-31 | 2002-10-23 | Neurogen Corp | Pirrolocarboxamidas fusionadas: ligandos receptores de acido gaba-aminobutirico cerebral. |
-
2001
- 2001-09-06 CA CA002419966A patent/CA2419966A1/en not_active Abandoned
- 2001-09-06 EP EP01966614A patent/EP1315703A1/en not_active Withdrawn
- 2001-09-06 MX MXPA03001945A patent/MXPA03001945A/es active IP Right Grant
- 2001-09-06 US US09/947,702 patent/US6656941B2/en not_active Expired - Fee Related
- 2001-09-06 WO PCT/US2001/027676 patent/WO2002020492A1/en active Application Filing
- 2001-09-06 JP JP2002525114A patent/JP2004508359A/ja active Pending
- 2001-09-06 AU AU2001287114A patent/AU2001287114A1/en not_active Abandoned
- 2001-09-06 BR BR0113697-6A patent/BR0113697A/pt not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1315703A1 (en) | 2003-06-04 |
| US6656941B2 (en) | 2003-12-02 |
| US20020055524A1 (en) | 2002-05-09 |
| CA2419966A1 (en) | 2002-03-14 |
| AU2001287114A1 (en) | 2002-03-22 |
| JP2004508359A (ja) | 2004-03-18 |
| WO2002020492A1 (en) | 2002-03-14 |
| BR0113697A (pt) | 2003-07-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |