PT81921B - Process for preparing quinolone inotropic agents - Google Patents
Process for preparing quinolone inotropic agentsInfo
- Publication number
- PT81921B PT81921B PT81921A PT8192186A PT81921B PT 81921 B PT81921 B PT 81921B PT 81921 A PT81921 A PT 81921A PT 8192186 A PT8192186 A PT 8192186A PT 81921 B PT81921 B PT 81921B
- Authority
- PT
- Portugal
- Prior art keywords
- alkyl
- het
- heterocyclic group
- attached
- inotropic agents
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/18—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Quinoline Compounds (AREA)
- Production Of Liquid Hydrocarbon Mixture For Refining Petroleum (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Steroid Compounds (AREA)
Abstract
Quinolone inotropic agents (and their pharmaceutically acceptable salts) of the formula:-
<CHEM>
where n is 0, 1 or 2; R<1> is selected from -NR<4>R<5>, -NR<4>CO(C1-C4 alkyl), -NR<4>CONR<4>R<5>, - NR<4>COOR<5>, S(O)m(C1-C4 alkyl), -SO2NR<4>R<5>, -NR<4>SO2R<5>, -OCONR<4>R<5>, -OCO(C1-C4 alkyl), -OR<5>, -OCH2.Het, -COOR<4>, -CONR<4>R<5> and Het min ; R<4> is H or C1-C4 alkyl and R<5> is H, C2-C4 alkyl or -CH2CH2N(C1-C2 alkyl)2, or R<4> and R<5> taken together with the nitrogen atom to which they are attached form a saturated 5- or 6-membered heterocyclic group optionally containing a further heteroatom or group selected from O, S and N-R<6> where R<6> is H or C1-C4 alkyl;
m is 0, 1 or 2;
Het is a 5- or 6-membered nitrogen-containing aromatic heterocyclic group attached by a carbon atom to the adjacent -CH2- group;
Het min is a 5- or 6-membered nitrogen-containing heterocyclic group;
R<2>, which is attached to the 3-, 4-, 5-, 6-, 7- or 8-position, is H, C1-C4 alkyl, C1-C4 alkoxy, hydroxy, cyano, halo, CF3 or -NR<4>R<5> where R<4> and R<5> are as defined above;
R<3> is H or C1-C4 alkyl;
X is H, C1-C4 alkoxy, hydroxy, halo or CF3;
and the dotted line between the 3- and 4-positions represents an optional bond;
and the pharmaceutically acceptable salts of the compounds of the formula (I).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB858502267A GB8502267D0 (en) | 1985-01-30 | 1985-01-30 | Quinolone inotropic agents |
| CN85104392A CN85104392B (en) | 1985-01-30 | 1985-06-10 | The preparation method of quinolone inotropic agent |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PT81921A PT81921A (en) | 1986-02-01 |
| PT81921B true PT81921B (en) | 1987-11-16 |
Family
ID=25741743
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT81921A PT81921B (en) | 1985-01-30 | 1986-01-28 | Process for preparing quinolone inotropic agents |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US4728654A (en) |
| EP (1) | EP0190857B1 (en) |
| JP (1) | JPS61176568A (en) |
| KR (1) | KR880000132B1 (en) |
| CN (1) | CN85104392B (en) |
| AT (1) | ATE51224T1 (en) |
| AU (1) | AU557667B2 (en) |
| CA (1) | CA1255662A (en) |
| DE (1) | DE3669714D1 (en) |
| DK (1) | DK43286A (en) |
| ES (2) | ES8706122A1 (en) |
| FI (1) | FI860424A (en) |
| GB (1) | GB8502267D0 (en) |
| GR (1) | GR860249B (en) |
| HU (1) | HU194831B (en) |
| IE (1) | IE860258L (en) |
| PL (1) | PL257669A1 (en) |
| PT (1) | PT81921B (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4582909A (en) * | 1984-02-02 | 1986-04-15 | Warner-Lambert Company | Benzobicyclic lactam acids and derivatives as cognition activators |
| US4797490A (en) * | 1984-12-06 | 1989-01-10 | Pfizer Inc. | Process for the preparation of 3-(2'-fluorophenyl)pyridine |
| GB8709448D0 (en) * | 1987-04-21 | 1987-05-28 | Pfizer Ltd | Heterobicyclic quinoline derivatives |
| JP2686887B2 (en) * | 1992-08-11 | 1997-12-08 | キッセイ薬品工業株式会社 | Piperidino-3,4-dihydrocarbostyril derivative |
| MY146795A (en) * | 2005-06-09 | 2012-09-28 | Novartis Ag | Process for the synthesis of organic compounds |
| CN102532015B (en) * | 2012-01-18 | 2013-10-23 | 云南大学 | Solid-phase synthesis method of coumarin and analogue thereof |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3287459A (en) * | 1961-10-23 | 1966-11-22 | Chattanooga Medicine Co | Carbostyrils, coumarines and thiocoumarines |
| US3668207A (en) * | 1970-01-22 | 1972-06-06 | Ciba Geigy Corp | 2-amino-4-aryl-quinolines |
| DE2123923A1 (en) * | 1971-05-14 | 1972-11-23 | Boehringer Mannheim Gmbh, 6800 Mannheim | Square bracket on omega- (Flavon-7yl-oxy) -alkyl Square bracket on -pigerazine derivatives and process for their preparation |
| BE884459Q (en) * | 1971-05-14 | 1981-01-26 | Boehringer Mannheim Gmbh | 4- (OMEGA- (COUMARINE-7-YL-OXY) -ALKYL) -PIPERAZINE DERIVATIVES AND PREPARATION METHOD |
| JPS4976877A (en) * | 1972-11-28 | 1974-07-24 | ||
| US4004012A (en) * | 1975-10-14 | 1977-01-18 | Sterling Drug Inc. | 3-Cyano-5-(pyridinyl)-2(1H)-pyridinones |
| DE2827566A1 (en) * | 1978-06-23 | 1980-01-10 | Boehringer Mannheim Gmbh | 1,2-DIHYDRO-CHINOLIN-2-ON DERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF |
| HU190412B (en) * | 1981-09-17 | 1986-09-29 | Warner-Lambert Co,Us | Process for producing substituted 4,5-dihiydro-6-bracket-substituted-bracket closed-phenyl-3-bracket-2h-bracket closed-pyridazinones and 6-bracket-substituted-bracket closed-phenyl-3-bracket-2h-bracket closed-pyridazinones |
| IL69407A (en) * | 1982-08-23 | 1987-10-20 | Warner Lambert Co | 2(1h)-pyridinones,their preparation and pharmaceutical compositions containing them |
| US4503061A (en) * | 1983-07-22 | 1985-03-05 | Warner-Lambert Company | Substituted phenyl-pyridinones as cardiotonic agents |
| US4550119A (en) * | 1983-05-23 | 1985-10-29 | Warner-Lambert Company | 2,4-Dihydro-5-[(substituted)phenyl]-4,4-disubstituted-3H-pyrazol-3-ones |
| PT79699B (en) * | 1983-12-22 | 1986-12-10 | Pfizer | Process for preparing quinolone inotropic agents |
| GR851296B (en) * | 1984-05-29 | 1985-11-25 | Pfizer |
-
1985
- 1985-01-30 GB GB858502267A patent/GB8502267D0/en active Pending
- 1985-06-10 CN CN85104392A patent/CN85104392B/en not_active Expired
-
1986
- 1986-01-27 EP EP86300524A patent/EP0190857B1/en not_active Expired - Lifetime
- 1986-01-27 US US06/822,575 patent/US4728654A/en not_active Expired - Lifetime
- 1986-01-27 AT AT86300524T patent/ATE51224T1/en not_active IP Right Cessation
- 1986-01-27 DE DE8686300524T patent/DE3669714D1/en not_active Expired - Lifetime
- 1986-01-28 PT PT81921A patent/PT81921B/en unknown
- 1986-01-28 ES ES551343A patent/ES8706122A1/en not_active Expired
- 1986-01-28 CA CA000500469A patent/CA1255662A/en not_active Expired
- 1986-01-28 PL PL25766986A patent/PL257669A1/en unknown
- 1986-01-28 GR GR860249A patent/GR860249B/en unknown
- 1986-01-29 FI FI860424A patent/FI860424A/en not_active Application Discontinuation
- 1986-01-29 DK DK43286A patent/DK43286A/en not_active Application Discontinuation
- 1986-01-29 HU HU86408A patent/HU194831B/en not_active IP Right Cessation
- 1986-01-29 AU AU52798/86A patent/AU557667B2/en not_active Ceased
- 1986-01-29 IE IE860258A patent/IE860258L/en unknown
- 1986-01-29 KR KR1019860000571A patent/KR880000132B1/en not_active IP Right Cessation
- 1986-01-30 JP JP61019171A patent/JPS61176568A/en active Pending
-
1987
- 1987-02-27 ES ES557430A patent/ES8801902A1/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| EP0190857A2 (en) | 1986-08-13 |
| HUT40421A (en) | 1986-12-28 |
| ES551343A0 (en) | 1987-06-01 |
| PT81921A (en) | 1986-02-01 |
| ES557430A0 (en) | 1988-03-01 |
| EP0190857A3 (en) | 1987-08-19 |
| DE3669714D1 (en) | 1990-04-26 |
| CN85104392B (en) | 1988-02-17 |
| CA1255662A (en) | 1989-06-13 |
| ATE51224T1 (en) | 1990-04-15 |
| EP0190857B1 (en) | 1990-03-21 |
| US4728654A (en) | 1988-03-01 |
| IE860258L (en) | 1986-07-30 |
| FI860424A0 (en) | 1986-01-29 |
| FI860424A (en) | 1986-07-31 |
| HU194831B (en) | 1988-03-28 |
| AU557667B2 (en) | 1987-01-08 |
| KR880000132B1 (en) | 1988-03-12 |
| DK43286D0 (en) | 1986-01-29 |
| JPS61176568A (en) | 1986-08-08 |
| AU5279886A (en) | 1986-08-07 |
| ES8801902A1 (en) | 1988-03-01 |
| DK43286A (en) | 1986-07-31 |
| PL257669A1 (en) | 1987-05-18 |
| CN85104392A (en) | 1986-12-24 |
| ES8706122A1 (en) | 1987-06-01 |
| KR860005790A (en) | 1986-08-13 |
| GR860249B (en) | 1986-05-29 |
| GB8502267D0 (en) | 1985-02-27 |
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