[go: up one dir, main page]

ES8504719A1 - Un metodo para preparar derivados de 4-hidroxi-2-quinolona. - Google Patents

Un metodo para preparar derivados de 4-hidroxi-2-quinolona.

Info

Publication number
ES8504719A1
ES8504719A1 ES530392A ES530392A ES8504719A1 ES 8504719 A1 ES8504719 A1 ES 8504719A1 ES 530392 A ES530392 A ES 530392A ES 530392 A ES530392 A ES 530392A ES 8504719 A1 ES8504719 A1 ES 8504719A1
Authority
ES
Spain
Prior art keywords
straight
chain length
hydrogen
lower alkyl
branched
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES530392A
Other languages
English (en)
Other versions
ES530392A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Shinyaku Co Ltd
Original Assignee
Nippon Shinyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Shinyaku Co Ltd filed Critical Nippon Shinyaku Co Ltd
Publication of ES8504719A1 publication Critical patent/ES8504719A1/es
Publication of ES530392A0 publication Critical patent/ES530392A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/10—Expectorants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE 4-HIDROXI-2-QUINOLONA Y DE SUS SALES, DE FORMULA (I), EN LA QUE R-R PUEDEN SER VARIOS TIPOS DE RADICALES.CONSISTE EN LA REACCION DE SUSTITUCION DE FRIEDEL-CRAFTS DE UN COMPUESTO DE FORMULA (II), POR TRATAMIENTO CON UN COMPUESTO DE FORMULA (III), EN LAS QUE X ES UN HALOGENO Y LOS DEMAS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I).ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SU ACTIVIDAD ANTIINFLAMATORIA, ANTIALERGICA Y EXPECTORANTE.
ES530392A 1982-06-21 1984-03-08 Un metodo para preparar derivados de 4-hidroxi-2-quinolona. Granted ES530392A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP57107366A JPS58225065A (ja) 1982-06-21 1982-06-21 ２−キノロン誘導体

Publications (2)

Publication Number Publication Date
ES8504719A1 true ES8504719A1 (es) 1985-05-01
ES530392A0 ES530392A0 (es) 1985-05-01

Family

ID=14457260

Family Applications (4)

Application Number Title Priority Date Filing Date
ES523419A Granted ES523419A0 (es) 1982-06-21 1983-06-20 Un metodo para preparar derivados de 4-hidroxi-2-quinolona
ES530392A Granted ES530392A0 (es) 1982-06-21 1984-03-08 Un metodo para preparar derivados de 4-hidroxi-2-quinolona.
ES530393A Granted ES530393A0 (es) 1982-06-21 1984-03-08 Un metodo para preparar derivados de 4-hidroxi-2-quinolonas.
ES530391A Granted ES530391A0 (es) 1982-06-21 1984-03-08 Un metodo para preparar derivados de 4-hidroxi-2-quinolona.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES523419A Granted ES523419A0 (es) 1982-06-21 1983-06-20 Un metodo para preparar derivados de 4-hidroxi-2-quinolona

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES530393A Granted ES530393A0 (es) 1982-06-21 1984-03-08 Un metodo para preparar derivados de 4-hidroxi-2-quinolonas.
ES530391A Granted ES530391A0 (es) 1982-06-21 1984-03-08 Un metodo para preparar derivados de 4-hidroxi-2-quinolona.

Country Status (7)

Country Link
US (1) US4526894A (es)
EP (1) EP0101330B1 (es)
JP (1) JPS58225065A (es)
KR (1) KR900004041B1 (es)
CA (1) CA1191140A (es)
DE (1) DE3377797D1 (es)
ES (4) ES523419A0 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5916878A (ja) * 1982-07-20 1984-01-28 Mitsubishi Yuka Yakuhin Kk ２，４−ジヒドロキシ−３−アセチルキノリン類の製造方法
US5179107A (en) * 1990-09-07 1993-01-12 Schering Corporation Antiviral quinolinone compounds
CA2091173A1 (en) * 1990-09-07 1992-03-08 Adriano Afonso Antiviral compounds and antihypertensive compounds
US5412104A (en) * 1990-09-07 1995-05-02 Schering Corporation Ester and alkoxy substituted benzopyrans
US5179093A (en) * 1991-05-10 1993-01-12 Schering Corporation Quinoline-diones
JP2943725B2 (ja) * 1996-01-17 1999-08-30 大日本インキ化学工業株式会社 キノリノン誘導体及びそれを有効成分とする抗アレルギー剤
KR100908418B1 (ko) 2001-06-20 2009-07-21 액티버스 파마 컴퍼니 리미티드 퀴놀리논 유도체 의약 조성물 및 그의 제조 방법
US7858640B2 (en) * 2005-09-30 2010-12-28 Pulmagen Therapeutics (Asthma) Limited Quinolines and their therapeutic use
GB0519969D0 (en) * 2005-09-30 2005-11-09 Argenta Discovery Ltd Quinoline compounds
CN101679359B (zh) * 2007-04-04 2013-03-06 普尔玛根治疗(哮喘)有限公司 喹啉类化合物及它们的治疗用途
EP2326650B9 (en) 2008-08-06 2014-09-10 BioMarin Pharmaceutical Inc. Dihydropyridophthalazinone inhibitors of poly(adp-ribose)polymerase (parp)
CA2787844C (en) 2010-02-03 2019-08-27 Biomarin Pharmaceutical Inc. Dihydropyridophthalazinone inhibitors of poly(adp-ribose) polymerase (parp) for use in treatment of diseases associated with a pten deficiency
HUE030794T2 (en) * 2010-02-08 2017-06-28 Medivation Technologies Inc Synthesis Processes of Dihydro-Pyrido-Phthalazinone Derivatives
EP3757106A1 (en) 2010-10-21 2020-12-30 Medivation Technologies LLC Crystaline (8s,9r)-5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1h-1,2,4-triazol-5-yl)-8,9-dihydro-2h-pyrido[4,3,2-de]phtalazin-3(7h)-one tosylate salt
CN102146068A (zh) * 2011-01-20 2011-08-10 南开大学 3-苯甲酰基-4-羟基香豆素衍生物及其类似物与在除草方面的应用
IT202000023815A1 (it) * 2020-10-09 2022-04-09 Igm Resins Italia Srl Ketoquinolones as photonitiators

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1770480B2 (de) * 1968-05-22 1977-09-29 Basf Ag, 6700 Ludwigshafen Verfahren zur herstellung von 2,4- dihydroxychinolin
CH606285A5 (es) * 1974-12-17 1978-10-31 Ciba Geigy Ag
US4086349A (en) * 1975-07-30 1978-04-25 Mitsubishi Yuka Pharmaceutical Co., Ltd. Quinolopyran-4-one-2-carboxylic acid derivatives and salts thereof as novel compounds and as medicines for treatment of allergic asthma
DE2806879A1 (de) * 1978-02-17 1979-08-23 Sandoz Ag 4-hydroxy-2-chinolinon-3-carbonsaeure- esterderivate
ATE27451T1 (de) * 1981-03-24 1987-06-15 Ciba Geigy Ag Acyl-chinolinonderivate, verfahren zu ihrer herstellung, diese enthaltende pharmazeutische praeparate und ihre verwendung.

Also Published As

Publication number Publication date
EP0101330A3 (en) 1984-08-22
KR900004041B1 (ko) 1990-06-09
CA1191140A (en) 1985-07-30
US4526894A (en) 1985-07-02
ES8504718A1 (es) 1985-05-01
ES8504723A1 (es) 1985-05-01
JPH0249306B2 (es) 1990-10-29
ES8504130A1 (es) 1985-04-01
ES530391A0 (es) 1985-05-01
EP0101330A2 (en) 1984-02-22
KR840005101A (ko) 1984-11-03
ES523419A0 (es) 1985-04-01
ES530393A0 (es) 1985-05-01
JPS58225065A (ja) 1983-12-27
DE3377797D1 (en) 1988-09-29
EP0101330B1 (en) 1988-08-24
ES530392A0 (es) 1985-05-01

Similar Documents

Publication Publication Date Title
MA18694A1 (fr) Nouveaux derives de piperidinyl alkyl-quinazoline
ES8504718A1 (es) Un metodo para preparar derivados de 4-hidroxi-2-quinolona.
ATE48991T1 (de) 11-substituierte-16-phenoxy und 16phenoxysubstituierte prostatriensaeurederivate.
ATE117681T1 (de) Chinolinderivate, ihre herstellung und verwendung.
DE3776044D1 (de) Pyridazinon-derivate.
DK415789D0 (da) Tetracykliske antidepressive midler
ATE43588T1 (de) Benzofuranderivate, verfahren zu ihrer herstellung und sie enthaltende antihypertensive mittel.
ES8504761A1 (es) Un metodo para preparar derivados de 3-metilflavona
AU553826B2 (en) Benzopyran-6-yl ethane-carboxylic acid and derivatives
IE43651L (en) Benzisoquinolin-piperidine derivatives
ES446325A1 (es) Procedimiento para preparar tieno-(3,2-c)-piridina y deriva-dos de la misma.
ATE53833T1 (de) Derivate des phenylacetanilids.
JPS5473797A (en) Pyride 3.2.1-jk carbazole derivative
DE3361834D1 (en) Dithiino (1,4) (2,3-c) pyrrole derivatives, their preparation and pharmaceutical compositions containing them
JPS51138700A (en) Pro cess for preparation of novel pteridine derivatives

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970401