MX9504262A - Procedimiento novedoso para la preparacion de derivados de clonidina. - Google Patents
Procedimiento novedoso para la preparacion de derivados de clonidina.Info
- Publication number
- MX9504262A MX9504262A MX9504262A MX9504262A MX9504262A MX 9504262 A MX9504262 A MX 9504262A MX 9504262 A MX9504262 A MX 9504262A MX 9504262 A MX9504262 A MX 9504262A MX 9504262 A MX9504262 A MX 9504262A
- Authority
- MX
- Mexico
- Prior art keywords
- novel process
- preparation
- clonidine derivatives
- discovered
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D239/08—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms directly attached in position 2
- C07D239/12—Nitrogen atoms not forming part of a nitro radical
- C07D239/14—Nitrogen atoms not forming part of a nitro radical with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to said nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/04—Derivatives of thiourea
- C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/44—Nitrogen atoms not forming part of a nitro radical
- C07D233/50—Nitrogen atoms not forming part of a nitro radical with carbocyclic radicals directly attached to said nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/04—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 3
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Se ha descubierto un procedimiento novedoso para la preparacion de derivados de clonidina que es más corto, menos costoso y más seguro que los métodos anteriormente conocidos; un nuevo complejo de tiourea de la formula (I); en donde: Ar es un fenilo o naftilo sustituido o no substituido con una o más porciones seleccionadas a partir del grupo que consiste de: Cl, F, Br, I, alquilo de 1 a 4 átomos de carbono, arilo, alcoxi o arilalcoxi de 1 a 4 átomos de carbono; NO2 está en la posicion para u ortho; y n es de 1 a 4; y se ha descubierto también puede ciclizarse directamente para producir el producto heterocíclico correspondiente.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19331994A | 1994-02-08 | 1994-02-08 | |
| US193,319 | 1994-02-08 | ||
| US193319 | 1994-02-08 | ||
| PCT/US1995/001641 WO1995021818A1 (en) | 1994-02-08 | 1995-02-07 | Novel process for preparation of clonidine derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX9504262A true MX9504262A (es) | 1997-12-31 |
| MXPA95004262A MXPA95004262A (es) | 1998-09-18 |
Family
ID=
Also Published As
| Publication number | Publication date |
|---|---|
| US5684156A (en) | 1997-11-04 |
| CN1220261A (zh) | 1999-06-23 |
| CN1107056C (zh) | 2003-04-30 |
| FI113649B (fi) | 2004-05-31 |
| DE69500313D1 (de) | 1997-06-26 |
| FI954749A0 (fi) | 1995-10-05 |
| NO953988D0 (no) | 1995-10-06 |
| WO1995021818A1 (en) | 1995-08-17 |
| JP2686367B2 (ja) | 1997-12-08 |
| CN1046501C (zh) | 1999-11-17 |
| ATE153330T1 (de) | 1997-06-15 |
| DK0693055T3 (da) | 1997-12-15 |
| EP0693055B1 (en) | 1997-05-21 |
| CN1123026A (zh) | 1996-05-22 |
| AU1840895A (en) | 1995-08-29 |
| KR960701836A (ko) | 1996-03-28 |
| NZ281460A (en) | 1996-10-28 |
| NO305432B1 (no) | 1999-05-31 |
| KR100218978B1 (ko) | 1999-09-01 |
| ES2103151T3 (es) | 1997-08-16 |
| FI954749L (fi) | 1995-10-05 |
| CA2158763A1 (en) | 1995-08-17 |
| JPH08509005A (ja) | 1996-09-24 |
| AU677513B2 (en) | 1997-04-24 |
| DE69500313T2 (de) | 1997-11-06 |
| HK1019742A1 (en) | 2000-02-25 |
| GR3024164T3 (en) | 1997-10-31 |
| CA2158763C (en) | 2002-10-29 |
| EP0693055A1 (en) | 1996-01-24 |
| NO953988L (no) | 1995-12-07 |
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