MXPA01004982A - Manufactura de bajo costo de oligosacaridos. - Google Patents
Manufactura de bajo costo de oligosacaridos.Info
- Publication number
- MXPA01004982A MXPA01004982A MXPA01004982A MXPA01004982A MXPA01004982A MX PA01004982 A MXPA01004982 A MX PA01004982A MX PA01004982 A MXPA01004982 A MX PA01004982A MX PA01004982 A MXPA01004982 A MX PA01004982A MX PA01004982 A MXPA01004982 A MX PA01004982A
- Authority
- MX
- Mexico
- Prior art keywords
- oligosaccharides
- recombinant cells
- low cost
- glycosyltransferase
- useful
- Prior art date
Links
- 229920001542 oligosaccharide Polymers 0.000 title abstract 2
- 150000002482 oligosaccharides Chemical class 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 102000051366 Glycosyltransferases Human genes 0.000 abstract 2
- 108700023372 Glycosyltransferases Proteins 0.000 abstract 2
- 230000015572 biosynthetic process Effects 0.000 abstract 2
- 150000001720 carbohydrates Chemical class 0.000 abstract 2
- 230000002255 enzymatic effect Effects 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 239000011541 reaction mixture Substances 0.000 abstract 2
- 238000003786 synthesis reaction Methods 0.000 abstract 2
- 229930186217 Glycolipid Natural products 0.000 abstract 1
- 102000003886 Glycoproteins Human genes 0.000 abstract 1
- 108090000288 Glycoproteins Proteins 0.000 abstract 1
- 150000004676 glycans Chemical class 0.000 abstract 1
- 239000002773 nucleotide Substances 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
- 229920001282 polysaccharide Polymers 0.000 abstract 1
- 239000005017 polysaccharide Substances 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- 239000000758 substrate Substances 0.000 abstract 1
- 230000002194 synthesizing effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/18—Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Esta invencion proporciona celulas recombinantes, mezclas de reaccion y metodos que son utiles para la sintesis enzimaticas de productos sacaridos. Las celulas recombinantes contienen un gen heterologo que codifica a una glicosiltransferasa que cataliza al menos una etapa de la sintesis enzimatica, asi como un sistema para la generacion de un azucar nucleotido que puede servir como un substrato para la glicosiltransferasa. Las celulas recombinantes, mezclas de reaccion y los metodos son utiles para la sintesis eficiente de una gran variedad de sacaridos, incluyendo polisacaridos, oligosacaridos, glicoproteinas y glicolipidos utilizando materiales de inicio de relativo bajo costo.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10903198P | 1998-11-18 | 1998-11-18 | |
| US10909698P | 1998-11-19 | 1998-11-19 | |
| PCT/US1999/027599 WO2000029603A2 (en) | 1998-11-18 | 1999-11-18 | Low cost manufacture of oligosaccharides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA01004982A true MXPA01004982A (es) | 2004-09-27 |
Family
ID=26806557
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MXPA01004982A MXPA01004982A (es) | 1998-11-18 | 1999-11-18 | Manufactura de bajo costo de oligosacaridos. |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20020001831A1 (es) |
| EP (1) | EP1131415A4 (es) |
| JP (1) | JP2002530087A (es) |
| AU (2) | AU773845B2 (es) |
| CA (1) | CA2351022A1 (es) |
| MX (1) | MXPA01004982A (es) |
| WO (1) | WO2000029603A2 (es) |
Families Citing this family (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69942636D1 (de) | 1998-12-09 | 2010-09-09 | Phyton Holdings Llc | Verfahren zur herstellung von glycoprotein mit menschlichem glycosylierungsbild |
| FR2796082B1 (fr) * | 1999-07-07 | 2003-06-27 | Centre Nat Rech Scient | Procede de production d'oligosaccharides |
| NZ518532A (en) | 1999-10-26 | 2004-02-27 | Plant Res Internat B | Transgenic plant expressing mammalian beta-1,4- galactosyltransferase |
| AU783973B2 (en) * | 2000-02-08 | 2006-01-12 | Genentech Inc. | Improved galactosylation of recombinant glycoproteins |
| US20020132320A1 (en) * | 2001-01-10 | 2002-09-19 | Wang Peng George | Glycoconjugate synthesis using a pathway-engineered organism |
| BRPI0206546B1 (pt) | 2001-01-19 | 2015-07-21 | Phyton Holdings Llc | Método para a produção secretória de glicoproteína que tem cadeia de açúcar do tipo humana, usando célula vegetal |
| WO2002081723A1 (fr) * | 2001-04-02 | 2002-10-17 | Keio University | Methode de production d'une chaine d'oligosaccharide |
| JP2002335988A (ja) * | 2001-05-22 | 2002-11-26 | Yamasa Shoyu Co Ltd | オリゴ糖の製造法 |
| ES2466024T3 (es) * | 2001-10-10 | 2014-06-09 | Ratiopharm Gmbh | Remodelación y glicoconjugación de factor de crecimiento de fibroblastos (FGF) |
| US7157277B2 (en) | 2001-11-28 | 2007-01-02 | Neose Technologies, Inc. | Factor VIII remodeling and glycoconjugation of Factor VIII |
| US7173003B2 (en) | 2001-10-10 | 2007-02-06 | Neose Technologies, Inc. | Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF |
| US7214660B2 (en) | 2001-10-10 | 2007-05-08 | Neose Technologies, Inc. | Erythropoietin: remodeling and glycoconjugation of erythropoietin |
| EP1485486B1 (en) | 2002-03-19 | 2012-11-21 | Stichting Dienst Landbouwkundig Onderzoek | Optimizing glycan processing in plants |
| AU2003219402B2 (en) | 2002-03-19 | 2008-05-08 | Stichting Dienst Landbouwkundig Onderzoek | GnTIII (UDP-n-acethylglucosamine:beta-D mannoside beta (1,4)-N-acethylglucosaminy ltransferase III) expression in plants |
| AR042145A1 (es) | 2002-11-27 | 2005-06-08 | Dow Agrociences Llc | Produccion de inmunoglobulinas en plantas con una fucocilacion reducida |
| AU2003303394B2 (en) | 2002-12-23 | 2009-02-19 | Bristol-Myers Squibb Company | Product quality enhancement in mammalian cell culture processes for protein production |
| US8791070B2 (en) | 2003-04-09 | 2014-07-29 | Novo Nordisk A/S | Glycopegylated factor IX |
| US20070026485A1 (en) | 2003-04-09 | 2007-02-01 | Neose Technologies, Inc. | Glycopegylation methods and proteins/peptides produced by the methods |
| WO2005012484A2 (en) | 2003-07-25 | 2005-02-10 | Neose Technologies, Inc. | Antibody-toxin conjugates |
| JP4431334B2 (ja) * | 2003-07-29 | 2010-03-10 | 独立行政法人科学技術振興機構 | 改良されたatpの増幅方法およびその利用 |
| US20080305992A1 (en) | 2003-11-24 | 2008-12-11 | Neose Technologies, Inc. | Glycopegylated erythropoietin |
| US20060040856A1 (en) | 2003-12-03 | 2006-02-23 | Neose Technologies, Inc. | Glycopegylated factor IX |
| EP2365089B1 (en) * | 2004-03-17 | 2014-05-14 | GlycoFi, Inc. | Method of engineering a cytidine monophosphate-sialic acid synthetic pathway in yeast |
| EP1732139B1 (en) * | 2004-03-25 | 2018-12-12 | Kaneka Corporation | Method for producing a substrate for thin-film solar cell |
| JP4382617B2 (ja) * | 2004-09-13 | 2009-12-16 | 東北リコー株式会社 | 難燃剤及び難燃性樹脂組成物 |
| US20080145899A1 (en) * | 2004-09-17 | 2008-06-19 | Neose Technologies Inc | Production of Oligosaccharides By Microorganisms |
| ES2566670T3 (es) | 2004-10-29 | 2016-04-14 | Ratiopharm Gmbh | Remodelación y glucopegilación del factor de crecimiento de fibroblastos (FGF) |
| JP4951527B2 (ja) | 2005-01-10 | 2012-06-13 | バイオジェネリックス アーゲー | 糖peg化顆粒球コロニー刺激因子 |
| JP2006271372A (ja) * | 2005-03-01 | 2006-10-12 | Yamasa Shoyu Co Ltd | 糖鎖の製造法 |
| JP4639904B2 (ja) | 2005-03-30 | 2011-02-23 | チッソ株式会社 | 蛍光活性を有するルシフェラーゼの活性増強方法 |
| US20070154992A1 (en) | 2005-04-08 | 2007-07-05 | Neose Technologies, Inc. | Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants |
| JP4609177B2 (ja) | 2005-04-28 | 2011-01-12 | チッソ株式会社 | カルシウム結合型発光蛋白質溶液の発光時間延長方法 |
| EP2975135A1 (en) | 2005-05-25 | 2016-01-20 | Novo Nordisk A/S | Glycopegylated factor IX |
| US20070105755A1 (en) | 2005-10-26 | 2007-05-10 | Neose Technologies, Inc. | One pot desialylation and glycopegylation of therapeutic peptides |
| US20090048440A1 (en) | 2005-11-03 | 2009-02-19 | Neose Technologies, Inc. | Nucleotide Sugar Purification Using Membranes |
| US20080248959A1 (en) | 2006-07-21 | 2008-10-09 | Neose Technologies, Inc. | Glycosylation of peptides via o-linked glycosylation sequences |
| EP2054521A4 (en) | 2006-10-03 | 2012-12-19 | Novo Nordisk As | PROCESS FOR CLEANING POLYPEPTIDE CONJUGATES |
| PL2144923T3 (pl) | 2007-04-03 | 2013-12-31 | Biogenerix Ag | Sposoby leczenia z użyciem glikopegilowanego G-CSF |
| DK2147108T3 (da) | 2007-04-17 | 2014-06-16 | Stichting Dienst Landbouwkundi | Mammalia-type glycosylering i planter ved ekspression af non-mammalia-glycosyltransferaser |
| EP2170919B8 (en) | 2007-06-12 | 2016-01-20 | ratiopharm GmbH | Improved process for the production of nucleotide sugars |
| KR101589554B1 (ko) | 2008-01-03 | 2016-02-01 | 코넬 리서치 파운데이션 인코포레이티드 | 원핵생물에서의 글리코실화 단백질 발현 |
| EP2626079A3 (en) | 2008-02-27 | 2014-03-05 | Novo Nordisk A/S | Conjungated factor VIII molecules |
| KR20110056518A (ko) * | 2008-09-04 | 2011-05-30 | 산토리 홀딩스 가부시키가이샤 | 글루쿠론산 전이효소 및 그것을 코딩하는 폴리뉴클레오티드 |
| CA2738028A1 (en) | 2008-09-25 | 2010-04-01 | Glycosyn, Inc. | Compositions and methods for engineering probiotic yeast |
| KR101045516B1 (ko) | 2008-10-06 | 2011-06-30 | 부산대학교 산학협력단 | 식물 세포벽을 구성하는 다양한 다당류를 분해하는 효소를 생산하는 클렙시엘라 속 미생물 |
| MY183602A (en) | 2008-12-19 | 2021-03-02 | Chr Hansen Hmo Gmbh | Synthesis of fucosylated compounds |
| WO2011078987A1 (en) * | 2009-12-21 | 2011-06-30 | Trustees Of Dartmouth College | Recombinant prokaryotes and use thereof for production of o-glycosylated proteins |
| ES2733307T3 (es) * | 2011-12-16 | 2019-11-28 | Inbiose Nv | Microorganismos mutantes para sintetizar ácido colánico, oligosacáridos manosilados y/o fucosilados |
| TWI510627B (zh) * | 2012-08-20 | 2015-12-01 | 中央研究院 | 寡醣之大規模酵素合成 |
| US20160177355A1 (en) * | 2013-03-14 | 2016-06-23 | Adam C. Fisher | Oligosaccharide compositions, glycoproteins and methods to produce the same in prokaryotes |
| CN111133112B (zh) * | 2017-07-26 | 2024-09-10 | 科汉森母乳低聚糖股份有限公司 | 唾液酸转移酶及其在生产唾液酸化低聚糖中的用途 |
| EP3743520A4 (en) * | 2018-01-23 | 2021-11-10 | Lanzatech, Inc. | TWO-STAGE FERMENTATION PROCESS FOR MANUFACTURING A PRODUCT |
| ES2962132T3 (es) * | 2018-07-11 | 2024-03-15 | Ajinomoto Kk | Método para la sulfurilación enzimática de alcoholes y aminas que utiliza una bacteria de la familia Enterobacteriaceae |
| CN109402098B (zh) * | 2018-11-06 | 2021-09-17 | 王喆明 | 苏氨酸醛缩酶、突变体及其在制备取代苯丝氨酸衍生物中的应用 |
| JP6684976B1 (ja) * | 2020-01-31 | 2020-04-22 | 三井E&S環境エンジニアリング株式会社 | 有機性廃棄物処理の前処理設備に用いる夾雑物画像解析システム及び夾雑物画像解析システムを用いた前処理設備の運転システム |
| WO2021199445A1 (en) * | 2020-04-03 | 2021-10-07 | Rensselaer Polytechnic Institute | Method for producing sulfated polysaccharide and method for producing paps |
| WO2022034068A1 (en) * | 2020-08-10 | 2022-02-17 | Inbiose N.V. | Production of a mixture of mammalian milk oligosaccharides by a cell |
| CN112941131B (zh) * | 2021-03-11 | 2023-08-18 | 上海应用技术大学 | 一种发酵法制备微生物源壳寡糖的方法 |
| CN113136357B (zh) * | 2021-04-25 | 2022-10-11 | 江南大学 | 一种产乳酰-n-新四糖的基因工程菌及生产方法 |
| CN116240251B (zh) * | 2021-12-07 | 2025-09-30 | 江南大学 | 一种酶催化合成核苷酸糖的方法 |
| CN114507649B (zh) * | 2022-02-16 | 2023-11-21 | 吉林大学 | 嗜热酶及一锅法高效合成udp-葡萄糖和udp-葡萄糖醛酸的方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5047335A (en) * | 1988-12-21 | 1991-09-10 | The Regents Of The University Of Calif. | Process for controlling intracellular glycosylation of proteins |
| US5541083A (en) * | 1989-10-24 | 1996-07-30 | The Regents Of The University Of California | Method for producing secretable glycosyltransferases and other golgi processing enzymes |
| US5545553A (en) * | 1994-09-26 | 1996-08-13 | The Rockefeller University | Glycosyltransferases for biosynthesis of oligosaccharides, and genes encoding them |
| US5922577A (en) * | 1995-04-11 | 1999-07-13 | Cytel Corporation | Enzymatic synthesis of glycosidic linkages |
| US5945314A (en) * | 1997-03-31 | 1999-08-31 | Abbott Laboratories | Process for synthesizing oligosaccharides |
-
1999
- 1999-11-18 JP JP2000582584A patent/JP2002530087A/ja active Pending
- 1999-11-18 AU AU18261/00A patent/AU773845B2/en not_active Ceased
- 1999-11-18 MX MXPA01004982A patent/MXPA01004982A/es active IP Right Grant
- 1999-11-18 WO PCT/US1999/027599 patent/WO2000029603A2/en not_active Ceased
- 1999-11-18 EP EP99961744A patent/EP1131415A4/en not_active Withdrawn
- 1999-11-18 CA CA002351022A patent/CA2351022A1/en not_active Abandoned
-
2001
- 2001-01-08 US US09/757,289 patent/US20020001831A1/en not_active Abandoned
-
2004
- 2004-09-10 AU AU2004210567A patent/AU2004210567A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU773845B2 (en) | 2004-06-10 |
| US20020001831A1 (en) | 2002-01-03 |
| AU2004210567A1 (en) | 2004-10-07 |
| WO2000029603A2 (en) | 2000-05-25 |
| JP2002530087A (ja) | 2002-09-17 |
| CA2351022A1 (en) | 2000-05-25 |
| EP1131415A4 (en) | 2002-09-11 |
| WO2000029603A8 (en) | 2001-03-15 |
| EP1131415A2 (en) | 2001-09-12 |
| WO2000029603A3 (en) | 2000-11-16 |
| AU1826100A (en) | 2000-06-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration | ||
| GB | Transfer or rights |