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MX376739B - Compuestos sustituidos de 4-fenilpiridina como agonistas de tgr5 no sistemicos - Google Patents

Compuestos sustituidos de 4-fenilpiridina como agonistas de tgr5 no sistemicos

Info

Publication number
MX376739B
MX376739B MX2018007351A MX2018007351A MX376739B MX 376739 B MX376739 B MX 376739B MX 2018007351 A MX2018007351 A MX 2018007351A MX 2018007351 A MX2018007351 A MX 2018007351A MX 376739 B MX376739 B MX 376739B
Authority
MX
Mexico
Prior art keywords
diabetes
substituted
pyridine compounds
phenyl pyridine
systemic
Prior art date
Application number
MX2018007351A
Other languages
English (en)
Other versions
MX2018007351A (es
Inventor
Dean Dragoli
Jason G Lewis
Jeffrey W Jacobs
Jeremy Caldwell
Matthew Siegel
Michael Robert Leadbetter
Noah Bell
Patricia Finn
Rakesh Jain
Tao Chen
Original Assignee
Ardelyx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ardelyx Inc filed Critical Ardelyx Inc
Publication of MX2018007351A publication Critical patent/MX2018007351A/es
Publication of MX376739B publication Critical patent/MX376739B/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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Abstract

La invencion se refiere al agonista de TGR5 no sistemico de utilidad en el tratamiento de diarrea inducida por quimioterapia, diabetes, diabetes de tipo II, diabetes gestacional, glucosa en ayunas alterada, tolerancia a la glucosa alterada, resistencia a la insulina, hiperglicemia, obesidad, sindrome metabolico, colitis ulcerante, enfermedad de Crohn, trastornos asociados con nutricion parenteral en especial durante el sindrome de intestino delgado y sindrome de colon irritable (IBS) y otras enfermedades y trastornos asociados con TGR5, que tiene la formula:(ver formula) donde Ra, R1, R2, R2', R3, R4, X1, X2, X3, X4, Y, Q, Q1 y n se describen en la presente.
MX2018007351A 2015-12-18 2016-12-19 Compuestos sustituidos de 4-fenilpiridina como agonistas de tgr5 no sistemicos MX376739B (es)

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