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KR100491941B1 - 푸린유도체의제조방법 - Google Patents

푸린유도체의제조방법 Download PDF

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Publication number
KR100491941B1
KR100491941B1 KR10-1998-0705709A KR19980705709A KR100491941B1 KR 100491941 B1 KR100491941 B1 KR 100491941B1 KR 19980705709 A KR19980705709 A KR 19980705709A KR 100491941 B1 KR100491941 B1 KR 100491941B1
Authority
KR
South Korea
Prior art keywords
group
amino
formula
acid
methoxy
Prior art date
Application number
KR10-1998-0705709A
Other languages
English (en)
Korean (ko)
Other versions
KR19990081991A (ko
Inventor
험버토 비 아르제노
스티븐 디 액스트
콜린 씨 비어드
찰스 에이 드보락
폴 알 파더리
로렌스 이 피셔
윤-퀘이 한
에릭 알 험프리스
잔 피 룬드
샘 린 구옌
더글라스 레슬리 렌
Original Assignee
에프. 호프만-라 로슈 아게
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 에프. 호프만-라 로슈 아게 filed Critical 에프. 호프만-라 로슈 아게
Publication of KR19990081991A publication Critical patent/KR19990081991A/ko
Application granted granted Critical
Publication of KR100491941B1 publication Critical patent/KR100491941B1/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
KR10-1998-0705709A 1996-01-26 1997-01-21 푸린유도체의제조방법 KR100491941B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US59207996A 1996-01-26 1996-01-26
US8/592,079 1996-01-26
US08/592,079 1996-01-26

Publications (2)

Publication Number Publication Date
KR19990081991A KR19990081991A (ko) 1999-11-15
KR100491941B1 true KR100491941B1 (ko) 2005-08-05

Family

ID=24369197

Family Applications (1)

Application Number Title Priority Date Filing Date
KR10-1998-0705709A KR100491941B1 (ko) 1996-01-26 1997-01-21 푸린유도체의제조방법

Country Status (10)

Country Link
JP (1) JP4094667B2 (zh)
KR (1) KR100491941B1 (zh)
CN (1) CN1064683C (zh)
AT (1) ATE222909T1 (zh)
AU (1) AU1543797A (zh)
CA (1) CA2243650C (zh)
DE (1) DE69714971T3 (zh)
ES (1) ES2180923T5 (zh)
MX (1) MX9805935A (zh)
WO (1) WO1997027198A1 (zh)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5869493A (en) 1996-02-16 1999-02-09 Medivir Ab Acyclic nucleoside derivatives
US6703394B2 (en) 1996-02-16 2004-03-09 Medivir Ab Acyclic nucleoside derivatives
CN1878783A (zh) * 2003-09-11 2006-12-13 弗·哈夫曼-拉罗切有限公司 制备抗病毒核苷衍生物的方法
ZA200702234B (en) * 2006-03-21 2008-07-30 Cipla Ltd Preparation of ester of purine derivatives
CN103562207B (zh) * 2011-05-31 2016-08-17 法尔玛赞公司 用于制备缬更昔洛韦的2-氨基-9-((2-苯基-1，3-二噁烷-5-基氧基)甲基)-1h-嘌呤-6(9h)-酮化合物的制备方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0165164A1 (en) * 1984-06-06 1985-12-18 Merck & Co. Inc. Anti-viral compounds, their preparation and anti-viral compositions

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL8202626A (nl) * 1982-06-29 1984-01-16 Stichting Rega V Z W Derivaten van 9-(2-hydroxyethoxymethyl)guanine.
AP160A (en) * 1987-08-15 1991-11-18 The Wellcome Foundation Ltd Therapeutic acyclic nucleosides.
EP0375329B1 (en) * 1988-12-19 1995-05-31 The Wellcome Foundation Limited Antiviral pyrimidine and purine compounds, process for their preparation and pharmaceutical compositions containing them
JP3225545B2 (ja) * 1991-09-18 2001-11-05 味の素株式会社 非環状ヌクレオシド類の製造法
PE32296A1 (es) * 1994-07-28 1996-08-07 Hoffmann La Roche Ester de l-monovalina derivado de 2-(2-amino-1,6-dihidro-6-oxo-purin-9-il) metoxi-1,3-propandiol y sus sales farmaceuticamente aceptables

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0165164A1 (en) * 1984-06-06 1985-12-18 Merck & Co. Inc. Anti-viral compounds, their preparation and anti-viral compositions

Also Published As

Publication number Publication date
CA2243650C (en) 2006-08-15
ES2180923T3 (es) 2003-02-16
MX9805935A (es) 1998-11-30
JP2000503977A (ja) 2000-04-04
CN1064683C (zh) 2001-04-18
DE69714971T3 (de) 2005-12-15
ES2180923T5 (es) 2005-10-16
WO1997027198A1 (en) 1997-07-31
CA2243650A1 (en) 1997-07-31
ATE222909T1 (de) 2002-09-15
AU1543797A (en) 1997-08-20
CN1212693A (zh) 1999-03-31
KR19990081991A (ko) 1999-11-15
DE69714971D1 (de) 2002-10-02
DE69714971T2 (de) 2003-05-28
JP4094667B2 (ja) 2008-06-04

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