MX9805935A - Proceso para la preparacion de derivados de purina. - Google Patents
Proceso para la preparacion de derivados de purina.Info
- Publication number
- MX9805935A MX9805935A MX9805935A MX9805935A MX9805935A MX 9805935 A MX9805935 A MX 9805935A MX 9805935 A MX9805935 A MX 9805935A MX 9805935 A MX9805935 A MX 9805935A MX 9805935 A MX9805935 A MX 9805935A
- Authority
- MX
- Mexico
- Prior art keywords
- preparing
- purine derivatives
- intermediates
- preparing purine
- purin
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 229940083251 peripheral vasodilators purine derivative Drugs 0.000 title 1
- 125000000561 purinyl group Chemical class N1=C(N=C2N=CNC2=C1)* 0.000 title 1
- 239000000543 intermediate Substances 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 238000010521 absorption reaction Methods 0.000 abstract 1
- 239000003443 antiviral agent Substances 0.000 abstract 1
- 239000007795 chemical reaction product Substances 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- IRSCQMHQWWYFCW-UHFFFAOYSA-N ganciclovir Chemical compound O=C1NC(N)=NC2=C1N=CN2COC(CO)CO IRSCQMHQWWYFCW-UHFFFAOYSA-N 0.000 abstract 1
- 239000012535 impurity Substances 0.000 abstract 1
- 239000000047 product Substances 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- 239000004474 valine Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US59207996A | 1996-01-26 | 1996-01-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX9805935A true MX9805935A (es) | 1998-11-30 |
Family
ID=24369197
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX9805935A MX9805935A (es) | 1996-01-26 | 1998-07-23 | Proceso para la preparacion de derivados de purina. |
Country Status (10)
| Country | Link |
|---|---|
| JP (1) | JP4094667B2 (zh) |
| KR (1) | KR100491941B1 (zh) |
| CN (1) | CN1064683C (zh) |
| AT (1) | ATE222909T1 (zh) |
| AU (1) | AU1543797A (zh) |
| CA (1) | CA2243650C (zh) |
| DE (1) | DE69714971T3 (zh) |
| ES (1) | ES2180923T5 (zh) |
| MX (1) | MX9805935A (zh) |
| WO (1) | WO1997027198A1 (zh) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5869493A (en) | 1996-02-16 | 1999-02-09 | Medivir Ab | Acyclic nucleoside derivatives |
| US6703394B2 (en) | 1996-02-16 | 2004-03-09 | Medivir Ab | Acyclic nucleoside derivatives |
| CN1878783A (zh) * | 2003-09-11 | 2006-12-13 | 弗·哈夫曼-拉罗切有限公司 | 制备抗病毒核苷衍生物的方法 |
| ZA200702234B (en) * | 2006-03-21 | 2008-07-30 | Cipla Ltd | Preparation of ester of purine derivatives |
| CN103562207B (zh) * | 2011-05-31 | 2016-08-17 | 法尔玛赞公司 | 用于制备缬更昔洛韦的2-氨基-9-((2-苯基-1，3-二噁烷-5-基氧基)甲基)-1h-嘌呤-6(9h)-酮化合物的制备方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816447A (en) * | 1981-08-26 | 1989-03-28 | Merck & Co., Inc. | Anti-viral guanine compounds |
| NL8202626A (nl) * | 1982-06-29 | 1984-01-16 | Stichting Rega V Z W | Derivaten van 9-(2-hydroxyethoxymethyl)guanine. |
| AP160A (en) * | 1987-08-15 | 1991-11-18 | The Wellcome Foundation Ltd | Therapeutic acyclic nucleosides. |
| EP0375329B1 (en) * | 1988-12-19 | 1995-05-31 | The Wellcome Foundation Limited | Antiviral pyrimidine and purine compounds, process for their preparation and pharmaceutical compositions containing them |
| JP3225545B2 (ja) * | 1991-09-18 | 2001-11-05 | 味の素株式会社 | 非環状ヌクレオシド類の製造法 |
| PE32296A1 (es) * | 1994-07-28 | 1996-08-07 | Hoffmann La Roche | Ester de l-monovalina derivado de 2-(2-amino-1,6-dihidro-6-oxo-purin-9-il) metoxi-1,3-propandiol y sus sales farmaceuticamente aceptables |
-
1997
- 1997-01-21 AU AU15437/97A patent/AU1543797A/en not_active Abandoned
- 1997-01-21 KR KR10-1998-0705709A patent/KR100491941B1/ko not_active IP Right Cessation
- 1997-01-21 JP JP52651797A patent/JP4094667B2/ja not_active Expired - Lifetime
- 1997-01-21 CA CA002243650A patent/CA2243650C/en not_active Expired - Lifetime
- 1997-01-21 AT AT97901569T patent/ATE222909T1/de active
- 1997-01-21 CN CN97192606A patent/CN1064683C/zh not_active Expired - Lifetime
- 1997-01-21 DE DE69714971T patent/DE69714971T3/de not_active Expired - Lifetime
- 1997-01-21 WO PCT/EP1997/000262 patent/WO1997027198A1/en active IP Right Grant
- 1997-01-21 ES ES97901569T patent/ES2180923T5/es not_active Expired - Lifetime
-
1998
- 1998-07-23 MX MX9805935A patent/MX9805935A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2243650C (en) | 2006-08-15 |
| ES2180923T3 (es) | 2003-02-16 |
| KR100491941B1 (ko) | 2005-08-05 |
| JP2000503977A (ja) | 2000-04-04 |
| CN1064683C (zh) | 2001-04-18 |
| DE69714971T3 (de) | 2005-12-15 |
| ES2180923T5 (es) | 2005-10-16 |
| WO1997027198A1 (en) | 1997-07-31 |
| CA2243650A1 (en) | 1997-07-31 |
| ATE222909T1 (de) | 2002-09-15 |
| AU1543797A (en) | 1997-08-20 |
| CN1212693A (zh) | 1999-03-31 |
| KR19990081991A (ko) | 1999-11-15 |
| DE69714971D1 (de) | 2002-10-02 |
| DE69714971T2 (de) | 2003-05-28 |
| JP4094667B2 (ja) | 2008-06-04 |
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