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MXPA02005806A - Agente de contraste fluorescente cercano al infrarrojo y formacion de imagen fluorescente. - Google Patents

Agente de contraste fluorescente cercano al infrarrojo y formacion de imagen fluorescente.

Info

Publication number
MXPA02005806A
MXPA02005806A MXPA02005806A MXPA02005806A MXPA02005806A MX PA02005806 A MXPA02005806 A MX PA02005806A MX PA02005806 A MXPA02005806 A MX PA02005806A MX PA02005806 A MXPA02005806 A MX PA02005806A MX PA02005806 A MXPA02005806 A MX PA02005806A
Authority
MX
Mexico
Prior art keywords
contrast agent
near infrared
infrared fluorescent
fluorescent contrast
fluorescence
Prior art date
Application number
MXPA02005806A
Other languages
English (en)
Inventor
Naoto Miwa
Michihito Inagaki
Hiroaki Eguchi
Masafumi Okumura
Yoshio Inagaki
Toru Harada
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of MXPA02005806A publication Critical patent/MXPA02005806A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032—Methine dyes, e.g. cyanine dyes

Landscapes

  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Indole Compounds (AREA)

Abstract

Se proporciona un agente de contraste fluorescente cercano al infrarrojo, que comprende un compuesto que tiene 3 o más grupos de ácido sulfónico en una molécula y un método para la formación de imágenes fluorescentes, que comprende introducir el agente de contraste fluorescente cercano al infrarrojo de la presente invención en un ser vivo, exponer el cuerpo del ser vivo a una luz de excitación y detectar la fluorescencia cercana al infrarrojo del agente de contraste. El agente de contraste fluorescente cercano al infrarrojo de la presente invención se excita mediante una luz de excitación y emite fluorescencia cerca del infrarrojo. Esta fluorescencia en el infrarrojo es superior en transmisión a través de los tejidos biológicos. De esta manera, la detección de lesiones en partes profundas del cuerpo de un ser vivo se hace posible. Además, el agente de contraste de la invención es superior en solubilidad en agua y baja toxicidad y por lo tanto se puede usar con seguridad.
MXPA02005806A 1999-12-15 1999-12-15 Agente de contraste fluorescente cercano al infrarrojo y formacion de imagen fluorescente. MXPA02005806A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/EP1999/009959 WO2001043781A1 (en) 1999-12-15 1999-12-15 Near infrared fluorescent contrast agent and fluorescence imaging

Publications (1)

Publication Number Publication Date
MXPA02005806A true MXPA02005806A (es) 2010-10-26

Family

ID=8167530

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA02005806A MXPA02005806A (es) 1999-12-15 1999-12-15 Agente de contraste fluorescente cercano al infrarrojo y formacion de imagen fluorescente.

Country Status (19)

Country Link
EP (1) EP1237583A1 (es)
JP (1) JP2003517025A (es)
KR (1) KR20020082207A (es)
CN (1) CN1217701C (es)
AU (1) AU2097500A (es)
BG (1) BG106822A (es)
BR (1) BR9917587A (es)
CA (1) CA2394539C (es)
EA (1) EA200200635A1 (es)
EE (1) EE200200321A (es)
HU (1) HUP0204024A2 (es)
IL (1) IL149798A0 (es)
MX (1) MXPA02005806A (es)
NO (1) NO328630B1 (es)
PL (1) PL355891A1 (es)
SK (1) SK8142002A3 (es)
TR (1) TR200201567T2 (es)
WO (1) WO2001043781A1 (es)
YU (1) YU44402A (es)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7682602B2 (en) * 2003-12-19 2010-03-23 Konica Minolta Medical & Graphic, Inc. Near-infrared fluorescent contrast medium
JP2005220045A (ja) * 2004-02-04 2005-08-18 Konica Minolta Medical & Graphic Inc 蛍光造影剤
JP5074044B2 (ja) * 2007-01-18 2012-11-14 オリンパス株式会社 蛍光観察装置および蛍光観察装置の作動方法
WO2009023813A1 (en) * 2007-08-15 2009-02-19 Applied Soil Water Technologies Llc Metals recovery from mining heap leach ore
US20090214436A1 (en) 2008-02-18 2009-08-27 Washington University Dichromic fluorescent compounds
US8401618B2 (en) 2009-08-28 2013-03-19 Visen Medical, Inc. Systems and methods for tomographic imaging in diffuse media using a hybrid inversion technique
JP2011046663A (ja) 2009-08-28 2011-03-10 Fujifilm Corp 近赤外蛍光造影剤
JP5945226B2 (ja) 2009-09-22 2016-07-05 ビセン メディカル， インコーポレイテッド 拡散媒質の仮想屈折率整合のためのシステムおよび方法
JP2013517067A (ja) * 2010-01-14 2013-05-16 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 乳管への炎症メディエータの侵入を検知して、低減、阻止するデバイス、システム、および方法
GB201010878D0 (en) 2010-06-29 2010-08-11 Ge Healthcare As Dye compositiion and dye syntheses
WO2013112554A1 (en) 2012-01-23 2013-08-01 Washington University Goggle imaging systems and methods
CN104853669B (zh) 2012-10-15 2017-07-21 文森医学公司 具有荧光及生物发光源的交叉形态加权特征的漫射介质成像的系统、方法及设备
CA2903994C (en) 2013-03-15 2017-08-22 Philip S. Low Synthesis and composition of amino acid linking groups conjugated to compounds used for the targeted imaging of tumors
US20170232119A1 (en) 2013-03-15 2017-08-17 Purdue Research Foundation Synthesis and composition of amino acid linking groups conjugated to compounds used for the targeted imaging of tumors
CN106455979A (zh) 2013-12-31 2017-02-22 纪念斯隆-凯特琳癌症中心 用于荧光源实时多通道成像的系统、方法和设备
CN107249647A (zh) 2014-12-15 2017-10-13 纪念斯隆-凯特琳癌症中心 具有增强的神经结合选择性的环状肽、与所述环状肽结合的纳米颗粒和此二者用于实时体内神经组织成像的用途
US10806804B2 (en) 2015-05-06 2020-10-20 Washington University Compounds having RD targeting motifs and methods of use thereof
WO2016193396A1 (en) * 2015-06-03 2016-12-08 Surgimab S.A.S. Fluorescent conjugates
CN105222828B (zh) * 2015-09-30 2017-05-24 东南大学 一种贴壁射流速度场和浓度场的同步测量装置与方法
AU2016374246A1 (en) 2015-12-15 2018-06-28 Cornell University Imaging systems and methods for tissue differentiation, e.g., for intraoperative visualization
JP2020500863A (ja) 2016-11-30 2020-01-16 メモリアル スローン ケタリング キャンサー センター 阻害剤官能化超小型ナノ粒子およびその方法
US11989803B2 (en) 2018-03-30 2024-05-21 Perkinelmer Health Sciences, Inc. Systems and methods for 3D reconstruction of anatomical organs and inclusions using short-wave infrared (SWIR) projection tomography
US11712482B2 (en) 2019-12-13 2023-08-01 Washington University Near infrared fluorescent dyes, formulations and related methods
US11964965B2 (en) * 2020-05-08 2024-04-23 On Target Laboratories, LLC Methods of manufacture and synthesis of fluorescent dye compounds and uses thereof
EP4015004A1 (en) 2020-12-18 2022-06-22 Phi Pharma SA Proteoglycan specific branched peptides
WO2022235371A1 (en) * 2021-05-04 2022-11-10 University Of Notre Dame Du Lac Deuterated indole heptamethine cyanine dyes
CN114459862B (zh) * 2022-01-13 2024-12-17 华腾实业（深圳）股份有限公司 一种高识别的真菌荧光染色液

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0529002B1 (en) * 1990-05-15 2001-10-04 Hyperion, Inc. Fluorescent porphyrin, and fluorescent phthalocyanine - polyethylene glycol, polyol, and saccharide derivatives as fluorescent probes
WO1996023525A1 (fr) * 1995-01-30 1996-08-08 Daiichi Pure Chemicals Co., Ltd. Marqueur de diagnostic
JP2000095758A (ja) * 1998-09-18 2000-04-04 Schering Ag 近赤外蛍光造影剤および蛍光造影方法

Also Published As

Publication number Publication date
CA2394539A1 (en) 2001-06-21
EE200200321A (et) 2003-10-15
AU2097500A (en) 2001-06-25
EA200200635A1 (ru) 2002-12-26
WO2001043781A1 (en) 2001-06-21
NO20022837L (no) 2002-06-14
BR9917587A (pt) 2002-08-06
TR200201567T2 (tr) 2002-11-21
CN1384760A (zh) 2002-12-11
NO328630B1 (no) 2010-04-12
JP2003517025A (ja) 2003-05-20
KR20020082207A (ko) 2002-10-30
YU44402A (sh) 2005-03-15
IL149798A0 (en) 2002-11-10
SK8142002A3 (en) 2002-12-03
CN1217701C (zh) 2005-09-07
EP1237583A1 (en) 2002-09-11
NO20022837D0 (no) 2002-06-14
HUP0204024A2 (en) 2003-04-28
BG106822A (bg) 2003-01-31
CA2394539C (en) 2009-10-27
PL355891A1 (en) 2004-05-31

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