[go: up one dir, main page]

MX9304787A - Prodrogas de acidos de imidazolcarboxilicos y composiciones farmaceuticasque las contienen. - Google Patents

Prodrogas de acidos de imidazolcarboxilicos y composiciones farmaceuticasque las contienen.

Info

Publication number
MX9304787A
MX9304787A MX9304787A MX9304787A MX9304787A MX 9304787 A MX9304787 A MX 9304787A MX 9304787 A MX9304787 A MX 9304787A MX 9304787 A MX9304787 A MX 9304787A MX 9304787 A MX9304787 A MX 9304787A
Authority
MX
Mexico
Prior art keywords
pharmaceutical compositions
prodroges
imidazolcarboxilic
acids
contain
Prior art date
Application number
MX9304787A
Other languages
English (en)
Inventor
Robert John Ardecky
Carol Lee Ensinger
James Russell Prutt
Original Assignee
Du Pont
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont filed Critical Du Pont
Publication of MX9304787A publication Critical patent/MX9304787A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención se relaciona con prodrogas de ácidosimidazolcarboxílicos los cuales son antagonistas de la AII útiles en eltratamiento de la hipertensión, las composiciones farmacéuticas de losmismos y un método de tratamiento de la hipertensión utilizando talesprodrogas.
MX9304787A 1992-08-06 1993-08-06 Prodrogas de acidos de imidazolcarboxilicos y composiciones farmaceuticasque las contienen. MX9304787A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/926,795 US5310929A (en) 1992-08-06 1992-08-06 Prodrugs of imidazole carboxylic acids as angiotensin II receptor antagonists

Publications (1)

Publication Number Publication Date
MX9304787A true MX9304787A (es) 1995-01-31

Family

ID=25453732

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9304787A MX9304787A (es) 1992-08-06 1993-08-06 Prodrogas de acidos de imidazolcarboxilicos y composiciones farmaceuticasque las contienen.

Country Status (18)

Country Link
US (1) US5310929A (es)
EP (1) EP0654027A1 (es)
JP (1) JP2892838B2 (es)
CN (1) CN1090275A (es)
AU (1) AU688735B2 (es)
BR (1) BR9306911A (es)
CA (1) CA2141692C (es)
FI (1) FI950485A0 (es)
HU (1) HU9500349D0 (es)
IL (1) IL106553A0 (es)
MX (1) MX9304787A (es)
NO (1) NO950404D0 (es)
PL (1) PL307309A1 (es)
SG (1) SG47108A1 (es)
SK (1) SK13195A3 (es)
TW (1) TW239131B (es)
WO (1) WO1994003435A1 (es)
ZA (1) ZA935693B (es)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5616599A (en) * 1991-02-21 1997-04-01 Sankyo Company, Limited Angiotensin II antagosist 1-biphenylmethylimidazole compounds and their therapeutic use
CZ283315B6 (cs) * 1992-12-17 1998-02-18 Sankyo Company Limited Bifenylové deriváty, způsob výroby a farmaceutické prostředky k léčení hypertense a srdečních onemocnění, které tyto deriváty obsahují
KR100211446B1 (ko) * 1994-03-16 1999-08-02 가와무라 요시부미 안압 저하제
US6221335B1 (en) * 1994-03-25 2001-04-24 Isotechnika, Inc. Method of using deuterated calcium channel blockers
US5510495A (en) * 1994-09-19 1996-04-23 The Du Pont Merck Pharmaceutical Company Process for the isolation and purification of ester functionalized imidazole intermediates by selective hydrolysis
DE69507887T2 (de) * 1994-09-20 1999-06-17 Wakunaga Seiyaku K.K., Osaka Verfahren zur herstellung von n-biphenylmethylthiadiazolin derivaten oder deren salzen sowie dafür benötigte zwischen verbindungen
IT1292437B1 (it) * 1997-06-30 1999-02-08 Zambon Spa Processo di orto-metallazione utile per la sintesi di 1 - tetrazol- 5-il) benzeni 2-sostituiti
IT1295405B1 (it) * 1997-09-30 1999-05-12 Merck Sharp & Dohme Italia S P Uso di un antagonista recettoriale di angiotensina ii per la preparazione di farmaci per aumentare il tasso di sopravvivenza di
DE19820064A1 (de) * 1998-05-06 1999-11-11 Hoechst Marion Roussel De Gmbh Substituierte Sulfonylcyanamide, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikament
DE19832429A1 (de) * 1998-07-18 2000-01-20 Hoechst Marion Roussel De Gmbh Imidazolderivate mit Biphenylsulfonylsubstitution, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19832428A1 (de) * 1998-07-18 2000-01-20 Hoechst Marion Roussel De Gmbh Imidazolderivate mit Biphenylsulfonylsubstitution, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
ES2154191B1 (es) * 1998-11-24 2001-10-16 Ferrer Int Nuevos acetales derivados de los 2-alquil-5-halo-3-(2'-(tetrazol-5-il)-bifenil-4-ilmetil)-3h-imidazol-4-carbaldehidos.
GR20000100281A (el) * 2000-08-17 2002-05-24 Ιωαννης Ματσουκας Ανταγωνιστες του υποδοχεα της αγγεοτενσινης ιι και συνθετικες μεθοδοι για την θεραπεια της υπερτασης και καρδιοαγγειακων ασθενειων
AU2002257970B2 (en) 2001-05-31 2007-08-02 Vicore Pharma Ab Tricyclic compounds useful as angiotensin II agonists
ES2281312T3 (es) * 2003-01-16 2008-08-01 Teva Pharmaceutical Industries Ltd. Nueva sintesis de irbesartan.
ES2390967T3 (es) 2004-01-20 2012-11-20 Aichi Prefecture Epítopo/péptido reconocido por LTC específico para Ep-CAM con restricción por ALH-A2402 y su utilización
US7157584B2 (en) * 2004-02-25 2007-01-02 Takeda Pharmaceutical Company Limited Benzimidazole derivative and use thereof
KR100953878B1 (ko) * 2004-09-02 2010-04-22 테바 파마슈티컬 인더스트리즈 리미티드 올메살탄 메독소밀의 정제
US20070054948A1 (en) * 2004-09-02 2007-03-08 Lilach Hedvati Purification of olmesartan medoxomil
WO2006115834A1 (en) * 2005-04-20 2006-11-02 Merck & Co., Inc. Angiotensin ii receptor antagonists
JP2009515834A (ja) * 2006-08-29 2009-04-16 テバ ファーマシューティカル インダストリーズ リミティド ５−フェニル−１−トリチル−１ｈ−テトラゾールの合成のための方法
AU2007306171B2 (en) * 2006-10-09 2013-02-21 Cipla Limited Process for preparing trityl olmesartan medoxomil and olmesartan medoxomil
WO2008067687A1 (fr) * 2006-12-06 2008-06-12 Shanghai Allist Pharmaceutical., Inc. Sels de dérivés d'acide imidazol-5-carboxylique, procédés de préparation et utilisation
EP2521545B1 (en) * 2010-01-07 2019-11-27 Alkermes Pharma Ireland Limited Prodrugs of heteroaromatic compounds
EP2455388A1 (en) 2010-11-23 2012-05-23 LanthioPep B.V. Novel angiotensin type 2 (AT2) receptor agonists and uses thereof.
CN104610232B (zh) * 2013-11-01 2019-09-20 深圳信立泰药业股份有限公司 阿利沙坦酯无定形及其制备方法及含所述无定形的药物组合物
CN114514032A (zh) 2019-08-02 2022-05-17 兰提欧派普有限公司 用于治疗癌症的血管紧张素2型(at2)受体激动剂

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5138069A (en) * 1986-07-11 1992-08-11 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking imidazoles
CA1338238C (en) * 1988-01-07 1996-04-09 David John Carini Angiotensin ii receptor blocking imidazoles and combinations thereof with diuretics and nsaids
EP0479892A1 (en) * 1989-06-30 1992-04-15 E.I. Du Pont De Nemours And Company Fused-ring aryl substituted imidazoles
EP0479903B1 (en) * 1989-06-30 1996-02-21 E.I. Du Pont De Nemours And Company Substituted imidazoles useful as angiotensin ii blockers
GB8927277D0 (en) * 1989-12-01 1990-01-31 Glaxo Group Ltd Chemical compounds
US5196444A (en) * 1990-04-27 1993-03-23 Takeda Chemical Industries, Ltd. 1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate and compositions and methods of pharmaceutical use thereof
US5137902A (en) * 1990-07-13 1992-08-11 E. I. Du Pont De Nemours And Company 4-alkylimidazole derivatives and anti-hypertensive use thereof
DE69329982T2 (de) * 1992-06-02 2001-09-27 Sankyo Co., Ltd. 4-Carboxyimidazolderivate als Angiotensin-II-Antagonisten und ihre therapeutische Verwendung

Also Published As

Publication number Publication date
CN1090275A (zh) 1994-08-03
US5310929A (en) 1994-05-10
AU4790393A (en) 1994-03-03
ZA935693B (en) 1995-02-06
EP0654027A1 (en) 1995-05-24
SG47108A1 (en) 1998-03-20
WO1994003435A1 (en) 1994-02-17
FI950485A (fi) 1995-02-03
JP2892838B2 (ja) 1999-05-17
AU688735B2 (en) 1998-03-19
SK13195A3 (en) 1995-07-11
PL307309A1 (en) 1995-05-15
BR9306911A (pt) 1998-12-08
CA2141692A1 (en) 1994-02-17
TW239131B (es) 1995-01-21
FI950485A0 (fi) 1995-02-03
JPH08500103A (ja) 1996-01-09
CA2141692C (en) 2006-05-30
IL106553A0 (en) 1993-12-08
NO950404D0 (no) 1995-02-03
HU9500349D0 (en) 1995-03-28

Similar Documents

Publication Publication Date Title
MX9304787A (es) Prodrogas de acidos de imidazolcarboxilicos y composiciones farmaceuticasque las contienen.
DE69334035D1 (de) Verfahren zur vorbeugung von nmda-rezeptor vermittelten neuronalen schäden
DE122009000012I1 (de) Substituierte pyrazolyl-benzolsulfonamide zur behandlung von entzundungen.
MX9602818A (es) Un metodo de tratamiento de infeccion parasitaria usando antagonistas ige.
DE69733132D1 (de) Verwendung von antioxidantien zur behandlung cholestatischer lebererkrankungen
ATE201597T1 (de) Verabreichung von riluzol zur behandlung von neuro-aids
IT1265101B1 (it) Derivati dell'acido 2-ammino-4-fenil-4-osso butirrico
DE69405919D1 (de) Zusammensetzungen zur Behandlung von Keratinfasern
ATE258789T1 (de) 5-ht2-antagonisten in der behandlung venöser zustände
ATE230609T1 (de) Verfahren zur behandlung von entzündungen und zusammensetzungen dafür
DE69818823D1 (de) Dipohosphonsäuresalze für die behandlung von osteoporose
FI935064A0 (fi) Nya heterocykliska karboxylsyror
ES2069915T3 (es) Dicarbonatos y uretanos de los acidos 4,5-dihidroxi- y 4,5,8-trihidroxi-9,10-dihidro-9,10-dioxo-2-antracenocarboxilicos que tienen actividades terapeuticas.
ATE225171T1 (de) Aminosäurederivate zur behandlung von schlaganfall
BR9611472A (pt) Compostos de di-terc-butilfenol contendo enxofre úteis como agentes antiinflamatórios
ATE99946T1 (de) Lagerstabile orale glucosaminsulfat-dosisformen und verfahren zu deren herstellung.
DE69705967D1 (de) Stabilisierte pharmazeutische zusammensetzungen und verfahren zu ihrer herstellung
ATE330604T1 (de) Behandlung von manischen erkrankungen
MX9400072A (es) Agentes antiinflamatorios derivados de difluoropentapeptido.
BG98888A (en) Method for the preparation of 3-acylestratrienes and acylbezenes
EA199900174A1 (ru) Способ лечения биполярного расстройства
IT1157268B (it) Derivati dagli acidi alfa o beta mercaptopropionilammidoacetici, processo per la loro preparazione e composizioni terapeutiche che li comprendono come principio attivo
DE69824862D1 (de) Zusammenstellungen zur verbesserten wundheilung
ES8407021A1 (es) Un procedimiento para la preparacion de derivados de acido 5-oxo-2-pirrolidinpropanoico.
IT1263913B (it) Composti terapeuticamente attivi, utili per il trattamento di malattieconnesse con alterata funzionalita' del sistema immunitario, procedimento per la loro preparazione e composizioni farmaceutiche che li contengono