MX372774B - Variantes mejoradas de acetil-coa carboxilasa. - Google Patents
Variantes mejoradas de acetil-coa carboxilasa.Info
- Publication number
- MX372774B MX372774B MX2016003255A MX2016003255A MX372774B MX 372774 B MX372774 B MX 372774B MX 2016003255 A MX2016003255 A MX 2016003255A MX 2016003255 A MX2016003255 A MX 2016003255A MX 372774 B MX372774 B MX 372774B
- Authority
- MX
- Mexico
- Prior art keywords
- acetyl
- coa carboxylase
- improved variants
- coa
- malonyl
- Prior art date
Links
- 102000000452 Acetyl-CoA carboxylase Human genes 0.000 title abstract 3
- 108010016219 Acetyl-CoA carboxylase Proteins 0.000 title abstract 3
- 108010018763 Biotin carboxylase Proteins 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- LTYOQGRJFJAKNA-KKIMTKSISA-N Malonyl CoA Natural products S(C(=O)CC(=O)O)CCNC(=O)CCNC(=O)[C@@H](O)C(CO[P@](=O)(O[P@](=O)(OC[C@H]1[C@@H](OP(=O)(O)O)[C@@H](O)[C@@H](n2c3ncnc(N)c3nc2)O1)O)O)(C)C LTYOQGRJFJAKNA-KKIMTKSISA-N 0.000 abstract 1
- 229940053200 antiepileptics fatty acid derivative Drugs 0.000 abstract 1
- 238000004113 cell culture Methods 0.000 abstract 1
- LTYOQGRJFJAKNA-DVVLENMVSA-N malonyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)CC(O)=O)O[C@H]1N1C2=NC=NC(N)=C2N=C1 LTYOQGRJFJAKNA-DVVLENMVSA-N 0.000 abstract 1
- LTYOQGRJFJAKNA-VFLPNFFSSA-N malonyl-coa Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)C(O)C(=O)NCCC(=O)NCCSC(=O)CC(O)=O)O[C@H]1N1C2=NC=NC(N)=C2N=C1 LTYOQGRJFJAKNA-VFLPNFFSSA-N 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
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- C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
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Abstract
La presente invención se refiere a variantes de acetil-CoA carboxilasa (ACC) y células hospederas que las expresan para la producción de compuestos derivados de malonil-CoA incluyendo derivados de ácidos grasos. Adicionalmente, se contemplan métodos para producir mayores cantidades de compuestos derivados de malonil-CoA y cultivos celulares relacionados.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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US201361877418P | 2013-09-13 | 2013-09-13 | |
US201361892242P | 2013-10-17 | 2013-10-17 | |
PCT/US2014/055510 WO2015038970A2 (en) | 2013-09-13 | 2014-09-12 | Improved acetyl-coa carboxylase variants |
Publications (2)
Publication Number | Publication Date |
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MX2016003255A MX2016003255A (es) | 2016-06-07 |
MX372774B true MX372774B (es) | 2025-03-05 |
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MX2016003255A MX372774B (es) | 2013-09-13 | 2016-03-11 | Variantes mejoradas de acetil-coa carboxilasa. |
MX2020004514A MX2020004514A (es) | 2013-09-13 | 2016-03-11 | Variantes mejoradas de acetil-coa carboxilasa. |
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MX2020004514A MX2020004514A (es) | 2013-09-13 | 2016-03-11 | Variantes mejoradas de acetil-coa carboxilasa. |
Country Status (12)
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US (2) | US10604750B2 (es) |
EP (3) | EP2964756B1 (es) |
JP (2) | JP6486372B2 (es) |
KR (1) | KR102215530B1 (es) |
CN (3) | CN105705513B (es) |
AU (2) | AU2014318531B2 (es) |
BR (1) | BR112016006859A2 (es) |
CA (1) | CA2923730C (es) |
ES (1) | ES2631807T3 (es) |
MX (2) | MX372774B (es) |
MY (1) | MY176277A (es) |
WO (1) | WO2015038970A2 (es) |
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CN108913724B (zh) * | 2018-07-05 | 2021-02-02 | 青岛农业大学 | 一种以丙二酸盐为原料合成3-羟基丙酸的制备方法及其相应重组细胞和应用 |
CN112813092B (zh) * | 2020-08-06 | 2023-03-21 | 中国农业科学院棉花研究所 | GbBCCP5蛋白质及其编码基因在调控生物油脂含量中的应用 |
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US417721A (en) | 1889-12-24 | Combination-valve for air-brakes | ||
WO1991016427A1 (en) | 1990-04-24 | 1991-10-31 | Stratagene | Methods for phenotype creation from multiple gene populations |
US5801233A (en) * | 1992-10-02 | 1998-09-01 | Arch Development Corporation | Nucleic acid compositions encoding acetyl-coa carboxylase and uses therefor |
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2014
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- 2014-09-12 BR BR112016006859-9A patent/BR112016006859A2/pt not_active Application Discontinuation
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CN113493759A (zh) | 2021-10-12 |
AU2014318531A1 (en) | 2016-03-10 |
EP3255145A1 (en) | 2017-12-13 |
WO2015038970A3 (en) | 2015-07-23 |
EP2964756A2 (en) | 2016-01-13 |
CN105705513A (zh) | 2016-06-22 |
US11142756B2 (en) | 2021-10-12 |
EP2964756B1 (en) | 2017-05-03 |
KR102215530B1 (ko) | 2021-02-15 |
JP6837089B2 (ja) | 2021-03-03 |
MX2016003255A (es) | 2016-06-07 |
MY176277A (en) | 2020-07-27 |
JP6486372B2 (ja) | 2019-03-20 |
ES2631807T3 (es) | 2017-09-05 |
AU2020233672A1 (en) | 2020-10-08 |
MX2020004514A (es) | 2020-08-13 |
EP3739042A1 (en) | 2020-11-18 |
AU2020233672B2 (en) | 2022-04-14 |
WO2015038970A2 (en) | 2015-03-19 |
CA2923730A1 (en) | 2015-03-19 |
US20210009983A1 (en) | 2021-01-14 |
US10604750B2 (en) | 2020-03-31 |
CA2923730C (en) | 2023-03-14 |
KR20160049016A (ko) | 2016-05-04 |
JP2019103507A (ja) | 2019-06-27 |
EP3255145B1 (en) | 2020-07-29 |
US20160230164A1 (en) | 2016-08-11 |
JP2016529917A (ja) | 2016-09-29 |
BR112016006859A2 (pt) | 2018-05-02 |
CN110791482A (zh) | 2020-02-14 |
CN105705513B (zh) | 2021-06-01 |
AU2014318531B2 (en) | 2020-10-08 |
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