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MX347157B - Derivados de acido 3-heteroaroilamino-propionico sustituidos y su uso como sustancias farmaceuticas. - Google Patents

Derivados de acido 3-heteroaroilamino-propionico sustituidos y su uso como sustancias farmaceuticas.

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Publication number
MX347157B
MX347157B MX2014010974A MX2014010974A MX347157B MX 347157 B MX347157 B MX 347157B MX 2014010974 A MX2014010974 A MX 2014010974A MX 2014010974 A MX2014010974 A MX 2014010974A MX 347157 B MX347157 B MX 347157B
Authority
MX
Mexico
Prior art keywords
sup
heteroaroylamino
pharmaceuticals
substituted
diseases
Prior art date
Application number
MX2014010974A
Other languages
English (en)
Inventor
Ruf Sven
Sadowski Thorsten
Schreuder Herman
Buning Christian
Wirth Klaus
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44041622&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX347157(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of MX347157B publication Critical patent/MX347157B/es

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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
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Abstract

La presente invención se refiere a compuestos de fórmula I, (ver Fórmula) en la que A, D, E, L, G, R10, R30, R40, R50 y R60 tienen los significados indicados en las reivindicaciones, que son compuestos farmacéuticos activos valiosos. Son inhibidores de la proteasa catepsina A, y son útiles, por ejemplo, para el tratamiento de enfermedades tales como aterosclerosis, insuficiencia cardiaca, enfermedades renales, enfermedades hepáticas o enfermedades inflamatorias. La invención se refiere además a procedimientos para preparar los compuestos de fórmula I, a su uso y a composiciones farmacéuticas que los comprenden.
MX2014010974A 2011-01-26 2012-01-26 Derivados de acido 3-heteroaroilamino-propionico sustituidos y su uso como sustancias farmaceuticas. MX347157B (es)

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US8669370B2 (en) 2014-03-11
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UY33874A (es) 2012-08-31
US20140135328A1 (en) 2014-05-15
CL2013002129A1 (es) 2013-12-20
WO2012101197A1 (en) 2012-08-02
JP5957467B2 (ja) 2016-07-27
CA2822120A1 (en) 2012-08-02
SI2667870T1 (sl) 2016-12-30
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RU2632897C2 (ru) 2017-10-11
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