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MX9700725A - Coleccion combinatoria soluble. - Google Patents

Coleccion combinatoria soluble.

Info

Publication number
MX9700725A
MX9700725A MX9700725A MX9700725A MX9700725A MX 9700725 A MX9700725 A MX 9700725A MX 9700725 A MX9700725 A MX 9700725A MX 9700725 A MX9700725 A MX 9700725A MX 9700725 A MX9700725 A MX 9700725A
Authority
MX
Mexico
Prior art keywords
molecules
soluble
combinatorial libraries
biphasic
macromolecular support
Prior art date
Application number
MX9700725A
Other languages
English (en)
Inventor
Kin Janda
Han Hyunsoo
Original Assignee
Scripps Research Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scripps Research Inst filed Critical Scripps Research Inst
Publication of MX9700725A publication Critical patent/MX9700725A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00592—Split-and-pool, mix-and-divide processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00596—Solid-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00599—Solution-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/08—Liquid phase synthesis, i.e. wherein all library building blocks are in liquid phase or in solution during library creation; Particular methods of cleavage from the liquid support

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Liquid Crystal Substances (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Pyrrole Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

La presente invencion se refiere a colecciones combinatorias solubles novedosas que comprenden una fase soluble en solucion fijada a una molécula de centro, y permitiendo el alto rendimiento mejorado y produccion eficiente de colecciones combinatorias solubles. Algunos ejemplos específicos de las colecciones combinatorias solubles que aquí se reclaman comprenden uno o más de los siguientes: aminoácidos, aminoácidos de alfa-azetina, moléculas de triazinodiona, moléculas de t-lactamida, moléculas de 8-lactamtiotida, moléculas que contienen nucleo de beta-lactam, moléculas que contienen nucleo de alcaloide licoramina, y moléculas que contienen nucleo de beta-bloqueador. Además, la técnica de síntesis y division para generar colecciones de moléculas combinatorias emplea un soporte macromolecular bifásico que es soluble durante los pasos de formacion de abastecimiento, division y copulacion pero que es insoluble durante el paso de lavado. El uso de un soporte macromolecular bifásico en su fase soluble incrementa significativamente la eficiencia y rendimiento de los pasos de formacion de deposito, division y copulacion. El uso de un soporte macromolecular bifásico en su fase insoluble incrementa significativamente la eficiencia y el rendimiento del paso de lavado.
MX9700725A 1994-07-26 1995-07-26 Coleccion combinatoria soluble. MX9700725A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US28120094A 1994-07-26 1994-07-26
US48415395A 1995-06-07 1995-06-07
PCT/US1995/009614 WO1996003418A1 (en) 1994-07-26 1995-07-26 Soluble combinatorial libraries

Publications (1)

Publication Number Publication Date
MX9700725A true MX9700725A (es) 1997-05-31

Family

ID=26960765

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9700725A MX9700725A (es) 1994-07-26 1995-07-26 Coleccion combinatoria soluble.

Country Status (8)

Country Link
US (1) US20030059826A1 (es)
EP (1) EP0772623A1 (es)
JP (1) JPH10506379A (es)
AU (1) AU697920B2 (es)
CA (1) CA2195321A1 (es)
MX (1) MX9700725A (es)
NZ (1) NZ291554A (es)
WO (1) WO1996003418A1 (es)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2234159A1 (en) 1995-10-19 1997-04-24 Alecia Settle Method for solution phase synthesis of oligonucleotides
US6043353A (en) * 1995-12-22 2000-03-28 University Technologies International, Inc. Reusable solid support for oligonucleotide synthesis, process for production thereof and process for use thereof
WO1997035199A1 (en) * 1996-03-20 1997-09-25 The Scripps Research Institute Azatide peptidomimetics
GB2316941A (en) * 1996-07-02 1998-03-11 Merck & Co Inc Combinatorial sythesis on soluble polyvalent supports
US6132953A (en) * 1996-07-02 2000-10-17 Merck & Co., Inc. Combinatorial synthesis on soluble polyvalent supports having a discrete architecture
WO1998003452A1 (en) * 1996-07-19 1998-01-29 The Procter & Gamble Company Polymers as a support for combinatorial synthesis
DE19642751A1 (de) * 1996-10-16 1998-04-23 Deutsches Krebsforsch Saccharid-Bibliothek
EP0998280A4 (en) * 1997-05-29 2002-11-06 Incara Pharmaceuticals Corp CARBOHYDRATE COMPOUNDS WITH SCAFFOLDING STRUCTURE AND BANKS CONTAINING SAME
US6362009B1 (en) 1997-11-21 2002-03-26 Merck & Co., Inc. Solid phase synthesis of heterocycles
DE10059890A1 (de) * 2000-12-01 2002-06-20 Hte Ag Verfahren zur Herstellung einer Vielzahl von Bausteinen einer Materialbibliothek
WO2002102820A1 (en) 2001-06-20 2002-12-27 Nuevolution A/S Nucleoside derivatives for library preparation
IL163822A0 (en) 2002-03-15 2005-12-18 Nuevolution As An improved method for synthesising templated molecules
EP1539980B1 (en) 2002-08-01 2016-02-17 Nuevolution A/S Library of complexes comprising small non-peptide molecules and double-stranded oligonucleotides identifying the molecules
WO2004028682A2 (en) 2002-09-27 2004-04-08 Carlsberg A/S Spatially encoded polymer matrix
DK3299463T3 (da) 2002-10-30 2020-12-07 Nuevolution As Enzymatisk kodning
DE60330406D1 (de) 2002-12-19 2010-01-14 Nuevolution As Durch quasizufallsstrukturen und funktionen geführte synthesemethode
WO2004074429A2 (en) 2003-02-21 2004-09-02 Nuevolution A/S Method for producing second-generation library
US20060159715A1 (en) * 2003-07-09 2006-07-20 Yukio Nagasaki Conjugate of fine porous particles with polymer molecules and the utilization thereof
DK1670939T3 (da) 2003-09-18 2010-03-01 Nuevolution As Fremgangsmåde til opnåelse af strukturel information om et kodet molekyle og fremgangsmåde til udvælgelse af forbindelser
LT3305900T (lt) 2005-12-01 2021-11-10 Nuevolution A/S Fermentiniai kodavimo būdai didelių bibliotekų efektyviai sintezei
GB0820865D0 (en) * 2008-11-14 2008-12-24 Membrane Extraction Tech Ltd Degradable supports for tide synthesis
KR101789216B1 (ko) 2009-02-13 2017-10-23 엑스-켐, 인크. Ｄｎａ―코딩된 라이브러리의 생성 및 스크리닝 방법
WO2011127933A1 (en) 2010-04-16 2011-10-20 Nuevolution A/S Bi-functional complexes and methods for making and using such complexes
EP2748357B1 (en) 2011-09-07 2018-04-04 X-Chem, Inc. Methods for tagging dna-encoded libraries
EA201992285A1 (ru) 2012-07-13 2020-05-31 Икс-Чем, Инк. Днк-кодированные библиотеки, содержащие связи кодирующих олигонуклеотидов, не доступные для считывания полимеразами
JP2017505619A (ja) * 2014-02-03 2017-02-23 ノクソン ファーマ エージー ポリアルコキシル化核酸分子の調製のための方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5723286A (en) * 1990-06-20 1998-03-03 Affymax Technologies N.V. Peptide library and screening systems
US5650489A (en) * 1990-07-02 1997-07-22 The Arizona Board Of Regents Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof
DK0604552T3 (da) * 1991-09-18 1997-08-04 Affymax Tech Nv Fremgangsmåde til syntese af forskellige samlinger af oligomerer
US5573905A (en) * 1992-03-30 1996-11-12 The Scripps Research Institute Encoded combinatorial chemical libraries

Also Published As

Publication number Publication date
JPH10506379A (ja) 1998-06-23
AU3272295A (en) 1996-02-22
CA2195321A1 (en) 1996-02-08
WO1996003418A1 (en) 1996-02-08
AU697920B2 (en) 1998-10-22
US20030059826A1 (en) 2003-03-27
EP0772623A1 (en) 1997-05-14
NZ291554A (en) 1999-02-25

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