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MX371053B - Anticuerpos anti-ige humanizados que reticulan cd23 en los linfocitos b pero no sensibilizan los mastocitos. - Google Patents

Anticuerpos anti-ige humanizados que reticulan cd23 en los linfocitos b pero no sensibilizan los mastocitos.

Info

Publication number
MX371053B
MX371053B MX2016015838A MX2016015838A MX371053B MX 371053 B MX371053 B MX 371053B MX 2016015838 A MX2016015838 A MX 2016015838A MX 2016015838 A MX2016015838 A MX 2016015838A MX 371053 B MX371053 B MX 371053B
Authority
MX
Mexico
Prior art keywords
ige
lymphocytes
mast cells
bound
humanized anti
Prior art date
Application number
MX2016015838A
Other languages
English (en)
Other versions
MX2016015838A (es
Inventor
Chen Jiun-Bo
Chang Tse-Wen
SHIUNG Yu-yu
Original Assignee
Academia Sinica
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Academia Sinica filed Critical Academia Sinica
Publication of MX2016015838A publication Critical patent/MX2016015838A/es
Publication of MX371053B publication Critical patent/MX371053B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C07K16/4283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig
    • C07K16/4291—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig against IgE
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2851—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Otolaryngology (AREA)
  • Transplantation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Se divulga un novedoso anticuerpo anti-IgE humanizado. El anticuerpo es capaz de enlazarse a IgE libre, IgE enlazado a membrana en linfocitos B, IgE enlazado por CD23, pero no a IgE enlazado por un receptor IgE.Fc de alta afinidad en los mastocitos. La presente invención se relaciona con el tratamiento de enfermedades mediadas por IgE, incluyendo asma alérgica, rinitis alérgica, dermatitis atópica, alergia alimentaria, urticaria (idiopática) espontánea crónica, rinosinusitis crónica, mastocitosis sistémica, mastocitosis cutánea, aspergilosis broncopulmonar alérgica, angioedema idiopática recurrente y trastorno gastrointestinal asociado con eosinófilos administrando el anticuerpo anti-IgE de la presente invención.
MX2016015838A 2014-06-17 2015-06-16 Anticuerpos anti-ige humanizados que reticulan cd23 en los linfocitos b pero no sensibilizan los mastocitos. MX371053B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462013196P 2014-06-17 2014-06-17
PCT/US2015/035981 WO2015195631A1 (en) 2014-06-17 2015-06-16 HUMANIZED ANTI-IgE ANTIBODIES THAT CROSSLINK CD23 ON B LYMPHOCYTES BUT DO NOT SENSITIZE MAST CELLS

Publications (2)

Publication Number Publication Date
MX2016015838A MX2016015838A (es) 2017-02-02
MX371053B true MX371053B (es) 2020-01-14

Family

ID=54936031

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016015838A MX371053B (es) 2014-06-17 2015-06-16 Anticuerpos anti-ige humanizados que reticulan cd23 en los linfocitos b pero no sensibilizan los mastocitos.

Country Status (15)

Country Link
US (1) US10047166B2 (es)
EP (1) EP3157951B1 (es)
JP (1) JP6397938B2 (es)
KR (1) KR101892837B1 (es)
CN (1) CN106573972B (es)
AU (1) AU2015277379B2 (es)
CA (1) CA2943588C (es)
DK (1) DK3157951T3 (es)
ES (1) ES2811303T3 (es)
MX (1) MX371053B (es)
NZ (1) NZ723520A (es)
PT (1) PT3157951T (es)
SG (1) SG11201607046VA (es)
TW (1) TWI542598B (es)
WO (1) WO2015195631A1 (es)

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AU2018205484B2 (en) * 2017-01-06 2024-11-21 Sixal, Inc. Therapeutic anti-lgE antibodies and methods and compositions thereof
EP3882274A4 (en) * 2018-09-21 2022-06-29 Riken Anti-ige antibody specifically binding to membrane-bound ige antibody of ige antibody-producing b cells and method for diagnosing and treating allergic symptoms using the same
CN113372450A (zh) * 2020-03-10 2021-09-10 北京万华生物工程有限公司 IgE嵌合性双特异性抗体制备及应用
RU2760825C1 (ru) * 2020-11-30 2021-11-30 Федеральное государственное бюджетное образовательное учреждение дополнительного профессионального образования «Российская медицинская академия непрерывного профессионального образования» Министерства здравоохранения Российской Федерации Способ лечения больных аллергическим ринитом в сочетании с хроническим риносинуситом бактериальной этиологии с использованием отечественного топического иммунокорректора
CN112552403A (zh) * 2020-12-25 2021-03-26 南京英瀚斯生物科技有限公司 一种人源抗人CD23抗体的Fab片段、药物组合物及其应用
CN112646036B (zh) * 2021-01-21 2022-05-31 苏州百道医疗科技有限公司 一种抗cd23特异性单克隆抗体及其应用
KR20240082392A (ko) * 2021-10-12 2024-06-10 유나이티드 바이오파마, 인크. Ige-매개된 질환의 치료

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US5530101A (en) * 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US20030229208A1 (en) * 1988-12-28 2003-12-11 Protein Design Labs, Inc. Humanized immunoglobulins
US6685939B2 (en) * 1991-08-14 2004-02-03 Genentech, Inc. Method of preventing the onset of allergic disorders
US6329509B1 (en) * 1991-08-14 2001-12-11 Genentech, Inc. Anti-IgE antibodies
US6066718A (en) * 1992-09-25 2000-05-23 Novartis Corporation Reshaped monoclonal antibodies against an immunoglobulin isotype
US5958708A (en) * 1992-09-25 1999-09-28 Novartis Corporation Reshaped monoclonal antibodies against an immunoglobulin isotype
US6037453A (en) * 1995-03-15 2000-03-14 Genentech, Inc. Immunoglobulin variants
US5994511A (en) * 1997-07-02 1999-11-30 Genentech, Inc. Anti-IgE antibodies and methods of improving polypeptides
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ATE531812T1 (de) * 1997-12-05 2011-11-15 Scripps Research Inst Humanisierung von nager-antikörpern
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Also Published As

Publication number Publication date
JP6397938B2 (ja) 2018-09-26
KR20160131115A (ko) 2016-11-15
PT3157951T (pt) 2020-08-24
JP2017518320A (ja) 2017-07-06
WO2015195631A1 (en) 2015-12-23
ES2811303T3 (es) 2021-03-11
MX2016015838A (es) 2017-02-02
SG11201607046VA (en) 2016-10-28
KR101892837B1 (ko) 2018-08-28
US10047166B2 (en) 2018-08-14
CA2943588A1 (en) 2015-12-23
AU2015277379B2 (en) 2017-06-29
CN106573972B (zh) 2021-04-06
DK3157951T3 (da) 2020-08-17
TWI542598B (zh) 2016-07-21
AU2015277379A1 (en) 2016-09-08
TW201600528A (zh) 2016-01-01
EP3157951A1 (en) 2017-04-26
EP3157951A4 (en) 2017-12-13
NZ723520A (en) 2018-06-29
CN106573972A (zh) 2017-04-19
US20170121425A1 (en) 2017-05-04
EP3157951B1 (en) 2020-05-13
CA2943588C (en) 2019-04-30

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