MX9303977A - Composicion farmaceutica y metodo para el mejoramiento de la capacitacion de una sustancia farmacologicamente activa a traves de las membranas mucosas de un animal. - Google Patents
Composicion farmaceutica y metodo para el mejoramiento de la capacitacion de una sustancia farmacologicamente activa a traves de las membranas mucosas de un animal.Info
- Publication number
- MX9303977A MX9303977A MX9303977A MX9303977A MX9303977A MX 9303977 A MX9303977 A MX 9303977A MX 9303977 A MX9303977 A MX 9303977A MX 9303977 A MX9303977 A MX 9303977A MX 9303977 A MX9303977 A MX 9303977A
- Authority
- MX
- Mexico
- Prior art keywords
- animal
- improvement
- pharmacologically active
- mucous membranes
- training
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 3
- 239000013543 active substance Substances 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 210000004400 mucous membrane Anatomy 0.000 title abstract 2
- 229930182490 saponin Natural products 0.000 abstract 4
- 150000007949 saponins Chemical class 0.000 abstract 4
- 235000017709 saponins Nutrition 0.000 abstract 4
- 241001454523 Quillaja saponaria Species 0.000 abstract 2
- 235000009001 Quillaja saponaria Nutrition 0.000 abstract 2
- 206010022998 Irritability Diseases 0.000 abstract 1
- 125000003172 aldehyde group Chemical group 0.000 abstract 1
- 235000014113 dietary fatty acids Nutrition 0.000 abstract 1
- 229930195729 fatty acid Natural products 0.000 abstract 1
- 239000000194 fatty acid Substances 0.000 abstract 1
- 150000004665 fatty acids Chemical class 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 230000004048 modification Effects 0.000 abstract 1
- 238000012986 modification Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
- C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/28—Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Mycology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Steroid Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Se describen los métodos para el mejoramiento del transporte de substancias farmacológicamente activas a través de las membranas mucosas de un animal, mediante la administración de composiciones farmacéuticas que comprenden saponinas modificadas o fracciones de las mismas, obtenibles mediante modificación de un extracto de Quillaja saponaria crudo, o mediante modificación de saponinas purificadas obtenibles de un extracto crudo de Quillaja saponaria. También se describen las saponinas modificadas que tienen irritabilidad reducida, en donde la porción de ácido graso se elimina mediante hidrólisis o se reduce el grupo aldehído. También se describen las composiciones farmacéuticas que comprenden las saponinas modificadas de la invención.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/906,870 US5273965A (en) | 1992-07-02 | 1992-07-02 | Methods for enhancing drug delivery with modified saponins |
Publications (1)
Publication Number | Publication Date |
---|---|
MX9303977A true MX9303977A (es) | 1994-04-29 |
Family
ID=25423119
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX9303977A MX9303977A (es) | 1992-07-02 | 1993-07-01 | Composicion farmaceutica y metodo para el mejoramiento de la capacitacion de una sustancia farmacologicamente activa a traves de las membranas mucosas de un animal. |
Country Status (11)
Country | Link |
---|---|
US (2) | US5273965A (es) |
EP (1) | EP0658111B1 (es) |
JP (1) | JP3684370B2 (es) |
AU (1) | AU687005B2 (es) |
BR (1) | BR9306594A (es) |
CA (1) | CA2139437A1 (es) |
DE (1) | DE69326772T2 (es) |
FI (1) | FI946173L (es) |
HU (1) | HUT73814A (es) |
MX (1) | MX9303977A (es) |
WO (1) | WO1994001118A1 (es) |
Families Citing this family (78)
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US5650398A (en) * | 1992-07-02 | 1997-07-22 | Cambridge Biotech Corporation | Drug delivery enhancement via modified saponins |
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KR970701043A (ko) * | 1994-02-25 | 1997-03-17 | 데이비드 키즈키스 | 항-염증성 및 감염 보호 효과를 갖는 세사민-기본 리그난(anti-inflammatory and infection protective effects of sesamin-based lignans) |
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BR9809149A (pt) * | 1997-05-20 | 2000-08-01 | Galenica Pharmaceuticals Inc | Análogos de triterpeno saponina dotados de adjuvante e atividade imonoestimulatória |
US8765177B2 (en) | 1997-09-12 | 2014-07-01 | Columbia Laboratories, Inc. | Bioadhesive progressive hydration tablets |
US7153845B2 (en) | 1998-08-25 | 2006-12-26 | Columbia Laboratories, Inc. | Bioadhesive progressive hydration tablets |
US20040265377A1 (en) * | 1997-10-27 | 2004-12-30 | Harry Seager | Solid dispersing vaccine composition for oral delivery |
US20070059327A2 (en) * | 1998-01-15 | 2007-03-15 | Wyeth | Streptococcus equi compositions and methods of use |
US7070799B1 (en) * | 1998-02-10 | 2006-07-04 | Generex Pharmaceuticals, Inc. | Method for administering insulin to the buccal region |
CA2328946C (en) | 1998-04-17 | 2008-02-12 | Her Majesty The Queen In Right Of Canada As Represented By The Minister Of Agriculture And Agri-Food Canada | Process for recovery and purification of saponins and sapogenins from quinoa (chenopodium quinoa) |
US20010034330A1 (en) * | 1998-08-10 | 2001-10-25 | Charlotte Kensil | Innate immunity-stimulating compositions of CpG and saponin and methods thereof |
ATE315405T1 (de) | 1998-08-10 | 2006-02-15 | Antigenics Inc | Cpg-zusammensetzungen, saponin-adjuvantien und verfahren zu deren verwendung |
WO2000009075A2 (en) | 1998-08-14 | 2000-02-24 | Galenica Pharmaceuticals, Inc. | Chemically modified saponins and the use thereof as adjuvants |
CA2362204C (en) | 1999-02-17 | 2011-11-08 | John Cooper Cox | Immunogenic complexes and methods relating thereto |
ES2311478T3 (es) * | 1999-11-19 | 2009-02-16 | Csl Limited | Composiciones de vacuna contra el hcv. |
CZ304942B6 (cs) * | 2000-03-31 | 2015-02-04 | Purdue Research Foundation | Léčivo pro zvyšování specifické eliminace populace tumorových buněk a farmaceutický prostředek obsahující konjugát fosfát-FITC nebo fosfát-dinitrofenyl |
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US7666914B2 (en) * | 2004-06-03 | 2010-02-23 | Richlin David M | Topical preparation and method for transdermal delivery and localization of therapeutic agents |
US20080287662A1 (en) * | 2005-06-22 | 2008-11-20 | Zeev Wiesman | Balanites Aegyptiaca Saponins and Uses Thereof |
WO2007092299A2 (en) * | 2006-02-03 | 2007-08-16 | Purdue Research Foundation | Targeted conjugates and radiation |
CA2692221A1 (en) * | 2007-06-27 | 2008-12-31 | Coloplast A/S | Treatment of urinary tract infections with a mixture of saponin and an antibiotic |
EP2222328A4 (en) * | 2007-11-15 | 2013-06-05 | Endocyte Inc | PROCESS FOR THE ADMINISTRATION OF CONJUGATES |
CN102946900A (zh) | 2010-03-11 | 2013-02-27 | 免疫设计公司 | 用于大流行流感的疫苗 |
US9332776B1 (en) | 2010-09-27 | 2016-05-10 | ZoomEssence, Inc. | Methods and apparatus for low heat spray drying |
US8939388B1 (en) | 2010-09-27 | 2015-01-27 | ZoomEssence, Inc. | Methods and apparatus for low heat spray drying |
SG192759A1 (en) | 2011-02-15 | 2013-09-30 | Immune Design Corp | Methods for enhancing immunogen specific immune responses by vectored vaccines |
JP2014515597A (ja) | 2011-03-04 | 2014-07-03 | インターナショナル フレーバーズ アンド フラグランシズ インコーポレイテッド | 揮発性化合物を保持することができる噴霧乾燥組成物および該組成物を製造する方法 |
US20130022728A1 (en) * | 2011-03-04 | 2013-01-24 | International Flavor & Fragrances Inc. | Spray-Dried Compositions Capable of Retaining Volatile Compounds and Methods of Producing the Same |
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US20120288515A1 (en) | 2011-04-27 | 2012-11-15 | Immune Design Corp. | Synthetic long peptide (slp)-based vaccines |
JP6619648B2 (ja) | 2012-05-16 | 2019-12-11 | イミューン デザイン コーポレイション | Hsv−2のためのワクチン |
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US10569244B2 (en) | 2018-04-28 | 2020-02-25 | ZoomEssence, Inc. | Low temperature spray drying of carrier-free compositions |
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WO2021014026A2 (en) * | 2019-07-25 | 2021-01-28 | Sapreme Technologies B.V. | Bioactive saponin linked to a functional moiety |
KR20220149505A (ko) | 2019-12-03 | 2022-11-08 | 누보젠 인코포레이티드 | 종양 세포 백신 |
US20230117744A1 (en) | 2020-03-23 | 2023-04-20 | Loyola University Of Chicago | Coronavirus vaccines compositions and method of using same |
EP4171644A2 (en) * | 2020-06-24 | 2023-05-03 | Sapreme Technologies B.V. | Saponin derivatives for use in medicine |
IL299356A (en) * | 2020-06-24 | 2023-02-01 | Sapreme Tech Bv | Hydrazone-based saponin derivatives |
EP4236995A2 (en) | 2020-11-02 | 2023-09-06 | Neuvogen, Inc. | Tumor cell vaccines |
CN113480985A (zh) * | 2021-07-07 | 2021-10-08 | 东营煜煌能源技术有限公司 | 一种微纳米膨胀胶束弹性颗粒驱油乳液制备方法及应用 |
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DD160763A3 (de) * | 1978-06-05 | 1984-03-07 | Loeffler Friedrich Inst | Verfahren zur herstellung von konzentratvakzinen |
FR2456116A1 (fr) * | 1979-05-11 | 1980-12-05 | Sarget Lab | Nouvelle saponine triterpenique derivee de la caulophyllogenine et ses applications therapeutiques |
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US5166139A (en) * | 1987-02-26 | 1992-11-24 | Indena, S.P.A. | Complexes of saponins and their aglycons with phospholipids and pharmaceutical and cosmetic compositions containing them |
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-
1992
- 1992-07-02 US US07/906,870 patent/US5273965A/en not_active Expired - Lifetime
-
1993
- 1993-07-01 JP JP50560193A patent/JP3684370B2/ja not_active Expired - Fee Related
- 1993-07-01 MX MX9303977A patent/MX9303977A/es not_active IP Right Cessation
- 1993-07-01 HU HU9500001A patent/HUT73814A/hu unknown
- 1993-07-01 BR BR9306594A patent/BR9306594A/pt not_active Application Discontinuation
- 1993-07-01 EP EP93916972A patent/EP0658111B1/en not_active Expired - Lifetime
- 1993-07-01 WO PCT/US1993/006348 patent/WO1994001118A1/en active IP Right Grant
- 1993-07-01 AU AU46649/93A patent/AU687005B2/en not_active Ceased
- 1993-07-01 CA CA002139437A patent/CA2139437A1/en not_active Abandoned
- 1993-07-01 DE DE69326772T patent/DE69326772T2/de not_active Expired - Fee Related
- 1993-09-24 US US08/126,190 patent/US5443829A/en not_active Expired - Lifetime
-
1994
- 1994-12-30 FI FI946173A patent/FI946173L/fi not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
AU687005B2 (en) | 1998-02-19 |
JPH07509440A (ja) | 1995-10-19 |
WO1994001118A1 (en) | 1994-01-20 |
DE69326772D1 (de) | 1999-11-18 |
EP0658111A4 (en) | 1996-02-07 |
JP3684370B2 (ja) | 2005-08-17 |
FI946173L (fi) | 1995-02-15 |
US5273965A (en) | 1993-12-28 |
US5443829A (en) | 1995-08-22 |
EP0658111B1 (en) | 1999-10-13 |
HUT73814A (en) | 1996-09-30 |
EP0658111A1 (en) | 1995-06-21 |
BR9306594A (pt) | 1998-12-08 |
AU4664993A (en) | 1994-01-31 |
CA2139437A1 (en) | 1994-01-20 |
FI946173A0 (fi) | 1994-12-30 |
DE69326772T2 (de) | 2000-06-29 |
HU9500001D0 (en) | 1995-03-28 |
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