MX9604017A - Derivados de cefalosporina y procedimiento para su preparacion. - Google Patents
Derivados de cefalosporina y procedimiento para su preparacion.Info
- Publication number
- MX9604017A MX9604017A MX9604017A MX9604017A MX9604017A MX 9604017 A MX9604017 A MX 9604017A MX 9604017 A MX9604017 A MX 9604017A MX 9604017 A MX9604017 A MX 9604017A MX 9604017 A MX9604017 A MX 9604017A
- Authority
- MX
- Mexico
- Prior art keywords
- substituted
- alkyl
- hydroxyphenyl
- fluoro
- carboxyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/22—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with radicals containing only hydrogen and carbon atoms, attached in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
El presente invento se refiere a derivados de cefalosporina de la formula general I: en donde R1 es un grupo elegido entre 2-, 3- y 4-hidroxifenilo, 2- y 3-metoxifenilo, 4-carboxifenilo, 4-carbamoilfenilo, 3-trifluorometilfenilo, 2- y 3-fluoro-fenilo, 3-nitrofenilo, 3-fluoro-4-hidroxifenilo, 2-fluoro-4-hidroxifenilo, 3-fluoro-2-hidroxifenilo, 3-, 4-dihidroxi-fenilo, bencilo, -CHR-fenilo, 3-hidroxibencilo, 4-amino-bencilo, 2-, 3- y 4-fluorobencilo, 2-, 3- y 4-metoxibencilo, 4-nitrobencilo, 4-carboxibencilo, 4-trifluorometilbencilo, 1-naftilo y 2-naftilo, estando todos los sustituyentes hidroxilo, amino, carboxilo y carbamoilo opcionalmente sustituidos, o es piridinilo mono-sustituido por halogeno, pirimidilo, piracinilo di-sustituido por alquilo inferior, piridacinilo mono-sustituido por halogeno, piperidinilo en donde el grupo amino puede estar sustituido por un grupo acilo, tiadiazolilo, oxo-tetra-hidrofuranilo, tiofenilo mono-sustituido por alcoxicarbonilo inferior o carbamoilo, tetrazolil-alquilo inferior, tetrahidrofuranil-alquilo inferior, tiofenil-alquilo inferior o bencimidazolil-alquilo inferior; y R es carboxilo o carboxilo esterificado; sus ésteres fácilmente hidrolizables, sales farmacéuticamente aceptables de dichos compuestos e hidratos de los compuestos de formula I y de sus ésteres y sales, así como su empleo y el procedimiento para la preparacion de estos compuestos.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP95114303 | 1995-09-12 | ||
| EP95114304 | 1995-09-12 | ||
| EP95114304.9 | 1995-09-12 | ||
| EP95114303.1 | 1995-09-12 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX9604017A true MX9604017A (es) | 1997-07-31 |
| MXPA96004017A MXPA96004017A (es) | 1997-12-01 |
Family
ID=
Also Published As
| Publication number | Publication date |
|---|---|
| AU709077B2 (en) | 1999-08-19 |
| CA2184971A1 (en) | 1997-03-13 |
| NO963805D0 (no) | 1996-09-11 |
| NO963805L (no) | 1997-03-13 |
| TR199600715A2 (tr) | 1997-03-21 |
| CN1060778C (zh) | 2001-01-17 |
| JPH09132578A (ja) | 1997-05-20 |
| HUP9602433A3 (en) | 2001-04-28 |
| PL316032A1 (en) | 1997-03-17 |
| US5804577A (en) | 1998-09-08 |
| HU9602433D0 (en) | 1996-10-28 |
| AU6550696A (en) | 1997-03-20 |
| IL119215A0 (en) | 1996-12-05 |
| KR100209839B1 (ko) | 1999-07-15 |
| CN1150950A (zh) | 1997-06-04 |
| HUP9602433A2 (en) | 1997-05-28 |
| MA23970A1 (fr) | 1997-04-01 |
| CO4750667A1 (es) | 1999-03-31 |
| KR970015593A (ko) | 1997-04-28 |
| CZ251896A3 (en) | 1997-04-16 |
| SG52841A1 (en) | 1998-09-28 |
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