MX350145B - Extracto proteolitico a partir de bromelaina para el tratamiento de trastornos del tejido conectivo. - Google Patents
Extracto proteolitico a partir de bromelaina para el tratamiento de trastornos del tejido conectivo.Info
- Publication number
- MX350145B MX350145B MX2014000748A MX2014000748A MX350145B MX 350145 B MX350145 B MX 350145B MX 2014000748 A MX2014000748 A MX 2014000748A MX 2014000748 A MX2014000748 A MX 2014000748A MX 350145 B MX350145 B MX 350145B
- Authority
- MX
- Mexico
- Prior art keywords
- bromelain
- treatment
- connective tissue
- proteolytic extract
- tissue disorders
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/4873—Cysteine endopeptidases (3.4.22), e.g. stem bromelain, papain, ficin, cathepsin H
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- A61K38/1732—Lectins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/22—Cysteine endopeptidases (3.4.22)
- C12Y304/22031—Ananain (3.4.22.31)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/22—Cysteine endopeptidases (3.4.22)
- C12Y304/22032—Stem bromelain (3.4.22.32)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Zoology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Marine Sciences & Fisheries (AREA)
- Alternative & Traditional Medicine (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Endocrinology (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
Abstract
La presente invención se refiere a un extracto proteolítico obtenido a partir de bromelaína para el tratamiento de enfermedades del tejido conectivo; en particular, la presente invención se relaciona con una composición farmacéutica que comprende un extracto proteolitico obtenido a partir de bromelaína para el tratamiento de enfermedades tale como la enfermedad de Dupuytren y enfermedad de Peyronie. El uso de una composición farmacéutica que comprende un extracto proteolítico para la preparación de un medicamento para tratar una enfermedad del tejido conectivo, en donde el extracto proteolítico comprende la proteasa de cisteína del tallo de bromelaína EC3.4.22.32 y ananaína EC 3.4.22.31, y una lectina similar a jabalina, en donde la enfermedad del tejido conectivo está asociada con deposición en exceso de colágeno.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161509612P | 2011-07-20 | 2011-07-20 | |
| PCT/IL2012/050261 WO2013011514A1 (en) | 2011-07-20 | 2012-07-19 | Proteolytic extract from bromelain for the treatment of connective tissue disorders |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2014000748A MX2014000748A (es) | 2014-10-15 |
| MX350145B true MX350145B (es) | 2017-08-28 |
Family
ID=47557739
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2014000748A MX350145B (es) | 2011-07-20 | 2012-07-19 | Extracto proteolitico a partir de bromelaina para el tratamiento de trastornos del tejido conectivo. |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US9511126B2 (es) |
| EP (1) | EP2734216B1 (es) |
| JP (1) | JP6049714B2 (es) |
| KR (1) | KR101921363B1 (es) |
| CN (1) | CN103687607B (es) |
| AU (1) | AU2012285378B2 (es) |
| BR (1) | BR112014001439B1 (es) |
| CA (1) | CA2842291C (es) |
| DK (1) | DK2734216T3 (es) |
| ES (1) | ES2690568T3 (es) |
| HU (1) | HUE039689T2 (es) |
| MX (1) | MX350145B (es) |
| PL (1) | PL2734216T3 (es) |
| PT (1) | PT2734216T (es) |
| RU (1) | RU2625726C2 (es) |
| WO (1) | WO2013011514A1 (es) |
| ZA (1) | ZA201400946B (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20170304411A1 (en) * | 2014-10-24 | 2017-10-26 | Hprd - Health Products Research And Development Lda | Topical formulation for treating skin or mucosal infections, preparation method and uses thereof |
| NZ745240A (en) * | 2016-01-31 | 2022-12-23 | Mediwound Ltd | Debriding composition for treating wounds |
| AU2017252085B2 (en) * | 2016-04-18 | 2021-09-16 | Mediwound Ltd | Methods of debridement of chronic wounds |
| KR101800788B1 (ko) * | 2017-03-31 | 2017-11-27 | 박영오 | 켈로이드 흉터 개선용 화장료 조성물 |
| AU2021293982A1 (en) * | 2020-06-16 | 2023-02-02 | Anatara Lifesciences Limited | Protease composition |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4197291A (en) | 1974-01-08 | 1980-04-08 | Gerold K. V. Klein | Hydrolytic enzyme material |
| GB8724728D0 (en) | 1987-10-22 | 1987-11-25 | Genzyme Corp | Cysteine proteinase |
| DE69019141T2 (de) * | 1989-01-27 | 1996-01-18 | Immunolytics Inc | Zusammensetzung und verfahren für die behandlung gutartiger prostata-hypertrophie. |
| IL103969A (en) | 1991-12-03 | 1997-01-10 | Gerold K V Klein | Proteolytic mixture containing escharase and method of isolating same |
| US5589171A (en) | 1994-08-22 | 1996-12-31 | Advance Biofactures Of Curacao | Treatment of Dupuytren's disease with collagenase |
| US6086872A (en) | 1997-03-27 | 2000-07-11 | Advance Biofactures Of Curacao, Nv | Amelioration of dupuytren's disease |
| US6031005A (en) | 1998-08-03 | 2000-02-29 | Easterling; W. Jerry | Composition and method for treating Peyronie's disease and related connective tissue disorders |
| US6022539A (en) | 1999-06-03 | 2000-02-08 | Advance Biofactures Of Curacao | Amelioration of peyronie's disease |
| WO2002074329A1 (en) * | 2001-03-19 | 2002-09-26 | Ribeiro Santana Cristiano Albe | Pharmaceutical composition applied to the treatment of the peyronie disease and corresponding obtention process |
| US20030026794A1 (en) * | 2001-07-31 | 2003-02-06 | Howard Fein | Selective enzyme treatment of skin conditions |
| AU2003286555A1 (en) | 2002-10-22 | 2004-05-13 | Harbor-Ucla Research And Education Institute | Phosphodiester inhibitors and nitric oxide modulators for treating peyronie's disease, arteriosclerosis and other fibrotic diseases |
| US20060240037A1 (en) * | 2003-06-04 | 2006-10-26 | Edward Fey | Methods and compositions for the treatment and prevention of degenerative joint disorders |
| JP2007519756A (ja) * | 2004-01-30 | 2007-07-19 | アンジオテック インターナショナル アーゲー | 拘縮を治療するための組成物および方法 |
| IL165334A0 (en) * | 2004-11-22 | 2006-01-15 | Mediwound Ltd | Debriding composition from bromelain and methods of producing same |
| ITPD20050207A1 (it) | 2005-07-07 | 2007-01-08 | Fidia Farmaceutici | Nuove composizioni farmaceutiche contenenti acido ialuronico e collagenas nel trattamento topico di ferite, ustioni ed ulcere |
| US7811560B2 (en) | 2006-01-30 | 2010-10-12 | Auxilium Us Holdings, Llc | Compositions and methods for treating collagen-mediated diseases |
| BRPI0801929A2 (pt) * | 2008-05-13 | 2010-01-12 | Santana Cristiano Alberto Ribeiro | processo e composição farmacêutica compreendendo enzimas proteolìticas vegetais em nanopartìculas supramoleculares, para tratamento da doença de peyronie, colagenoses e patologias fibróticas e uso |
-
2012
- 2012-07-19 AU AU2012285378A patent/AU2012285378B2/en not_active Ceased
- 2012-07-19 KR KR1020147001264A patent/KR101921363B1/ko active IP Right Grant
- 2012-07-19 WO PCT/IL2012/050261 patent/WO2013011514A1/en active Application Filing
- 2012-07-19 MX MX2014000748A patent/MX350145B/es active IP Right Grant
- 2012-07-19 US US14/233,082 patent/US9511126B2/en active Active
- 2012-07-19 CN CN201280035497.XA patent/CN103687607B/zh active Active
- 2012-07-19 ES ES12815526.4T patent/ES2690568T3/es active Active
- 2012-07-19 PL PL12815526T patent/PL2734216T3/pl unknown
- 2012-07-19 JP JP2014520790A patent/JP6049714B2/ja active Active
- 2012-07-19 BR BR112014001439-6A patent/BR112014001439B1/pt active IP Right Grant
- 2012-07-19 EP EP12815526.4A patent/EP2734216B1/en active Active
- 2012-07-19 PT PT12815526T patent/PT2734216T/pt unknown
- 2012-07-19 CA CA2842291A patent/CA2842291C/en active Active
- 2012-07-19 HU HUE12815526A patent/HUE039689T2/hu unknown
- 2012-07-19 DK DK12815526.4T patent/DK2734216T3/en active
- 2012-07-19 RU RU2014106299A patent/RU2625726C2/ru active
-
2014
- 2014-02-07 ZA ZA2014/00946A patent/ZA201400946B/en unknown
-
2016
- 2016-11-07 US US15/345,482 patent/US10293033B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| ES2690568T3 (es) | 2018-11-21 |
| ZA201400946B (en) | 2015-11-25 |
| CA2842291C (en) | 2020-09-15 |
| BR112014001439B1 (pt) | 2021-05-25 |
| KR20140079757A (ko) | 2014-06-27 |
| CA2842291A1 (en) | 2013-01-24 |
| US20170049865A1 (en) | 2017-02-23 |
| MX2014000748A (es) | 2014-10-15 |
| PL2734216T3 (pl) | 2018-12-31 |
| EP2734216A4 (en) | 2015-03-11 |
| DK2734216T3 (en) | 2018-11-19 |
| HUE039689T2 (hu) | 2019-01-28 |
| KR101921363B1 (ko) | 2018-11-22 |
| EP2734216A1 (en) | 2014-05-28 |
| US20140154229A1 (en) | 2014-06-05 |
| WO2013011514A1 (en) | 2013-01-24 |
| BR112014001439A2 (pt) | 2017-07-18 |
| CN103687607B (zh) | 2018-01-30 |
| EP2734216B1 (en) | 2018-07-25 |
| RU2625726C2 (ru) | 2017-07-18 |
| AU2012285378B2 (en) | 2017-03-02 |
| JP6049714B2 (ja) | 2016-12-21 |
| AU2012285378A1 (en) | 2014-01-23 |
| US9511126B2 (en) | 2016-12-06 |
| JP2014520881A (ja) | 2014-08-25 |
| US10293033B2 (en) | 2019-05-21 |
| CN103687607A (zh) | 2014-03-26 |
| RU2014106299A (ru) | 2015-08-27 |
| PT2734216T (pt) | 2018-11-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |